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Goat farming is a promising branch of animal husbandry, as statistics show a rapid increase in global demand for goat milk and meat products. To meet market demand, new methodological approaches are needed to improve animal productivity while maintaining the quality of the raw materials. In this context, this study aims to determine the impact of autonomic nervous system tone on lipid metabolism in goats. The study involved Saanen goats, with the experimental groups formed based on the results of variation-pulsometric study and electrocardiography, followed by the determination of autonomic nervous system tone using the Baevsky method. The serum lipid profile of goats was studied using a LabLine-010 spectrophotometer. The following indicators were biochemically analysed in serum samples: content of triacylglycerols, cholesterol, high-density, low-density, and very-low-density lipoproteins, and the atherogenic index was calculated. It was established that the content of triacylglycerols was 23% lower (P < 0.05) in sympathotonic animals and 41% lower (P < 0.001) in vagotonic animals compared to normotonic animals. The level of lowdensity lipoproteins in the blood serum of sympathotonic animals decreased by 40% (P < 0.05), and in vagotonic animals - by 76% (P < 0.01), relative to normotonic animals. The content of highdensity lipoproteins in sympathotonic animals increased by 36% (P < 0.001), relative to normotonic animals. The level of cholesterol in the blood serum of goats differed by 16% (P < 0.01) in sympathotonic animals and 15% (P < 0.01) in vagotonic animals compared to normotonic animals. A significant influence of autonomic nervous system tone on the processes of maintaining lipid homeostasis in goats was determined. Taking into account the individual features of the influence of the autonomic nervous system on lipid metabolism when distributing animals will contribute to the effective adjustment of diets. After all, each animal has a different tone of the autonomic nervous system, which significantly affects the features of substance transformation in its body. [ABSTRACT FROM AUTHOR]

The relevance of the study subject is due to the need to create effective methods for preventing the poisoning of animals with heavy metals because lead and cadmium are among the environmental pollutants that negatively affect agriculture and are potentially dangerous to animal and human health. The purpose of the study was to establish the effect of the feed additive Butaselmevit-Plus on the antioxidant protection of the rat body under the chronic action of cadmium and lead. Experimental studies were performed on 2 groups of male rats, 6 animals each. In the control and experimental groups, rats were given a 16.6% aqueous solution of lead acetate at a dose of 100 mg/kg (0.6 ml/kg) of body weight and 0.029% aqueous solution of cadmium chloride at a dose of 2.0 mg/kg (6.9 ml/kg) of body weight. In the experimental group, the rats were additionally provided with food containing the feed additive Butaselmevit-Plus in the amount of 0.1 g per 100 g of body weight. Experimental lead-cadmium toxicosis in the blood serum of rats demonstrated a substantial decrease in the indicators of the antioxidant protection system (reduced glutathione - by 38.4%, superoxide dismutase - by 27.6%, catalase - by 22.7%). On the fourteenth day of the experiment, the lowest activity of the antioxidant protection system indicators in the blood of control rats was observed with the combined administration of heavy metals. Under the experimental load of lead and cadmium, the feed additive Butaselmevit-Plus demonstrated antioxidant properties, which is due to its chemical composition (milk thistle, selenium, methionine, and vitamins). The introduction of the feed additive Butaselmevit-Plus to the rats of the experimental group contributed to an increase in the activity of superoxide dismutase and catalase in the blood serum by 22.7 and 20.7%, respectively. When providing this feed additive to rats of the experimental group, an increase in the level of reduced glutathione was also identified, which reached its maximum value on the 28th day of the experiment. Thus, the results of the study confirm the effectiveness of using the supplement Butaselmevit-Plus to improve the antioxidant status of animals in conditions of chronic intoxication of the rat body with lead and cadmium. The practical value of the results obtained is to substantiate the feasibility of using the feed additive Butaselmevit-Plus in animal husbandry to prevent the negative impact of heavy metals on the animal body [ABSTRACT FROM AUTHOR]