1. Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium
- Author
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Zhiqiang Sha, Daan van Rooij, Evdokia Anagnostou, Celso Arango, Guillaume Auzias, Marlene Behrmann, Boris Bernhardt, Sven Bolte, Geraldo F. Busatto, Sara Calderoni, Rosa Calvo, Eileen Daly, Christine Deruelle, Meiyu Duan, Fabio Luis Souza Duran, Sarah Durston, Christine Ecker, Stefan Ehrlich, Damien Fair, Jennifer Fedor, Jacqueline Fitzgerald, Dorothea L. Floris, Barbara Franke, Christine M. Freitag, Louise Gallagher, David C. Glahn, Shlomi Haar, Liesbeth Hoekstra, Neda Jahanshad, Maria Jalbrzikowski, Joost Janssen, Joseph A. King, Luisa Lazaro, Beatriz Luna, Jane McGrath, Sarah E. Medland, Filippo Muratori, Declan G. M. Murphy, Janina Neufeld, Kirsten O’Hearn, Bob Oranje, Mara Parellada, Jose C. Pariente, Merel C. Postema, Karl Lundin Remnelius, Alessandra Retico, Pedro Gomes Penteado Rosa, Katya Rubia, Devon Shook, Kristiina Tammimies, Margot J. Taylor, Michela Tosetti, Gregory L. Wallace, Fengfeng Zhou, Paul M. Thompson, Simon E. Fisher, Jan K. Buitelaar, Clyde Francks, Donders Center for Cognitive Neuroimaging, Donders Centre for Cognitive Neuroimaging, Radboud University [Nijmegen]-Radboud University [Nijmegen], Holland Bloorview Kids Rehabilitation Hospital [Toronto, ON, Canada], University of Toronto, Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Karolinska Institutet [Stockholm], Stockholm Health Care Services (SLSO), Curtin University [Perth], Planning and Transport Research Centre (PATREC), Universidade de São Paulo = University of São Paulo (USP), University of Pisa - Università di Pisa, Department of Child and Adolescent Psychiatry and Psychology, Centro de Investigación Biomédica en Red de Salut Mental (CIBER-SAM Network), Hospital Clinic Barcelona, King‘s College London, University Medical Center [Utrecht], Goethe-Universität Frankfurt am Main, MetaGenoPolis (MGP (US 1367)), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Oregon Health and Science University [Portland] (OHSU), McConnell Brain Imaging Centre (MNI), Montreal Neurological Institute and Hospital, and McGill University = Université McGill [Montréal, Canada]-McGill University = Université McGill [Montréal, Canada]
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Neuroinformatics ,Biochemistry & Molecular Biology ,Autism Spectrum Disorder ,[SDV]Life Sciences [q-bio] ,CHILDREN ,ORGANIZATION ,ACTIVATION ,Cellular and Molecular Neuroscience ,CONNECTIVITY ,130 000 Cognitive Neurology & Memory ,CEREBRAL-CORTEX ,Neural Pathways ,Humans ,HETEROGENEITY ,Molecular Biology ,11 Medical and Health Sciences ,Psychiatry ,Cerebral Cortex ,Brain Mapping ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,Science & Technology ,LANGUAGE LATERALIZATION ,Neurosciences ,Brain ,06 Biological Sciences ,Magnetic Resonance Imaging ,17 Psychology and Cognitive Sciences ,Psychiatry and Mental health ,INDIVIDUALS ,MORPHOMETRY ,Neurosciences & Neurology ,Life Sciences & Biomedicine ,CORTICAL THICKNESS - Abstract
Contains fulltext : 251394.pdf (Publisher’s version ) (Open Access) Small average differences in the left-right asymmetry of cerebral cortical thickness have been reported in individuals with autism spectrum disorder (ASD) compared to typically developing controls, affecting widespread cortical regions. The possible impacts of these regional alterations in terms of structural network effects have not previously been characterized. Inter-regional morphological covariance analysis can capture network connectivity between different cortical areas at the macroscale level. Here, we used cortical thickness data from 1455 individuals with ASD and 1560 controls, across 43 independent datasets of the ENIGMA consortium's ASD Working Group, to assess hemispheric asymmetries of intra-individual structural covariance networks, using graph theory-based topological metrics. Compared with typical features of small-world architecture in controls, the ASD sample showed significantly altered average asymmetry of networks involving the fusiform, rostral middle frontal, and medial orbitofrontal cortex, involving higher randomization of the corresponding right-hemispheric networks in ASD. A network involving the superior frontal cortex showed decreased right-hemisphere randomization. Based on comparisons with meta-analyzed functional neuroimaging data, the altered connectivity asymmetry particularly affected networks that subserve executive functions, language-related and sensorimotor processes. These findings provide a network-level characterization of altered left-right brain asymmetry in ASD, based on a large combined sample. Altered asymmetrical brain development in ASD may be partly propagated among spatially distant regions through structural connectivity.
- Published
- 2022