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This report describes a 6-month screening study comparing the tissue responses of several bioglass natural tooth implants in adult female baboons. The dental implants were designed to elicit osteogenesis at the interface of the implant and the oral tissues. This is in contrast to those types of implant materials that are merely biologically acceptable. Incisor teeth were extracted, dupplicated in bioglass, returned to the natural sockets, and splinted to the adjacent natural tooth, where they remained splinted for 3 months and then free standing for an additional 3 months. Microscopic evaluation revealed distinct histopathologic characteristics with certain bioglass formulas, such as ankylosis, a pseudofibrous capsule with fibers running parallel to the root surface, or an apparently true periodontal membrane with properly oriented Sharpey's fibers. True cementogenesis was not found.