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The effects of the new structural analogue of benactyzine, a derivative of fluorencarbonic acid, on monoamine levels in brain structures were studied in male Wistar rats with experimental depression. Depressive state in rats was modeled by single injection of reserpine (4 mg/kg). The concentrations of norepinephrine (NE), dopamine (DA), serotonin (5-HT), and their metabolites 3,4-dihydroxyphenylacetic acid (DOPAC), homovanilic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) in the hypothalamus and striatum were measured by HPLC. It was found that preliminary treatment (30 days) with the derivative of fluorencarbonic acid prevented a decrease in monoamine level in the hypothalamus (NE, 5-HT, and 5-HIAA) and striatum (DA, 5-HT, and 5-HIAA). The neurochemical shifts (correction of 5-HT deficiency and stabilization of DA and NE levels) correlated with the high antidepressant activity of this agent observed in Porsolt forced swimming test.

It was found that 3 hours after electrostimulation of the immobilized rats there was observed in addition to destructive lesions in the gastric mucosa a significant decrease of noradrenaline, dopamine, DOPA, homovanillic acid and creatine phosphate levels in the brain tissue involving the hypothalamus and the midbrain surrounding it. The use before the extreme impact of neurotropic agents blocking transmission of the damaging impulses from the site of stimulation of reflexogenic zones through the central adrenergic synapses which activate genome in the nerve cell or prevent depletion of catecholamine stores and disturbance of energy formation processes in the brain tissue protects against the development of neurogenic damage of the stomach.