1. Steroids CCXXVIII. The synthesis of equilin
- Author
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J. A. Zderic, Bowers Albert, Humberto Carpio, and Carl Djerassi
- Subjects
Pharmacology ,Corynebacterium simplex ,Stereochemistry ,Organic Chemistry ,Clinical Biochemistry ,Female sex ,Biology ,Biochemistry ,Equilin ,Endocrinology ,medicine ,Organic chemistry ,Dehydrogenation ,Molecular Biology ,medicine.drug - Abstract
The conversion of 19-nortestosterone acetate into 19-norandrosta-4,7-diene-3,17-dione (X) is described. The latter compound is transformed directly into equilin by a microbiological dehydrogenation process with Corynebacterium simplex , thus representing the first synthesis of this important female sex hormone. Alternate attempts to synthesise equilin are discussed.
- Published
- 1963
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