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Start Over Author "Yannik Brack" Topic biochemistry
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1. Discovery of Novel Tyrosine Ammonia Lyases for the Enzymatic Synthesis of p-Coumaric Acid

Author

Chenghai Sun, Uwe Bornscheuer, Yannik Brack, and Dong Yi

Subjects
Ammonia-Lyases, Coumaric Acids, Organic Chemistry, Escherichia coli, Molecular Medicine, Tyrosine, Molecular Biology, Biochemistry, Phylogeny, Phenylalanine Ammonia-Lyase
Abstract

p-Coumaric acid (p-CA) is a key precursor for the biosynthesis of flavonoids. Tyrosine ammonia lyases (TALs) specifically catalyze the synthesis of p-CA from l-tyrosine, which is a convenient enzymatic pathway. To explore novel and highly active TALs, a phylogenetic tree-building approach was conducted including 875 putative TALs and 46 putative phenylalanine/tyrosine ammonia lyases (PTALs). Among them, 5 TALs and 3 PTALs were successfully characterized and found to exhibit the proposed enzymatic activity. The TAL from Chryseobacterium luteum sp. nov (TAL

Published
2022

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