1. Cryoglobulinaemia in a patient with Proteus mirabilis sepsis
- Author
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Antonietta Cargnel, Massimo Galli, G. Del Giudice, Morelli R, Paolo Viganò, Anna Maria Fiorenza, C. Davoli, and Maria Carmela Perna
- Subjects
Microbiology (medical) ,Paraproteinemias ,Cryoglobulins ,Sepsis ,Immune system ,medicine ,Humans ,Immune Complex Diseases ,Properdin factor b ,Proteus mirabilis ,biology ,Complement C4 ,General Medicine ,Complement C3 ,Middle Aged ,biology.organism_classification ,medicine.disease ,Infectious Diseases ,Cryoglobulinemia ,Immunoglobulin M ,Immunoglobulin G ,General practice ,Immunology ,Female ,Early phase ,Proteus Infections - Abstract
Mixed polyclonal cryoglobulinaemia was evidenced in a 49-year-old woman admitted to our hospital because of Proteus mirabilis sepsis associated with polyarthralgia and purpuric manifestations on the lower limbs. Cryoglobulins and circulating immune complexes decreased during the second week of illness and disappeared after recovery. CH50, C3 and properdin factor B, which were low during the early phase of the illness, returned to normal; C4 was normal throughout. The rapid clearance of cryoglobulins and immune complexes and the restoration of a normal complement profile might all be explained by the gradual elimination of P. mirabilis due to chemotherapeutic treatment.
- Published
- 1982