1. Pure red cell aplasia of pregnancy: a distinct clinical entity
- Author
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R. I. Baker, A. Manoharan, E. De, null Luca, and C. G. Begley
- Subjects
Adult ,medicine.medical_specialty ,Blood transfusion ,medicine.medical_treatment ,Pure red cell aplasia ,Red-Cell Aplasia, Pure ,Gastroenterology ,Immunoglobulin G ,Pregnancy ,Erythroblast ,hemic and lymphatic diseases ,Internal medicine ,Normal haemoglobin ,medicine ,Humans ,Blood Transfusion ,Aplastic anemia ,Erythropoietin ,biology ,business.industry ,Pregnancy Complications, Hematologic ,Hematology ,Hematopoietic Stem Cells ,medicine.disease ,Immunology ,biology.protein ,Gestation ,Female ,business - Abstract
We describe a 31-year-old patient with pure red cell aplasia of pregnancy, successfully managed with regular blood transfusions. In vitro studies showed specific inhibition of day 14 erythroid colonies (BFU-E) using serum and purified immunoglobulin G (IgG) obtained from the patient at diagnosis (before blood transfusion). The inhibition of BFU-E disappeared when haematological remission occurred 3 weeks after delivery and she remains clinically well with a normal haemoglobin 4 years later.
- Published
- 2008