1. Oxygen-wasting effect of inotropy in the 'virtual work model.'
- Author
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Korvald, Christian, Elvenes, Odd P., Ytrebo, Lars M., Sorlie, Dag G., and Myrmel, Truls
- Subjects
Cardiotonic agents -- Physiological aspects ,Oxygen consumption -- Physiological aspects ,Heart ventricle, Left -- Physiological aspects ,Heart -- Physiological aspects ,Biological sciences - Abstract
The virtual work model, where the left ventricular total mechanical energy is linearly related to myocardial oxygen consumption (MV(sub O2)), is dependent on inotropic stimulation. Furthermore, this concept does not provide new insight into myocardial chemomechanical coupling. These were the findings of a reexamination of the effect of inotropic stimulation on the metabolic to mechanical energy transfer in nine open-chest anesthetized pigs. A highly linear relationship was found between MV(sub O2) and mechanical energy for all three indexes during control and dopamine runs.
- Published
- 1999