1. Gender-specific side effects of chemotherapy in pancreatic cancer patients
- Author
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De Francia, Silvia, Mancardi, Daniele, Berchialla, Paola, Armando, Tiziana, Storto, Silvana, Allegra, Sarah, Soave, Giulia, Racca, Silvia, Chiara, Francesco, Carnovale, Jennifer, Ciuffreda, Libero, and Mussa, Maria Valentina
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Medical research ,Medicine, Experimental ,Sex factors in disease -- Research ,Drugs -- Adverse and side effects ,Chemotherapy -- Complications and side effects -- Demographic aspects ,Cancer -- Chemotherapy ,Pancreatic cancer -- Drug therapy ,Biological sciences - Abstract
Pancreatic carcinoma incidence showed a significant increase in men over the last few years and the prognosis remains poor. Patients are treated with different pharmacological plans with no evidence about gender-specific adverse effects. We aimed to investigate differences in the incidence of chemotherapy side effects in the treatment of pancreatic cancer, to provide insights toward a personalized assistance based in individual needs. The sample population is composed of 207 patients. Regression model highlighted the predictive role of female gender for alopecia, constipation, hand- foot syndrome, and epigastric pain. Also, considering single therapeutic schemes, gender differences have been reported. Moreover, evaluating the effect of age, a general reduced risk of toxicity has been reported in younger patients. To personalize chemotherapy and increase patient survival rate and life quality during the therapy, gender medicine and pharmacology studies are recommended. Key words: gender differences, adverse effects, drugs toxicity, chemotherapy, pancreatic carcinoma. La frequence du cancer du pancreas chez l'homme a decrit une courbe nettement ascendante au cours des dernieres annees et le pronostic demeure defavorable. Les patients sont traites a l'aide de differents schemas pharmacologiques sans donnees probantes quant aux effets indesirables specifiques a leur sexe. Nous avons vise a etudier les differences entre la frequence des effets indesirables de la chimiotherapie dans le traitement du cancer du pancreas en vue de fournir des elements de reflexion quant a l'aide personnalisee fondee sur des besoins individuels. La population echantillonnee est composee de 207 patients. Le modele de regression a mis en evidence le role predictif du sexe feminin quant a l'alopecie, a la constipation, au syndrome pied-main et aux douleurs epigastriques. Nous avons aussi rapporte des differences entre les sexes selon des schemas therapeutiques individuels. En outre, une evaluation selon l'age a permis de rapporter un decroissement general du risque de toxicite chez les patients jeunes. Nous recommandons de proceder a des etudes medicales et pharmacologiques selon le sexe en vue d'offrir aux patients une chimiotherapie personnalisee et de faire augmenter leur taux de survie de meme que leur qualite de vie pendant le traitement. [Traduit par la Redaction] Mots-cles : differences entre les sexes, effets indesirables, toxicite medicamenteuse, chimiotherapie, cancer du pancreas., 1. Introduction Recent studies demonstrate gender-specific incidence, progression, and severity of different tumors. Differences in parameters such as body weight, fat distribution, hormonal profile, metabolism, immune response, and genetics were [...]
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- 2022
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