1. Briarane-Related Diterpenoids from Octocoral Briareum stechei
- Author
-
Yu-Chi Tsai, Thanh-Hao Huynh, Zhi-Kang Yao, Ping-Jyun Sung, Yu-Jen Wu, Jih Jung Chen, Choo-Aun Neoh, Zhi-Hong Wen, Pin-Chang Huang, and Li-Guo Zheng
- Subjects
Anti-Inflammatory Agents ,Nitric Oxide Synthase Type II ,Pharmaceutical Science ,briastecholide ,Organic chemistry ,briaexcavatolie ,Article ,Analytical Chemistry ,Mice ,QD241-441 ,Drug Discovery ,Animals ,Physical and Theoretical Chemistry ,biology ,Chemistry ,Briareum stechei ,Anthozoa ,Nitric oxide synthase ,iNOS ,RAW 264.7 Cells ,Biochemistry ,Chemistry (miscellaneous) ,briarane ,biology.protein ,Molecular Medicine ,Mouse Macrophage ,Diterpenes - Abstract
A known polyoxygenated briarane, briaexcavatolide P (1), was isolated from a Formosan octocoral Briareum stechei. Moreover, the same species B. stechei, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B (2) and C (3) as well as a known analogue, briarenol R (4). The structures of 1–4 were established using spectroscopic methods. In addition, briarane 1 demonstrated anti-inflammatory activity in lipo-polysaccharide-induced RAW 264.7 mouse macrophage cells by suppressing the expression of inducible nitric oxide synthase (iNOS) protein.
- Published
- 2021