Integrated fixed film activated sludge-oxic settling anoxic system (IFAS-OSA) is a new, modified system for excess-sludge reduction. In this research, the efficiency of the IFAS-OSA system in biological excess-sludge reduction with the addition of an anoxic sludge-holding tank to the return line of the system was studied. The results showed that the average oxidation reduction potentials (ORPs) in the IFASAerobic , IFASRAS , IFAS-OSA2 h , and IFAS-OSA4 h processes were +80±15 , −62±22,–102±8 , and −140±13 mV , respectively. The average values of Yobs in the IFAS, IFAS-OSA2 h , and IFAS-OSA4 h processes were 0.43±0.01 , 0.31±0.02 , and 0.23±0.01 g MLSS/g COD, respectively. Accordingly, in the IFAS-OSA2 h and IFAS-OSA4 h processes, the sludge production was reduced by 27.9% and 46.5%, and the excess sludge was reduced by 13.65% and 22%, respectively, compared with the control system. Furthermore, as the average SVIs reached 95±12,63±6 , and 49±4 mL/g , the TSS values in the effluents of the IFAS, IFAS-OSA2 h , and IFAS-OSA4 h processes reached 16.5±3 , 7.2±1.5 , and 5.5±1.2 mg/L , respectively. The average percentages of total nitrogen (TN) removal efficiency in the IFAS, IFAS-OSA2 h , and IFAS-OSA4 h processes were 78.56±2.46 , 83.60±0.92 , and 85.03±1.69 , respectively, whereas the percentages of phosphorus removal efficiency in these processes were 32.69±8.25 , 36.35±6.73 , and 39.87±3.61 , respectively. This study revealed that the modified IFAS-OSA system had a more efficient performance than the IFAS system. [ABSTRACT FROM AUTHOR]