1. Association between polymorphisms in MRE11 and HIV-1 susceptibility and AIDS progression in a northern Chinese MSM population
- Author
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Songbin Fu, Haiming Sun, Jie Wu, Xueyuan Jia, Jiawei Wu, Kaili Wang, Chang Liu, Qingbu Mei, Qiuyan Li, Yuandong Qiao, Lidan Xu, Xuelong Zhang, and Wenjing Sun
- Subjects
Adult ,Male ,0301 basic medicine ,Microbiology (medical) ,China ,Adolescent ,Genotype ,030106 microbiology ,Population ,HIV Infections ,Single-nucleotide polymorphism ,Biology ,Polymorphism, Single Nucleotide ,Linkage Disequilibrium ,Young Adult ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Gene Frequency ,Odds Ratio ,Humans ,Genetic Predisposition to Disease ,Pharmacology (medical) ,030212 general & internal medicine ,Homosexuality, Male ,Allele ,education ,Allele frequency ,Gene ,Alleles ,Aged ,Aged, 80 and over ,Pharmacology ,Genetics ,Acquired Immunodeficiency Syndrome ,MRE11 Homologue Protein ,education.field_of_study ,Haplotype ,Middle Aged ,Viral Load ,Infectious Diseases ,Bonferroni correction ,Haplotypes ,MRN complex ,Case-Control Studies ,HIV-1 ,symbols - Abstract
BACKGROUND Previous studies reported that DNA damage repair (DDR) genes may play an important role in HIV-1 infection. The MRE11 gene, a member of the MRN complex, plays an essential part in the homologous recombination pathway, which is one of the classical DDR pathways. Previous reports have demonstrated that MRE11 has an effect on HIV-1 replication. However, the role of SNPs in the MRE11 gene and their impact on HIV-1 infection and AIDS progression remain unknown. METHODS In this study, 434 MSM HIV-1-infected patients in northern China and 431 age-matched healthy controls were enrolled. Five SNPs (rs2155209, rs10831234, rs13447720, rs601341 and rs11020803) at the MRE11 gene were genotyped. Another series of cases (409 MSM HIV-1-infected patients) and controls (403 age-matched healthy males) were recruited as the validation set. RESULTS In our study, rs10831234 showed differences in allele frequencies between cases and controls (P = 0.005). Additionally, there was an association between rs10831234 and HIV-1 infection susceptibility in dominant and additive models (P = 0.005 and P = 0.006, respectively). All significant associations were replicated in the validation set, and the associations were still significant after Bonferroni correction for multiple testing when the two data sets were combined. Furthermore, in haplotype association analyses between the case and control groups, the frequencies of the haplotypes Crs11020803Crs10831234 and Trs11020803Trs10831234 showed significant differences (P = 0.0181 and P = 0.0068, respectively). CONCLUSIONS We demonstrated that the MRE11 rs10831234-T allele may confer increased risk of HIV-1 infection.
- Published
- 2019