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Your search keyword '"Zhao, Lishuang"' showing total 1 results
Start Over Author "Zhao, Lishuang" Topic bioactivity Topic photoinduced electron transfer
1 results on '"Zhao, Lishuang"'

1. Photo-induced synthesis and in vitro biological activity of a Sansalvamide A analog.

Author

Zhao, Lishuang, Zhang, Hongyue, Tan, Guanghui, Wang, Zhiqiang, and Jin, Yingxue

Subjects
*SINGLE electron transfer mechanisms, *PHOTOINDUCED electron transfer, *RING formation (Chemistry), *CHEMICAL processes, *CYCLIC peptides
Abstract

Photoinduced single electron transfer (SET) cyclization processes for synthesis of a Sansalvamide A analog containing double pharmacophores (cyclicpeptides and O-phthalimide moiety) is described to develop novel antitumor cyclopeptide drug. The resultant compound is active in drug-sensitive HeLa, HepG-2 and MCF-7 cell lines. Specifically, the title compound was found to inhibit MCF-7 cells with an IC 50 value of 15 μM (13.4 μg/mL), which may serve as a potential candidate for antitumor drug development. [ABSTRACT FROM AUTHOR]

Published
2017
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