1. Novel strategies in nephrology: what to expect from the future?
- Author
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Copur, Sidar, Tanriover, Cem, Yavuz, Furkan, Soler, Maria, Ortiz, Alberto, Covic, Adrian, Kanbay, Mehmet, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Copur S, Tanriover C, Yavuz F] Department of Medicine, Koc University School of Medicine, Istanbul, Turkey. [Soler MJ] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Grup de Recerca de Nefrologia i Trasplantament Renal, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Ortiz A] Department of Medicine, Universidad Autonoma de Madrid and IIS-Fundacion Jimenez Diaz, Madrid, Spain. [Covic A] Nephrology Clinic, Dialysis and Renal Transplant Center, ‘C.I. PARHON’ University Hospital, and ‘Grigore T. Popa’ University of Medicine, Iasi, Romania. [Kanbay M] Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey, and Vall d'Hebron Barcelona Hospital Campus
- Subjects
terapéutica::tratamiento de reemplazo renal [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Induced pluripotent stem cells ,Transplantation ,Nephrology ,Artificial kidney ,Chronic kidney disease ,Ronyons - Trasplantació ,enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::insuficiencia renal::insuficiencia renal crónica [ENFERMEDADES] ,Bioengineering ,Xenotransplantation ,Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Renal Insufficiency, Chronic [DISEASES] ,Therapeutics::Renal Replacement Therapy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Insuficiència renal crònica - Tractament - Abstract
Artificial kidney; Chronic kidney disease; Xenotransplantation Ronyó artificial; Malaltia renal crònica; Xenotrasplantament Riñón artificial; Enfermedad renal crónica; Xenotrasplante Chronic kidney disease (CKD) will become the fifth global case of death by 2040. Its largest impact is on premature mortality but the number of persons with kidney failure requiring renal replacement therapy (RRT) is also increasing dramatically. Current RRT is suboptimal due to the shortage of kidney donors and dismal outcomes associated with both hemodialysis and peritoneal dialysis. Kidney care needs a revolution. In this review, we provide an update on emerging knowledge and technologies that will allow an earlier diagnosis of CKD, addressing the current so-called blind spot (e.g. imaging and biomarkers), and improve renal replacement therapies (wearable artificial kidneys, xenotransplantation, stem cell-derived therapies, bioengineered and bio-artificial kidneys). Research by A.O. is supported by IS/Fondos FEDER (PI18/01 366, PI19/00 588, PI19/00 815, DTS18/00 032, ERA-PerMed-JTC2018 (KIDNEY ATTACK AC18/00 064) and PERSTIGAN AC18/00 071, ISCIII-RETIC REDinREN RD016/0009), Sociedad Española de Nefrología, FRIAT, Comunidad de Madrid en Biomedicina B2017/BMD-3686 CIFRA2-CM, Instituto de Salud Carlos III (ISCIII) RICORS program to RICORS2040 (RD21/0005/0001) and SPACKDc PMP21/00 109, FEDER funds. RD16/0009.
- Published
- 2023