1. First structural insights into the TpsB/Omp85 superfamily.
- Author
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Jacob-Dubuisson, Francoise, Villeret, Vincent, Clantin, Bernard, Delattre, Anne-Sophie, and Saint, Nathalie
- Subjects
PROTEINS ,BIOLOGICAL membranes ,GRAM-negative bacteria ,EUKARYOTIC cells ,CHLOROPLASTS ,MITOCHONDRIA - Abstract
Proteins of the TpsB/Omp85 superfamily are involved in protein transport across, or assembly into, the outer membrane of Gram-negative bacteria, and their distant eukaryotic relatives exert similar functions in chloroplasts and mitochondria. The X-ray structure of one TpsB transporter, FhaC, provides the bases to decipher the mechanisms of action of these proteins. With two POTRA domains in the periplasm, a transmembrane β barrel and a large loop harboring a functionally important motif, FhaC epitomizes the conserved features of the super-family. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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