1. Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum
- Author
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Weize Yuan, Lixin Zhang, Xueting Liu, Mostafa Basiony, Zhaoxi Han, Guoliang Zhu, Huanqin Dai, Wanying Lu, Jie Zhang, and Tom Hsiang
- Subjects
0303 health sciences ,Natural products ,QH301-705.5 ,010405 organic chemistry ,Biomedical Engineering ,Fusarium proliferatum ,Biology ,Pathogenic fungus ,biology.organism_classification ,01 natural sciences ,Applied Microbiology and Biotechnology ,Article ,0104 chemical sciences ,Microbiology ,Antibacterial ,03 medical and health sciences ,Aliphatic unsaturated alcohols ,Structural Biology ,Genetics ,Biology (General) ,TP248.13-248.65 ,Biotechnology ,030304 developmental biology - Abstract
Phytopathogenic fungi have attracted great attention as a promising source for new drug discovery. In the progress of our ongoing study for bioactive natural products from an in-house phytopathogenic fungi library, a pathogenic fungus, Fusarium proliferatum strain 13294 (FP13294), was selected for chemical investigation. Two novel aliphatic unsaturated alcohols named fusariumnols A and B (1 and 2), together with one previously characterized sesquiterpenoid lignoren (3) were identified. Structures of 1–3 were assigned by mass spectrometry and NMR spectroscopy. Their bioactivities were assessed against Staphylococcus epidermidis, S. aureus, and Methicillin-resistant S. aureus (MRSA). Compounds 1 and 2 exhibited weak antibacterial activity against S. epidermidis (MIC = 100 μM).
- Published
- 2021