1. miR-142-5p Inhibits Cell Invasion and Migration by Targeting DNMT1 in Breast Cancer
- Author
-
Hui Li, Tong-Cun Zhang, Li Hanhan, Li Wang, Jia Peng Li, Yuan Xiang, Xiao-Yu Zhang, Yuan-Yuan Duan, Chang Chang Fan, Zhang Huimin, You Huang, Qian Chen, Xing-Hua Liao, Chao Jiang Gu, and Yu-Yang Wang
- Subjects
DNA (Cytosine-5-)-Methyltransferase 1 ,Cancer Research ,miR-142-5p ,Breast Neoplasms ,Biology ,Article ,Breast cancer ,Cell Movement ,Transcription (biology) ,Cell Line, Tumor ,microRNA ,Transcriptional regulation ,medicine ,Humans ,3' Untranslated Regions ,Cell Proliferation ,DNMT1 ,MKL-1 ,Maspin ,Cancer ,General Medicine ,medicine.disease ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,Oncology ,embryonic structures ,Cancer research ,Female ,Signal transduction - Abstract
Abnormal cell proliferation caused by abnormal transcription regulation mechanism seems to be one of the reasons for the progression of breast cancer and also the pathological basis. MicroRNA-142-5p (miR-142-5p) is a low-expressed miRNA in breast cancer. The role of MKL-1s regulation of DNMT1 in breast cancer cell proliferation and migration is still unclear. MKL-1 (myocardin related transcription factor A) can bind to the conserved cis-regulatory element CC (A/T) 6GG (called CarG box) in the promoter to regulate the transcription of miR-142-5p. The expressions of miR-142-5p and MKL-1 are positively correlated. In addition, it has been proved that DNMT1 is the target of miR-142-5p, which inhibits the expression of DNMT1 by targeting the 3-UTR of DNMT1, thereby forming a feedback loop and inhibiting the migration and proliferation of breast cancer. Our data provide important and novel insights into the MKL-1/miR-142-5p/DNMT1/maspin signaling pathway and may become a new idea for breast cancer diagnosis, treatment, and prognosis.
- Published
- 2021