1. A Photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase.
- Author
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Nollmann FI, Heinrich AK, Brachmann AO, Morisseau C, Mukherjee K, Casanova-Torres ÁM, Strobl F, Kleinhans D, Kinski S, Schultz K, Beeton ML, Kaiser M, Chu YY, Phan Ke L, Thanwisai A, Bozhüyük KA, Chantratita N, Götz F, Waterfield NR, Vilcinskas A, Stelzer EH, Goodrich-Blair H, Hammock BD, and Bode HB
- Subjects
- Animals, Biological Products chemistry, Biological Products metabolism, Enzyme Inhibitors chemistry, Enzyme Inhibitors metabolism, Epoxide Hydrolases metabolism, Insecta, Structure-Activity Relationship, Urea analogs & derivatives, Urea metabolism, Biological Products pharmacology, Enzyme Inhibitors pharmacology, Epoxide Hydrolases antagonists & inhibitors, Photorhabdus chemistry, Urea pharmacology
- Abstract
Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence., (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2015
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