1. One-step fabrication of functionalized poly(etheretherketone) surfaces with enhanced biocompatibility and osteogenic activity.
- Author
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Liu, Sidi, Zhu, Yuting, Gao, Hainan, Ge, Peng, Ren, Keli, Gao, Jingwei, Cao, Yupeng, Han, Dong, and Zhang, Junhu
- Subjects
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BIOCOMPATIBILITY , *BONE morphogenetic proteins , *SURFACE chemistry , *ULTRAVIOLET radiation , *ADHESION - Abstract
Polyetheretherketone (PEEK) has an elastic modulus similar to that of the bone; however, its use as a material for bone repair is limited by bio-inert surface chemistry and poor osteogenesis-inducing capacity. To address this issue, the PEEK surface was activated by ultraviolet radiation-induced grafting of methacrylated hyaluronic acid (MeHA) and titanium dioxide (TiO 2 ) nanofibers via a one-step process. The modified PEEK surface was characterized by X-ray photoelectron and Fourier-transform infrared spectroscopy, and the extent of surface modification was evaluated by measuring static contact angles. Atomic force microscopy revealed that the PEEK surface grafted with electrospun TiO 2 had abundant nanofibers and a roughness that was comparable to that of human cortical bone. In vitro experiment, rat bone mesenchymal stem cells showed increased adhesion, proliferation, and osteogenic differentiation capacity on TiO 2 -modified as compared to unmodified PEEK. Thus, PEEK that is surface-modified with electrospun TiO 2 and MeHA has enhanced biocompatibility and can be an effective material for use in orthopedic implants and medical devices. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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