1. Chronic toxicological effects of β-diketone antibiotics on Zebrafish (Danio rerio) using transcriptome profiling of deep sequencing.
- Author
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Wang, Huili, Yin, Xiaohan, Li, Fanghui, Dahlgren, Randy A, Zhang, Yuna, Zhang, Hongqin, and Wang, Xuedong
- Subjects
Liver ,Animals ,Zebrafish ,Ketones ,Anti-Bacterial Agents ,Microscopy ,Electron ,Gene Expression Profiling ,Sequence Analysis ,RNA ,Down-Regulation ,Up-Regulation ,High-Throughput Nucleotide Sequencing ,Transcriptome ,deep sequencing ,immune system ,transcriptome ,zebrafish ,β-diketone antibiotics ,beta-diketone antibiotics ,Microscopy ,Electron ,Sequence Analysis ,RNA ,Toxicology ,Chemical Sciences ,Environmental Sciences ,Biological Sciences - Abstract
Transcriptome analysis is important for interpreting the functional elements of the genome and revealing the molecular constituents of cells and tissues. Herein, differentially transcribed genes were identified by deep sequencing after zebrafish (Danio rerio) were exposed to β-diketone antibiotics (DKAs); 23,129 and 23,550 mapped genes were detected in control and treatment groups, a total of 3238 genes were differentially expressed between control and treatment groups. Of these genes, 328 genes (213 up- and 115 down-regulation) had significant differential expression (p < 0.05) and an expression ratio (control/treatment) of >2 or
- Published
- 2016