Search

A recent report from the University of North Texas discusses the challenges in developing treatments for Idiopathic Pulmonary Fibrosis (IPF), a fatal lung disorder. The lack of effective therapies for IPF is attributed to a limited understanding of the disease's progression. The report highlights the importance of advanced 3D lung models, such as lung-on-a-chip systems, in replicating the microenvironments crucial for studying IPF and developing new treatments. Researchers aim to advance the understanding of IPF and create novel devices to assess the effectiveness of potential treatments. [Extracted from the article]

A recent preprint abstract discusses the development of a lung-on-a-chip model for studying Mycobacterium fortuitum lung infection. The model incorporates primary human cells, such as pulmonary vascular endothelial cells, alveolar cells, and monocyte-derived macrophages, to mimic the human alveolar microenvironment. The researchers found that M. fortuitum primarily infected macrophages in the model, with few bacteria inside alveolar cells. They also observed upregulation of transcripts for cytokines, chemokines, and secreted protease inhibitors in infected chips. The authors suggest that this humanized lung-on-a-chip system could be used to study other non-tuberculous mycobacteria and for antibiotic research. [Extracted from the article]

A patent application titled "Apparatus And Method For A Biomimetic Human Alveolar Lung-On-A-Chip Model" has been published online. The inventor, Yu Shrike Zhang, highlights the need for reliable and physiologically relevant models for studying human respiratory diseases. The patent application describes a lung model called the "alveolar lung-on-a-chip," which mimics the structure and physiology of the human lung's alveoli. The model includes a 3D porous hydrogel made of gelatin methacryloyl (GelMA) and a compartmentalized polydimethylsiloxane (PDMS) chip device that provides the necessary medium supply, air-liquid interface, and mechanical movements. This model aims to improve drug development in respiratory medicine by providing a more accurate representation of the human lung. [Extracted from the article]

A recent report from Xiamen University in China discusses the development of a lung-on-a-chip model that mimics the structure and mechanical stimulation of the human lung. The researchers used a composite membrane made of styrene-butadiene-styrene (SBS) nanofibers and porous polydimethylsiloxane (PDMS) to create an alveolar air-blood barrier. The chip was able to replicate the multi-layered structure of the air-blood barrier and could be used for various applications such as drug screening and customized medicine. This research has been peer-reviewed and provides a potential platform for creating in vitro alveolar physiological models. [Extracted from the article]

Researchers at Seoul National University have conducted a study on lung-on-a-chip technology, which combines organ-on-a-chip technology with the air-liquid interface (ALI) culture method. This new platform aims to mimic the microenvironment and physiological motions of the human lungs, allowing for the study of respiratory diseases and airway dysfunction. The chip system integrates lung epithelial cells, extracellular matrix, and microstructures, providing a realistic environment for studying pulmonary diseases such as infections, inflammation, fibrosis, and malignancy. This research highlights the potential of lung-on-a-chip technology in revolutionizing respiratory health research. [Extracted from the article]

A study conducted by researchers at the Sichuan Cancer Hospital and Institute focuses on the development and application of lung-on-a-chip technology for lung cancer. Lung cancer is a highly prevalent and deadly disease, and the lack of efficient models for evaluating drug response hinders effective therapy strategies. The lung-on-a-chip platform, which mimics the microenvironment of the lungs, shows promise in clinical drug research by enhancing therapeutic effectiveness and minimizing side effects. The combination of this technology with nanomedicine may provide a reliable treatment for preclinical evaluation. [Extracted from the article]

Researchers from Southern Medical University in Shenzhen, China have published a review on the use of lung-on-a-chip technology for lung cancer research and drug evaluation. Lung cancer is a leading cause of cancer-related deaths due to its high recurrence rate, ability to metastasize easily, and development of drug resistance. The review highlights the advancements in three-dimensional (3D) culture systems such as lung organoids and lung-on-a-chip models, which can simulate the pathological and physiological microenvironment of the lung. These models have the potential to revolutionize lung cancer research and personalized treatment strategies. [Extracted from the article]

Keywords for this news article include: Irvine, California, United States, North and Central America, Bioengineering, Biomedical Engineering, Biomedicine, Biophysics, Biotechnology, Health and Medicine, Lung-on-a-Chip, Respiratory Tract Diseases and Conditions, Technology, Tissue Engineering, University of California Irvine. Keywords: Irvine; State:California; United States; North and Central America; Bioengineering; Biomedical Engineering; Biomedicine; Biophysics; Biotechnology; Health and Medicine; Lung-on-a-Chip; Respiratory Tract Diseases and Conditions; Technology; Tissue Engineering EN Irvine State:California United States North and Central America Bioengineering Biomedical Engineering Biomedicine Biophysics Biotechnology Health and Medicine Lung-on-a-Chip Respiratory Tract Diseases and Conditions Technology Tissue Engineering 301 301 1 07/17/23 20230720 NES 230720 2023 JUL 20 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- Investigators publish new report on Biotechnology - Lung-on-a-Chip. [Extracted from the article]

The hydrogel or hydrogel membrane may be seeded with cells by delivering a cell-containing liquid to the fluidic channel, optionally while contacting the hydrogel with media provided in a media reservoir residing above the hydrogel layer. A method of forming a hydrogel in-situ within a fluidic device, the method comprising: providing the fluidic device according to claim 1; dispensing a hydrogel precursor solution such that the hydrogel precursor solution contacts said base surface and said geometrical hydrogel retention structure, and such that the hydrogel precursor solution extends across the aperture without flowing into the fluidic channel; and hardening the hydrogel precursor solution to form the hydrogel in-situ within the hydrogel chamber, such that the hydrogel contacts, at least in part, the geometrical hydrogel retention structure. The fluidic device according to claim 1 wherein said hydrogel chamber and said aperture are configured such that when a hydrogel precursor solution is dispensed such that the hydrogel precursor solution contacts said base surface, the hydrogel precursor solution extends across said aperture without flowing into said fluidic channel, thereby facilitating in-situ formation of the hydrogel within said hydrogel chamber. The method according to claim 18 further comprising: extracting the hydrogel membrane from the hydrogel chamber, thereby obtaining an extracted hydrogel membrane; and performing one or more analytical procedures to characterize the cells of the extracted hydrogel. [Extracted from the article]