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Start Over Author "Sun, Zeyu" Topic bioinformatics Topic proteomics
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1. Phosphoproteomics and molecular cardiology: Techniques, applications and challenges

Author

Sun, Zeyu, Hamilton, Karyn L., and Reardon, Kenneth F.

Subjects
*MOLECULAR cardiology, *PROTEOMICS, *PHOSPHORYLATION, *HEART diseases, *MASS spectrometry, *BIOINFORMATICS
Abstract

Abstract: Protein phosphorylation has been widely documented as a key regulatory and signaling mechanism associated with many cardiac diseases. Recent advances in phosphoproteomic technologies such as phosphopeptide enrichment, novel mass spectrometry applications, and bioinformatic tools have resulted in high-throughput identification and quantitation of protein phosphorylation in a global manner. This review summarizes mainstream phosphoproteomic workflows and highlights the most recent applications of phosphoproteomics used in a range of molecular cardiology research. [Copyright &y& Elsevier]

Published
2012
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