1. Association between a functional variant at PTGS2 gene 3'UTR and its mRNA expression in lymphoblastoid cell lines.
- Author
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Wang, Xueting, Zhao, Yunzhao, Wang, Yanru, Wang, Zexing, and Guan, Xiaoxiang
- Subjects
MESSENGER RNA ,GENE expression ,LYMPHOBLASTOID cell lines ,BINDING sites ,CANCER risk factors ,BIOINFORMATICS - Abstract
PTGS2 genetic 3' untranslated region (3'UTR) miRNA binding sites variants are significantly associated with cancer risk; however, the roles of genetic variants in PTGS2 gene 3'UTR and post-transcriptional regulation have not been elucidated. We report that rs689470 and rs5275 in the PTGS2 3'UTR have potential miRNA-binding sites by using bioinformatics analysis. However, only the rs689470 was significantly associated with PTGS2 mRNA expression in lymphoblastoid cell lines (P = 0.026), but not for rs5275 (P = 0.626). rs689470 might be putative variants mediating the post-transcriptional regulation of target PTGS2 gene. Better understanding of how 3'UTR variants regulate PTGS2 activity will pave the way to targeting the PTGS2 pathway in cancer therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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