1. Convergent evolution of mevalonate pathway in Inonotus obliquus and Betula pendula
- Author
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Niko Silvan, Pia Laine, Uwe Richter, Kirk Overmyer, Jarkko Salojärvi, Nina Sipari, Guleycan Lutfullahoglu-Bal, Pezhman Safdari, Tytti Sarjala, Jaakko Kangasjärvi, Sitaram Rajaraman, Omid Safronov, Olli-Pekka Smolander, Maya Wilkens, Brendan J. Battersby, Lars Paulin, Jenna Lihavainen, and Petri Auvinen
- Subjects
0106 biological sciences ,Genetics ,0303 health sciences ,Genome evolution ,Contig ,Hymenochaetaceae ,Biology ,biology.organism_classification ,01 natural sciences ,Genome ,3. Good health ,03 medical and health sciences ,Convergent evolution ,Gene duplication ,Inonotus obliquus ,Mevalonate pathway ,030304 developmental biology ,010606 plant biology & botany - Abstract
Inonotus obliquus, Chaga mushroom, is a fungal species from Hymenochaetaceae family (Basidiomycota) which has been widely used for traditional medicine in Europe and Asia. Here, chaga genome was sequenced using Pacbio sequencing into a 50.7Mbp assembly consisting of 301 primary contigs with an N50 value of 375 kbp. Genome evolution analyses revealed a lineage-specific whole genome duplication event and an expansion of Cytochrome P450 superfamily. Fungal biosynthetic clusters were enriched for tandemly duplicated genes, suggesting that biosynthetic pathway evolution has proceeded through small-scale duplications. Metabolomic fingerprinting confirmed a highly complex terpene biosynthesis chemistry when compared against related fungal species lacking the genome duplication event.
- Published
- 2021