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Your search keyword '"Zohra Saci"' showing total 10 results
Start Over Author "Zohra Saci" Topic biological psychiatry
10 results on '"Zohra Saci"'

1. Impact of Copy Number Variants and Polygenic Risk Scores on Psychopathology in the UK Biobank

Author

Josephine Mollon, Schultz, Laura M., Guillaume Huguet, Em, Emma Knowles, Mathias, Samuel R., Amanda Rodrigue, Aaron Alexander-Bloch, Zohra Saci, Martineau Jean Louis, Kuldeep Kumar, Elise Douard, Laura Almasy, Sebastien Jacquemont, and Glahn, David C.

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering, Biological Psychiatry
Published
2023

2. Investigating the contributions of circadian pathway and insomnia risk genes to autism and sleep disturbances

Author

Rackeb Tesfaye, Guillaume Huguet, Zoe Schmilovich, Thomas Renne, Mor Absa Loum, Elise Douard, Zohra Saci, Martineau Jean-Louis, Jean Luc Martineau, Rob Whelan, Sylvane Desrivieres, Andreas Heinz, Gunter Schumann, Caroline Hayward, Mayada Elsabbagh, and Sebastien Jacquemont

Subjects
circadian rhythm, Sleep Wake Disorders, Adolescent, Autism Spectrum Disorder, Autism, insomnia, sleep disturbance, Cellular and Molecular Neuroscience, Psychiatry and Mental health, copy number variations, Sleep Initiation and Maintenance Disorders, GWAS, Humans, Autistic Disorder, Child, Sleep, Biological Psychiatry
Abstract

Sleep disturbance is prevalent in youth with Autism Spectrum Disorder (ASD). Researchers haveposited that circadian dysfunction may contribute to sleep problems or exacerbate ASDsymptomatology. However, there is limited genetic evidence of this. It is also unclear howinsomnia risk genes identified through GWAS in general populations are related to ASD andcommon sleep problems like insomnia traits in ASD. We investigated the contribution of copynumber variants (CNVs) encompassing circadian pathway genes and insomnia risk genes toASD risk as well as sleep disturbances in children with ASD. We studied 5860 ASD probandsand 2092 unaffected siblings from the Simons Simplex Collection (SSC) and MSSNG database,as well as 7509 individuals from two unselected populations (IMAGEN and GenerationScotland). Sleep duration and insomnia symptoms were parent reported for SSC probands.We identified 335 and 616 rare CNVs encompassing circadian and insomnia risk genesrespectively. Deletions and duplications with circadian genes were overrepresented in ASDprobands compared to siblings and unselected controls. For insomnia-risk genes, deletions (notduplications) were associated with ASD in both cohorts. Results remained significant afteradjusting for cognitive ability. CNVs containing circadian pathway and insomnia risk genesshowed a stronger association with ASD, compared to CNVs containing other genes. Circadiangenes did not influence sleep duration or insomnia traits in ASD. Insomnia risk genes intolerantto haploinsufficiency increased risk for insomnia when duplicated. CNVs encompassingcircadian and insomnia risk genes increase ASD liability with little to no observable impacts onsleep disturbances.

Published
2022

4. Prevalence of Rate of Deleterious Copy Number Variants Similar in Early Onset Psychosis and Autism Spectrum Disorders: Implications for Clinical Practice

Author

Catherine Brownstein, Elise Douard, Josephine Mollon, Richard Smith, Margaret Hojlo, Emily Garvey, Kristin Cabral, Joshua Bowen, Emma Deaso, Abhijit Rao, Casie Genetti, Devon Carroll, Emma Knowles, Pankaj Agrawal, Alan Beggs, Eugene D’Angelo, Laura Almasy, Zohra Saci, Clara Moreau, Guillaume Huguet, Sébastien Jacquemont, David Glahn, and Joseph Gonzalez-Heydrich

Subjects
Biological Psychiatry
Published
2022

8. Analysis of Genomic Copy Number Variation Across Psychiatric Disorders

Author

Oanh Hong, Jake Humphrey, Agathe de Pins, Elise Douard, Zohra Saci, Jeffrey R. MacDonald, Marieke Klein, Stan Stan Letovsky, Stephen W. Scherer, Omar Shanta, Sébastien Jacquemont, Alexander W. Charney, Bhooma Thiruvahindrapuram, and Jonathan Sebat

Subjects
Genetics, Copy-number variation, Biology, Biological Psychiatry
Published
2021

9. THE EFFECT SIZE OF GENES ON COGNITIVE ABILITIES IS LINKED TO THEIR EXPRESSION ALONG THE MAJOR HIERARCHICAL GRADIENT IN THE HUMAN BRAIN

Author

Zohra Saci, Sébastien Jacquemont, Laura Almasy, Guillaume Huguet, Elise Douard, Guillaume Dumas, and David C. Glahn

Subjects
Pharmacology, Cognition, Human brain, Biology, Psychiatry and Mental health, medicine.anatomical_structure, Neurology, Expression (architecture), medicine, Pharmacology (medical), Neurology (clinical), Gene, Neuroscience, Biological Psychiatry
Published
2021

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