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Your search keyword '"Siracusa, Maria Angela"' showing total 2 results
Start Over Author "Siracusa, Maria Angela" Topic biochemistry
2 results on '"Siracusa, Maria Angela"'

1. New pyrimido[5,4-b]indoles and [1]benzothieno[3,2-d]pyrimidines: High affinity ligands for the α1-adrenoceptor subtypes

Author

Romeo, Giuseppe, Materia, Luisa, Marucci, Gabriella, Modica, Maria, Pittalà, Valeria, Salerno, Loredana, Siracusa, Maria Angela, Buccioni, Michela, Angeli, Piero, and Minneman, Kenneth P.

Subjects
*PTERIDINES, *LIGANDS (Biochemistry), *ADRENERGIC receptors, *BIOCHEMISTRY
Abstract

Abstract: A number of new pyrimido[5,4-b]indole and [1]benzothieno[3,2-d]pyrimidine derivatives were synthesized and evaluated for their binding and functional properties at α1-adrenergic receptor (α1-AR) subtypes. They behaved as potent α1-AR antagonists. In binding experiments, some of them (RC24 and RC23) showed very high affinity for the α1D-AR subtype. [Copyright &y& Elsevier]

Published
2006
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2. 3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective α1-adrenoceptor ligands

Author

Pittalà, Valeria, Romeo, Giuseppe, Salerno, Loredana, Siracusa, Maria Angela, Modica, Maria, Materia, Luisa, Mereghetti, Ilario, Cagnotto, Alfredo, Mennini, Tiziana, Marucci, Gabriella, Angeli, Piero, and Russo, Filippo

Subjects
*LIGANDS (Biochemistry), *BIOCHEMISTRY, *PHARMACEUTICAL chemistry, *CHEMISTRY
Abstract

Abstract: The discovery of a new series of selective and high-affinity α1-adrenoceptor (α1-AR) ligands, characterized by a 1H-pyrrolo[2,3-d]-pyrimidine-2,4(3H,7H)-dione system, is described in this paper. Some synthesized compounds, including 20, 22, and 30, displayed affinity in the nanomolar range for α1-ARs and substantial selectivity with respect to 5-HT1A and dopaminergic D1 and D2 receptors. Functional assays, performed on selected derivatives, showed antagonistic properties. [Copyright &y& Elsevier]

Published
2006
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