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Abstract: Magnetic molecularly imprinted polymers (M-MIPs) for bisphenol A (BPA) and its structural analogues have been prepared by a multi-step swelling and polymerization method using uniformly-sized magnetic particles as a shape template. Binding experiments and Scatchard analyses revealed that two classes of binding sites were formed on M-MIPBPA. The retention and molecular-recognition properties of M-MIPs for BPA and its structural analogues were evaluated using a mixture of phosphate buffer and acetonitrile or a mixture of water and acetonitrile as a mobile phase by LC. M-MIPs for BPA and [2H16]BPA (BPA-d16), M-MIPBPA and M-MIPBPA-d16, showed almost the same imprinting factors for BPA, while M-MIP for bisphenol B (2,2-bis(4-hydroxyphenyl)butane, BPB), M-MIPBPB, gave the moderate imprinting factor for BPA. Furthermore, M-MIPBPB was applied for the selective extraction and determination of BPA in environmental water samples. The concentration of BPA in river water samples was determined to be 68ng/L. [Copyright &y& Elsevier]

Abstract: Matrine (MT)- and oxymatrine (OMT)-imprinted monodisperse polymers have been prepared by precipitation polymerization. The prepared molecularly imprinted polymers (MIPs) for MT and OMT, MIPMT and MIPOMT, were monodispersed microspheres of 3.3 and 3.9μm in diameter, respectively. Binding experiments and Scatchard analyses revealed that two classes of binding sites were formed on MIPMT and MIPOMT. In addition to shape recognition, ionic and hydrophobic interactions seemed to affect the retention and recognition of MT and OMT on MIPMT and MIPOMT, respectively, in low acetonitrile content, and ionic and hydrophilic interactions affected these properties in high acetonitrile content. MIPMT was used to selectively extract MT and sophocarpine (13,14-dehydromatrine) from Sophora flavescens root, while MIPOMT was used to extract OMT and oxysophocarpine (13,14-dehydrooxymatrine). [Copyright &y& Elsevier]