1. Effects of TSP-1 -696 C/T polymorphism on bladder cancer susceptibility and clinicopathologic features.
- Author
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Gu, Jinbao, Tao, Jun, Yang, Xiao, Li, Pengchao, Yang, Xuejian, Qin, Chao, Cao, Qiang, Cai, Hongzhou, Zhang, Zhengdong, Wang, Meilin, Gu, Min, Lu, Qiang, and Yin, Changjun
- Subjects
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THROMBOSPONDIN-1 , *GENETIC polymorphisms , *CYTOSINE , *BLADDER cancer , *DISEASE susceptibility , *GLYCOPROTEINS , *BIOLOGICAL assay - Abstract
Thrombospondin-1 (TSP-1) is a glycoprotein that plays a major role in bladder cancer. We investigated the relationship between the distribution of the TSP-1 -696 C/T polymorphism (rs2664139) and the clinical features of bladder cancer. TaqMan assay was used to determine the genotype among the 609 cases and 670 controls in a Chinese population. Logistic regression was used to assess the association between the polymorphism and bladder cancer risk. Compared with the CT/TT genotypes, the CC genotype was associated with a significantly increased risk of bladder cancer (adjusted odds ratio [OR] 1.43, 95% CI 1.01–2.04), which was more prominent among the male participants (OR 1.82, 95% CI 1.20–2.76). The polymorphism was associated with a higher risk of developing grade 3 (OR 1.84, 95% CI 1.00–3.36), multiple-tumor (OR 1.81, 95% CI 1.08–3.02), and large-tumor (OR 1.94, 95% CI 1.22–3.10) bladder cancers. These observations suggest that the TSP-1 -696 C/T polymorphism may contribute to bladder cancer susceptibility in the Chinese population. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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