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Your search keyword '"Pedatella, S."' showing total 3 results
Start Over Author "Pedatella, S." Topic biochemistry
3 results on '"Pedatella, S."'

1. A new approach to the synthesis of enantiomerically pure 4-deoxy sugars

Author

Romualdo Caputo, Annalisa Guaragna, Giovanni Palumbo, Silvana Pedatella, Francesco Solla, R., Caputo, A., Guaragna, G., Palumbo, Pedatella, Silvana, F., Solla, Caputo, Romualdo, Guaragna, A., Palumbo, Giovanni, Pedatella, S., Solla, F., Guaragna, Annalisa, Silvana, Pedatella, and Francesco, Solla

Subjects
chemistry.chemical_classification, Primary (chemistry), Double bond, Stereochemistry, hexoses, Organic Chemistry, Allylic alcohol, Biochemistry, Aldehyde, chemistry, Electrophile, monosaccharide, Moiety, Cis–trans isomerism
Abstract

In a recent paper2 we have reported the design and synthesis of 3-C-lithiated 5,6-dihydro-1,4-dithiin-2-yl[(4-methoxybenzyl)oxy]methane (1) which can be utilized as an allylic alcohol anion equivalent and leads to three-carbon elongations of various electrophiles by introduction of a fully protected hydroxypropenyl moiety. The latter contains a double bond, which can be unravelled to the cis configuration by diastereoselective removal3 of the dimethylene-disulfur bridge, as well as a protected primary hydroxyl group that, depending on the deprotection conditions used (DDQ/NaBH4 or DDQ), may either lead to the free allylic alcohol or to an α,β-unsaturated aldehyde.

Published
2000

2. A Versatile Synthesis of Enantiomerically Pure D- and L-Pyranosyl Nucleoside Analogues

Author

Romualdo Caputo, Annalisa Guaragna, Silvana Pedatella, Giovanni Palumbo, Caputo, Romualdo, Guaragna, A., Palumbo, G., Pedatella, S., Romualdo, Caputo, Guaragna, Annalisa, Palumbo, Giovanni, Silvana, Pedatella, R., Caputo, A., Guaragna, G., Palumbo, and Pedatella, Silvana

Subjects
Nucleoside analogues, Chemistry, Reagent, Genetics, chemistry.chemical_element, Biochemistry, Combinatorial chemistry, Carbon, Modified nucleosides, Nucleoside
Abstract

2-[[O-(p-Methoxybenzyl)-oxy]methyl]-5,6-dihydro-1,4-dithiin 1 is a versatile three carbon homologation reagent which has been conveniently used in the synthesis of enantiomerically pure modified nucleosides.

Published
1999
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3. A new three carbon homologation via sulfur containing heterocyclic systems

Author

Giovanni Palumbo, Annalisa Guaragna, Silvana Pedatella, Romualdo Caputo, Caputo, Romualdo, Guaragna, A., Palumbo, G., Pedatella, S., Romualdo, Caputo, Guaragna, Annalisa, Palumbo, Giovanni, and Silvana, Pedatella

Subjects
chemistry.chemical_classification, Propenyl, Allylic rearrangement, Double bond, Organic Chemistry, Acrolein, Biochemistry, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Reagent, Electrophile, Organic chemistry, Molecule, Moiety
Abstract

A new reagent, based on a 5,6-dihydro-1,4-dithiin heterocyclic system1, has been devised and conveniently used for 3 carbon elongations of various electrophiles. In fact, it acts as either a propenyl alcohol or an acrolein anion equivalent, introducing into the new molecule a moiety consisting of fully protected double bond and allylic oxygen.

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