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The enzymogel nanoparticle made of a magnetic core and polymer brush shell demonstrates a novel type of remote controlled phase-boundary biocatalysis that involves remotely directed binding to and engulfing insoluble substrates, high mobility, and stability of the catalytic centers. The mobile enzymes reside in the polymer brush scaffold and shuttle between the enzymogel interior and surface of the engulfed substrate in the bioconversion process. Biocatalytic activity of the mobile enzymes is preserved in the enzymogel while the brush-like architecture favors the efficient interfacial interaction when the enzymogel spreads over the substrate and extends substantially the reaction area as compared with rigid particles. [ABSTRACT FROM AUTHOR]

An enzymogel that shows a novel type of phase‐boundary biocatalysis is described by S. Minko, A. Voronov, et al. in their Communication on page 483 ff. The enzymogel particles combine biocatalysis involving enzymes in the particle, stimuli‐triggered extracapsular biocatalysis, biocatalytic conversion of substrates contacting the enzymogel when the enzymes engulf the substrate, and stimuli‐triggered reattachment of the released enzymes for their reuse (cover image courtesy of Ella Marushchenko). [ABSTRACT FROM AUTHOR]