Author: "Müller, C." / Topic: biology - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Müller, C."' showing total 49 results

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49 results on '"Müller, C."'

1. Urolithen bei Katzen in der Schweiz von 2002 bis 2009

Author: Gerber, B, Brandenberger-Schenk, F, Rothenanger, E, Müller, C, University of Zurich, and Gerber, B
Subjects: 10253 Department of Small Animals, 630 Agriculture, 3400 General Veterinary, 570 Life sciences, biology
Published: 2016

2. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

Author: Okada, Y, Sim, X, Go, Mj, Wu, Jy, Gu, D, Takeuchi, F, Takahashi, A, Maeda, S, Tsunoda, T, Chen, P, Lim, Sc, Wong, Ty, Liu, J, Young, Tl, Aung, T, Seielstad, M, Teo, Yy, Kim, Yj, Lee, Jy, Han, Bg, Kang, D, Chen, Ch, Tsai, Fj, Chang, Lc, Fann, Sj, Mei, H, Rao, Dc, Hixson, Je, Chen, S, Katsuya, T, Isono, M, Ogihara, T, Chambers, Jc, Zhang, W, Kooner, Js, Kidneygen, Consortium, Ckdgen, Consortium, Albrecht, E, Gugc, Consortium, Yamamoto, K, Kubo, M, Nakamura, Y, Kamatani, N, Kato, N, He, J, Chen, Yt, Cho, Ys, Tai, Es, Tanaka, T., Lord, Gm, van der Harst, P, Lawlor, Da, Sehmi, Js, Gale, Dp, Wass, Mn, Ahmadi, Kr, Bakker, Sj, Beckmann, J, Bilo, Hj, Bochud, M, Brown, Mj, Caulfield, Mj, Connell, Jm, Cook, Ht, Cotlarciuc, I, Smith, Gd, de Silva, R, Deng, G, Devuyst, O, Dikkeschei, Ld, Dimkovic, N, Dockrell, M, Dominiczak, A, Ebrahim, S, Eggermann, T, Farrall, M, Ferrucci, L, Floege, J, Forouhi, Ng, Gansevoort, Rt, Han, X, Hedblad, B, van der Heide JJ, Hepkema, Bg, Hernandez Fuentes, M, Hypponen, E, Johnson, T, de Jong PE, Kleefstra, N, Lagou, V, Lapsley, M, Li, Y, Loos, Rj, Luan, J, Luttropp, K, Maréchal, C, Melander, O, Munroe, Pb, Nordfors, L, Parsa, A, Peltonen, L, Penninx, Bw, Perucha, E, Pouta, A, Prokopenko, I, Roderick, Pj, Ruokonen, A, Samani, Nj, Sanna, S, Schalling, M, Schlessinger, D, Schlieper, G, Seelen, Ma, Shuldiner, Ar, Sjögren, M, Smit, Jh, Snieder, H, Soranzo, N, Spector, Td, Stenvinkel, P, Sternberg, Mj, Swaminathan, R, Tanaka, T, Ubink Veltmaat LJ, Uda, M, Vollenweider, P, Wallace, C, Waterworth, D, Zerres, K, Waeber, G, Wareham, Nj, Maxwell, Ph, Mccarthy, Mi, Jarvelin, Mr, Mooser, V, Abecasis, Gr, Lightstone, L, Scott, J, Navis, G, Elliott, P, Köttgen, A, Pattaro, C, Böger, Ca, Fuchsberger, C, Olden, M, Glazer, Nl, Gao, X, Yang, Q, Smith, Av, O'Connell, Jr, Li, M, Schmidt, H, Isaacs, A, Ketkar, S, Hwang, Sj, Johnson, Ad, Dehghan, A, Teumer, A, Paré, G, Atkinson, Ej, Zeller, T, Lohman, K, Cornelis, Mc, Probst Hensch NM, Kronenberg, F, Tönjes, A, Hayward, C, Aspelund, T, Eiriksdottir, G, Launer, Lj, Harris, Tb, Rampersaud, E, Mitchell, Bd, Arking, De, Boerwinkle, E, Struchalin, M, Cavalieri, M, Singleton, A, Giallauria, F, Metter, J, de Boer IH, Haritunians, T, Lumley, T, Siscovick, D, Psaty, Bm, Zillikens, Mc, Oostra, Ba, Feitosa, M, Province, M, de Andrade, M, Turner, St, Schillert, A, Ziegler, A, Wild, Ps, Schnabel, Rb, Wilde, S, Munzel, Tf, Leak, Ts, Illig, T, Klopp, N, Meisinger, C, Wichmann, He, Koenig, W, Zgaga, L, Zemunik, T, Kolcic, I, Minelli, C, Hu, Fb, Johansson, Å, Igl, W, Zaboli, G, Wild, Sh, Wright, Af, Campbell, H, Ellinghaus, D, Schreiber, S, Aulchenko, Ys, Felix, Jf, Rivadeneira, F, Uitterlinden, Ag, Hofman, A, Imboden, M, Nitsch, D, Brandstätter, A, Kollerits, B, Kedenko, L, Mägi, R, Stumvoll, M, Kovacs, P, Boban, M, Campbell, S, Endlich, K, Völzke, H, Kroemer, Hk, Nauck, M, Völker, U, Polasek, O, Vitart, V, Badola, S, Parker, An, Ridker, Pm, Kardia, Sl, Blankenberg, S, Liu, Y, Curhan, Gc, Franke, A, Rochat, T, Paulweber, B, Wang, W, Gudnason, V, Coresh, J, Schmidt, R, Shlipak, Mg, van Duijn CM, Borecki, I, Krämer, Bk, Rudan, I, Gyllensten, U, Wilson, Jf, Witteman, Jc, Pramstaller, Pp, Rettig, R, Hastie, N, Chasman, Di, Kao, Wh, Heid, Im, Fox, Cs, Krumsiek, J, Hundertmark, C, Pistis, G, Ruggiero, D, O'Seaghdha, M, Haller, T, Kutalik, Z, Shi, J, Middelberg, Ps, Gaffo, Al, Pirastu, N, Li, G, Huffman, J, Yengo, L, Zhao, Jh, Demirkan, A, Feitosa, Mf, Liu, X, Malerba, Giovanni, Lopez, Lm, Li, X, Kleber, Me, Hicks, Aa, Nolte, Im, Johansson, A, Murgia, F, Peden, Jf, Steri, M, Tenesa, A, Salo, P, Mangino, M, Rose, Lm, Lehtimäki, T, Woodward, Om, Tin, A, Müller, C, Oldmeadow, C, Putku, M, Czamara, D, Kraft, P, Frogheri, L, Thun, Ga, Grotevendt, A, Gislason, Gk, Mcardle, P, Schallert, M, Martin, Ng, Montgomery, Gw, Jacobs DR Jr, Liu, K, D'Adamo, P, Ulivi, S, Rotter, Ji, Navaro, P, Balkau, B, Froguel, P, Esko, T, Salumets, A, Khaw, Kt, Langenberg, C, Kraja, A, Zhang, Q, Scott, Rj, Holliday, Eg, Org, E, Viigimaa, M, Bandinelli, S, Metter, Je, Lupo, Antonio, Trabetti, Elisabetta, Sorice, R, Döring, A, Lattka, E, Strauch, K, Theis, F, Waldenberger, M, Davies, G, Gow, Aj, Bruinenberg, M, Stolk, Rp, Winkelmann, Br, Boehm, Bo, Lucae, S, Curhan, G, Mudgal, P, Plenge, Rm, Portas, L, Persico, I, Kirin, M, Mateo Leach, I, van Gilst WH, Goel, A, Ongen, H, von Eckardstein, A, Cucca, F, Nagaraja, R, Piras, Mg, Schurmann, C, Budde, K, Ernst, F, Farrington, Sm, Theodoratou, E, Jula, A, Perola, M, Salomaa, V, Shin, Sy, Sala, C, Kähönen, M, Viikari, J, Hengstenberg, C, Nelson, Cp, Meschia, Jf, Nalls, Ma, Sharma, P, Singleton, Ab, Burnier, M, Attia, J, Laan, M, Hillege, Hl, Kloiber, S, Choi, H, Pirastu, M, Tore, S, Whitfield, Jb, Fornage, M, Gasparini, P, Siscovick, Ds, Bouatia Naji, N, Metspalu, A, Borecki, Ib, Gambaro, G, Deary, Ij, Wolffenbuttel, Bh, März, W, Watkins, H, Schipf, S, Dunlop, Mg, Ripatti, S, Toniolo, D, Raitakari, O, Ciullo, M, Caulfield, M, Gieger, C., Okada, Y, Sim, X, Go, Mj, Wu, Jy, Gu, D, Takeuchi, F, Takahashi, A, Maeda, S, Tsunoda, T, Chen, P, Lim, Sc, Wong, Ty, Liu, J, Young, Tl, Aung, T, Seielstad, M, Teo, Yy, Kim, Yj, Lee, Jy, Han, Bg, Kang, D, Chen, Ch, Tsai, Fj, Chang, Lc, Fann, Sj, Mei, H, Rao, Dc, Hixson, Je, Chen, S, Katsuya, T, Isono, M, Ogihara, T, Chambers, Jc, Zhang, W, Kooner, J, Albrecht, E, Yamamoto, K, Kubo, M, Nakamura, Y, Kamatani, N, Kato, N, He, J, Chen, Yt, Cho, Y, Tai, E, Tanaka, T, Lord, Gm, van der Harst, P, Lawlor, Da, Sehmi, J, Gale, Dp, Wass, Mn, Ahmadi, Kr, Bakker, Sj, Beckmann, J, Bilo, Hj, Bochud, M, Brown, Mj, Caulfield, Mj, Connell, Jm, Cook, Ht, Cotlarciuc, I, Smith, Gd, de Silva, R, Deng, G, Devuyst, O, Dikkeschei, Ld, Dimkovic, N, Dockrell, M, Dominiczak, A, Ebrahim, S, Eggermann, T, Farrall, M, Ferrucci, L, Floege, J, Forouhi, Ng, Gansevoort, Rt, Han, X, Hedblad, B, van der Heide, Jj, Hepkema, Bg, Hernandez Fuentes, M, Hypponen, E, Johnson, T, de Jong, Pe, Kleefstra, N, Lagou, V, Lapsley, M, Li, Y, Loos, Rj, Luan, J, Luttropp, K, Maréchal, C, Melander, O, Munroe, Pb, Nordfors, L, Parsa, A, Peltonen, L, Penninx, Bw, Perucha, E, Pouta, A, Prokopenko, I, Roderick, Pj, Ruokonen, A, Samani, Nj, Sanna, S, Schalling, M, Schlessinger, D, Schlieper, G, Seelen, Ma, Shuldiner, Ar, Sjögren, M, Smit, Jh, Snieder, H, Soranzo, N, Spector, Td, Stenvinkel, P, Sternberg, Mj, Swaminathan, R, Ubink Veltmaat, Lj, Uda, M, Vollenweider, P, Wallace, C, Waterworth, D, Zerres, K, Waeber, G, Wareham, Nj, Maxwell, Ph, Mccarthy, Mi, Jarvelin, Mr, Mooser, V, Abecasis, Gr, Lightstone, L, Scott, J, Navis, G, Elliott, P, Köttgen, A, Pattaro, C, Böger, Ca, Fuchsberger, C, Olden, M, Glazer, Nl, Gao, X, Yang, Q, Smith, Av, O'Connell, Jr, Li, M, Schmidt, H, Isaacs, A, Ketkar, S, Hwang, Sj, Johnson, Ad, Dehghan, A, Teumer, A, Paré, G, Atkinson, Ej, Zeller, T, Lohman, K, Cornelis, Mc, Probst Hensch, Nm, Kronenberg, F, Tönjes, A, Hayward, C, Aspelund, T, Eiriksdottir, G, Launer, Lj, Harris, Tb, Rampersaud, E, Mitchell, Bd, Arking, De, Boerwinkle, E, Struchalin, M, Cavalieri, M, Singleton, A, Giallauria, F, Metter, J, de Boer, Ih, Haritunians, T, Lumley, T, Siscovick, D, Psaty, Bm, Zillikens, Mc, Oostra, Ba, Feitosa, M, Province, M, de Andrade, M, Turner, St, Schillert, A, Ziegler, A, Wild, P, Schnabel, Rb, Wilde, S, Munzel, Tf, Leak, T, Illig, T, Klopp, N, Meisinger, C, Wichmann, He, Koenig, W, Zgaga, L, Zemunik, T, Kolcic, I, Minelli, C, Hu, Fb, Johansson, Å, Igl, W, Zaboli, G, Wild, Sh, Wright, Af, Campbell, H, Ellinghaus, D, Schreiber, S, Aulchenko, Y, Felix, Jf, Rivadeneira, F, Uitterlinden, Ag, Hofman, A, Imboden, M, Nitsch, D, Brandstätter, A, Kollerits, B, Kedenko, L, Mägi, R, Stumvoll, M, Kovacs, P, Boban, M, Campbell, S, Endlich, K, Völzke, H, Kroemer, Hk, Nauck, M, Völker, U, Polasek, O, Vitart, V, Badola, S, Parker, An, Ridker, Pm, Kardia, Sl, Blankenberg, S, Liu, Y, Curhan, Gc, Franke, A, Rochat, T, Paulweber, B, Wang, W, Gudnason, V, Coresh, J, Schmidt, R, Shlipak, Mg, van Duijn, Cm, Borecki, I, Krämer, Bk, Rudan, I, Gyllensten, U, Wilson, Jf, Witteman, Jc, Pramstaller, Pp, Rettig, R, Hastie, N, Chasman, Di, Kao, Wh, Heid, Im, Fox, C, Krumsiek, J, Hundertmark, C, Pistis, G, Ruggiero, D, O'Seaghdha, M, Haller, T, Kutalik, Z, Shi, J, Middelberg, P, Gaffo, Al, Pirastu, Nicola, Li, G, Huffman, J, Yengo, L, Zhao, Jh, Demirkan, A, Feitosa, Mf, Liu, X, Malerba, G, Lopez, Lm, Li, X, Kleber, Me, Hicks, Aa, Nolte, Im, Johansson, A, Murgia, F, Peden, Jf, Steri, M, Tenesa, A, Salo, P, Mangino, M, Rose, Lm, Lehtimäki, T, Woodward, Om, Tin, A, Müller, C, Oldmeadow, C, Putku, M, Czamara, D, Kraft, P, Frogheri, L, Thun, Ga, Grotevendt, A, Gislason, Gk, Mcardle, P, Schallert, M, Martin, Ng, Montgomery, Gw, Jacobs DR, Jr, Liu, K, D'Adamo, ADAMO PIO, Ulivi, S, Rotter, Ji, Navaro, P, Balkau, B, Froguel, P, Esko, T, Salumets, A, Khaw, Kt, Langenberg, C, Kraja, A, Zhang, Q, Scott, Rj, Holliday, Eg, Org, E, Viigimaa, M, Bandinelli, S, Metter, Je, Lupo, A, Trabetti, E, Sorice, R, Döring, A, Lattka, E, Strauch, K, Theis, F, Waldenberger, M, Davies, G, Gow, Aj, Bruinenberg, M, Stolk, Rp, Winkelmann, Br, Boehm, Bo, Lucae, S, Curhan, G, Mudgal, P, Plenge, Rm, Portas, L, Persico, I, Kirin, M, Mateo Leach, I, van Gilst, Wh, Goel, A, Ongen, H, von Eckardstein, A, Cucca, F, Nagaraja, R, Piras, Mg, Schurmann, C, Budde, K, Ernst, F, Farrington, Sm, Theodoratou, E, Jula, A, Perola, M, Salomaa, V, Shin, Sy, Sala, C, Kähönen, M, Viikari, J, Hengstenberg, C, Nelson, Cp, Meschia, Jf, Nalls, Ma, Sharma, P, Singleton, Ab, Burnier, M, Attia, J, Laan, M, Hillege, Hl, Kloiber, S, Choi, H, Pirastu, M, Tore, S, Whitfield, Jb, Fornage, M, Gasparini, Paolo, Bouatia Naji, N, Metspalu, A, Borecki, Ib, Gambaro, G, Deary, Ij, Wolffenbuttel, Bh, März, W, Watkins, H, Schipf, S, Dunlop, Mg, Ripatti, S, Toniolo, D, Raitakari, O, Ciullo, M, Caulfield, M, Gieger, C., KidneyGen Consortium, CKDGen Consortium, GUGC consortium, Chambers, J.C., Zhang, W., Lord, G.M., van der Harst, P., Lawlor, D.A., Sehmi, J.S., Gale, D.P., Wass, M.N., Ahmadi, K.R., Bakker, S.J., Beckmann, J., Bilo, H.J., Bochud, M., Brown, M.J., Caulfield, M.J., Connell, J.M., Cook, H.T., Cotlarciuc, I., Smith, G.D., de Silva, R., Deng, G., Devuyst, O., Dikkeschei, L.D., Dimkovic, N., Dockrell, M., Dominiczak, A., Ebrahim, S., Eggermann, T., Farrall, M., Ferrucci, L., Floege, J., Forouhi, N.G., Gansevoort, R.T., Han, X., Hedblad, B., van der Heide, J.J., Hepkema, B.G., Hernandez-Fuentes, M., Hypponen, E., Johnson, T., de Jong, P.E., Kleefstra, N., Lagou, V., Lapsley, M., Li, Y., Loos, R.J., Luan, J., Luttropp, K., Maréchal, C., Melander, O., Munroe, P.B., Nordfors, L., Parsa, A., Peltonen, L., Penninx, B.W., Perucha, E., Pouta, A., Prokopenko, I., Roderick, P.J., Ruokonen, A., Samani, N.J., Sanna, S., Schalling, M., Schlessinger, D., Schlieper, G., Seelen, M.A., Shuldiner, A.R., Sjögren, M., Smit, J.H., Snieder, H., Soranzo, N., Spector, T.D., Stenvinkel, P., Sternberg, M.J., Swaminathan, R., Tanaka, T., Ubink-Veltmaat, L.J., Uda, M., Vollenweider, P., Wallace, C., Waterworth, D., Zerres, K., Waeber, G., Wareham, N.J., Maxwell, P.H., McCarthy, M.I., Jarvelin, M.R., Mooser, V., Abecasis, G.R., Lightstone, L., Scott, J., Navis, G., Elliott, P., Kooner, J.S., Köttgen, A., Pattaro, C., Böger, C.A., Fuchsberger, C., Olden, M., Glazer, N.L., Gao, X., Yang, Q., Smith, A.V., O'Connell, J.R., Li, M., Schmidt, H., Isaacs, A., Ketkar, S., Hwang, S.J., Johnson, A.D., Dehghan, A., Teumer, A., Paré, G., Atkinson, E.J., Zeller, T., Lohman, K., Cornelis, M.C., Probst-Hensch, N.M., Kronenberg, F., Tönjes, A., Hayward, C., Aspelund, T., Eiriksdottir, G., Launer, L.J., Harris, T.B., Rampersaud, E., Mitchell, B.D., Arking, D.E., Boerwinkle, E., Struchalin, M., Cavalieri, M., Singleton, A., Giallauria, F., Metter, J., de Boer, I.H., Haritunians, T., Lumley, T., Siscovick, D., Psaty, B.M., Zillikens, M.C., Oostra, B.A., Feitosa, M., Province, M., de Andrade, M., Turner, S.T., Schillert, A., Ziegler, A., Wild, P.S., Schnabel, R.B., Wilde, S., Munzel, T.F., Leak, T.S., Illig, T., Klopp, N., Meisinger, C., Wichmann, H.E., Koenig, W., Zgaga, L., Zemunik, T., Kolcic, I., Minelli, C., Hu, F.B., Johansson, Å., Igl, W., Zaboli, G., Wild, S.H., Wright, A.F., Campbell, H., Ellinghaus, D., Schreiber, S., Aulchenko, Y.S., Felix, J.F., Rivadeneira, F., Uitterlinden, A.G., Hofman, A., Imboden, M., Nitsch, D., Brandstätter, A., Kollerits, B., Kedenko, L., Mägi, R., Stumvoll, M., Kovacs, P., Boban, M., Campbell, S., Endlich, K., Völzke, H., Kroemer, H.K., Nauck, M., Völker, U., Polasek, O., Vitart, V., Badola, S., Parker, A.N., Ridker, P.M., Kardia, S.L., Blankenberg, S., Liu, Y., Curhan, G.C., Franke, A., Rochat, T., Paulweber, B., Wang, W., Gudnason, V., Coresh, J., Schmidt, R., Shlipak, M.G., van Duijn, C.M., Borecki, I., Krämer, B.K., Rudan, I., Gyllensten, U., Wilson, J.F., Witteman, J.C., Pramstaller, P.P., Rettig, R., Hastie, N., Chasman, D.I., Kao, W.H., Heid, I.M., Fox, C.S., Albrecht, E., Krumsiek, J., Hundertmark, C., Pistis, G., Ruggiero, D., O'Seaghdha, M., Haller, T., Kutalik, Z., Shi, J., Middelberg, P.S., Gaffo, A.L., Pirastu, N., Li, G., Huffman, J., Yengo, L., Zhao, J.H., Demirkan, A., Feitosa, M.F., Liu, X., Malerba, G., Lopez, L.M., Li, X., Kleber, M.E., Hicks, A.A., Nolte, I.M., Johansson, A., Murgia, F., Peden, J.F., Steri, M., Tenesa, A., Salo, P., Mangino, M., Rose, L.M., Lehtimäki, T., Woodward, O.M., Okada, Y., Tin, A., Müller, C., Oldmeadow, C., Putku, M., Czamara, D., Kraft, P., Frogheri, L., Thun, G.A., Grotevendt, A., Gislason, G.K., McArdle, P., Schallert, M., Martin, N.G., Montgomery, G.W., Kubo, M., Nakamura, Y., Jacobs, D.R., Liu, K., D'Adamo, P., Ulivi, S., Rotter, J.I., Navaro, P., Balkau, B., Froguel, P., Esko, T., Salumets, A., Khaw, K.T., Langenberg, C., Kraja, A., Zhang, Q., Scott, R.J., Holliday, E.G., Org, E., Viigimaa, M., Bandinelli, S., Metter, J.E., Lupo, A., Trabetti, E., Sorice, R., Döring, A., Lattka, E., Strauch, K., Theis, F., Waldenberger, M., Davies, G., Gow, A.J., Bruinenberg, M., Stolk, R.P., Winkelmann, B.R., Boehm, B.O., Lucae, S., Curhan, G., Mudgal, P., Plenge, R.M., Portas, L., Persico, I., Kirin, M., Mateo Leach, I., van Gilst, W.H., Goel, A., Ongen, H., von Eckardstein, A., Cucca, F., Nagaraja, R., Piras, M.G., Schurmann, C., Budde, K., Ernst, F., Farrington, S.M., Theodoratou, E., Jula, A., Perola, M., Salomaa, V., Shin, S.Y., Sala, C., Kähönen, M., Viikari, J., Hengstenberg, C., Nelson, C.P., Meschia, J.F., Nalls, M.A., Sharma, P., Singleton, A.B., Kamatani, N., Burnier, M., Attia, J., Laan, M., Hillege, H.L., Kloiber, S., Choi, H., Pirastu, M., Tore, S., Whitfield, J.B., Fornage, M., Gasparini, P., Siscovick, D.S., Bouatia-Naji, N., Metspalu, A., Borecki, I.B., Gambaro, G., Deary, I.J., Wolffenbuttel, B.H., März, W., Watkins, H., Schipf, S., Dunlop, M.G., Ripatti, S., Toniolo, D., Raitakari, O., Ciullo, M., Caulfield, M., Obstetrics & Gynecology, Medical Informatics, Okada, Yukinori, Sim, Xueling, Go, Min Jin, Wu, Jer-Yuarn, Gu, Dongfeng, Takeuchi, Fumihiko, Takahashi, Atsushi, Maeda, Shiro, Tsunoda, Tatsuhiko, Chen, Peng, Lim, Su-Chi, Wong, Tien-Yin, Liu, Jianjun, Young, Terri L., Aung, Tin, Seielstad, Mark, Teo, Yik-Ying, Kim, Young Jin, Lee, Jong-Young, Han, Bok-Ghee, Kang, Daehee, Chen, Chien-Hsiun, Tsai, Fuu-Jen, Chang, Li-Ching, Cathy Fann, S. -J. C., Mei, Hao, Rao, Dabeeru C., Hixson, James E., Chen, Shufeng, Katsuya, Tomohiro, Isono, Masato, Ogihara, Toshio, Chambers, John C., Zhang, Weihua, Kooner, Jaspal S., Albrecht, Eva, Yamamoto, Kazuhiko, Kubo, Michiaki, Nakamura, Yusuke, Kamatani, Naoyuki, Kato, Norihiro, He, Jiang, Chen, Yuan-Tsong, Cho, Yoon Shin, Tai, E-Shyong, Tanaka, Toshihiro, de Silva, R Deng G, Hernandez-Fuentes, M, Ubink-Veltmaat, Lj, Probst-Hensch, Nm, Giallauria, Francesco, Pirastu, N, D'Adamo, P, Gasparini, P, and Bouatia-Naji, N
Subjects: Asian Continental Ancestry Group, kidney, Population, Renal function, Genome-wide association study, Biology, Kidney, Polymorphism, Single Nucleotide, Article, Blood Urea Nitrogen, Cohort Studies, chemistry.chemical_compound, SDG 3 - Good Health and Well-being, Asian People, loci, Asian, medicine, Humans, genetics, Genetic Predisposition to Disease, Renal Insufficiency, Chronic, education, meta-analysis, Genome-Wide Association Study, Genetic association, Genetics, Creatinine, education.field_of_study, ta3121, medicine.disease, Uric Acid, Asian Continental Ancestry Group/genetics, Creatinine/blood, Glomerular Filtration Rate/genetics, Kidney/physiology, Renal Insufficiency, Chronic/genetics, Uric Acid/blood, medicine.anatomical_structure, chemistry, Genetic epidemiology, Cohort Studie, Human, Kidney disease, Glomerular Filtration Rate
Abstract: Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genomewide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 x 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of similar to 110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.
Published: 2012

3. Effects of ecological compensation meadows on arthropod diversity in adjacent intensively managed grassland

Author: Albrecht, M., Duelli, P., Obrist, M.K., Müller, C., Schüpbach, B., Kleijn, D., Schmid, B., University of Zurich, and Albrecht, M
Subjects: body-size, edge, Biodiversity, EDGE species, Biology, promoting biodiversity, Arthropod diversity, Grassland, 2309 Nature and Landscape Conservation, 10127 Institute of Evolutionary Biology and Environmental Studies, landscapes, Abundance (ecology), CE - Molecular Ecology Ecotoxicology and Wildlife Management, environment schemes, positive edge effect, Wageningen Environmental Research, species richness, Restoration ecology, Ecology, Evolution, Behavior and Systematics, trophic guild, Nature and Landscape Conservation, agri-environment schemes, geography, geography.geographical_feature_category, Ecology, conservation, Species diversity, Centrum Ecosystemen, Centre for Ecosystem Studies, communities, 1105 Ecology, Evolution, Behavior and Systematics, meadow restoration, Guild, Agri, 570 Life sciences, biology, 590 Animals (Zoology), insect, Species richness, agricultural intensification, body size
Abstract: An important goal of ecological compensation areas (ECAs) is to increase biodiversity in adjacent intensively managed farmland and the agricultural landscape at large. We tested whether this goal can be achieved in the case of the agri-environmental restoration scheme implemented for Swiss grassland using five large arthropod taxa (bees, true bugs, orthopterans, ground beetles and spiders) representing different ecological and functional groups. The species richness and abundance of all groups and species, respectively, was measured along 100 m transects from ECA-meadows into the adjacent intensively managed grassland at 24 sites. Species richness of all arthropod taxa except ground beetles, and the abundance of 63% of the 234 arthropod species sampled with at least five individuals were higher in ECA-meadows than in their surroundings, while the total abundance of spiders and ground beetles was higher in intensively managed meadows. The abundance of 8% of these species were only increased in the ECA-meadows themselves (“stenotopic” species) but 40% had increased abundance both in the ECA-meadows and the adjacent grassland, declining exponentially with increasing distance from ECA-meadows (“edge species”). The 90%-decay distances for these edge species differed among taxonomic groups (117 ± 18 m for true bugs, 137 ± 24 m for spiders, 152 ± 34 m for bees, 167 ± 5.7 m for orthopterans, 185 ± 34 m for ground beetles; mean ±1 standard error) and independent of taxonomic group were larger for large-sized or predacious species than for small-sized or phytophagous species. Because the average distance between neighbouring ECA-meadows in Swiss grassland is only 73 ± 4 m, the current agri-environment scheme very likely enhances arthropod diversity and possibly associated ecosystem services in the Swiss agricultural landscape at large.
Published: 2010

4. Symptome, Syndrome und abnorme Laborwerte

Author: Müller, C, Sieber-Ruckstuhl, Nadja S, Kook, Peter H, Braun, C, Burgener, I, Boretti, Felicitas S, University of Zurich, Lutz, H, Kohn, B, and Forterre, F
Subjects: 10253 Department of Small Animals, 630 Agriculture, 570 Life sciences, biology
Published: 2014

5. Expression von löslischem und transmembranärem VEGF Rezeptor 1 in Brustkrebs- und Endothelzellen unter Hypoxie und Normoxie

Author: Müller, C, University of Zurich, and Müller, C
Subjects: UZHDISS UZH Dissertations, 10032 Clinic for Oncology and Hematology, 570 Life sciences, biology, 610 Medicine & health, 10052 Institute of Physiology
Published: 2010

6. Kidnapping and infanticide between groups of banded mongooses

Author: Müller, C A, Bell, M B V, University of Zurich, and Müller, C A
Subjects: 10127alt Institute of Zoology (former), 1105 Ecology, Evolution, Behavior and Systematics, Mungos mungo, Group augmentation, Infanticide, 570 Life sciences, biology, 590 Animals (Zoology), 1103 Animal Science and Zoology, Kidnapping
Published: 2009

7. Costs and Benefits of a Stress Response on Postnatal : Development in the Eurasian Kestrel (Falco tinnunculus)

Author: Müller, C, University of Zurich, and Müller, C
Subjects: 10127 Institute of Evolutionary Biology and Environmental Studies, UZHDISS UZH Dissertations, 570 Life sciences, biology, 590 Animals (Zoology)
Published: 2009

8. The information banded mongooses extract from heterospecific alarms

Author: Müller, C A, Manser, M B, University of Zurich, and Müller, C A
Subjects: urgency level, 10127 Institute of Evolutionary Biology and Environmental Studies, 1105 Ecology, Evolution, Behavior and Systematics, Mungos mungo, Herpestidae, vigilance, playback, antipredator behaviour, 570 Life sciences, biology, 590 Animals (Zoology), banded mongoose, 1103 Animal Science and Zoology, heterospecific alarming
Published: 2008

9. Scent-marking and intrasexual competition in a cooperative carnivore with low reproductive skew

Author: Müller, C A, Manser, M B, University of Zurich, and Müller, C A
Subjects: 10127 Institute of Evolutionary Biology and Environmental Studies, 1105 Ecology, Evolution, Behavior and Systematics, 570 Life sciences, biology, 590 Animals (Zoology), 1103 Animal Science and Zoology
Published: 2008

10. Mutual recognition of pups and providers in the cooperatively breeding banded mongoose

Author: Müller, C A, Manser, M B, University of Zurich, and Müller, C A
Subjects: 10127 Institute of Evolutionary Biology and Environmental Studies, 1105 Ecology, Evolution, Behavior and Systematics, cooperative breeding, Mungos mungo, Herpestidae, playback, 570 Life sciences, biology, 590 Animals (Zoology), banded mongoose, individual recognition, 1103 Animal Science and Zoology
Published: 2008

11. Complex multi-species interactions in natural communities

Author: Müller, C B, University of Zurich, and Müller, C B
Subjects: 10127 Institute of Evolutionary Biology and Environmental Studies, 570 Life sciences, biology, 590 Animals (Zoology)
Published: 2007

12. 'Nasty neighbours' rather than 'dear enemies' in a social carnivore

Author: Müller, C A, Manser, M B, University of Zurich, and Müller, C A
Subjects: 2300 General Environmental Science, 10127 Institute of Evolutionary Biology and Environmental Studies, 1300 General Biochemistry, Genetics and Molecular Biology, olfactory discrimination, Herpestidae, 2400 General Immunology and Microbiology, territoriality, 570 Life sciences, biology, 590 Animals (Zoology), neighbour recognition, 1100 General Agricultural and Biological Sciences, sociality, habituation
Published: 2007

13. C/EBPɛ Directly Interacts With the DNA Binding Domain of c-myb and Cooperatively Activates Transcription of Myeloid Promoters

Author: Koeffler Hp, W Verbeek, Alan D. Friedman, Chumakov Am, Müller C, and Gombart Af
Subjects: Gene isoform, Ccaat-enhancer-binding proteins, biology, Immunology, Promoter, Cell Biology, Hematology, DNA-binding domain, Biochemistry, Molecular biology, Jurkat cells, Transactivation, Neutrophil elastase, biology.protein, Transcription factor
Abstract: C/EBPɛ is essential for granulocytic differentiation. We investigated the role of C/EBPɛ in the transcriptional activation of various myeloid-specific genes. We found that two C/EBPɛ isoforms, p32 and p30, possessing transcriptional activation domains were coexpressed in myeloid cells. Interestingly, isoform C/EBPɛ p30 but not p32 was differentially upregulated in NB-4 promyelocytic leukemia cells treated with retinoids. Both isoforms bound specifically to C/EBP sites in myeloid promoters. The kd for C/EBPɛ binding to the C/EBP site of the neutrophil elastase promoter was 4.2 nmol/L. In transfection assays using the nonhematopoietic cell line, CV-1, the p32 isoform activated promoters from the myeloid-specific mim-1, neutrophil elastase, and granulocyte colony-stimulating factor (G-CSF) receptor genes by 2.5-, 1.8-, and 1.6-fold, respectively. The p30 isoform lacked significant transcriptional activity, suggesting that other hematopoietic-specific factors were required for its function. Consistent with this prediction, transfections into the hematopoietic cell line Jurkat showed a 9.0- and 2.5-fold activation of the mim-1 promoter by the p32 and p30 isoforms, respectively. The additional 32 NH2-terminal residues made p32 a significantly more potent transcriptional activator than p30. T lymphoblasts (Jurkat cells) and immature myeloid cells (eg, Kcl22 cells) expressed high levels of the c-myb hematopoietic transcription factor. Cotransfection of c-myb with either the p32 or p30 isoform of C/EBPɛ in CV-1 cells cooperatively transactivated the mim-1 promoter by 20- and 16-fold, respectively, and the neutrophil elastase promoter by 10-and 7-fold, respectively. Pulldown assays showed that each C/EBPɛ isoform interacted directly with the DNA binding domain of the c-myb protein. Further studies showed that Kcl22 myeloid cells only contained active C/EBPɛ, but not C/EBP, C/EBPβ, or C/EBPδ. A mutation of the C/EBP site in the neutrophil elastase promoter markedly decreased the transactivation of the promoter in Kcl22 myeloblasts. These results demonstrate a role for C/EBPɛ in regulating myeloid promoters, such as neutrophil elastase, probably through a direct interaction with c-myb.
Published: 1999

14. Symbiosis between grasses and asexual fungal endophytes

Author: Müller, C B, Krauss, J, University of Zurich, and Müller, C B
Subjects: 10127 Institute of Evolutionary Biology and Environmental Studies, ryegrass, Lolium perenne, 1110 Plant Science, drought stress, 570 Life sciences, biology, 590 Animals (Zoology), Neotyphodium endophytes, entomopathogenic nematode, host genotype
Published: 2005

15. Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study

Author: Prosperi, Mc1, Mackie, N, Di Giambenedetto, S, Zazzi, M, Camacho, R, Fanti, I, Torti, C, Sönnerborg, A, Kaiser, R, Codoñer, Fm, Van Laethem, K, Bansi, L, van de Vijver DA, Geretti, Am, De Luca, A, Giacometti A, SEHERE c. o. n. s. o. r. t. i. u. m., Butini, L, del Gobbo, R, Menzo, S, Tacconi, D, Corbelli, G, Zanussi, S, Monno, L, Punzi, G, Maggiolo, F, Callegaro, A, Calza, L, Carla Re, M, Pristerà, R, Turconi, P, Mandas, A, Tini, S, Zoncada, A, Paolini, E, Amadio, G, Sighinolfi, L, Zuccati, G, Morfini, M, Manetti, R, Corsi, P, Galli, L, Di Pietro, M, Bartalesi, F, Colao, G, Tosti, A, Di Biagio, A, Setti, M, Bruzzone, B, Penco, G, Trezzi, M, Orani, A, Pardelli, R, De Gennaro, M, Chiodera, A, Scalzini, A, Palvarini, L, Almi, P, Todaro, G, d'Arminio Monforte, A, Cicconi, P, Rusconi, S, Gismondo, Mr, Micheli, V, Biondi, Ml, Gianotti, N, Capetti, A, Meraviglia, P, Boeri, E, Mussini, C, Pecorari, M, Soria, A, Vecchi, L, Santirocchi, M, Brustia, D, Ravanini, P, Bello, Fd, Romano, N, Mancuso, S, Calzetti, C, Maserati, R, Filice, G, Baldanti, F, Francisci, D, Parruti, G, Polilli, E, Sacchini, D, Martinelli, C, Consolini, R, Vatteroni, L, Vivarelli, A, Dionisio, D, Nerli, A, Lenzi, L, Magnani, G, Ortolani, P, Andreoni, M, Palamara, G, Fimiani, C, Palmisano, L, Fadda, G, Vullo, Vincenzo, Turriziani, O, Montano, M, Cenderello, G, Gonnelli, A, Palumbo, M, Ghisetti, V, Bonora, S, Foglie, Pd, Rossi, C, Grossi, P, Seminari, E, Poletti, F, Mondino, V, Malena, M, Lattuada, E, Lengauer, T, Däumer, M, Hoffmann, D, Schülter, E, Müller, C, Oette, M, Reuter, S, Esser, S, Fätkenheuer, G, Rockstroh, J, Incardona, F, Rosen Zvi, M, Clotet, B, Thalme, A, Svedhem, V, Bratt, G, Gargiulo, F, Lapadula, G, Manca, N, Paraninfo, G, Quiros Roldan, E, Carosi, G, Castelnuovo, F, Vandamme, Am, Van Wijngaerden, E, Ainsworth, J, Anderson, J, Babiker, A, Dunn, D, Easterbrook, P, Fisher, M, Gazzard, B, Garrett, N, Gilson, R, Gompels, M, Hill, T, Johnson, M, Leen, C, Orkin, C, Phillips, A, Pillay, D, Porter, K, Post, F, Sabin, C, Sadiq, T, Schwenk, A, Walsh, J, Delpech, V, Palfreeman, A, Glabay, A, Lynch, J, Hand, J, de Souza, C, Perry, N, Tilbury, S, Churchill, D, Nelson, M, Waxman, M, Mandalia, S, Kall, M, Korat, H, Taylor, C, Ibrahim, F, Campbell, L, James, L, Brima, N, Williams, I, Youle, M, Lampe, F, Smith, C, Grabowska, H, Chaloner, C, Puradiredja, Di, Weber, J, Ramzan, F, Carder, M, Wilson, A, Dooley, D, Asboe, D, Pozniak, A, Cameron, S, Cane, P, Chadwick, D, Clark, D, Collins, S, Lazarus, L, Dolling, D, Fearnhill, E, Castro, H, Coughlin, K, Zuckerman, M, Booth, C, Goldberg, D, Hale, A, Kaye, S, Kellam, P, Leigh Brown, A, Smit, E, Templeton, K, Tilston, P, Tong, W, Zhang, H, Ushiro Lumb, I, Oliver, T, Bibby, D, Mitchell, S, Mbisa, T, Wildfire, A, Tandy, R, Shepherd, J, Maclean, A, Bennett, D, Hopkins, M, Garcia Diaz, A, Kirk, S, Sloot, P. M., Virology, Prosperi, M, Mackie, N, di Giambenedetto, S, Zazzi, M, Camacho, R, Fanti, I, Torti, C, Sönnerborg, A, Kaiser, R, Codoñer, F, van laethem, K, Bansi, L, van de Vijver, D, Geretti, A, de luca, A, and Mancuso, S
Subjects: Male, Drug Resistance, HIV Infections, Drug resistance, Cohort Studies, 0302 clinical medicine, Genotype, HIV Infection, Pharmacology (medical), 030212 general & internal medicine, Viral, 0303 health sciences, Proteolytic enzymes, Genotypic testing, HIV, Viral load, Adult, Anti-HIV Agents, CD4 Lymphocyte Count, Europe, Female, HIV-1, Humans, RNA, Viral, Viral Proteins, Drug Resistance, Viral, Mutation, Missense, Viral Load, Pharmacology, Infectious Diseases, 3. Good health, Cohort, Cohort study, Human, Microbiology (medical), Biology, Settore MED/17 - MALATTIE INFETTIVE, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Viral Protein, 030306 microbiology, Anti-HIV Agent, Virology, Reverse transcriptase, Regimen, genotypic testing, viral load, Immunology, Mutation, RNA, Missense, Cohort Studie
Abstract: Background and objectives: Guidelines indicate a plasma HIV-1 RNA load of 500-1000 copies/mL as the minimal threshold for antiretroviral drug resistance testing. Resistance testing at lower viral load levels may be useful to guide timely treatment switches, although data on the clinical utility of this remain limited. We report here the influence of viral load levels on the probability of detecting drug resistance mutations (DRMs) and other mutations by routine genotypic testing in a large multicentre European cohort, with a focus on tests performed at a viral load
Published: 2011

16. Effect of plant species loss on aphid–parasitoid communities

Author: Petermann, J S, Müller, C B, Weigelt, A, Weisser, W W, Schmid, B, University of Zurich, and Petermann, J S
Subjects: 10127 Institute of Evolutionary Biology and Environmental Studies, 1105 Ecology, Evolution, Behavior and Systematics, biodiversity effects, bottom–up control, multi, 570 Life sciences, biology, 590 Animals (Zoology), 1103 Animal Science and Zoology, species richness, herbivores, trophic interactions
Published: 2010

17. Aphid genotypes vary in their response to the presence of fungal endosymbionts in host plants

Author: Bieri, A P S, Härri, S A, Vorburger, C, Müller, C B, and University of Zurich
Subjects: genotype–environment interaction, life history evolution, herbivory, Plant–herbivore interaction, Endophytic fungi, mutualism, tall fescue, Neotyphodium coenophialum, offs, 10127 Institute of Evolutionary Biology and Environmental Studies, 1105 Ecology, Evolution, Behavior and Systematics, 570 Life sciences, biology, 590 Animals (Zoology), microbes, trade
Published: 2009

18. Indirect interactions between invasive and native plants via pollinators

Author: Kaiser-Bunbury, C N, Müller, C B, and University of Zurich
Subjects: Indirect interaction, 10127 Institute of Evolutionary Biology and Environmental Studies, Plant reproductive success, 1105 Ecology, Evolution, Behavior and Systematics, Psidium cattleianum, Invasive plant, 570 Life sciences, biology, 590 Animals (Zoology), Apis mellifera, Bertiera zaluzania
Published: 2009

19. Effective Long-Distance Pollen Dispersal in Centaurea jacea

Author: Albrecht, M., Duelli, P., Obrist, M.K., Müller, C., Kleijn, D., Schmid, B., University of Zurich, and Albrecht, M
Subjects: Pollen source, Ecology/Community Ecology and Biodiversity, Pollination, lcsh:Medicine, Metapopulation, Centaurea, 1100 General Agricultural and Biological Sciences, medicine.disease_cause, Gene flow, 10127 Institute of Evolutionary Biology and Environmental Studies, Centaurea jacea, Pollinator, 1300 General Biochemistry, Genetics and Molecular Biology, Ecology/Conservation and Restoration Ecology, Pollen, Botany, medicine, Life Science, Wageningen Environmental Research, lcsh:Science, 1000 Multidisciplinary, Multidisciplinary, biology, Ecology, lcsh:R, fungi, food and beverages, biology.organism_classification, Centrum Ecosystemen, Centre for Ecosystem Studies, Biological dispersal, 570 Life sciences, 590 Animals (Zoology), lcsh:Q, Research Article
Abstract: BACKGROUND: Agri-environment schemes play an increasingly important role for the conservation of rare plants in intensively managed agricultural landscapes. However, little is known about their effects on gene flow via pollen dispersal between populations of these species. METHODOLOGY/PRINCIPAL FINDINGS: In a 2-year experiment, we observed effective pollen dispersal from source populations of Centaurea jacea in restored meadows, the most widespread Swiss agri-environment scheme, to potted plants in adjacent intensively managed meadows without other individuals of this species. Potted plants were put in replicated source populations at 25, 50, 100 m and where possible 200 m distance from these source populations. Pollen transfer among isolated plants was prevented by temporary bagging, such that only one isolated plant was accessible for flower visitors at any one time. Because C. jacea is self-incompatible, seed set in single-plant isolates indicated insect mediated effective pollen dispersal from the source population. Seed set was higher in source populations (35.7+/-4.4) than in isolates (4.8+/-1.0). Seed set declined from 18.9% of that in source populations at a distance of 25 m to 7.4% at 200 m. At a distance of 200 m seed set was still significantly higher in selfed plants, indicating long-distance effective pollen dispersal up to 200 m. Analyses of covariance suggested that bees contributed more than flies to this long-distance pollen dispersal. We found evidence that pollen dispersal to single-plant isolates was positively affected by the diversity and flower abundance of neighboring plant species in the intensively managed meadow. Furthermore, the decline of the dispersal was less steep when the source population of C. jacea was large. CONCLUSIONS: We conclude that insect pollinators can effectively transfer pollen from source populations of C. jacea over at least 200 m, even when "recipient populations" consisted of single-plant isolates, suggesting that gene flow by pollen over this distance is very likely. Source population size and flowering environment surrounding recipient plants appear to be important factors affecting pollen dispersal in C. jacea. It is conceivable that most insect-pollinated plants in a network of restored sites within intensively managed grassland can form metapopulations, if distances between sites are of similar magnitude as tested here.
Published: 2009

20. A 'Click Chemistry' approach to the efficient synthesis of multiple imaging probes derived from a single precursor

Author: Mindt, T L, Müller, C, Stuker, F, Salazar, J F, Hohn, A, Mueggler, T, Rudin, M, Schibli, R, and University of Zurich
Subjects: 170 Ethics, 3004 Pharmacology, 1502 Bioengineering, 1305 Biotechnology, 3003 Pharmaceutical Science, 570 Life sciences, biology, 10050 Institute of Pharmacology and Toxicology, 2204 Biomedical Engineering, 610 Medicine & health, 10237 Institute of Biomedical Engineering, 1605 Organic Chemistry
Published: 2009

21. Invasive ants disrupt gecko pollination and seed dispersal of the endangered plant Roussea simplex in Mauritius

Author: Hansen, D M, Müller, C B, and University of Zurich
Subjects: introduced species, Technomyrmex albipes, 10127 Institute of Evolutionary Biology and Environmental Studies, plant–animal interactions, 1105 Ecology, Evolution, Behavior and Systematics, island, conservation, Phelsuma cepediana, 570 Life sciences, biology, 590 Animals (Zoology), Rousseaceae, Indian Ocean
Published: 2009

22. Extended larval development time for aphid parasitoids in the presence of plant endosymbionts

Author: Härri, S A, Krauss, J, Müller, C B, and University of Zurich
Subjects: larval mortality, life, 1109 Insect Science, Neotyphodium lolii, development time, Aphidius ervi, Metopolophium festucae, multitrophic interactions, sex ratio, parasitoid interactions, 10127 Institute of Evolutionary Biology and Environmental Studies, host, longevity, 570 Life sciences, biology, 590 Animals (Zoology), 2303 Ecology, history traits
Published: 2009

23. Community structure of pollination webs of Mauritian heathland habitats

Author: Kaiser-Bunbury, C N, Memmott, J, Müller, C B, University of Zurich, and Kaiser-Bunbury, C N
Subjects: 10127 Institute of Evolutionary Biology and Environmental Studies, 1105 Ecology, Evolution, Behavior and Systematics, Complex mutualistic network, Restoration, 1110 Plant Science, Alien invasive species, Plant–animal interaction, 570 Life sciences, biology, 590 Animals (Zoology), Oceanic island
Published: 2009
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24. Seed dispersal and establishment of endangered plants on Oceanic Islands: the Janzen-Connell model, and the use of ecological analogues

Author: Hansen, D M, Kaiser, C N, Müller, C B, University of Zurich, and Hansen, D M
Subjects: 10127 Institute of Evolutionary Biology and Environmental Studies, 1000 Multidisciplinary, 1300 General Biochemistry, Genetics and Molecular Biology, 570 Life sciences, biology, 590 Animals (Zoology), 1100 General Agricultural and Biological Sciences
Published: 2008

25. Exotic pest insects: another perspective on coffee and conservation

Author: Kaiser, C N, Hansen, D M, Müller, C B, University of Zurich, and Kaiser, C N
Subjects: 10127 Institute of Evolutionary Biology and Environmental Studies, 1105 Ecology, Evolution, Behavior and Systematics, 570 Life sciences, biology, 590 Animals (Zoology), 2309 Nature and Landscape Conservation
Published: 2008

26. Habitat structure affects reproductive success of the rare endemic tree Syzygium mamillatum (Myrtaceae) in restored and unrestored sites in Mauritius

Author: Kaiser, C N, Hansen, D M, Müller, C B, University of Zurich, and Kaiser, C N
Subjects: 10127 Institute of Evolutionary Biology and Environmental Studies, 1105 Ecology, Evolution, Behavior and Systematics, cauliflory, bird pollination, herbivory, Zosterops mauritianus, 570 Life sciences, biology, 590 Animals (Zoology), habitat restoration, invasive species
Published: 2008
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27. Fungal endosymbionts of plants reduce lifespan of an aphid secondary parasitoid and influence host selection

Author: Härri, S A, Krauss, J, Müller, C B, and University of Zurich
Subjects: endophytic fungi, oviposition strategy, Neotyphodium lolii, mummy parasitoids, 1100 General Agricultural and Biological Sciences, up cascade, Asaphes vulgaris, 2300 General Environmental Science, bottom, 10127 Institute of Evolutionary Biology and Environmental Studies, 1300 General Biochemistry, Genetics and Molecular Biology, 2400 General Immunology and Microbiology, 570 Life sciences, biology, 590 Animals (Zoology)
Published: 2008
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28. Natural enemies act faster than endophytic fungi in population control of cereal aphids

Author: Härri, S A, Krauss, J, Müller, C B, and University of Zurich
Subjects: bottom, down control, 10127 Institute of Evolutionary Biology and Environmental Studies, 1105 Ecology, Evolution, Behavior and Systematics, 570 Life sciences, biology, 590 Animals (Zoology), up control, multitrophic interactions, top, 1103 Animal Science and Zoology, microbes, predator exclusion
Published: 2008

29. Trophic cascades initiated by fungal plant endosymbionts impair reproductive performance of parasitoids in the second generation

Author: Härri, S A, Krauss, J, Müller, C B, and University of Zurich
Subjects: 10127 Institute of Evolutionary Biology and Environmental Studies, up cascades, Indirect eVects, 1105 Ecology, Evolution, Behavior and Systematics, Multi, Neotyphodium lolii, 570 Life sciences, biology, 590 Animals (Zoology), Bottom, Endophyte, trophic interactions
Published: 2008

30. How do local habitat management and landscape structure at different spatial scales affect fritillary butterfly distribution on fragmented wetlands?

Author: Cozzi, G, Müller, C B, Krauss, J, University of Zurich, and Krauss, J
Subjects: Landscape context, Connectivity, Metapopulations, Dispersal, 2309 Nature and Landscape Conservation, Detectability, 10127 Institute of Evolutionary Biology and Environmental Studies, 3305 Geography, Planning and Development, 570 Life sciences, biology, 590 Animals (Zoology), Population density, 2303 Ecology, Fens, Switzerland, Habitat quality
Abstract: Habitat fragmentation, patch quality and landscape structure are important predictors for species richness. However, conservation strategies targeting single species mainly focus on habitat patches and neglect possible effects of the surrounding landscape. This project assesses the impact of management, habitat fragmentation and landscape structure at different spatial scales on the distribution of three endangered butterfly species, Boloria selene, Boloria titania and Brenthis ino. We selected 36 study sites in the Swiss Alps differing in (1) the proportion of suitable habitat (i.e., wetlands); (2) the proportion of potential dispersal barriers (forest) in the surrounding landscape; (3) altitude; (4) habitat area and (5) management (mowing versus grazing). Three surveys per study site were conducted during the adult flight period to estimate occurrence and density of each species. For the best disperser B. selene the probability of occurrence was positively related to increasing proportion of wetland on a large spatial scale (radius: 4,000m), for the medium disperser B. ino on an intermediate spatial scale (2,000m) and for the poorest disperser B. titania on a small spatial scale (1,000m). Nearby forest did not negatively affect butterfly species distribution but instead enhanced the probability of occurrence and the population density of B. titania. The fen-specialist B. selene had a higher probability of occurrence and higher population densities on grazed compared to mown fens. The altitude of the habitat patches affected the occurrence of the three species and increasing habitat area enhanced the probability of occurrence of B. selene and B. ino. We conclude that, the surrounding landscape is of relevance for species distribution, but management and habitat fragmentation are often more important. We suggest that butterfly conservation should not focus only on a patch scale, but also on a landscape scale, taking into account species-specific dispersal abilities
Published: 2008

31. Positive indirect interactions between neighboring plant species via a lizard pollinator

Author: Hansen, D M, Kiesbüy, H C, Jones, C G, Müller, C B, University of Zurich, and Hansen, D M
Subjects: 10127 Institute of Evolutionary Biology and Environmental Studies, 1105 Ecology, Evolution, Behavior and Systematics, 570 Life sciences, biology, 590 Animals (Zoology)
Published: 2007

32. Effects of fertilizer, fungal endophytes and plant cultivar on the performance of insect herbivores and their natural enemies

Author: Krauss, J, Härri, S A, Bush, L, Husi, R, Bigler, L, Power, S A, Müller, C B, University of Zurich, and Krauss, J
Subjects: 10127 Institute of Evolutionary Biology and Environmental Studies, cereal aphids, endophytic fungi, 1105 Ecology, Evolution, Behavior and Systematics, Neotyphodium lolii, 570 Life sciences, biology, 590 Animals (Zoology), trophic cascades, parasitoids
Published: 2007

33. Coloured nectar: distribution, ecology, and evolution of an enigmatic floral trait

Author: Hansen, D M, Olesen, J M, Mione, T, Johnson, S D, Müller, C B, University of Zurich, and Hansen, D M
Subjects: 10127 Institute of Evolutionary Biology and Environmental Studies, 1300 General Biochemistry, Genetics and Molecular Biology, 570 Life sciences, biology, 590 Animals (Zoology), 1100 General Agricultural and Biological Sciences
Published: 2007

34. The Swiss agri-environment scheme enhances pollinator diversity and plant reproductive succes in nearby intensively managed farmland

Author: Albrecht, M, Duelli, P, Müller, C, Kleijn, D, Schmid, B, University of Zurich, and Duelli, P
Subjects: extinction, renosterveld shrublands, Plant Ecology and Nature Conservation, PE&RC, promoting biodiversity, agricultural landscapes, crop pollination, 10127 Institute of Evolutionary Biology and Environmental Studies, forest, seed production, 570 Life sciences, biology, 590 Animals (Zoology), Plantenecologie en Natuurbeheer, bees, habitat fragmentation, community structure, 2303 Ecology
Abstract: 1. Agri-environment schemes attempt to counteract the loss of biodiversity and associated ecosystem services such as pollination and natural pest control in agro-ecosystems. However, only a few studies have evaluated whether these attempts are successful. 2. We studied the effects of managing meadows according to the prescriptions of ecological compensation areas (ECA), the most widely adopted agri-environment scheme in Switzerland, on both pollinator species richness and abundance, and the reproductive success of plants in nearby intensively managed meadows (IM). 3. We established arrays of four pots, each containing individuals of three insect-pollinated, non-autogamous `phytometer¿ species (Raphanus sativus, Hypochaeris radicata and Campanula glomerata), in ECA and adjacent IM at increasing distances from the ECA at 13 sites. 4. Species richness and abundance of hoverflies, solitary bees and large-sized pollinators (mainly social bees and butterflies) were significantly higher in ECA than in adjacent IM. Species richness and abundance of small-sized pollinators in IM declined significantly with increasing distance from ECA, whereas large-sized pollinators were not significantly affected by distance. Plant species richness and flower abundance were the major drivers of pollinator species richness and abundance; the area of an ECA had no significant influence. 5. Individual plants of R. sativus and C. glomerata produced more and heavier seeds in ECA than in IM. Furthermore, the number of seeds of these two phytometer species was positively correlated with species richness and abundance of bees. No such effects were observed for individual plants of H. radicata. The number of fruits and seeds per plant of R. sativus in IM decreased with increasing distance from ECA. 6. Synthesis and applications. We conclude that establishing ECA is an effective method of enhancing both pollinator species richness and abundance and pollination services to nearby intensely managed farmland. Our study emphasizes the importance of connectivity between ECA in maintaining diverse pollinator communities and thereby providing pollination services in agricultural landscapes.
Published: 2007

35. High viral loads despite absence of clinical and pathological findings in cats experimentally infected with feline coronavirus (FCoV) type I and in naturally FCoV-infected cats

Author: Meli, Marina L, Kipar, Anja, Müller, C, Jenal, K, Gönczi, E, Borel, Nicole, Gunn-Moore, D, Chalmers, S, Lin, F, Reinacher, M, Lutz, H, University of Zurich, and Meli, Marina L
Subjects: 10187 Department of Farm Animals, 3404 Small Animals, 570 Life sciences, biology, 10184 Institute of Veterinary Pathology
Published: 2004

36. Synergistic effects of germ cell expressed genes on male fertility in mice

Author: Andreas Meinhardt, Steckel M, Müller C, Ibrahim M. Adham, Wolfgang Engel, Karim Nayernia, Drabent B, and Ulrich Sancken
Subjects: Infertility, Male, medicine.medical_specialty, Ratón, media_common.quotation_subject, Gene Expression, Fertility, Biology, Histones, 03 medical and health sciences, Embryonic and Fetal Development, Mice, 0302 clinical medicine, Testis, Genetics, medicine, Animals, Spermatogenesis, Molecular Biology, Gene, Genetics (clinical), Infertility, Male, 030304 developmental biology, media_common, Mice, Knockout, 0303 health sciences, Acrosin, Enzyme Precursors, 030219 obstetrics & reproductive medicine, Cytogenetics, Nuclear Proteins, medicine.disease, Null allele, Spermatozoa, DNA-Binding Proteins, medicine.anatomical_structure, Fertilization, Knockout mouse, Sperm Motility, Female, Germ cell
Abstract: Over 200 genes have been shown to be associated with infertility in mouse models. However, knockout mice reveal unexpected functional redundancy of some germ cell expressed genes. Single null mutations in mouse genes encoding four male germ cell proteins, transition protein 2 (Tnp2), proacrosin (Acr), histone H1.1 (H1.1), histone H1t (H1t) and sperm mitochondria-associated cysteine-rich protein (Smcp) have been generated and analysed. Tnp2 is believed to participate in the removal of the nuclear histones and initial condensation of the spermatid nucleus. Proacrosin is an acrosomal protease synthesized as a proenzyme and activated into acrosin during the acrosome reaction. The linker histone subtype H1.1 belongs to the group of main-type histones and is synthesized in somatic tissues as well as in germ cells during the S-phase of the cell cycle. The histone gene Hist1h1t is expressed exclusively in spermatocytes and may have a function in establishing an open chromatin structure for the replacement of histones by transition proteins and protamines. Sperm mitochondria-associated cysteine-rich protein (Smcp) is a major structural element of the mitochondria in the midpiece of the sperm tail. Male mutant mice lacking any of these proteins show no apparent defects in spermatogenesis or fertility. To examine the synergistic effects of these proteins in spermatogenesis and during fertilization four lines of double knockout mice Hist1h1a/Mcsp, Hist1h1t/Mcsp, Tnp2/Mcsp and Acr/Mcsp were established. It was found that even when knockout mice are heterozygous for one allele (–/+) and homozygous for the other allele (–/–), mice were subfertile. Homozygous double knockout mice of all four lines are nearly infertile. However, in the four homozygous double knockout mouse lines, different characteristic abnormalities are prominently manifested: In Hist1h1a–/–/Mcsp–/– the migration of spermatozoa is disturbed in female genital tract, in Hist1h1t–/–/Mcsp–/– spermatozoa show morphological head abnormalities, in Tnp2–/–/Mcsp–/– the motility of sperm is affected, and in Acr–/–/Mcsp–/– the sperm-oocyte interaction is impaired. These findings indicate strongly that male germ cell expressed genes have synergistic effects on male fertility.
Published: 2003

37. Fas (CD95) expression on CD4+ T cells from HIV-infected patients increases with disease progression

Author: Bernhard Schaaf, S. P. Aries, Klaus Dalhoff, Müller C, and Reinhard H. Dennin
Subjects: Adult, CD4-Positive T-Lymphocytes, Male, T cell, Biology, Antiviral Agents, Antigen, Immunopathology, Drug Discovery, HIV Seropositivity, medicine, Humans, fas Receptor, Genetics (clinical), Aged, virus diseases, T lymphocyte, Middle Aged, Fas receptor, Immune complex, medicine.anatomical_structure, Apoptosis, HIV p24 Antigen, Immunology, Disease Progression, Molecular Medicine, Female
Abstract: Active T cell suicide (apoptosis) is supposed to be involved in the CD4+ T cell depletion in the course of HIV infection. We investigated the expression of the apoptosis-related antigen Fas on CD4+ T cells from 25 HIV-positive individuals (CDC I-III) and 8 HIV-negative controls by two-colour flowcytometry. In addition, we evaluated: total CD4 count, HIV p24 antigen concentration in serum after immune complex dissociation, and clinical course of infection in HIV-positive individuals. We found a significant increase in mean Fas expression on CD4+ T cells from HIV-positive individuals compared to HIV-negative individuals (85.84 +/- 14.92% vs. 64.28 +/- 7.59%, P0.001). Within the HIV-positive group the increase in Fas expression was correlated with the decline in CD4 count (r = -0.76, P0.001), p24 antigen concentration in serum, after immune complex dissociation (r = 0.67, P0.001), and CDC stage (r = 0.73, P0.001). The upregulation of Fas antigen on CD4 cells is associated with CD4 depletion and other virological and clinical marker of disease progression in HIV infection.
Published: 1995

38. Restricted infection with canine distemper virus leads to down-regulation of myelin gene transcription in cultured oligodendrocytes

Author: M. Vandevelde, Hans U. Graber, Andreas Zurbriggen, and Müller C
Subjects: Proteolipid protein 1, Time Factors, Paramyxoviridae, Transcription, Genetic, Viral protein, viruses, Down-Regulation, medicine.disease_cause, Infections, Virus, Pathology and Forensic Medicine, Cellular and Molecular Neuroscience, Myelin, Dogs, medicine, Animals, RNA, Messenger, Cloning, Molecular, Distemper Virus, Canine, Cells, Cultured, In Situ Hybridization, biology, Canine distemper, medicine.disease, biology.organism_classification, Virology, Immunohistochemistry, Oligodendrocyte, Myelin basic protein, Cell biology, Oligodendroglia, medicine.anatomical_structure, biology.protein, Neurology (clinical), Myelin Proteins, Demyelinating Diseases
Abstract: Canine distemper virus (CDV) induces oligodendroglial degeneration and multifocal demyelination in the central nervous system. The mechanism of oligodendrocyte degeneration is not understood but it has been shown that there is a restricted infection of these cells without viral protein production. Using a combination of immunocytochemistry and in situ hybridization we were able to demonstrate the transcription of the entire virus genome throughout the whole observation period (7-35 days after infection) in oligodendrocytes in CDV-infected brain cell cultures. Therefore, the lack of viral protein and particle production can not be explained on the basis of a defective viral transcription. The present study also shows that a restricted infection of oligodendrocytes with CDV down-regulates the transcription of the major myelin genes coding for proteolipid protein, myelin basic protein (MBP) and myelin-associated glycoprotein in a very similar way. Using densitometry for in situ hybridization products of MBP in populations of normal and infected oligodendrocytes, an effect could be observed long before morphological changes were detectable. The present results strongly suggest that demyelination in distemper is induced by a restricted CDV infection of oligodendrocytes which down-regulates the expression of a variety of cellular genes, in particular those coding for myelin proteins. Consequently, the infected cells are no longer able to synthesize all the membrane compounds which are necessary for maintaining their structural integrity.
Published: 1995

39. Antibodies to natural killer cells in HIV-infected patients

Author: Müller C, S. Kukel, and Ralf Bauer
Subjects: Lymphokine-activated killer cell, biology, business.industry, T-Lymphocytes, Immunology, HIV Infections, Natural killer T cell, Virology, Killer Cells, Natural, Infectious Diseases, biology.protein, Immunology and Allergy, Hiv infected patients, Medicine, Humans, Antibody, business, Antilymphocyte Serum, Autoantibodies
Published: 1993

40. The intestinal immune system and its relation to disease

Author: Laissue, J A, Chappuis, B B, Müller, C, Reubi, J C, and Gebbers, J-O
Subjects: 570 Life sciences, biology, 610 Medicine & health
Abstract: The essential protective structure against the heavy enteric antigenic burden, the gut mucosa, prevents penetration of noxious agents, but allows a minimal exchange of large molecules and particles between the gut lumen and the 'milieu intérieur' of the body. M cells in the follicle-associated epithelium of the gut, ideal gateways for the presentation of enteric antigens to the cells of the gut-associated lymphoid tissue (GALT), are also weak links in the mucosal barrier, and may provide access for various microorganisms. The afferent limb of the GALT consists of distinct aggregates of lymphoid cells located in Peyer's patches, the vermiform appendix and the solitary lymphatic follicles, and of the mesenteric lymph nodes. The efferent limb subsumes the diffusely scattered mucosal leukocytes, mainly lymphocytes and plasma cells. Intraepithelial and mucosal T lymphocytes are instrumental in launching local immune responses, producing lymphokines, and in the specific lysis of virally infected cells. Antigenic stimulation of the GALT results in local secretion of antibodies, or in suppression of systemic immunologic responses to ingested antigens ('oral tolerance'). Poorly controlled mucosal immune responses result in organ-specific diseases. Extranodal lymphomas that mimic structures of the GALT may arise on a background of inflammatory or immunologic (autoimmune) disorders.
Published: 1993
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41. Tuberkulöse Meningoenzephalitis bei Zustand nach Embryotransfer

Author: Müller C and Seelos Kc
Subjects: Infertility, Pediatrics, medicine.medical_specialty, Pregnancy, Tuberculosis, Meningism, Obstetrics and Gynecology, Meningoencephalitis, Salpingitis, Biology, Abortion, medicine.disease, Embryo transfer, Surgery, Maternity and Midwifery, medicine, medicine.symptom
Abstract: A 30-year old pregnant woman, who received an embryo transfer, suffered since the 12th week of pregnancy from therapy-resistant attacks of fever for several weeks. With progressive deterioration, the increasingly somnolent patient showed by now clear signs of meningism and acid-fast bacilli were found in the cerebrospinal fluid. NMR showed a finding consistent with bacterial meningoencephalitis. During therapy with INH, Rifa and EMB, the clinical course and the CSF findings showed rapid improvement. Nevertheless, spontaneous abortion occurred in the 23rd week of pregnancy. Previous history revealed, that granulomatous salpingitis had been diagnosed several years earlier as the reason for infertility.
Published: 1994

42. Quantitative and qualitative differences in the distribution of HLA class I antigenic determinants in the human thymic compartments

Author: Müller C, Ziegler A, Wernet P, and Harald Stein
Subjects: Pathology, medicine.medical_specialty, medicine.drug_class, Immunology, Fluorescent Antibody Technique, Human leukocyte antigen, Thymus Gland, Monoclonal antibody, Antibodies, Immunoenzyme Techniques, Epitopes, Antigen, HLA Antigens, medicine, Immunology and Allergy, Humans, biology, Immunoperoxidase, Infant, Molecular biology, Staining, Thymic Tissue, Phenotype, Child, Preschool, Monoclonal, biology.protein, Antibody
Abstract: The topographical distribution of HLA class I antigens has been investigated by the immunoperoxidase technique on normal frozen thymic tissue sections with a panel of mono- and polymorphic monoclonal anti-HLA antibodies. HLA class I framework determinants detected by the monoclonal antibody W6/32. HL were present on 80–90% of cortical thymocytes, as well as on all cortical epithelial and medullary cells. However the staining intensity of cortical thymocytes with this reagent was about threefold weaker than that of the medullary thymocytes. Labeling patterns of selected monoclonal antibodies against matching HLA-A/B allospecificities revealed striking variations in the quantitative expression of certain HLA-A vs. HLA-B locus alloantigenic determinants on cortical thymocytes compared to a consistent staining on almost all medullary cells.
Published: 1983

43. Simian Virus 40 and Polyoma Virus Gene Expression Explored by the Microinjection Technique

Author: Müller C, Graessmann A, and Graessmann M
Subjects: Gene expression, Polyoma virus, Biology, Simian, biology.organism_classification, Virology, Microinjection, Virus
Published: 1979

44. The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation

Author: Tcymbarevich, Irina V, Eloranta, Jyrki J, Rossel, Jean-Benoît, Obialo, Nicole, Spalinger, Marianne, Cosin-Roger, Jesus, Lang, Silvia, Kullak-Ublick, Gerd A, Wagner, Carsten A, Scharl, Michael, Seuwen, Klaus, Ruiz, Pedro A, Rogler, Gerhard, de Vallière, Cheryl, Misselwitz, Benjamin, Swiss IBD Cohort Study Group, Marot, Astrid, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de gastro-entérologie, University of Zurich, de Vallière, Cheryl, Petit, Laëtitia Marie, Swiss IBD Cohort Study Group, Abdelrahman, K., Ademi, G., Aepli, P., Thomas, A., Anderegg, C., Antonino, A.T., Archanioti, E., Arrigoni, E., de Jong, D.B., Balsiger, B., Bastürk, P., Bauerfeind, P., Becocci, A., Belli, D., Bengoa, J.M., Biedermann, L., Binek, J., Blattmann, M., Boehm, S., Boldanova, T., Borovicka, J., Braegger, C.P., Brand, S., Brügger, L., Brunner, S., Bühr, P., Burnand, B., Burk, S., Burri, E., Buyse, S., Cao, D.T., Carstens, O., Criblez, D.H., Cunningham, S., D'Angelo, F., de Saussure, P., Degen, L., Delarive, J., Doerig, C., Dora, B., Drerup, S., Egger, M., El-Wafa, A., Engelmann, M., Ezri, J., Felley, C., Fliegner, M., Fournier, N., Fraga, M., Franc, Y., Frei, P., Frei, R., Fried, M., Froehlich, F., Furlano, R.I., Garzoni, L., Geyer, M., Girard, L., Girardin, M., Golay, D., Good, I., Bigler, U.G., Gysi, B., Haarer, J., Halama, M., Haldemann, J., Heer, P., Heimgartner, B., Helbling, B., Hengstler, P., Herzog, D., Hess, C., Hessler, R., Heyland, K., Hinterleitner, T., Hirschi, C., Hruz, P., Juillerat, P., Bakker, C.K., Kayser, S., Keller, C., Knellwolf, C., Knoblauch, C., Köhler, H., Koller, R., Krieger, C., Künzler, P., Kusche, R., Lehmann, F.S., Macpherson, A., Maillard, M.H., Manz, M., Marot, A., Meier, R., Meyenberger, C., Meyer, P., Michetti, P., Misselwitz, B., Mosler, P., Mottet, C., Müller, C., Müllhaupt, B., Musso, L., Neagu, M., Nichita, C., Niess, J., Nydegger, A., Obialo, N., Ollo, D., Oropesa, C., Peter, U., Peternac, D., Petit, L.M., Pittet, V., Pohl, D., Porzner, M., Preissler, C., Raschle, N., Rentsch, R., Restellini, A., Restellini, S., Richterich, J.P., Ris, F., Risti, B., Ritz, M.A., Rogler, G., Röhrich, N., Rossel, J.B., Rueger, V., Rusticeanu, M., Sagmeister, M., Saner, G., Sauter, B., Sawatzki, M., Scharl, M., Schelling, M., Schibli, S., Schlauri, H., Schluckebier, D., Schmid, D., Schmid, S., Schnegg, J.F., Schoepfer, A., Seematter, V., Seibold, F., Seirafi, M., Semadeni, G.M., Senning, A., Sokollik, C., Sommer, J., Spalinger, J., Spangenberger, H., Stadler, P., Staub, P., Staudenmann, D., Stenz, V., Steuerwald, M., Straumann, A., Strebel, B., Stulz, A., Sulz, M., Tatu, A., Tempia-Caliera, M., Thorens, J., Truninger, K., Tutuian, R., Urfer, P., Vavricka, S., Viani, F., Vögtlin, J., Von Känel, R., Vouillamoz, D., Vulliamy, R., Wiesel, P., Wiest, R., Wöhrle, S., Zamora, S., Zander, S., Wylie, T., Zeitz, J., and Zimmermann, D.
Subjects: Male, RHOA, pH-sensing, Lipopolysaccharide Receptors, 10052 Institute of Physiology, Receptors, G-Protein-Coupled, 0302 clinical medicine, UC, Risk Factors, Genotype, Adult, Alleles, Cyclic AMP/blood, Female, Galactosylceramidase/genetics, Genetic Predisposition to Disease, Homozygote, Humans, Hydrogen-Ion Concentration, Inflammatory Bowel Diseases/genetics, Inflammatory Bowel Diseases/physiopathology, Macrophages/immunology, Macrophages/metabolism, Middle Aged, Polymorphism, Single Nucleotide, Receptors, G-Protein-Coupled/genetics, Receptors, G-Protein-Coupled/physiology, Signal Transduction, rhoA GTP-Binding Protein/blood, Acidic pH, CD, IBD, Inflammatory bowel diseases, RhoA, cAMP, Cyclic AMP, Receptor, ddc:618, biology, Gastroenterology, General Medicine, 3. Good health, 10219 Clinic for Gastroenterology and Hepatology, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Research Article, Galactosylceramidase, medicine.medical_specialty, CD14, Single-nucleotide polymorphism, 610 Medicine & health, 03 medical and health sciences, Internal medicine, medicine, Extracellular, SNP, 2715 Gastroenterology, Allele, lcsh:RC799-869, business.industry, Macrophages, digestive system diseases, Endocrinology, 10036 Medical Clinic, 10199 Clinic for Clinical Pharmacology and Toxicology, biology.protein, lcsh:Diseases of the digestive system. Gastroenterology, business, rhoA GTP-Binding Protein
Abstract: Background Tissue inflammation in inflammatory bowel diseases (IBD) is associated with a decrease in local pH. The gene encoding G-protein-coupled receptor 65 (GPR65) has recently been reported to be a genetic risk factor for IBD. In response to extracellular acidification, proton activation of GPR65 stimulates cAMP and Rho signalling pathways. We aimed to analyse the clinical and functional relevance of the GPR65 associated single nucleotide polymorphism (SNP) rs8005161. Methods 1138 individuals from a mixed cohort of IBD patients and healthy volunteers were genotyped for SNPs associated with GPR65 (rs8005161, rs3742704) and galactosylceramidase (rs1805078) by Taqman SNP assays. 2300 patients from the Swiss IBD Cohort Study (SIBDC) were genotyped for rs8005161 by mass spectrometry based SNP genotyping. IBD patients from the SIBDC carrying rs8005161 TT, CT, CC and non-IBD controls (CC) were recruited for functional studies. Human CD14+ cells were isolated from blood samples and subjected to an extracellular acidic pH shift, cAMP accumulation and RhoA activation were measured. Results In our mixed cohort, but not in SIBDC patients, the minor variant rs8005161 was significantly associated with UC. In SIBDC patients, we observed a consistent trend in increased disease severity in patients carrying the rs8005161-TT and rs8005161-CT alleles. No significant differences were observed in the pH associated activation of cAMP production between IBD (TT, CT, WT/CC) and non-IBD (WT/CC) genotype carriers upon an acidic extracellular pH shift. However, we observed significantly impaired RhoA activation after an extracellular acidic pH shift in IBD patients, irrespective of the rs8005161 allele. Conclusions The T allele of rs8005161 might confer a more severe disease course in IBD patients. Human monocytes from IBD patients showed impaired pH associated RhoA activation upon an acidic pH shift. Electronic supplementary material The online version of this article (10.1186/s12876-018-0922-8) contains supplementary material, which is available to authorized users.
Published: 2019

45. Relative importance of fertiliser addition to plants and exclusion of predators for aphid growth in the field

Author: Christine B. Müller, Mark D. E. Fellowes, H. Charles J. Godfray, University of Zurich, and Müller, C B
Subjects: Food Chain, Population Dynamics, natural enemies, Generalist and specialist species, Predation, 10127 Institute of Evolutionary Biology and Environmental Studies, Animals, Senecio, Aphis jacobaeae, Fertilizers, Ecology, Evolution, Behavior and Systematics, Trophic level, Analysis of Variance, Aphid, Herbivore, biology, Ants, Ecology, fungi, Jacobaea, food and beverages, Aphididae, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Senecio jacobaea, Aphis, 1105 Ecology, Evolution, Behavior and Systematics, England, Aphids, Predatory Behavior, 570 Life sciences, 590 Animals (Zoology), community ecology
Abstract: Herbivore dynamics and community structure are influenced both by plant quality and the actions of natural enemies. A factorial experiment manipulating both higher and lower trophic levels was designed to explore the determinants of colony growth of the aphid Aphis jacobaeae, a specialist herbivore on ragwort Senecio jacobaea. Potential plant quality was manipulated by regular addition of NPK-fertiliser and predator pressure was reduced by interception traps; the experiment was carried out at two sites. The size and persistence of aphid colonies were measured. Fertiliser addition affected plant growth in only one site, but never had a measurable effect on aphid colony growth. In both habitats the action of insect predators dominated, imposing strong and negative effects on aphid colony performance. Ants were left unmanipulated in both sites and their performance on the aphid colonies did not significantly differ between sites or between treatments. Our results suggest that, at least for aphid herbivores on S. jacobaea, the action of generalist insect predators appears to be the dominant factor affecting colony performance and can under certain conditions even improve plant productivity.
Published: 2016

46. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

Author: Jo Vandesompele, Peter Nürnberg, Shantanu Banerji, Lukas C. Heukamp, Stefanie Heynck, Matthias Fischer, Daniel Rauh, Sylvie Lantuejoul, Ingelore Baessmann, Holger Moch, Matthew Meyerson, Reinhard Büttner, Kwon-Sik Park, Ines Wilkening, Steinar Solberg, Stefan A. Haas, Egber Smit, Dennis Plenker, Zoe Wainer, Prudence A. Russell, Ilona Dahmen, William Pao, Erik Thunnissen, C. Ligorio, Bram De Wilde, Paul K. Brindle, Diana Böhm, Vito Michele Fazio, Vincenzo Di Cerbo, Benjamin Solomon, Stefania Damiani, Walburga Engel-Riedel, Erich Stoelben, Corinna Ludwig, Hannie Sietsma, Daniëlle A M Heideman, Jürgen Wolf, Thomas Muley, Elisabeth Brambilla, Ruping Sun, Wim Timens, Jay Shendure, Laura Pasqualucci, Kristian Cibulskis, Julien Sage, Gavin M. Wright, Mirjam Koker, Pierre Validire, Danila Seidel, Johannes M. Heuckmann, Harry J.M. Groen, Christian Becker, Philippe Lorimier, Peter J.F. Snijders, Sven Perner, Michael Brockmann, Xin Lu, Franziska Gabler, Scott L. Carter, Marius Lund-Iversen, Lucia Anna Muscarella, Jörg Sänger, Benjamin Besse, Hans Ulrich Schildhaus, Frauke Leenders, John K. Field, Odd Terje Brustugun, Christian Brambilla, Philipp A. Schnabel, Sascha Ansén, Christian Grütter, Michael Hallek, Gad Getz, Yuan Chen, Roopika Menon, Roman K. Thomas, Joachim H. Clement, Janine Altmüller, Martin L. Sos, Hans Hoffmann, Peter M. Schneider, Julie George, Christian Müller, Iver Petersen, Federico Cappuzzo, Lawryn H. Kasper, Robert Schneider, Martin Peifer, Lynnette Fernandez-Cuesta, Jean-Charles Soria, Alex Soltermann, Thomas Zander, Walter Weder, Pathology, Pulmonary medicine, CCA - Oncogenesis, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Research Institute for Asthma and COPD (GRIAC), Peifer M, Fernández-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, Plenker D, Leenders F, Sun R, Zander T, Menon R, Koker M, Dahmen I, Müller C, Di Cerbo V, Schildhaus HU, Altmüller J, Baessmann I, Becker C, de Wilde B, Vandesompele J, Böhm D, Ansén S, Gabler F, Wilkening I, Heynck S, Heuckmann JM, Lu X, Carter SL, Cibulskis K, Banerji S, Getz G, Park KS, Rauh D, Grütter C, Fischer M, Pasqualucci L, Wright G, Wainer Z, Russell P, Petersen I, Chen Y, Stoelben E, Ludwig C, Schnabel P, Hoffmann H, Muley T, Brockmann M, Engel-Riedel W, Muscarella LA, Fazio VM, Groen H, Timens W, Sietsma H, Thunnissen E, Smit E, Heideman DA, Snijders PJ, Cappuzzo F, Ligorio C, Damiani S, Field J, Solberg S, Brustugun OT, Lund-Iversen M, Sänger J, Clement JH, Soltermann A, Moch H, Weder W, Solomon B, Soria JC, Validire P, Besse B, Brambilla E, Brambilla C, Lantuejoul S, Lorimier P, Schneider PM, Hallek M, Pao W, Meyerson M, Sage J, Shendure J, Schneider R, Büttner R, Wolf J, Nürnberg P, Perner S, Heukamp LC, Brindle PK, Haas S, and Thomas RK.
Subjects: Mutation rate, EPH-RECEPTOR, Genome, Article, lung, 03 medical and health sciences, 0302 clinical medicine, E-CADHERIN, Genetics, PTEN, EP300, small cell carcinoma, neoplasms, Exome sequencing, ACUTE LYMPHOBLASTIC-LEUKEMIA, 030304 developmental biology, P53 REGULATION, 0303 health sciences, biology, EGFR MUTATIONS, MOUSE MODEL, GENE, humanities, PROSTATE-CANCER, respiratory tract diseases, 3. Good health, FREQUENT MUTATION, Gene expression profiling, Histone, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Human genome, NEUROENDOCRINE TUMORS
Abstract: Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis(1-3). We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an extremely high mutation rate of 7.4 +/- 1 protein-changing mutations per million base pairs. Therefore, we conducted integrated analyses of the various data sets to identify pathogenetically relevant mutated genes. In all cases, we found evidence for inactivation of TP53 and RB1 and identified recurrent mutations in the CREBBP, EP300 and MLL genes that encode histone modifiers. Furthermore, we observed mutations in PTEN, SLIT2 and EPHA7, as well as focal amplifications of the FGFR1 tyrosine kinase gene. Finally, we detected many of the alterations found in humans in SCLC tumors from Tp53 and Rb1 double knockout mice(4). Our study implicates histone modification as a major feature of SCLC, reveals potentially therapeutically tractable genomic alterations and provides a generalizable framework for the identification of biologically relevant genes in the context of high mutational background.
Published: 2012

47. Hepatitis contagiosa canis Infektion bei 4 Hunden in der Schweiz

Author: N. Sieber-Ruckstuhl, S Keller, Nicola Decaro, S Quante, M Wenger, Claudia E Reusch, Claudia Müller, F Tschuor, University of Zurich, and Müller, C
Subjects: Disseminated intravascular coagulation, Hepatitis, medicine.medical_specialty, Pathology, 10253 Department of Small Animals, 630 Agriculture, General Veterinary, biology, business.industry, 3400 General Veterinary, Antemortem Diagnosis, medicine.disease, biology.organism_classification, Gastroenterology, Diarrhea, Lethargy, Infectious canine hepatitis, Internal medicine, medicine, Vomiting, 570 Life sciences, Histopathology, medicine.symptom, business
Abstract: Infectious canine hepatitis in 4 Dogs in Switzerland. Four dogs presented with nonspecific symptoms of lethargy, vomiting, diarrhea, fever and weakness. Laboratory results were consistent with hepatopathy and disseminated intravascular coagulation. Three dogs died, one survived. In the three deceased dogs, a diagnosis of infectious canine hepatitis (ICH) was made based on histological findings and positive immunhistochemistry results for canine adenovirus-1 (CAV-1). In the surviving dog, an antemortem diagnosis of ICH was determined via positive polymerase chain reaction results from blood, occular, nasal and preputial discharge as well as from urine. Since the introduction of widespread vaccination, the incidence of CAV-1 infection in dogs is low. However, the disease has not been eradicated and should be considered when clinical signs consistent with ICH are present.
Published: 2010

48. Interaction diversity within quantified insect food webs in restored and adjacent intensively managed meadows

Author: Peter Duelli, Matthias Albrecht, Bernhard Schmid, Christine B. Müller, University of Zurich, and Müller, C B
Subjects: Male, Food Chain, Insecta, agroecosystems, Population Dynamics, Wasps, Biodiversity, Plant Development, Biology, Host-Parasite Interactions, 10127 Institute of Evolutionary Biology and Environmental Studies, Species Specificity, Abundance (ecology), host–parasitoid interaction, Animals, Human Activities, Biomass, Ecosystem, Ecology, Evolution, Behavior and Systematics, biodiversity, Trophic level, Ecology, food, fungi, Characteristics of common wasps and bees, Species diversity, Agriculture, web structure, Bees, Food web, 1105 Ecology, Evolution, Behavior and Systematics, Predatory Behavior, ecosystem functioning, 570 Life sciences, biology, 590 Animals (Zoology), Species evenness, Female, Animal Science and Zoology, Species richness, 1103 Animal Science and Zoology, human activities
Abstract: 1. We studied the community and food-web structure of trap-nesting insects in restored meadows and at increasing distances within intensively managed grassland at 13 sites in Switzerland to test if declining species diversity correlates with declining interaction diversity and changes in food-web structure. 2. We analysed 49 quantitative food webs consisting of a total of 1382 trophic interactions involving 39 host/prey insect species and 14 parasitoid/predator insect species. Species richness and abundance of three functional groups, bees and wasps as the lower trophic level and natural enemies as the higher trophic level, were significantly higher in restored than in adjacent intensively managed meadows. Diversity and abundance of specific trophic interactions also declined from restored to intensively managed meadows. 3. The proportion of attacked brood cells and the mortality of bees and wasps due to natural enemies were significantly higher in restored than in intensively managed meadows. Bee abundance and the rate of attacked brood cells of bees declined with increasing distance from restored meadows. These findings indicate that interaction diversity declines more rapidly than species diversity in our study system. 4. Quantitative measures of food-web structure (linkage density, interaction diversity, interaction evenness and compartment diversity) were higher in restored than in intensively managed meadows. This was reflected in a higher mean number of host/prey species per consumer species (degree of generalism) in restored than in intensively managed meadows. 5. The higher insect species and interaction diversity was related to higher plant species richness in restored than in intensively managed meadows. In particular, bees and natural enemies reacted positively to increased plant diversity. 6. Our findings provide empirical evidence for the theoretical prediction that decreasing species richness at lower trophic levels should reduce species richness at higher trophic levels, and in addition lead to even stronger reductions in interaction diversity at these higher levels. Species at higher trophic levels may thus benefit relatively more than species at lower trophic levels from habitat restoration in the grassland ecosystems studied. We also demonstrate enhanced compartment diversity and lower interaction evenness in restored than in intensively managed meadows, both of which are theoretically positively associated with increased ecosystem stability in restored meadows.
Published: 2007

49. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

Author: Jacqueline C.M. Witteman, Nicole Probst-Hensch, Gail Davies, Anna Köttgen, Qunyuan Zhang, Pio D'Adamo, Nicholas G. Martin, Silvia Tore, Stephan J. L. Bakker, Gian Andri Thun, Cinzia Sala, Peter P. Pramstaller, Tamara B. Harris, Aaron Isaacs, Sheila Ulivi, Rossella Sorice, Xuan Liu, Andrew A. Hicks, Henry Völzke, Daniela Ruggiero, Arnold von Eckardstein, Yukinori Okada, Andres Metspalu, Jeffrey Metter, Serena Sanna, Jennifer E. Huffman, Philipp S. Wild, Florian Ernst, Eva Albrecht, Mary F. Feitosa, Claudia Schurmann, Kathrin Budde, Veikko Salomaa, Darina Czamara, Elizabeth G. Holliday, Marcel Bruinenberg, Laura Portas, Maris Laan, Alan J. Gow, Caroline Hayward, Tim D. Spector, Ozren Polasek, Ilja M. Nolte, Rodney J. Scott, Massimo Mangino, David S. Siscovick, Nilesh J. Samani, Toomas Haller, Laura Frogheri, A. Jula, Mika Kähönen, Bruce H. R. Wolffenbuttel, Caroline S. Fox, David R. Jacobs, Julia Shi, Yusuke Nakamura, Daniel I. Chasman, Fabian J. Theis, Alan F. Wright, Ayse Demirkan, Francesco Cucca, Paolo Gasparini, Paul M. Ridker, Olli T. Raitakari, Daniela Toniolo, Maristella Steri, Mario Pirastu, Susan Campbell, Maksim Struchalin, So-Youn Shin, Mark J. Caulfield, H.-Erich Wichmann, Grant W. Montgomery, Åsa Johansson, Alexander Teumer, Ulf Gyllensten, Robert M. Plenge, Michel Burnier, Michael Schallert, Jan Krumsiek, Jing Hua Zhao, Andres Salumets, Poorva Mudgal, Anke Tönjes, James F. Meschia, Gauti Kjartan Gislason, Perttu Salo, Angela Döring, Afshin Parsa, Vilmundur Gudnason, Patrick F. McArdle, Rita P. S. Middelberg, W. H. Linda Kao, Aldi Kraja, Christopher Oldmeadow, Adrienne Tin, Loic Yengo, Murielle Bochud, Gerjan Navis, Christian Gieger, Toshiko Tanaka, Cornelia M. van Duijn, Samuli Ripatti, Terho Lehtimäki, Claudia Langenberg, Bernhard O. Boehm, Conall M. O'Seaghdha, Eric Boerwinkle, Nicole Soranzo, Tõnu Esko, Susan M. Farrington, Mike A. Nalls, John F. Peden, Hyon K. Choi, Anuj Goel, Andrew D. Johnson, Norman Klopp, Anne Grotevendt, Halit Ongen, Marcus E. Kleber, Myriam Fornage, Malcolm G. Dunlop, Igor Rudan, Federico Murgia, Beverley Balkau, Jorma Viikari, Christopher P. Nelson, Gérard Waeber, Lenore J. Launer, Ivana Persico, Inga Prokopenko, Guo Li, Tatijana Zemunik, Elisabetta Trabetti, Tanja Zeller, Hugh Watkins, Qiong Yang, James F. Wilson, Peter Vollenweider, Veronique Vitart, Markus Perola, Nicola Pirastu, Olivier Devuyst, Irene Mateo Leach, John Attia, Bruce M. Psaty, Nicholas J. Wareham, Susanne Lucae, Josef Coresh, Ingrid B. Borecki, Claudia Hundertmark, Weihua Zhang, Luigi Ferrucci, Jaspal S. Kooner, Stefan Kloiber, Lynda M. Rose, Naoyuki Kamatani, Zoltán Kutalik, Giovanni Malerba, Ian J. Deary, Albert V. Smith, Helena Schmidt, Eva Lattka, Philippe Froguel, Harry Campbell, Medea Imboden, Antonio Lupo, Angelo L. Gaffo, Vasiliki Lagou, Alan R. Shuldiner, John Whitfield, Abbas Dehghan, Winfried März, Elin Org, Albert Hofman, Margus Viigimaa, Konstantin Strauch, Toshihiro Tanaka, Andrew B. Singleton, Stefania Bandinelli, Christian Hengstenberg, Xinzhong Li, Wiek H. van Gilst, Pim van der Harst, Giorgio Pistis, Jerome I. Rotter, Maria Grazia Piras, Gary C. Curhan, Brenda W.J.H. Penninx, Ramaiah Nagaraja, Nabila Bouatia-Naji, Christian Müller, Ronald P. Stolk, Pau Navarro, Lorna M. Lopez, Ruth J. F. Loos, Albert Tenesa, Johannes H. Smit, Peter Kraft, Giovanni Gambaro, Sarah H. Wild, Patricia B. Munroe, André G. Uitterlinden, Ivana Kolcic, Bernhard R. Winkelmann, Pankaj Sharma, John C. Chambers, Nicholas D. Hastie, Matthias Nauck, Harold Snieder, Michael Stumvoll, Reinhold Schmidt, Hans L. Hillege, Kiang Liu, Fernando Rivadeneira, Owen M. Woodward, Morris J. Brown, Margus Putku, Sabine Schipf, Mirna Kirin, Kay-Tee Khaw, Melanie Waldenberger, Evropi Theodoratou, Marina Ciullo, Michiaki Kubo, Köttgen, A, Albrecht, E, Teumer, A, Vitart, V, Krumsiek, J, Hundertmark, C, Pistis, G, Ruggiero, D, O'Seaghdha, Cm, Haller, T, Yang, Q, Tanaka, T, Johnson, Ad, Kutalik, Z, Smith, Av, Shi, J, Struchalin, M, Middelberg, Rp, Brown, Mj, Gaffo, Al, Pirastu, Nicola, Li, G, Hayward, C, Zemunik, T, Huffman, J, Yengo, L, Zhao, Jh, Demirkan, A, Feitosa, Mf, Liu, X, Malerba, G, Lopez, Lm, van der Harst, P, Li, X, Kleber, Me, Hicks, Aa, Nolte, Im, Johansson, A, Murgia, F, Wild, Sh, Bakker, Sj, Peden, Jf, Dehghan, A, Steri, M, Tenesa, A, Lagou, V, Salo, P, Mangino, M, Rose, Lm, Lehtimäki, T, Woodward, Om, Okada, Y, Tin, A, Müller, C, Oldmeadow, C, Putku, M, Czamara, D, Kraft, P, Frogheri, L, Thun, Ga, Grotevendt, A, Gislason, Gk, Harris, Tb, Launer, Lj, Mcardle, P, Shuldiner, Ar, Boerwinkle, E, Coresh, J, Schmidt, H, Schallert, M, Martin, Ng, Montgomery, Gw, Kubo, M, Nakamura, Y, Munroe, Pb, Samani, Nj, Jacobs DR, Jr, Liu, K, D'Adamo, ADAMO PIO, Ulivi, S, Rotter, Ji, Psaty, Bm, Vollenweider, P, Waeber, G, Campbell, S, Devuyst, O, Navarro, P, Kolcic, I, Hastie, N, Balkau, B, Froguel, P, Esko, T, Salumets, A, Khaw, Kt, Langenberg, C, Wareham, Nj, Isaacs, A, Kraja, A, Zhang, Q, Wild, P, Scott, Rj, Holliday, Eg, Org, E, Viigimaa, M, Bandinelli, S, Metter, Je, Lupo, A, Trabetti, E, Sorice, R, Döring, A, Lattka, E, Strauch, K, Theis, F, Waldenberger, M, Wichmann, He, Davies, G, Gow, Aj, Bruinenberg, M, Stolk, Rp, Kooner, J, Zhang, W, Winkelmann, Br, Boehm, Bo, Lucae, S, Penninx, Bw, Smit, Jh, Curhan, G, Mudgal, P, Plenge, Rm, Portas, L, Persico, I, Kirin, M, Wilson, Jf, Leach, Im, van Gilst, Wh, Goel, A, Ongen, H, Hofman, A, Rivadeneira, F, Uitterlinden, Ag, Imboden, M, von Eckardstein, A, Cucca, F, Nagaraja, R, Piras, Mg, Nauck, M, Schurmann, C, Budde, K, Ernst, F, Farrington, Sm, Theodoratou, E, Prokopenko, I, Stumvoll, M, Jula, A, Perola, M, Salomaa, V, Shin, Sy, Spector, Td, Sala, C, Ridker, Pm, Kähönen, M, Viikari, J, Hengstenberg, C, Nelson, Cp, Meschia, Jf, Nalls, Ma, Sharma, P, Singleton, Ab, Kamatani, N, Zeller, T, Burnier, M, Attia, J, Laan, M, Klopp, N, Hillege, Hl, Kloiber, S, Choi, H, Pirastu, M, Tore, S, Probst Hensch, Nm, Völzke, H, Gudnason, V, Parsa, A, Schmidt, R, Whitfield, Jb, Fornage, M, Gasparini, Paolo, Siscovick, D, Polašek, O, Campbell, H, Rudan, I, Bouatia Naji, N, Metspalu, A, Loos, Rj, van Duijn, Cm, Borecki, Ib, Ferrucci, L, Gambaro, G, Deary, Ij, Wolffenbuttel, Bh, Chambers, Jc, März, W, Pramstaller, Pp, Snieder, H, Gyllensten, U, Wright, Af, Navis, G, Watkins, H, Witteman, Jc, Sanna, S, Schipf, S, Dunlop, Mg, Tönjes, A, Ripatti, S, Soranzo, N, Toniolo, D, Chasman, Di, Raitakari, O, Kao, Wh, Ciullo, M, Fox, C, Caulfield, M, Bochud, M, Gieger, C, LifeLines Cohort, Study, Cardiogram, Consortium, Diagram, Consortium, Icbp, Consortium, Magic, Consortium, Cardiovascular Centre (CVC), Life Course Epidemiology (LCE), Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP), Center for Liver, Digestive and Metabolic Diseases (CLDM), Psychiatry, EMGO - Mental health, EMGO+ - Mental Health, LifeLines Cohort Study, CARDIoGRAM Consortium, DIAGRAM Consortium, ICBP Consortium, MAGIC Consortium, Epidemiology, Public Health, and Internal Medicine
Subjects: Candidate gene, Inhibins/genetics, Genome-wide association study, GENETIC-LOCI, chemistry.chemical_compound, 0302 clinical medicine, serum urate, Gene Frequency, Gout/blood, association analysis, serum urate, Glucose/metabolism, Settore MED/14 - NEFROLOGIA, Hyperuricemia, serum, urate, gene, POPULATION, METABOLIC SYNDROME, Genetics, 0303 health sciences, education.field_of_study, biology, Polymorphism, Single Nucleotide/genetics, 3. Good health, HYPERURICEMIA, Genetic Loci/genetics, SLC22A12, Single Nucleotide/genetics, SNPs, Signal Transduction, MOLECULAR PHYSIOLOGY, serum urate concentrations, gout, genome-wide meta-analysis, European Continental Ancestry Group, Population, Polymorphism, Single Nucleotide, White People, Uric Acid/blood, serum urate concentrations, genome-wide meta-analysis, 03 medical and health sciences, SDG 3 - Good Health and Well-being, uric acid, medicine, Humans, Inhibins, Polymorphism, education, 030304 developmental biology, 030203 arthritis & rheumatology, Analysis of Variance, GOUT, IDENTIFICATION, TRANSPORTER, CARDIOVASCULAR-DISEASE RISK, ta3121, medicine.disease, association analysis, Gout, meta-analysis, Glucose, chemistry, Genetic Loci, genome-wide association studies, biology.protein, Signal Transduction/genetics, Uric acid, URIC-ACID LEVELS, Genome-Wide Association Study, SLC2A9
Abstract: Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout. © 2013 Nature America, Inc. All rights reserved.
Published: 2013

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