Search

Your search keyword '"Basundhara Das"' showing total 1 results
Start Over Author "Basundhara Das" Topic biochemistry
1 results on '"Basundhara Das"'

1. Novel thiophene Chalcones-Coumarin as acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, molecular docking, ADMET prediction and molecular dynamics simulation

Author

Aso Hameed Hasan, Sankaranarayanan Murugesan, Syazwani Itri Amran, Subhash Chander, Mohammed M. Alanazi, Taibi Ben Hadda, Sonam Shakya, Mohammad Rizki Fadhil Pratama, Basundhara Das, Subhrajit Biswas, and Joazaizulfazli Jamalis

Subjects
Models, Molecular, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Thiophenes, Biochemistry, Structure-Activity Relationship, Chalcone, Alzheimer Disease, Coumarins, Drug Design, Drug Discovery, Acetylcholinesterase, Humans, Cholinesterase Inhibitors, Molecular Biology, Cells, Cultured
Abstract

A series of around eight novel chalcone based coumarin derivatives (23a-h) was designed, subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass analytical techniques and evaluated as acetylcholinesterase (AChE) inhibitor for the treatment of Alzheimer's disease (AD). The results of predicted ADMET study demonstrated the drug-likeness properties of the titled compounds with developmental challenges in lipophilicity and solubility parameters. The in vitro assessment of the synthesized compounds revealed that all of them showed significant activity (IC

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results