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B-cell receptor (BCR) activation is a pivotal step in the progression of B-cell cancer. BCR signaling requires Bruton's tyrosine kinase (BTK). Ibrutinib (PCI-32765) is a small medication that covalently and permanently inhibits BTK. BTK's defining properties are its high potency and selectivity. The FDA and EMA have authorized ibrutinib for the second-line therapy for Mantle cell lymphoma (MCL) and marginal zone lymphoma (MZL) individuals who have had a minimum of one previous anti-CD20 (cluster of differentiate 20) based drug. It has been authorized by the FDA and the EMA for the management of Wald Enstrom's Patients with macroglobulinemia who have already had therapy or are unsuitable for immunochemotherapy. Ibrutinib nano formulations include nanoparticles composed of chitosan (CS) and sulfobutylether (SBE) ether-b-cyclodextrin that have been packed with the medication ibrutinib. Because of the inclusion of cyclodextrin, Nanoparticles have a high loading efficiency for the hydrophobic drug. Other nano versions of ibrutinib are also available, which improves Ibrutinib bioavailability. In addition, we combined clinical outcomes and side effects induced by ibrutinib in patients from several clinical and preclinical trials in one study. [Display omitted] • In B-cell receptor (BCR) signaling, Bruton's tyrosine kinase (BTK) plays key role. • Ibrutinib (PCI-32765) is a tiny drug that inhibits BTK covalently and irreversibly. • Great potency and great selectivity for BTK is its distinguishing features. • Various nanoformulations, pre-clinical & clinical findings have also been discussed. [ABSTRACT FROM AUTHOR]