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1. Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells

Author

Areejit Samal, Sara Zaldívar-López, Claire Maudet, Ana Eulalio, Miguel Mano, Juan J. Garrido, Carmen Aguilar, Susana P. G. Costa, R.P. Vivek-Ananth, [Aguilar, Carmen] Univ Wurzburg, Inst Mol Infect Biol IMIB, Host RNA Metab Grp, Wurzburg, Germany, [Maudet, Claire] Univ Wurzburg, Inst Mol Infect Biol IMIB, Host RNA Metab Grp, Wurzburg, Germany, [Eulalio, Ana] Univ Wurzburg, Inst Mol Infect Biol IMIB, Host RNA Metab Grp, Wurzburg, Germany, [Costa, Susana] Univ Coimbra, Ctr Neurosci & Cell Biol CNC, RNA & Infect Lab, Coimbra, Portugal, [Eulalio, Ana] Univ Coimbra, Ctr Neurosci & Cell Biol CNC, RNA & Infect Lab, Coimbra, Portugal, [Costa, Susana] Univ Coimbra, Ctr Neurosci & Cell Biol CNC, Funct Genom & RNA Based Therapeut Lab, Coimbra, Portugal, [Mano, Miguel] Univ Coimbra, Ctr Neurosci & Cell Biol CNC, Funct Genom & RNA Based Therapeut Lab, Coimbra, Portugal, [Costa, Susana] Univ Coimbra, Inst Interdisciplinary Res IIIUC, PhD Programme Expt Biol & Biomed PDBEB, Coimbra, Portugal, [Vivek-Ananth, R. P.] Homi Bhabha Natl Inst HBNI, Inst Math Sci IMSc, Chennai, Tamil Nadu, India, [Samal, Areejit] Homi Bhabha Natl Inst HBNI, Inst Math Sci IMSc, Chennai, Tamil Nadu, India, [Zaldivar-Lopez, Sara] Univ Cordoba, Fac Vet Sci, Dept Genet, Anim Breeding & Genom Grp, Cordoba, Spain, [Garrido, Juan J.] Univ Cordoba, Fac Vet Sci, Dept Genet, Anim Breeding & Genom Grp, Cordoba, Spain, [Zaldivar-Lopez, Sara] Maimonides Biomed Res Inst Cordoba IMIBIC, Immunogen & Mol Pathogenesis GA14 Grp, Cordoba, Spain, [Garrido, Juan J.] Maimonides Biomed Res Inst Cordoba IMIBIC, Immunogen & Mol Pathogenesis GA14 Grp, Cordoba, Spain, [Mano, Miguel] Univ Coimbra, Dept Life Sci, Coimbra, Portugal, [Eulalio, Ana] Univ Coimbra, Dept Life Sci, Coimbra, Portugal, [Maudet, Claire] Inst Pasteur, Biol Infect Unit, Paris, France, Bayerischen Gleichstellungsforderung (BGF) through the SCIENTIA Program, Portuguese Foundation for Science and Technology, Bavarian Ministry of Sciences, Research and the Arts, DFG, ERDF - European Regional Development Fund through COMPETE 2020, FCT Investigator Programme, Science and Engineering Research Board (SERB), Department of Science and Technology (DST), India, Ramanujan fellowship, Spanish Ministry of Economy and Competitiveness, [Aguilar,C, Maudet,C, Eulalio,A] Host RNA Metabolism Group, Institute for Molecular Infection Biology (IMIB), University of Würzburg, Würzburg, Germany. [Costa,S, Eulalio,A] RNA & Infection Laboratory, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal. [Costa,S, Mano,M] Functional Genomics and RNA-based Therapeutics Laboratory, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal. [Costa,S] PhD Programme in Experimental Biology and Biomedicine (PDBEB), Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Coimbra, Portugal. [Vivek-Ananth,RP, Samal,A] The Institute of Mathematical Sciences (IMSc), Homi Bhabha National Institute (HBNI), Chennai, India. [Zaldívar-López,S, Garrido,JJ] Animal Breeding and Genomics Group, Department of Genetics, Faculty of Veterinary Science, University of Córdoba, Córdoba, Spain. [Zaldívar-López,S, Garrido,JJ] Immunogenomics and Molecular Pathogenesis GA14 Group, Maimónides Biomedical Research Institute of Córdoba (IMIBIC), Córdoba, Spain. [Mano,M, Eulalio,A] Department of Life Sciences, University of Coimbra, Coimbra, Portugal., and This work was supported by grants from the Bavarian Ministry of Sciences, Research and the Arts in the framework of the Bavarian Molecular Biosystems Research Network (BioSysNet), DFG project BR 4837/1- 1, ERDF - European Regional Development Fund through COMPETE 2020 and the Portuguese Foundation for Science and Technology (POCI-01-0145-FEDER-007440, UIDB/ 04539/2020, and FCT Investigator Programme IF/01105/2015) to A.E., and the Science and Engineering Research Board (SERB), Department of Science and Technology (DST), India, Ramanujan fellowship (SB/S2/RJN-006/2014) to A.S., and the Spanish Ministry of Economy and Competitiveness (AGL2017-87415-R) to J.J.G.

Subjects
Salmonella typhimurium, 0301 basic medicine, Kinase, Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Shigella::Shigella flexneri [Medical Subject Headings], Swine, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Adaptor Proteins, Signal Transducing::Retinoblastoma Binding Proteins::E2F1 Transcription Factor [Medical Subject Headings], General Physics and Astronomy, Apoptosis, Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Negative Bacterial Infections::Enterobacteriaceae Infections::Salmonella Infections [Medical Subject Headings], Shigella flexneri, 0302 clinical medicine, Salmonella, Endothelial-cells, Bystander effect, E2F1, RNA-Seq, HMGB1 Protein, MicroARNs, Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Endoplasmic Reticulum Stress [Medical Subject Headings], Multidisciplinary, Endoplasmic Reticulum Stress, Cell biology, Messenger-rna, 030220 oncology & carcinogenesis, Er stress, Host-Pathogen Interactions, Salmonella Infections, miRNAs, Pathogens, Reprogramming, Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Communication::Bystander Effect [Medical Subject Headings], Endoplasmic-reticulum stress, Patógenos, MAP Kinase Signaling System, Science, Infecciones por Salmonella, Activation, Down-Regulation, Protein Serine-Threonine Kinases, Biology, Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Signal Transduction::MAP Kinase Signaling System [Medical Subject Headings], Article, General Biochemistry, Genetics and Molecular Biology, Transmembrane protein, 03 medical and health sciences, Downregulation and upregulation, Endoribonucleases, microRNA, Animals, Humans, Secretion, Cellular microbiology, Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Salmonella::Salmonella enterica::Salmonella typhimurium [Medical Subject Headings], Hmgb1, Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Down-Regulation [Medical Subject Headings], Endoplasmic reticulum, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Endonucleases::Endoribonucleases [Medical Subject Headings], Bystander Effect, General Chemistry, Bacterial pathogenesis, biology.organism_classification, Listeria monocytogenes, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases [Medical Subject Headings], Disease Models, Animal, MicroRNAs, 030104 developmental biology, Organisms::Bacteria::Gram-Positive Bacteria::Bacillales::Listeria::Listeria monocytogenes [Medical Subject Headings], Transcription factor, Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor::HeLa Cells [Medical Subject Headings], E2F1 Transcription Factor, HeLa Cells
Abstract

Cells infected with pathogens can contribute to clearing infections by releasing signals that instruct neighbouring cells to mount a pro-inflammatory cytokine response, or by other mechanisms that reduce bystander cells’ susceptibility to infection. Here, we show the opposite effect: epithelial cells infected with Salmonella Typhimurium secrete host factors that facilitate the infection of bystander cells. We find that the endoplasmic reticulum stress response is activated in both infected and bystander cells, and this leads to activation of JNK pathway, downregulation of transcription factor E2F1, and consequent reprogramming of microRNA expression in a time-dependent manner. These changes are not elicited by infection with other bacterial pathogens, such as Shigella flexneri or Listeria monocytogenes. Remarkably, the protein HMGB1 present in the secretome of Salmonella-infected cells is responsible for the activation of the IRE1 branch of the endoplasmic reticulum stress response in non-infected, neighbouring cells. Furthermore, E2F1 downregulation and the associated microRNA alterations promote Salmonella replication within infected cells and prime bystander cells for more efficient infection., Cells infected with pathogens can release signals that instruct neighbouring cells to mount an immune response or that reduce these cells’ susceptibility to infection. Here, Aguilar et al. show the opposite effect: cells infected with Salmonella Typhimurium secrete host factors that facilitate the infection of bystander cells by activating their ER-stress response.

Published
2021

2. Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice

Author

Mehmet Ozansoy, Rumeyza Kazancioglu, Ulkan Kilic, Arzu Şakul, Yasemin Yozgat, Şule Ayla, Kazim Sahin, Birsen Elibol, Mehmet Yalçın Günal, Huveyda Basaga, ALKÜ, 0-belirlenecek, ELİBOL, BİRSEN, Sakul, Arzu Istanbul Medipol Univ, Sch Med, Dept Med Pharmacol, Istanbul, Turkey, Ozansoy, Mehmet Istanbul Medipol Univ, Sch Med, Dept Physiol, Istanbul, Turkey, Elibol, Birsen Bezmialem Vakif Univ, Fac Med, Dept Med Biol, Istanbul, Turkey, Ayla, Sule Istanbul Medipol Univ, Sch Med, Dept Histol & Embryol, Istanbul, Turkey, Gunal, Mehmet Yalcin Alanya Alaaddin Keykubat Univ, Dept Physiol, Sch Med, Antalya, Turkey, Yozgat, Yasemin Istanbul Medipol Univ, Regenerat & Restorat Med Res Ctr REMER, Istanbul, Turkey, Basaga, Huveyda Sabanci Univ, Fac Engn & Nat Sci, Biol Sci & Bioengn Program, Istanbul, Turkey, Sahin, Kazim Firat Univ, Fac Vet Med, Dept Anim Nutr, Elazig, Turkey, Kazancioglu, Rumeyza Bezmialem Vakif Univ, Fac Med, Dept Nephrol, Istanbul, Turkey, Kilic, Ulkan Univ Hlth Sci, Fac Med, Dept Med Biol, Istanbul, Turkey, gunal, mehmet yalcin -- 0000-0001-7702-2441, and Sahin, Kazim -- 0000-0001-9542-5244

Subjects
cisplatin-induced nephrotoxicity, mice, Physiology, 0206 medical engineering, 02 engineering and technology, Biology, Pharmacology, squalene, medicine.disease_cause, Microbiology, Article, Nephrotoxicity, Proinflammatory cytokine, 03 medical and health sciences, Squalene, chemistry.chemical_compound, 0302 clinical medicine, Genetics, medicine, oxidative-stress, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Cisplatin, Kidney, AKT, Cell Biology, Sakul A., Ozansoy M., ELİBOL B., Ayla S., Gunal M. Y. , Yozgat Y., Basaga H., Sahin K., KAZANCIOĞLU R., Kilic U., -Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice-, TURKISH JOURNAL OF BIOLOGY, cilt.43, ss.179-188, 2019, 020601 biomedical engineering, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, mTOR, General Agricultural and Biological Sciences, Oxidative stress, Biyoloji, medicine.drug
Abstract

WOS: 000471268100003 The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been used in combination with cisplatin to cope with nephrotoxicity. Due to its high antitumor activity and oxygen-carrying capacity, we investigated the molecular effects of squalene against cisplatin-induced oxidative stress and kidney damage in mice. Single dose of cisplatin (7 mg/kg) was given to male Balb/c mice. Squalene (100 mg/kg/day) was administered orogastrically to mice for 10 days. Following sacrification, molecular alterations were investigated as analysis of the levels of oxidative stress index (OSI), inflammatory cytokines and cell survival-related proteins in addition to histopathological examinations in mice kidney tissue. The level OSI and Interferon-gamma (IFN-gamma) decreased in the cisplatin and squalene cotreated mice compared to cisplatin-treated mice. Squalene treatment also increased the activation of protein kinase B (AKT). Furthermore, cisplatin-induced inactivation of mammalian target of rapamycin (mTOR) and histopathological damages were reversed by squalene. It may be suggested that squalene ameliorated the cisplatin-induced histopathological damages in the kidney through activation of AKT/mTOR signaling pathway by regulating the balance of the redox system due to its antioxidative effect.

Published
2019

3. Aboveground and Belowground Plant Traits Explain Latitudinal Patterns in Topsoil Fungal Communities From Tropical to Cold Temperate Forests

Author

Jialing Teng, Jing Tian, Romain Barnard, Guirui Yu, Yakov Kuzyakov, Jizhong Zhou, Chinese Acad Sci, Key Lab Ecosystem Network Observat & Modeling, Inst Geog Sci & Nat Resources Res, Beijing, Peoples R China, Univ Chinese Acad Sci, Coll Resources & Environm, Beijing, Peoples R China. [Tian, Jing] China Agr Univ, Coll Resources & Environm Sci, Key Lab Plant Soil Interact, Minist Educ, Beijing, Peoples R China., Agroécologie [Dijon], Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Univ Gottingen, Dept Soil Sci Temperate Ecosyst, Gottingen, Germany., Cent South Univ Forestry & Technol, Fac Life Sci & Technol, Changsha, Peoples R China., Univ Oklahoma, Inst Environm Genom, Sch Civil Engn & Environm Sci, Dept Microbiol & Plant Biol, Norman, OK 73019 USA, and Lawrence Berkeley Natl Lab, Earth & Environm Sci, Berkeley, CA USA.

Subjects
leaf traits, 0106 biological sciences, Microbiology (medical), Biology, 010603 evolutionary biology, 01 natural sciences, Microbiology, Decomposer, soil, Glomeromycota, 03 medical and health sciences, Forest ecology, Temperate climate, soil fungi, community composition, Original Research, 030304 developmental biology, 0303 health sciences, Biomass (ecology), Topsoil, Ecology, forest ecosystems, fungi, food and beverages, 15. Life on land, biology.organism_classification, QR1-502, root traits, [SDE]Environmental Sciences, Species richness, Temperate rainforest
Abstract

International audience; Soil fungi predominate the forest topsoil microbial biomass and participate in biogeochemical cycling as decomposers, symbionts, and pathogens. They are intimately associated with plants but their interactions with aboveground and belowground plant traits are unclear. Here, we evaluated soil fungal communities and their relationships with leaf and root traits in nine forest ecosystems ranging from tropical to cold temperate along a 3,700-km transect in eastern China. Basidiomycota was the most abundant phylum, followed by Ascomycota, Zygomycota, Glomeromycota, and Chytridiomycota. There was no latitudinal trend in total, saprotrophic, and pathotrophic fungal richness. However, ectomycorrhizal fungal abundance and richness increased with latitude significantly and reached maxima in temperate forests. Saprotrophic and pathotrophic fungi were most abundant in tropical and subtropical forests and their abundance decreased with latitude. Spatial and climatic factors, soil properties, and plant traits collectively explained 45% of the variance in soil fungal richness. Specific root length and root biomass had the greatest direct effects on total fungal richness. Specific root length was the key determinant of saprotrophic and pathotrophic fungal richness while root phosphorus content was the main biotic factor determining ectomycorrhizal fungal richness. In contrast, spatial and climatic features, soil properties, total leaf nitrogen and phosphorus, specific root length, and root biomass collectively explained >60% of the variance in fungal community composition. Soil fungal richness and composition are strongly controlled by both aboveground and belowground plant traits. The findings of this study provide new evidence that plant traits predict soil fungal diversity distribution at the continental scale.

Published
2021
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4. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)

Author

Iurilli, Maria L. C., Zhou, Bin, Bennett, James E., Carrillo-Larco, Rodrigo M., Sophiea, Marisa K., Rodriguez-Martinez, Andrea, Bixby, Honor, Solomon, Bethlehem D., Taddei, Cristina, Danaei, Goodarz, Di Cesare, Mariachiara, Stevens, Gretchen A., Riley, Leanne M., Savin, Stefan, Cowan, Melanie J., Bovet, Pascal, Damasceno, Albertino, Chirita-Emandi, Adela, Hayes, Alison J., Ikeda, Nayu, Jackson, Rod T., Khang, Young-Ho, Laxmaiah, Avula, Liu, Jing, Miranda, J. Jaime, Saidi, Olfa, Sebert, Sylvain, Soric, Maroje, Starc, Gregor, Gregg, Edward W., Abarca-Gomez, Leandra, Abdeen, Ziad A., Abdrakhmanova, Shynar, Ghaffar, Suhaila Abdul, Rahim, Hanan F. Abdul, Abu-Rmeileh, Niveen M., Garba, Jamila Abubakar, Acosta-Cazares, Benjamin, Adams, Robert J., Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agdeppa, Imelda A., Aghazadeh-Attari, Javad, Aguilar-Salinas, Carlos A., Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmed, Soheir H., Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M., Al-Lahou, Badreya, Al-Raddadi, Rajaa, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M., Alkandari, Abdullah, Alkerwi, Ala'a, Allin, Kristine, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N., Amiri, Parisa, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A., Angquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Aounallah-Skhiri, Hajer, Araujo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E., Arlappa, Nimmathota, Aryal, Krishna K., Aspelund, Thor, Assah, Felix K., Assuncao, Maria Cecilia F., Aung, May Soe, Auvinen, Juha, Avdicova, Maria, Avi, Shina, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Azmin, Mehrdad, Babu, Bontha, Jorgensen, Maja Boksgaard, Baharudin, Azli, Bahijri, Suhad, Baker, Jennifer L., Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, Jose R., Baran, Joanna, Barbagallo, Carlo M., Barcelo, Alberto, Barkat, Amina, Barros, Aluisio Jd, Gomes Barros, Mauro Virgilio, Basit, Abdul, Bastos, Joao Luiz D., Bata, Iqbal, Batieha, Anwar M., Batista, Rosangela L., Battakova, Zhamilya, Batyrbek, Assembekov, Baur, Louise A., Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedics, Judith, Benet, Mikhail, Bergh, Ingunn Holden, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloisa, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K., Bhutta, Zulfiqar A., Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Lele, Elysee Claude Bika, Bikbov, Mukharram M., Bista, Bihungum, Bjelica, Dusko J., Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B., Bjorkelund, Cecilia, Bloch, Katia, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M., Boehm, Bernhard O., Boeing, Heiner, Boggia, Jose G., Bogova, Elena, Boissonnet, Carlos P., Bojesen, Stig E., Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn C. E., Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Breda, Joao, Brenner, Hermann, Brewster, Lizzy M., Brian, Garry R., Brinduse, Lacramioara, Brophy, Sinead, Bruno, Graziella, Bueno-de-Mesquita, H. Bas, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, Cabrera de Leon, Antonio, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, Jose, Can, Gunay, Candido, Ana Paula C., Canete, Felicia, Capanzana, Mario, Capkova, Nadezda, Capuano, Eduardo, Capuano, Vincenzo, Cardol, Marloes, Cardoso, Viviane C., Carlsson, Axel C., Carmuega, Esteban, Carvalho, Joana, Casajus, Jose A., Casanueva, Felipe F., Celikcan, Ertugrul, Censi, Laura, Cervantes-Loaiza, Marvin, Cesar, Juraci A., Chamukuttan, Snehalatha, Chan, Angelique W., Chan, Queenie, Chaturvedi, Himanshu K., Chaturvedi, Nish, Rahim, Norsyamlina Che Abdul, Chee, Miao Li, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chiolero, Arnaud, Chiou, Shu-Ti, Chirlaque, Maria-Dolores, Cho, Belong, Christensen, Kaare, Christofaro, Diego G. [UNESP], Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Claessens, Frank, Clarke, Janine, Clays, Els, Cohen, Emmanuel, Concin, Hans, Confortin, Susana C., Cooper, Cyrus, Coppinger, Tara C., Corpeleijn, Eva, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L., Crampin, Amelia C., Crujeiras, Ana B., Csilla, Semanova, Cucu, Alexandra M., Cui, Liufu, Cureau, Felipe, Czenczek-Lewandowska, Ewelina, D'Arrigo, Graziella, D'Orsi, Eleonora, Dacica, Liliana, Dal Re Saavedra, Maria Angeles, Dallongeville, Jean, Damsgaard, Camilla T., Dankner, Rachel, Dantoft, Thomas M., Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, De Backer, Guy, De Bacquer, Dirk, Gaetano, Giovanni de, De Henauw, Stefaan, Oliveira, Paula Duarte de, De Ridder, David, De Ridder, Karin, Rooij, Susanne R. de, De Smedt, Delphine, Deepa, Mohan, Deev, Alexander D., DeGennaro, Vincent, Dehghan, Abbas, Delisle, Helene, Delpeuch, Francis, Demarest, Stefaan, Dennison, Elaine, Deren, Katarzyna, Deschamps, Valerie, Dhimal, Meghnath, Di Castelnuovo, Augusto F., Dias-da-Costa, Juvenal Soares, Diaz-Sanchez, Maria Elena, Diaz, Alejandro, Dika, Zivka, Djalalinia, Shirin, Djordjic, Visnja, Do, Ha T. P., Dobson, Annette J., Donati, Maria Benedetta, Donfrancesco, Chiara, Donoso, Silvana P., Doring, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, Doua, Kouamelan, Dragano, Nico, Drygas, Wojciech, Duan, Jia Li, Duante, Charmaine A., Duboz, Priscilla, Duda, Rosemary B., Duleva, Vesselka, Dulskiene, Virginija, Dumith, Samuel C., Dushpanova, Anar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Eddie, Ricky, Eftekhar, Ebrahim, Egbagbe, Eruke E., Eggertsen, Robert, Eghtesad, Sareh, Eiben, Gabriele, Ekelund, Ulf, El-Khateeb, Mohammad, El Ati, Jalila, Eldemire-Shearer, Denise, Eliasen, Marie, Elliott, Paul, Engle-Stone, Reina, Enguerran, Macia, Erasmus, Rajiv T., Erbel, Raimund, Erem, Cihangir, Eriksen, Louise, Eriksson, Johan G., Escobedo-de la Pena, Jorge, Eslami, Saeid, Esmaeili, Ali, Evans, Alun, Faeh, David, Fakhretdinova, Albina A., Fall, Caroline H., Faramarzi, Elnaz, Farjam, Mojtaba, Sant'Angelo, Victoria Farrugia, Farzadfar, Farshad, Fattahi, Mohammad Reza, Fawwad, Asher, Felix-Redondo, Francisco J., Ferguson, Trevor S., Fernandes, Romulo A. [UNESP], Fernandez-Berges, Daniel, Ferrante, Daniel, Ferrao, Thomas, Ferrari, Marika, Ferrario, Marco M., Ferreccio, Catterina, Ferrer, Eldridge, Ferrieres, Jean, Figueiro, Thamara Hubler, Fijalkowska, Anna, Fink, Gunther, Fischer, Krista, Foo, Leng Huat, Forsner, Maria, Fouad, Heba M., Francis, Damian K., Franco, Maria do Carmo, Frikke-Schmidt, Ruth, Frontera, Guillermo, Fuchs, Flavio D., Fuchs, Sandra C., Fujiati, Isti I., Fujita, Yuki, Fumihiko, Matsuda, Furusawa, Takuro, Gaciong, Zbigniew, Gafencu, Mihai, Galbarczyk, Andrzej, Galenkamp, Henrike, Galeone, Daniela, Galfo, Myriam, Galvano, Fabio, Gao, Jingli, Garcia-de-la-Hera, Manoli, Garcia-Solano, Marta, Gareta, Dickman, Garnett, Sarah P., Gaspoz, Jean-Michel, Gasull, Magda, Araujo Gaya, Adroaldo Cesar, Gaya, Anelise Reis, Gazzinelli, Andrea, Gehring, Ulrike, Geiger, Harald, Geleijnse, Johanna M., Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Giampaoli, Simona, Gianfagna, Francesco, Gill, Tiffany K., Giovannelli, Jonathan, Gironella, Glen, Giwercman, Aleksander, Gkiouras, Konstantinos, Godos, Justyna, Gogen, Sibel, Goldberg, Marcel, Goldsmith, Rebecca A., Goltzman, David, Gomez, Santiago F., Gomula, Aleksandra, Cordeiro da Silva, Bruna Goncalves, Goncalves, Helen, Gonzalez-Chica, David A., Gonzalez-Gross, Marcela, Gonzalez-Leon, Margot, Gonzalez-Rivas, Juan P., Gonzalez-Villalpando, Clicerio, Gonzalez-Villalpando, Maria-Elena, Gonzalez, Angel R., Gottrand, Frederic, Graca, Antonio Pedro, Graff-Iversen, Sidsel, Grafnetter, Dusan, Grajda, Aneta, Grammatikopoulou, Maria G., Gregor, Ronald D., Grodzicki, Tomasz, Groholt, Else Karin, Grontved, Anders, Grosso, Giuseppe, Gruden, Gabriella, Gu, Dongfeng, Gualdi-Russo, Emanuela, Guallar-Castillon, Pilar, Gualtieri, Andrea, Gudmundsson, Elias F., Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L., Gulliford, Martin C., Gunnlaugsdottir, Johanna, Gunter, Marc J., Guo, Xiu-Hua, Guo, Yin, Gupta, Prakash C., Gupta, Rajeev, Gureje, Oye, Gurzkowska, Beata, Gutierrez-Gonzalez, Enrique, Gutierrez, Laura, Gutzwiller, Felix, Ha, Seongjun, Hadaegh, Farzad, Hadjigeorgiou, Charalambos A., Haghshenas, Rosa, Hakimi, Hamid, Halkjaer, Jytte, Hambleton, Ian R., Hamzeh, Behrooz, Hange, Dominique, Hanif, Abu A. M., Hantunen, Sari, Hao, Jie, Kumar, Rachakulla Hari, Hashemi-Shahri, Seyed Mohammad, Hassapidou, Maria, Hata, Jun, Haugsgjerd, Teresa, He, Jiang, He, Yuan, He, Yuna, Heidinger-Felso, Regina, Heinen, Mirjam, Hejgaard, Tatjana, Hendriks, Marleen Elisabeth, Henrique, Rafael dos Santos, Henriques, Ana, Hernandez Cadena, Leticia, Herrala, Sauli, Herrera, Victor M., Herter-Aeberli, Isabelle, Heshmat, Ramin, Hill, Allan G., Ho, Sai Yin, Ho, Suzanne C., Hobbs, Michael, Holdsworth, Michelle, Homayounfar, Reza, Homs, Clara, Hopman, Wilma M., Horimoto, Andrea R. V. 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Chitra Tirunal Inst Med Sci & Technol, Hellen Med Assoc Obes, Natl & Kapodistrian Univ Athens, Aarhus Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Pennington Biomed Res Ctr, Natl Inst Epidemiol, Univ Munster, Israel Ctr Dis Control, Res Inst Primordial Prevent Noncommunicable Dis, Amsterdam UMC Publ Hlth Res Inst, South African Med Res Council, Kyrgyz State Med Acad, Res Inst Child Nutr, Shahid Beheshti Univ Med Sci, Univ Cambridge, Mazandaran Univ Med Sci, Hypertens Res Ctr, Med Univ Innsbruck, Muhimbili Univ Hlth & Allied Sci, Yonsei Univ, Natl Canc Ctr, Univ Coll South Denmark, Stat Austria, BP Koirala Inst Hlth Sci, Univ Vienna, Tartu Univ Clin, Kansai Med Univ, Hungarian Sch Sport Federat, Minist Hlth & Qual Life, Univ Hosp Ulm, North West Univ, Univ Jyvaskyla, Amrita Inst Med Sci, Inst Endocrinol, All India Inst Med Sci, African Populat & Hlth Res Ctr, Hanoi Univ Publ Hlth, Hassan First Univ Settat, Harokopio Univ, Sahlgrens Acad, Endocrinol & Metab Res Ctr, Univ Publ Hlth, Int 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Technol, Brown Univ, London Sch Hyg & Trop Med, Univ Edinburgh, Shahid Sadoughi Univ Med Sci, Robert Koch Inst, Univ Lisbon, Womens Social & Hlth Studies Fdn, Democritus Univ, Grigore T Popa Univ Med & Pharm, Univ Firenze, Ain Shams Univ, Isfahan Cardiovasc Res Ctr, Univ Strasbourg, Mulago Hosp, Univ San Carlos, Univ Limpopo, Univ Med Sci Cienfuegos, Royal Coll Surgeons Ireland, Trobe Univ, Int Inst Mol & Cell Biol, Inst Conmemorat Gorgas Estudios Salud, Dept Publ Hlth, Univ Brescia, Minist Hlth & Social Protect, Univ Limerick, Croatian Inst Publ Hlth, Univ Kebangsaan Malaysia, Bushehr Univ Med Sci, Ulm Univ, Dept Stat, Kobe Univ, Suraj Eye Inst, UNICEF, Univ Med Greifswald, Natl Inst Hyg & Epidemiol, Univ Med & Pharm Ho Chi Minh City, Hanoi Med Univ, LifeDoc Hlth, Heartfile, Eastern Mediterranean Publ Hlth Network, Univ Manchester, State Univ Med & Pharm, Tachikawa Gen Hosp, Korea Ctr Dis Control & Prevent, Japan Wildlife Res Ctr, Istanbul Univ, Univ Fed Parana, Univ Madeira, Univ Puerto Rico, Ctr Clin Res & Prevent, MRC Lifecourse Epidemiol Unit, Kwame Nkrumah Univ Sci & Technol, UniSante, Inst Canc Res, Univ Wisconsin, Heidelberg Univ, IRCCS Ente Osped Specializzato Gastroenterol S de, Zayed Univ, Catholic Univ Daegu, Univ Med Pharm Sci & Technol Targu Mures, Jivandeep Hosp, Natl Dent Care Ctr Singapore, Univ Malaga, Univ Hosp Varese, Vietnam Natl Heart Inst, Clin Med Avanzada Dr Abel Gonzalez, Leibniz Inst Prevent Res & Epidemiol BIPS, Univ Sarajevo, Cardiovasc Prevent Ctr Udine, Pisa Univ Hosp, Publ Hlth Agcy Catalonia, Inst Hosp del Mar Invest Med, Ardabil Univ Med Sci, Ctr Dis Prevent & Control, Alborz Univ Med Sci, Pure Earth, Inst Epidemiol Dis Control & Res, Univ Turku, Inst Univ Invest Atenc Primaria Jordi Gol, Univ Putra Malaysia, Univ Malaya, Sotiria Hosp, Univ Valencia, Univ Philippines, Slovak Acad Sci, Nutr Res Fdn, Minas Gerais State Secretariat Hlth, CS S Agustin Ibsalut, Amsterdam Inst Global Hlth & Dev, Natl Inst Hlth Doutor Ricardo Jorge, Univ Nove Julho, Publ Hlth Agcy Canada, Canarian Hlth Serv, Univ Ind Santander, Assoc Calabrese Epatol, Univ Minho, Fiji Natl Univ, Spanish Nutr Fdn, Publ Hlth Agcy Sweden, Inst Food Sci Natl Res Council, Sitaram Bhartia Inst Sci & Res, Kindergarten Avlonari, Natl Inst Hlth, Catalan Dept Hlth, Biodonostia Hlth Res Inst, Inst Saude Ambiental, South Karelia Social & Hlth Care Dist, McMaster Univ, Hosp Italiano Buenos Aires, Rigshosp, Acad Med Ctr Univ Amsterdam, Ctr Oral Hlth Serv & Res Midnorway, Lagos State Univ, Univ Las Palmas Gran Canaria, Comenius Univ, Natl Ctr Dis Control & Publ Hlth, Nippon Med Sch, Sungkyunkwan Univ, Finnish Inst Occupat Hlth, Publ Hlth Promot & Dev Org, St Vincents Hosp, Nes Municipal, Hlth Polytech Jakarta II Inst, Diponegoro Univ, Univ Bari, Inst Reg Sante Publ, Univ Bordeaux, Oslo Metropolitan Univ, Univ Leuven, Lamprecht & Stamm Sozialforsch & Beratung AG, Univ Bonn, Kalina Malina Kindergarten, Jikei Univ, Fu Jen Catholic Univ, Natl Stat Off, Natl Inst Publ Hlth Natl Inst Hyg, Sci Res Inst Maternal & Child Hlth, Univ Lincoln, Cent Univ Kerala, Amsterdam Publ Hlth Res Inst, Hlth Serv Murcia, Inst Invest Sanitaria Illes Balears, Univ Bologna, Hellen Hlth Fdn, Govt Med Coll, Sefako Makgatho Hlth Sci Univ, Addis Ababa Univ, Univ Ctr Occidental Lisandro Alvarado, Meharry Med Coll, Dokuz Eylul Univ, Univ Tampere, Sabiha Gokcen Ilkokulu, Polytech Inst Porto, Icahn Sch Med Mt Sinai, Univ CEU San Pablo, Univ Miguel Hernandez, Vrije Univ Amsterdam, Sunflower Nursery Sch, North Karelia Ctr Publ Hlth, Univ Witwatersrand, Med Univ Vienna, Cork Inst Technol, Inst Med Res, Xinjiang Med Univ, Shanghai Educ Dev Co Ltd, Rebro Univ, St Georges Univ London, Univ Indonesia, Minist Agr & Rural Affairs, Fudan Univ, Univ Cyprus, Niigata Univ, Int Med Univ, Iran Univ Med Sci, Ctr Diabet & Endocrine Care, Peking Univ First Hosp, Jiangsu Prov Ctr Dis Control & Prevent, Sun Yat Sen Univ, West Kazakhstan Med Univ, Inner Mongolia Med Univ, and Przedszkole 81

Subjects
Life Sciences & Biomedicine - Other Topics, Science & Technology, AUSTRALIAN ADULTS, CHINESE ADULTS, nutritional and metabolic diseases, MALNUTRITION, TRENDS, DOUBLE BURDEN, PREVALENCE, POOLED ANALYSIS, US ADULTS, SYSTEMATIC ANALYSIS, HEALTH, sense organs, skin and connective tissue diseases, Life Sciences & Biomedicine, Biology
Abstract

Made available in DSpace on 2021-06-25T15:08:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-09 Wellcome Trust From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions. Imperial Coll London, London, England Harvard TH Chan Sch Publ Hlth, Boston, MA USA Middlesex Univ, London, England World Hlth Org, Geneva, Switzerland Minist Hlth, Victoria, Seychelles Univ Lausanne, Lausanne, Switzerland Eduardo Mondlane Univ, Maputo, Mozambique Victor Babes Univ Med & Pharm Timisoara, Timisoara, Romania Univ Sydney, Sydney, NSW, Australia Natl Inst Biomed Innovat Hlth & Nutr, Tokyo, Japan Univ Auckland, Auckland, New Zealand Seoul Natl Univ, Seoul, South Korea ICMR Natl Inst Nutr, Hyderabad, India Capital Med Univ, Beijing An Zhen Hosp, Beijing, Peoples R China Univ Peruana Cayetano Heredia, Lima, Peru Univ Tunis El Manar, Tunis, Tunisia Univ Oulu, Oulu, Finland Univ Zagreb, Zagreb, Croatia Univ Ljubljana, Ljubljana, Slovenia Caja Costarricense Seguro Social, San Jose, Costa Rica Al Quds Univ, East Jerusalem, State Of Palest, Palestine Natl Ctr Publ Healthcare, Nur Sultan, Kazakhstan Minist Hlth, Kuala Lumpur, Malaysia Qatar Univ, Doha, Qatar Birzeit Univ, Birzeit, State Of Palest, Israel Usmanu Danfodiyo Univ Teaching Hosp, Sokoto, Nigeria Inst Mexicano Seguro Social, Mexico City, DF, Mexico Flinders Univ S Australia, Adelaide, SA, Australia Mahidol Univ, Salaya, Nakhon Pathom, Thailand BRAC James P Grant Sch Publ Hlth, Dhaka, Bangladesh Univ Copenhagen, Copenhagen, Denmark Copenhagen Univ Hosp, Copenhagen, Denmark Food & Nutr Res Inst, Taguig, Philippines Urmia Univ Med Sci, Orumiyeh, Iran Inst Nacl Ciencias Med & Nut, Mexico City, DF, Mexico Univ Amsterdam, Amsterdam, Netherlands Shahrekord Univ Med Sci, Shahrekord, Iran Noncommunicable Dis Res Ctr, Tehran, Iran Univ Oslo, Oslo, Norway Univ Bremen, Bremen, Germany Republican Ctr Hlth Promot, Bishkek, Kyrgyzstan Natl Ctr Diabet Endocrinol & Genet, Amman, Jordan Princess Nourah Bint Abdulrahman Univ, Riyadh, Saudi Arabia Kuwait Inst Sci Res, Kuwait, Kuwait King Abdulaziz Univ, Jeddah, Saudi Arabia Dasman Diabet Inst, Kuwait, Kuwait Luxembourg Inst Hlth, Strassen, Luxembourg Aldara Hosp & Med Ctr, Riyadh, Saudi Arabia King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia Bispebjerg & Frederiksberg Hosp, Copenhagen, Denmark Barcelona Inst Global Hlth CIBERESP, Barcelona, Spain World Hlth Org Reg Off Eastern Mediterranean, Cairo, Egypt Bombay Hosp & Med Res Ctr, Mumbai, Maharashtra, India Res Ctr Social Determinants Hlth, Tehran, Iran UMR CNRS MNHN 7206 Ecoanthropologie, Paris, France Univ Lille, Lille, France Lille Univ Hosp, Lille, France Western Norway Univ Appl Sci, Sogndal, Norway Norwegian Sch Sport Sci, Oslo, Norway Madras Diabet Res Fdn, Chennai, Tamil Nadu, India Zahedan Univ Med Sci, Zahedan, Iran Natl Inst Publ Hlth, Tunis, Tunisia Univ Porto, Inst Publ Hlth, Porto, Portugal Norwegian Inst Publ Hlth, Oslo, Norway Univ Massachusetts, Amherst, MA 01003 USA Abt Associates Inc, Kathmandu, Nepal Univ Iceland, Reykjavik, Iceland Univ Yaounde I, Yaounde, Cameroon Univ Fed Pelotas, Pelotas, RS, Brazil Univ Med 1, Yangon, Myanmar Banska Bystrica Reg Author Publ Hlth, Banska Bystrica, Slovakia Tel Aviv Univ, Tel Aviv, Israel Hebrew Univ Jerusalem, Jerusalem, Israel Univ Porto, Med Sch, Porto, Portugal Neyshabur Univ Med Sci, Neyshabur, Iran Res Inst Endocrine Sci, Tehran, Iran Indian Council Med Res, New Delhi, India Natl Inst Publ Hlth, Copenhagen, Denmark Univ Sci & Technol, Sanaa, Yemen Med Univ Lodz, Lodz, Poland Med Univ Gdansk, Gdansk, Poland Univ Autonoma Madrid CIBERESP, Madrid, Spain Univ Rzeszow, Rzeszow, Poland Univ Palermo, Palermo, Italy Pan Amer Hlth Org, Washington, DC USA Mohammed V Univ Rabat, Rabat, Morocco Univ Pernambuco, Recife, PE, Brazil Baqai Inst Diabetol & Endocrinol, Karachi, Pakistan Univ Fed Santa Catarina, Florianopolis, SC, Brazil Dalhousie Univ, Halifax, NS, Canada Jordan Univ Sci & Technol, Irbid, Jordan Univ Fed Maranhao, Sao Luis, Brazil Farabi Kazakh Natl Univ, Alma Ata, Kazakhstan Univ Coll Dublin, Dublin, Ireland Christian Med Coll & Hosp, Vellore, Tamil Nadu, India Fed Minist Social Affairs Hlth Care & Consumer Pr, Vienna, Austria Cafam Univ Fdn, Bogota, Colombia Kazakh Natl Med Univ, Alma Ata, Kazakhstan Lithuanian Univ Hlth Sci, Kaunas, Lithuania Univ Sao Paulo, Sao Paulo, Brazil BJ Med Coll, Ahmadabad, Gujarat, India Chirayu Med Coll, New Delhi, India Sunder Lal Jain Hosp, Delhi, India Hosp Sick Children, Toronto, ON, Canada Shandong Univ Tradit Chinese Med, Jinan, Peoples R China Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China Univ Republica, Montevideo, Uruguay Inst Med Res & Med Plant Studies, Yaounde, Cameroon Ufa Eye Res Inst, Ufa, Russia Nepal Hlth Res Council, Kathmandu, Nepal Univ Montenegro, Niksic, Montenegro Univ Southern Denmark, Copenhagen, Denmark Univ Gothenburg, Gothenburg, Sweden Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands Univ Turin, Turin, Italy UCL, London, England Liverpool John Moores Univ, Liverpool, Merseyside, England Nanyang Technol Univ Singapore, Singapore, Singapore German Inst Human Nutr, Potsdam, Germany Endocrinol Res Ctr, Moscow, Russia Ctr Educ Med & Invest Clin, Buenos Aires, DF, Argentina IRCCS Neuromed, Pozzilli, Italy Toulouse Univ, Sch Med, Toulouse, France Univ Zurich, Zurich, Switzerland Univ Hosp KU Leuven, Leuven, Belgium Flemish Agcy Care & Hlth, Brussels, Belgium Univ Ghent, Ghent, Belgium FrieslandCampina, Amersfoort, Netherlands Univ Cent Venezuela, Caracas, Venezuela Bielefeld Univ, Bielefeld, Germany World Hlth Org Reg Off Europe, Moscow, Russia German Canc Res Ctr, Heidelberg, Germany Fred Hollows Fdn, Auckland, New Zealand Univ Med & Pharm Bucharest, Bucharest, Romania Swansea Univ, Swansea, W Glam, Wales Univ Coll Copenhagen, Copenhagen, Denmark Inst Publ Hlth, Tirana, Albania Munster Technol Univ, Cork, Ireland Univ La Laguna, Tenerife, Spain Univ Malta, Msida, Malta Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA Minist Hlth, Tongatapu, Tonga Canadian Fitness & Lifestyle Res Inst, Ottawa, ON, Canada Hosp Santa Maria, Lisbon, Portugal Istanbul Univ Cerrahpasa, Istanbul, Turkey Univ Fed Juiz de Fora, Juiz De Fora, Brazil Minist Publ Hlth, Asuncion, Paraguay Natl Inst Publ Hlth, Prague, Czech Republic Gaetano Fucito Hosp, Mercato San Severino, Italy Univ Groningen, Groningen, Netherlands Karolinska Inst, Huddinge, Sweden Ctr Estudios Nutr Infantil, Buenos Aires, DF, Argentina Univ Porto, Porto, Portugal Univ Zaragoza, Zaragoza, Spain Santiago de Compostela Univ, Santiago De Compostela, Spain Minist Hlth, Ankara, Turkey Council Agr Res & Econ, Rome, Italy Fed Univ Rio Grande, Rio Grande, Brazil India Diabet Res Fdn, Chennai, Tamil Nadu, India Duke NUS Med Sch, Singapore, Singapore ICMR Natl Inst Med Stat, New Delhi, India Singapore Eye Res Inst, Singapore, Singapore Acad Sinica, Taipei, Taiwan Capital Inst Pediat, Beijing, Peoples R China Duke Univ, Durham, NH USA Kailuan Gen Hosp, Tangshan, Peoples R China Univ Oxford, Oxford, England Ahvaz Jundishapur Univ Med Sci, Ahvaz, Iran Gertner Inst Epidemiol & Hlth Policy Res, Ramat Gan, Israel Natl Ctr Publ Hlth & Anal, Sofia, Bulgaria Univ Fribourg, Fribourg, Switzerland Minist Hlth & Welf, Taipei, Taiwan CIBER Epidemiol & Salud Publ, Murcia, Spain Univ Southern Denmark, Odense, Denmark Univ Estadual Paulista, Presidente Prudente, Brazil Med Univ Silesia, Katowice, Poland Charles Univ Prague, Prague, Czech Republic Primary Hlth Care, Floriana, Malta Carol Davila Univ Med & Pharm, Bucharest, Romania Katholieke Univ Leuven, Leuven, Belgium STAT Canada, Ottawa, ON, Canada UMR CNRS MNHN 7206 Ecoanthropol, Marseille, France Agcy Prevent & Social Med, Bregenz, Austria Univ Southampton, Southampton, Hants, England Inst Pasteur, Lille, France Malawi Epidemiol & Intervent Res Unit, Lilongwe, Malawi CIBEROBN, Madrid, Spain Univ Debrecen, Debrecen, Hungary Univ Med & Pharm Carol Davila, Bucharest, Romania Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil CNR, Reggio Di Calabria, Italy Eftimie Murgu Univ Resita, Resita, Romania Spanish Agcy Food Safety & Nutr, Madrid, Spain Indian Stat Inst, Kolkata, India Tabriz Hlth Serv Management Res Ctr, Tabriz, Iran Geneva Univ Hosp, Geneva, Switzerland Sciensano, Brussels, Belgium Univ Med Ctr Groningen, Groningen, Netherlands Natl Res Ctr Prevent Med, Moscow, Russia Innovating Hlth Int, Port Au Prince, Haiti Univ Montreal, Montreal, PQ, Canada French Natl Res Inst Sustainable Dev, Montpellier, France French Publ Hlth Agcy, St Maurice, France Mediterranea Cardioctr, Naples, Italy Univ Vale Rio dos Sinos, Sao Leopoldo, Brazil Natl Inst Hyg Epidemiol & Microbiol, Havana, Cuba Natl Council Sci & Tech Res, Buenos Aires, DF, Argentina Minist Hlth & Med Educ, Tehran, Iran Univ Novi Sad, Novi Sad, Serbia Natl Inst Nutr, Hanoi, Vietnam Univ Queensland, Brisbane, Qld, Australia Ist Super Sanita, Rome, Italy Univ Cuenca, Cuenca, Ecuador Helmholtz Zentrum Munchen, Munich, Germany Univ Tehran Med Sci, Tehran, Iran Minist Sante & Hyg Publ, Abidjan, Cote Ivoire Univ Hosp Dusseldorf, Dusseldorf, Germany Natl Inst 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Res, Dhaka, Bangladesh Univ Turku, Turku, Finland Inst Univ Invest Atenc Primaria Jordi Gol, Girona, Spain Univ Putra Malaysia, Serdang, Malaysia Univ Malaya, Kuala Lumpur, Malaysia Sotiria Hosp, Athens, Greece Univ Valencia, Valencia, Spain Univ Philippines, Manila, Philippines Slovak Acad Sci, Bratislava, Slovakia Nutr Res Fdn, Barcelona, Spain Minas Gerais State Secretariat Hlth, Belo Horizonte, MG, Brazil CS S Agustin Ibsalut, Palma De Mallorca, Spain Amsterdam Inst Global Hlth & Dev, Amsterdam, Netherlands Natl Inst Hlth Doutor Ricardo Jorge, Lisbon, Portugal Univ Nove Julho, Sao Paulo, Brazil Publ Hlth Agcy Canada, Ottawa, ON, Canada Canarian Hlth Serv, Tenerife, Spain Univ Ind Santander, Bucaramanga, Colombia Assoc Calabrese Epatol, Reggio Di Calabria, Italy Univ Minho, Braga, Portugal Fiji Natl Univ, Suva, Fiji Spanish Nutr Fdn, Madrid, Spain Publ Hlth Agcy Sweden, Stockholm, Sweden Inst Food Sci Natl Res Council, Avellino, Italy Sitaram Bhartia Inst Sci & Res, New Delhi, India 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Published
2021

5. Novel virocell metabolic potential revealed in agricultural soils by virus-enriched soil metagenome analysis

Author

Felipe H. Coutinho, Lars Hestbjerg Hansen, João C. Setubal, Lucas P. P. Braga, Deyvid Amgarten, Laurent Philippot, Witold Kot, Agroécologie [Dijon], Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Univ Sao Paulo, Inst Chem, Sao Paulo, Brazil, Univ Cambridge, Dept Plant Sci, Ecosyst & Global Change Grp, Cambridge, England, Univ Miguel Henandez, Evolutionary Genom Grp, Alicante, Spain, and Univ Copenhagen, Dept Plant & Environm Sci, Frederiksberg, Denmark

Subjects
Biogeochemical cycle, viruses, [SDV]Life Sciences [q-bio], Biology, GENOMAS, Carbon cycle, 03 medical and health sciences, Soil, Ecology, Evolution, Behavior and Systematics, Ecosystem, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, Rhizosphere, 030306 microbiology, Ecology, Aquatic ecosystem, 15. Life on land, Agricultural and Biological Sciences (miscellaneous), Metagenomics, Soil water, Horizontal gene transfer, Viruses, Metagenome, Terrestrial ecosystem
Abstract

International audience; Viruses are now recognized as important players in microbial dynamics and biogeochemical cycles in the oceans. Yet, compared with aquatic ecosystems, virus discovery in terrestrial ecosystems has been challenging partly due to the inherent complexity of soils. To expand our understanding of soil viruses and their putative contributions to soil microbial processes, we analysed metagenomes of community-level virus-enriched suspensions by tangential flow filtration obtained from two French agricultural soils. We found viral sequences representing a total of 239 viral operational taxonomic units that corresponded to 29.5% of the mapping reads in the metagenomic datasets. The analysis of their genomic sequences revealed novel virocell metabolic potential with implications to virus-host interactions, carbon cycling, plant-beneficial functions in the rhizosphere, horizontal gene transfer and other relevant microbial strategies applied to survive in soils.

Published
2021
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6. Temperature and pH define the realised niche space of arbuscular mycorrhizal fungi

Author

Sergey Dudov, Olivia Semboli, Talaat Ahmed, Mari Moora, Jean-Pierre Munyampundu, Martin Zobel, Vladimir G. Onipchenko, Juha M. Alatalo, Guillaume Decocq, Sydney I. Glassman, Siim-Kaarel Sepp, Ülo Mander, Claudia Paz, Saleh Al-Quraishy, Matthew Coghill, James F. Cahill, A. A. Akhmetzhanova, Lauchlan H. Fraser, Urmas Kõljalg, John Davison, Brenda B. Casper, Annelies J. Veraart, C. Guillermo Bueno, Indrek Hiiesalu, Maarja Öpik, Juan Jose Cantero, Sergei Põlme, Elena A. Andriyanova, Marina Semchenko, Kersti Püssa, Hugh A. L. Henry, Mohammad Bahram, Meelis Pärtel, Wael N. Hozzein, Vladimir E Fedosov, Surya Sudheer, Petr Kohout, Charlotte Brown, Kadri Koorem, Ülo Niinemets, Lena Neuenkamp, Cherdchai Phosri, Leho Tedersoo, Jane Oja, Bruno Hérault, Clara P. Peña-Venegas, Martti Vasar, Sten Anslan, Ladislav Mucina, Ana P Coelho, M. M. Cherosov, Aveliina Helm, Argo Ronk, Casper Nyamukondiwa, Lauri Laanisto, Inga Hiiesalu, Ezequiel Fabiano, Sakeenah Adenan, Saida Chideh, Amgaa Batbaatar, Tanel Vahter, Alexey Seregin, Alessandro Saitta, Davison J., Moora M., Semchenko M., Adenan S.B., Ahmed T., Akhmetzhanova A.A., Alatalo J.M., Al-Quraishy S., Andriyanova E., Anslan S., Bahram M., Batbaatar A., Brown C., Bueno C.G., Cahill J., Cantero J.J., Casper B.B., Cherosov M., Chideh S., Coelho A.P., Coghill M., Decocq G., Dudov S., Fabiano E.C., Fedosov V.E., Fraser L., Glassman S.I., Helm A., Henry H.A.L., Herault B., Hiiesalu I., Hozzein W.N., Kohout P., Koljalg U., Koorem K., Laanisto L., Mander U., Mucina L., Munyampundu J.-P., Neuenkamp L., Niinemets U., Nyamukondiwa C., Oja J., Onipchenko V., Partel M., Phosri C., Polme S., Pussa K., Ronk A., Saitta A., Semboli O., Sepp S.-K., Seregin A., Sudheer S., Pena-Venegas C.P., Paz C., Vahter T., Vasar M., Veraart A.J., Tedersoo L., Zobel M., Opik M., Univ Tartu, Univ Manchester, Qatar Univ, Moscow Lomonsov State Univ, King Saud Univ, Russian Acad Sci, Swedish Univ Agr Sci, Univ Alberta, Univ Nacl Cordoba, Univ Nacl Rio Cuarto, Univ Penn, Univ Djibouti, Univ Aveiro, Thompson Rivers Univ, Jules Verne Univ Picardie, Univ Namibia, RAS, Univ Calif Riverside, Univ Western Ontario, UPR Forets & Societes, Univ Montpellier, INP HB, Beni Suef Univ, Czech Acad Sci, Charles Univ Prague, Estonian Univ Life Sci, Murdoch Univ, Stellenbosch Univ, Univ Rwanda, Univ Bern, Botswana Int Univ Sci & Technol, Nakhon Phanom Univ, Univ Palermo, Univ Bangui, Inst Amazon Invest Cient Sinchi, Universidade Estadual Paulista (Unesp), and Radboud Univ Nijmegen

Subjects
0106 biological sciences, 0301 basic medicine, arbuscular mycorrhizal fungi, ecological niche, molecular taxa, niche optimum, niche width, pH, phylogenetic correlation, temperature, Ecosystem, Fungi, Hydrogen-Ion Concentration, Phylogeny, Soil, Soil Microbiology, Temperature, Mycorrhizae, Phylogénie, Physiology, Plant Science, 01 natural sciences, Soil, Mycorrhizae, Phylogeny, Soil Microbiology, Abiotic component, biology, Ecology, pH, Temperature, Hydrogen-Ion Concentration, Phytoécologie, niche width, Température du sol, pH de la rhizosphère, F40 - Écologie végétale, Acaulosporaceae, Niche, arbuscular mycorrhizal fungi, 03 medical and health sciences, Glomeraceae, ecological niche, Relative species abundance, Champignon du sol, Arbuscular mycorrhiza [EN], Ecosystem, Ecological niche, phylogenetic correlation, Fungi, P34 - Biologie du sol, molecular taxa, temperature, Aquatic Ecology, facteurs abiotiques, 15. Life on land, biology.organism_classification, niche optimum, 030104 developmental biology, 13. Climate action, Biological dispersal, 010606 plant biology & botany, Gigasporaceae
Abstract

Made available in DSpace on 2021-06-25T11:52:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-04 European Regional Development Fund (Centre of Excellence EcolChange) University of Tartu (Estonian Research Council ) Moscow State University Natural Sciences and Engineering Research Council of Canada Discovery Grant Russian Science Foundation Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Swedish Research Council (Vetenskapsradet) The arbuscular mycorrhizal (AM) fungi are a globally distributed group of soil organisms that play critical roles in ecosystem function. However, the ecological niches of individual AM fungal taxa are poorly understood. We collected > 300 soil samples from natural ecosystems worldwide and modelled the realised niches of AM fungal virtual taxa (VT; approximately species-level phylogroups). We found that environmental and spatial variables jointly explained VT distribution worldwide, with temperature and pH being the most important abiotic drivers, and spatial effects generally occurring at local to regional scales. While dispersal limitation could explain some variation in VT distribution, VT relative abundance was almost exclusively driven by environmental variables. Several environmental and spatial effects on VT distribution and relative abundance were correlated with phylogeny, indicating that closely related VT exhibit similar niche optima and widths. Major clades within the Glomeraceae exhibited distinct niche optima, Acaulosporaceae generally had niche optima in low pH and low temperature conditions, and Gigasporaceae generally had niche optima in high precipitation conditions. Identification of the realised niche space occupied by individual and phylogenetic groups of soil microbial taxa provides a basis for building detailed hypotheses about how soil communities respond to gradients and manipulation in ecosystems worldwide. Univ Tartu, Inst Ecol & Earth Sci, EE-51005 Tartu, Estonia Univ Manchester, Sch Earth & Environm Sci, Manchester M13 9PL, Lancs, England Qatar Univ, Environm Sci Ctr, Doha 2713, Qatar Moscow Lomonsov State Univ, Dept Ecol & Plant Geog, Fac Biol, Moscow 119991, Russia King Saud Univ, Zool Dept, Coll Sci, Riyadh 11451, Saudi Arabia Russian Acad Sci, Inst Biol Problems, North Far East Branch, Magadan 685000, Russia Swedish Univ Agr Sci, Dept Ecol, S-75651 Uppsala, Sweden Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada Univ Nacl Cordoba, Inst Multidisciplinario Biol Vegetal, CONICET, X5000HUA, Cordoba, Argentina Univ Nacl Rio Cuarto, Fac Agron & Vet, Dept Biol Agr, X5804BYA, Cordoba, Argentina Univ Penn, Dept Biol, Philadelphia, PA 19104 USA Russian Acad Sci, Inst Biol Problems Cryolithozone, Siberian Branch, Yakutsk 677000, Russia Univ Djibouti, Dept Rech Sci Environm, Private Bag 1904, Djibouti, Djibouti Univ Aveiro, Dept Biol, P-3810193 Aveiro, Portugal Univ Aveiro, CESAM, P-3810193 Aveiro, Portugal Thompson Rivers Univ, Dept Nat Resource Sci, Kamloops, BC V2C 0C8, Canada Jules Verne Univ Picardie, Ecol & Dynam Syst Anthropises, F-80037 Amiens, France Univ Namibia, Dept Wildlife Management & Ecotourism, Private Bag 1096, Katima Mulilo, Namibia RAS, FEB, Bot Garden Inst, Vladivostok 690024, Russia Univ Calif Riverside, Dept Microbiol & Plant Pathol, Riverside, CA 92521 USA Univ Western Ontario, Dept Biol, London, ON N6A 5B7, Canada UPR Forets & Societes, CIRAD, Yamoussoukro, Cote Ivoire Univ Montpellier, Forets & Societes, CIRAD, F-34000 Montpellier, France INP HB, Inst Natl Polytech Felix Houphouet Boigny, Yamoussoukro, Cote Ivoire Beni Suef Univ, Bot & Microbiol Dept, Fac Sci, Bani Suwayf 62511, Egypt Czech Acad Sci, Inst Microbiol, Prague 14220, Czech Republic Charles Univ Prague, Dept Expt Plant Biol, Fac Sci, Prague 12843, Czech Republic Estonian Univ Life Sci, Chair Biodivers & Nat Tourism, EE-51006 Tartu, Estonia Murdoch Univ, Harry Butler Inst, Iluka Chair Vegetat Sci & Biogeog, Perth, WA 6150, Australia Stellenbosch Univ, Dept Geog & Environm Studies, ZA-7602 Stellenbosch, South Africa Univ Rwanda, Sch Sci, Coll Sci & Technol, Kigali 3900, Rwanda Univ Bern, Inst Plant Sci, CH-3013 Bern, Switzerland Estonian Univ Life Sci, Chair Crop Sci & Plant Biol, EE-51006 Tartu, Estonia Botswana Int Univ Sci & Technol, Dept Biol Sci & Biotechnol, Private Bag 16, Palapye, Botswana Nakhon Phanom Univ, Dept Biol, Nakhon Phanom 48000, Thailand Univ Tartu, Nat Hist Museum, EE-51014 Tartu, Estonia Univ Palermo, Dept Agr Food & Forest Sci, I-90128 Palermo, Italy Univ Bangui, Ctr Studies & Res Pharmacopoeia & Tradit African, Bangui, Cent Afr Republ Inst Amazon Invest Cient Sinchi, Leticia 910001, Amazonas, Colombia Univ Estadual Paulista, Dept Biodivers, BR-13506900 Sao Paulo, Brazil Radboud Univ Nijmegen, Inst Water & Wetland Res, Dept Aquat Ecol & Environm Biol, NL-6525 AJ Nijmegen, Netherlands Univ Tartu, Dept Bot, EE-51005 Tartu, Estonia Univ Estadual Paulista, Dept Biodivers, BR-13506900 Sao Paulo, Brazil University of Tartu: PLTOM20903 (Estonian Research Council ): MOBTP 105 (Estonian Research Council ): MOBERC20 (Estonian Research Council ): PRG352 (Estonian Research Council ): PRG609 (Estonian Research Council ): PRG 1065 (Estonian Research Council ): PRG 1170 (Estonian Research Council ): PRG 1409 Moscow State University: AAAA-A16-116021660039-1 Russian Science Foundation: 19-14-00038 FAPESP: 2016/25197-0 Swedish Research Council (Vetenskapsradet): 2017-05019 Swedish Research Council (Vetenskapsradet): QUEX-CAS-QP-RD-18/19

Published
2021
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7. Nardostachys jatamansi (D.Don) DC.: An invaluable and constantly dwindling resource of the Himalayas

Author

Sergio Ochatt, Manoj M. Lekhak, Vijay Kumar, Harmeet Kaur, Devashan Naidoo, Swati Chahal, Priyanka Jha, Umesh Goutam, Lovely Profess Univ, Div Res & Dev, Plant Biotechnol Lab, Phagwara 144411, Punjab, India, Lovely Profess Univ, Lovely Fac Technol & Sci, Dept Biotechnol, Phagwara 144411, Punjab, India, Shivaji Univ, Dept Bot, Angiosperm Taxon Lab, Kolhapur, Maharashtra, India, Lovely Profess Univ, Lovely Fac Technol & Sci, Dept Mol Biol & Genet Engn, Phagwara 144411, Punjab, India, Amity Univ, Amity Inst Biotechnol, Kolkata Campus, Kolkata 700156, W Bengal, India, Mangosuthu Univ Technol, Ctr Algal Biotechnol, Fac Nat Sci, POB 12363, ZA-4026 Durban, South Africa, Agroécologie [Dijon], and Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
0106 biological sciences, Spikenard, jatamansi, Resource (biology), biology, Himalayas, Agroforestry, [SDV]Life Sciences [q-bio], rhizome, conservation, Nardostachys jatamansi, Plant Science, Tibetan medicine, 15. Life on land, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Critically endangered, Geography, indian spikenard, Plant species, Conservation status, 010606 plant biology & botany
Abstract

International audience; The use of medicinal plant species for different therapeutic effects is well recognized around the globe. Nardostachys jatamansi (D.Don) DC. (Family: Caprifoliaceae Juss.), commonly known as Indian spikenard is a critically endangered medicinal plant which grows at high altitudes in the alpine and sub-alpine regions of the Himalayas. Its medicinal use is well-recognized in the Bhutanese, Chinese, Indian, Japanese, Nepalese and Tibetan medicine. Moreover, its medicinal properties are well established in traditional medicines including Ayurveda, Ben-Cao- Shi-Yi, Homer's Iliad, the Old Testament, as in conventional systems. The increasing national and international demand of N. jatamansi, mostly for the rhizomes (underground tissue), as well as illegal/unsustainable harvesting has brought this valuable species to the edge of extinction. Therefore, more research input including in vitro biotechnological approaches is required to ensure its sustainable utilization and long-term conservation. Further research is also needed to improve our current knowledge about its conservation status, clinical relevance, and bioactive components. This review comprehensively summarizes the currently available information on the ethnomedicinal uses, pharmacology, phytochemistry, trade value and potential role of modern plant biotechnology tools for the conservation of this high value plant. (c) 2020 SAAB. Published by Elsevier B.V. All rights reserved.

Published
2020
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8. The acidophilic microalgaCoccomyxa onubensisand atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets

Author

Yina Montero, Carlos Vílchez, Rosario Pásaro, Sara Ramírez, Javier S. Perona, Miguel Ángel Castaño, Alberto Toimil, Juan Luis Fuentes, Francisco Navarro, José M. Vega, [Navarro, Francisco] Univ Huelva, RENSMA, Dept Integrated Sci, Cell Biol, Huelva 21007, Spain, [Toimil, Alberto] Univ Huelva, RENSMA, Dept Integrated Sci, Cell Biol, Huelva 21007, Spain, [Navarro, Francisco] Univ Huelva, Fac Expt Sci, Huelva 21007, Spain, [Toimil, Alberto] Univ Huelva, Fac Expt Sci, Huelva 21007, Spain, [Ramirez, Sara] Univ Huelva, Fac Expt Sci, Huelva 21007, Spain, [Ramirez, Sara] Univ Huelva, RENSMA, Dept Chem, Huelva, Spain, [Montero, Yina] Univ Cartagena, Sch Pharmaceut Sci, Environm & Computat Chem Grp, Zaragocilla Campus, Cartagena 130015, Colombia, [Luis Fuentes, Juan] Univ Huelva, RENSMA, CIDERTA, Algal Biotechnol Grp, Huelva 21007, Spain, [Vilchez, Carlos] Univ Huelva, RENSMA, CIDERTA, Algal Biotechnol Grp, Huelva 21007, Spain, [Luis Fuentes, Juan] Univ Huelva, Fac Sci, Huelva 21007, Spain, [Vilchez, Carlos] Univ Huelva, Fac Sci, Huelva 21007, Spain, [Perona, Javier S.] CSIC, Inst Grasa, Seville, Spain, [Angel Castano, Miguel] Hosp Huelva Infanta Elena, Huelva, Spain, [Pasaro, Rosario] Univ Seville, Fac Biol, Dept Physiol, Seville, Spain, [Vega, Jose M.] Univ Seville, Fac Chem, Dept Plant Biochem & Mol Biol, Seville, Spain, Andalusian Government, University of Huelva, Universidad de Huelva, Junta de Andalucía, and Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular

Subjects
0106 biological sciences, Algae, Atorvastatin, Lipid-metabolism, Hypercholesterolemia, Chlorophyceae, Plant Science, Aquatic Science, Overweight, 01 natural sciences, Rat metabolic syndrome, Plasma, Cognition, Dry weight, medicine, Microalgae, Food science, Supplements, chemistry.chemical_classification, biology, 010604 marine biology & hydrobiology, Coccomyxa onubensis, Brain, biology.organism_classification, Cholesterol, chemistry, Docosahexaenoic acid, Food, Hyperglycemia, Polyunsaturated fatty acids, medicine.symptom, Acids, 010606 plant biology & botany, Lipoprotein, Polyunsaturated fatty acid, medicine.drug
Abstract

2 Tablas.-- 3 Figuras, Biomass of the acidophilic green alga Coccomyxa onubensis may be used as a food source for animals without collateral toxic effects, as diet supplemented the microalga has significant hypoglycemic and hypocholesterolemic effects on healthy animals. Rats were fed for 108 days with a high-fat diet, and at the end of the experiment, they were overweight and had significantly increased serum levels of glucose (2.0-fold), total cholesterol (1.6-fold), and low-density lipoprotein (LDL)-cholesterol (7.7-fold). The supplement of C. onubensis powder (6.25% w/w dry weight) in the high-fat diet significantly protected the rats against cardiovascular risks by reducing the serum levels of glucose (38.47%), total cholesterol (22.65%), and LDL-cholesterol (26.70%). The protective effects of the microalga were comparable with that of 10 mg/kg body weight per day of atorvastatin. The high-fat diet decreased both ω–3 eicosapentaenoic and docosahexaenoic acids in the brain tissue of rats; however, C. onubensis powder could not restrict these changes. Simultaneously, the high-fat diet increased the levels of both palmitic and arachidonic (ω–6) acids in the telencephalon tissue of rats; this was prevented when microalga biomass was used in the diet of rats., This study is funded by the University of Huelva and Andalusian Government (research project BIO–214).

Published
2020

9. The effects of seasonal heavy-metal pollution of Ladik Lake on pike fish (Esox lucius)

Author

Şevket Kandemir, Okan Yazıcıoğlu, Nuh Korkmaz, Levent Altaş, Savaş Yilmaz, İsmail Şimşek, Ibrahim Orun, K. Erdogan, Arzu Dogru, Mehmet Ilker Doğru, Gülnihal Örün, Ondokuz Mayıs Üniversitesi, Kırşehir Ahi Evran Üniversitesi, Teknik Bilimler Meslek Yüksekokulu, Bitkisel ve Hayvansal Ürünler Bölümü, and [Erdogan, Kenan -- Dogru, Mehmet Ilker -- Korkmaz, Nuh -- Orun, Ibrahim] Aksaray Univ, Fac Sci & Letters, Dept Biol, Aksaray, Turkey -- [Kandemir, Sevket] Amasya Univ, Fac Educ, Dept Elementary Educ, Amasya, Turkey -- [Dogru, Arzu] Aksaray Univ, Fac Educ, Dept Elementary Educ, Aksaray, Turkey -- [Simsek, Ismail -- Altas, Levent] Aksaray Univ, Fac Engn, Dept Environm Engn, Aksaray, Turkey -- [Yilmaz, Savas] Ondokuz Mayis Univ, Fac Sci & Letters, Dept Biol, Samsun, Turkey -- [Orun, Gulnihal] Aksaray Univ, Tech Sci Vocat Sch, Aksaray, Turkey -- [Yazicioglu, Okan] Ahi Evran Univ, Tech Sci Vocat Sch, Kirsehir, Turkey

Subjects
Pollution, Physiology, media_common.quotation_subject, water, Biochemical parameters, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), heavy metals, Ecology, Evolution, Behavior and Systematics, Esox, Pike, computer.programming_language, media_common, biology, business.industry, 0402 animal and dairy science, Sediment, Heavy metals, 04 agricultural and veterinary sciences, Metal pollution, biology.organism_classification, 040201 dairy & animal science, Esox lucius, Fishery, sediment, Agriculture, histopathology, %22">Fish , Environmental science, business, computer, 030217 neurology & neurosurgery
Abstract

WOS: 000470363000001, Ladik Lake (Samsun, Turkey) is a natural landscape under the threat of pollution because of urban, agricultural and industrial activities. In this study, accumulation of heavy metals (Al, Ba, Cr, Cu, Fe, Mn, Pb and Zn) in the tissues (muscle, liver and gill) of sediment dwelling pike fish and in different substrates of Ladik Lake were investigated. Seasonal haematological, biochemical and histopathological parameters of the carp are also reported. In general, heavy-metal levels in water and sediment samples were found in the highest level in summer and the lowest in autumn. Histopathologic changes in the tissues of the fish (liver and gill) were at the minimum in winter while it was highest in summer. Blood biochemical parameters exhibited higher level in summer in comparison with other seasons. Al, Ba, Cr, Mn and Zn levels in the tissues of the fish were in the order gill>liver>muscle in all seasons. The levels of Cu, Fe and Pb were in the sequence liver>gill>muscle. Cr, Cu, Pb and Zn levels were determined to be in high level in the tissues of the fish with respect to the literature values. The heavy-metal levels in Ladik Lake and the fish health need to be regularly monitored for a sustainable environmental health.

Published
2020
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10. WUSCHEL: a master regulator in plant growth signaling

Author

Sergio Ochatt, Vijay Kumar, Priyanka Jha, Amity Univ, Amity Inst Biotechnol, Major Arterial Rd,Act Area 2, Kolkata, W Bengal, India. [Kumar, Vijay] Lovely Profess Univ, Plant Biotechnol Lab, Div Res & Dev, Phagwara 144411, Punjab, India. [Kumar, Vijay] Lovely Profess Univ, Dept Biotechnol, Lovely Fac Technol & Sci, Phagwara 144411, Punjab, India., Agroécologie [Dijon], Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Lovely Profess Univ, Plant Biotechnol Lab, Div Res & Dev, Phagwara 144411, Punjab, India., and Kumar, V (reprint author), Lovely Profess Univ, Dept Biotechnol, Lovely Fac Technol & Sci, Phagwara 144411, Punjab, India

Subjects
0106 biological sciences, 0301 basic medicine, Plant growth, Cytokinins, Meristem, Arabidopsis, Flowers, Plant Science, Biology, 01 natural sciences, Epigenesis, Genetic, 03 medical and health sciences, Regeneration, Primordium, Stem Cell Niche, Gene, Transcription factor, transcription factor, Homeodomain Proteins, Arabidopsis Proteins, transformation, fungi, food and beverages, Cell Differentiation, General Medicine, 15. Life on land, Plants, Genetically Modified, Plant cell, shoot meristem, Cell biology, 030104 developmental biology, [SDE]Environmental Sciences, Homeobox, embryogenesis, plant development, Signal transduction, Agronomy and Crop Science, Plant Shoots, Signal Transduction, Transcription Factors, 010606 plant biology & botany
Abstract

National audience; Key message This review summarizes recent knowledge on functions of WUS and WUS-related homeobox (WOX) transcription factors in diverse signaling pathways governing shoot meristem biology and several other aspects of plant dynamics. Transcription factors (TFs) are master regulators involved in controlling different cellular and biological functions as well as diverse signaling pathways in plant growth and development. WUSCHEL (WUS) is a homeodomain transcription factor necessary for the maintenance of the stem cell niche in the shoot apical meristem, the differentiation of lateral primordia, plant cell totipotency and other diverse cellular processes. Recent research about WUS has uncovered several unique features including the complex signaling pathways that further improve the understanding of vital network for meristem biology and crop productivity. In addition, several reports bridge the gap between WUS expression and plant signaling pathway by identifying different WUS and WUS-related homeobox (WOX) genes during the formation of shoot (apical and axillary) meristems, vegetative-to-embryo transition, genetic transformation, and other aspects of plant growth and development. In this respect, the WOX family of TFs comprises multiple members involved in diverse signaling pathways, but how these pathways are regulated remains to be elucidated. Here, we review the current status and recent discoveries on the functions of WUS and newly identified WOX family members in the regulatory network of various aspects of plant dynamics.

Published
2020
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11. Cytotoxic effect of Rosa canina extract on human colon cancer cells through repression of telomerase expression

Author

Ibrahim Turan, Ahmet Mentese, Serap Ozer Yaman, Kagan Kilinc, Berna Genc, Hanife Kara, Selim Demir, Orhan Deger, Sema Misir, Yuksel Aliyazicioglu, [Turan, Ibrahim -- Kilinc, Kagan -- Genc, Berna] Gumushane Univ, Fac Engn & Nat Sci, Dept Genet & Bioengn, TR-29100 Gumushane, Turkey -- [Turan, Ibrahim] Gumushane Univ, Med Plants Tradit Med Practice & Res Ctr, TR-29100 Gumushane, Turkey -- [Demir, Selim] Karadeniz Tech Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-61080 Trabzon, Turkey -- [Yaman, Serap Ozer -- Misir, Sema -- Kara, Hanife -- Aliyazicioglu, Yuksel -- Deger, Orhan] Karadeniz Tech Univ, Fac Med, Dept Med Biochem, TR-61080 Trabzon, Turkey -- [Misir, Sema] Cumhuriyet Univ, Fac Pharm, Dept Biochem, TR-58140 Sivas, Turkey -- [Mentese, Ahmet] Karadeniz Tech Univ, Vocat Sch Hlth Sci, Program Med Lab Tech, TR-61080 Trabzon, Turkey, and Demir, Selim -- 0000-0002-1863-6280

Subjects
0301 basic medicine, Telomerase, Cell cycle checkpoint, Cytotoxicity, Pharmaceutical Science, Apoptosis, Pharmacy, Analytical Chemistry, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Electrochemistry, Cytotoxic T cell, MTT assay, Rosa canina, Viability assay, Spectroscopy, biology, Chemistry, lcsh:RM1-950, Cell cycle, biology.organism_classification, Molecular biology, Colon cancer, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, 030220 oncology & carcinogenesis, Original Article
Abstract

WOS: 000451243800007, PubMed ID: 30595946, Rosa canina is a member of the genus Rosa that has long been used for medical objectives. Several studies have reported cytotoxic effects of different Rosa species, but there has been only limited investigation of the cytotoxic effect of R. canina. The purpose of the current study was to examine the potential effect of R. canina extract on cell viability, the cell cycle, apoptosis, and the expression of telomerase in human colon cancer (WiDr) cells. The cytotoxic effect of the extract was determined using MIT assay. The mechanism involved in the cytotoxic effect of the extract was then evaluated in terms of apoptosis and the cell cycle using flow cytometry. Mitochondrial membrane potential (MMP) was investigated using the fluorometric method, and expression levels of telomerase were studied using RT-PCR. R. canina extract exhibited a selective cytotoxic effect on WiDr cells compared with normal colon cells. The extract induced cell cycle arrest at the S phase and apoptosis via reduced MMP in WiDr cells. R. canina extract significantly repressed telomerase expressions at treatment times of 48 and 72 h in WiDr cells. Our results suggest that R. canina may have considerable potential for development as a novel natural product-based anticancer agent. (C) 2018 Xi'an Jiaotong University. Production and hosting by Elsevier B.V., Foundation of Scientific Research of Gumushane University [13.F5119.02.1], The authors would like to thank the Foundation of Scientific Research of Gumushane University for financially supporting this research under Project No: 13.F5119.02.1. The authors also wish to thank Professor Ersan Kalay from the Medical Biology Department, Karadeniz Technical University for professional assistance with the flow cytometry studies.

Published
2018

12. Phenolic Compounds, Antioxidant Properties and Enzyme Inhibition Ability of Adiantum capillus veneris L. linked to Alzheimer’s Disease, Diabetes Mellitus and Skin Disorders

Author

Ako Abdulqadir, Yavuz Selim Cakmak, Gokhan Zengin, [Abdulqadir, Ako -- Cakmak, Yavuz S.] Aksaray Univ, Fac Sci & Letters, Dept Biotechnol & Mol Biol, Aksaray, Turkey -- [Zengin, Gokhan] Selcuk Univ, Fac Sci, Dept Biol, Konya, Turkey, Zengin, Gokhan -- 0000-0001-6548-7823, and Sabire Yazıcı Fen Edebiyat Fakültesi

Subjects
Adiantum capillus-veneris L, Antioxidant, diabetes, biology, Chemistry, medicine.medical_treatment, Organic Chemistry, biological activities, Disease, Pharmacology, biology.organism_classification, medicine.disease, Adiantum capillus-veneris, skin disorders, Enzyme inhibition, Diabetes mellitus, Alzheimer, Diabetes Mellitus, medicine
Abstract

WOS: 000447281500005, Adiantum capillus-veneris L. is one of the best ferns that are used in traditional medicine for breaking kidney stones. This study aimed to evaluate antioxidant activity of the different extracts of A. capillus-veneris using the phosphomolybdenum assay, free radical scavenging activity (DPPH), ferric reducing antioxidant power (FRAP), and cupric ion reducing power activity test (CUPRAC). Besides, the enzyme inhibition activities were determined against acetylcholinesterase, tyrosinase, alpha-glucosidase and alpha-amylase. Total and individual phenolic compounds were also determined by spectrophotometric and HPLC methods, respectively. Total phenolic and flavonoid contents were found to change between 354-441 mg GAE/g and 23-123 mg QE/g, respectively. The major phenolic compounds were benzoic acid, epicatechin, syringic acid and catechin. Methanol and ethyl acetate extracts exhibited stronger antioxidant abilities compared to water extract. A. capillus-veneris extracts showed high enzyme inhibition activities except for butrylcholinesterase. The results indicated that the different extracts of A. capillus-veneris L. can be used as natural sources of antioxidants and enzyme inhibitors.

Published
2018
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13. Impact of sorafenib on epidural fibrosis: An immunohistochemical study

Author

Omur Gunaldi, Ilhan Yilmaz, Metehan Eseoğlu, Uzay Erdogan, Osman Tanriverdi, Ayca Arslanhan, Huseyin Utku Adilay, Canan Tanik, Tıp Fakültesi, Tanriverdi, Osman, Erdogan, Uzay, Gunaldi, Omur Univ Hlth Sci, Bakirky Prof Dr Mazhar Osman Training & Res Hosp, Dept Neurosurg & Psychiat, Tevfik Saglam Cad 1, TR-34303 Istanbul, Turkey, Tanik, Canan Univ Hlth Sci, Sisli Hamidiye Etfal Training & Res Hosp, Dept Pathol, TR-34303 Istanbul, Turkey, Yilmaz, Ilhan Univ Hlth Sci, Sisli Hamidiye Etfal Training & Res Hosp, Dept Neurosurg, TR-34303 Istanbul, Turkey, Adilay, Huseyin Utku Balikesir Univ, Med Fac, Dept Neurosurg, TR-31300 Balikesir, Turkey, Arslanhan, Ayca Marmara Univ, Inst Neurol Sci, TR-34303 Istanbul, Turkey, Eseoglu, Metehan Medipol Univ, Med Fac, Dept Neurosurg, TR-34303 Istanbul, Turkey, Tanriverdi, O., Department of Neurosurgery and Psychiatry, University of Health Sciences, Bakirky Prof. Dr. Mazhar Osman Training and Research Hospital for Neurology, Istanbul, 34303, Turkey, Erdogan, U., Department of Neurosurgery and Psychiatry, University of Health Sciences, Bakirky Prof. Dr. Mazhar Osman Training and Research Hospital for Neurology, Istanbul, 34303, Turkey, Tanik, C., Department of Pathology, University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, Istanbul, 34303, Turkey, Yilmaz, I., Department of Neurosurgery, University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, Istanbul, 34303, Turkey, Gunaldi, O., Department of Neurosurgery and Psychiatry, University of Health Sciences, Bakirky Prof. Dr. Mazhar Osman Training and Research Hospital for Neurology, Istanbul, 34303, Turkey, Adilay, H.U., Department of Neurosurgery, Medical Faculty, Balikesir University, Balikesir, 31300, Turkey, Arslanhan, A., Institute of Neurological Science, Marmara University, Istanbul, 34303, Turkey, and Eseoglu, M., Department of Neurosurgery, Medical Faculty, Medipol University, Istanbul, 34303, Turkey

Subjects
Sorafenib, Pathology, medicine.medical_specialty, medicine.medical_treatment, Neovascularization, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Fibrosis, medicine, Osteopontin, biology, business.industry, Vascular Endothelial Growth Factor, Laminectomy, General Medicine, Basic Study, medicine.disease, Staining, Vascular endothelial growth factor, CD105, Spinal Epidural Fibrosis, chemistry, 030220 oncology & carcinogenesis, biology.protein, Immunohistochemistry, medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Adilay, Hüseyin Utku (Balikesir Author), AIM To determine if sorafenib, an antineoplastic agent, could prevent the development of spinal epidural fibrosis (EF). METHODS The study used CD105 and osteopontin antibodies in an immunohistochemical approach to quantify EF that occurred as a consequence of laminectomy in rats. Wistar albino rats (n = 16) were divided into two groups: control (L1-2 level laminectomy only) and sorafenib treatment (L1-2 level laminectomy + topical sorafenib). The animals were euthanatized after 6 wk, and the EF tissues were examined for histopathological changes after immunohistochemical staining. The EF grades were assigned to the tissues, and the treatment and control groups were compared. RESULTS The EF thickness, inflammatory cell density, and arachnoid adherences determined by light microscopy were significantly higher in the control group compared to the sorafenib-treated group. Based on fibrosis scores, the extent of EF in the treatment group was significantly lower than in the controls. Immunohistochemical staining for CD105 to identify microvessels revealed that the EF grades based on vessel count were significantly lower in the treatment group. Staining for osteopontin did not show any significant differences between the groups in terms of the extent of EF. The staging of EF based on vascular counts observed after immunohistochemical staining for CD105, but not for osteopontin, was compatible with conventional staging methods. Neither toxic effects on tissues nor systemic side effects were observed with the use of sorafenib. CONCLUSION Local administration of sorafenib significantly reduced post-laminectomy EF. Decreased neovascularization in spinal tissue may be due to the sorafenib-induced inhibition of vascular endothelial growth factor.

Published
2018
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14. Protein adsorption and macrophage uptake of zwitterionic sulfobetaine containing micelles

Author

Suming Li, Xianglin Luo, Aijing Lu, Zhengzhong Wu, Sichuan Univ, Coll Polymer Sci & Engn, Chengdu 610065, Sichuan, Peoples R China., Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Sichuan University [Chengdu] (SCU), Institut Européen des membranes (IEM), and Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)

Subjects
Macrophage, Polymers, Surface Properties, Protein adsorption, Poly(sulfobetaine methacrylate), macromolecular substances, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Micelle, chemistry.chemical_compound, Colloid and Surface Chemistry, Adsorption, Betaine, Polymer chemistry, [CHIM]Chemical Sciences, Animals, Denaturation (biochemistry), Particle Size, Physical and Theoretical Chemistry, Bovine serum albumin, Poly(epsilon-caprolactone), Micelles, biology, Macrophages, technology, industry, and agriculture, Fibrinogen, Serum Albumin, Bovine, Surfaces and Interfaces, General Medicine, Zwitterionic, equipment and supplies, musculoskeletal system, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Poly(N, chemistry, biology.protein, Cattle, Muramidase, Absorption (chemistry), 0210 nano-technology, N-diethylaminoethyl methacrylate), Ethylene glycol, Biotechnology
Abstract

International audience; Micelles of poly(epsilon-caprolactone)-b-poly(N,N-diethylaminoethyl methacrylate)/(N-(3-sulfopropyl-N-methacryloxyethy-N,N-diethylammonium betaine)) (PCL-PDEAPS) and poly(epsilon-caprolactone)-b-poly(ethylene glycol) (PCL-PEG) were prepared and characterized. The interactions of micelles with model proteins such as bovine serum albumin (BSA), lysozyme (Ly), fibrinogen (Fg) and plasma were studied from adsorption quantity, micelle size, polydispersity index (PDI) and zeta-potential measurements. The adsorption quantity of negatively charged proteins on PCL-PDEAPS micelles containing zwitterionic sulfobetaine is larger than on non-ionic PEG-PCL micelles. The adsorption amount increases with the increase of zwitterionic content. And the quantity of adsorbed Fg is much higher than that of BSA because the former is much larger than the latter. In contrast, adsorption of positively charged Ly on copolymer micelle is very low. The interactions between micelles and model proteins are not only dependent on the hydration of zwitterions in PCL-PDEAPS micelles, but also on the electrostatic effect between proteins and micelles. Moreover, the adsorption of three model proteins on the mixed micelles of PCL-PDEAPS and PCL-PEG copolymers is related to the ratio of two copolymers. Denaturation of the proteins is not detected during adsorption and detachment process. PCL-PDEAPS micelles with positive charge are not swallowed by the macrophages after plasma absorption, in contrast to PCL-PEG micelles. (C) 2018 Elsevier B.V. All rights reserved.

Published
2018
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15. Efficient expression of recombinant human telomerase inhibitor 1 (hPinX1) in Pichia pastoris

Author

Melike Yildiz, Hakan Askin, Yagmur Unver, Deryanur Kilic, Abdulhadi Firat, Mesut Taskin, Sabire Yazıcı Fen Edebiyat Fakültesi, deryanur -- 0000-0002-9115-136X, and [Unver, Yagmur -- Yildiz, Melike -- Taskin, Mesut -- Firat, Abdulhadi -- Askin, Hakan] Ataturk Univ, Dept Mol Biol & Genet, Fac Sci, TR-25240 Erzurum, Turkey -- [Kilic, Deryanur] Aksaray Univ, Sabire Yazici Fac Sci & Letters, Dept Chem, Aksaray, Turkey

Subjects
Optimization, 0301 basic medicine, Tumor suppressor gene, Blotting, Western, Cell Culture Techniques, hPinX1, Telomerase Inhibitor, Cell Cycle Proteins, Expression, Pichia Pastoris, Biochemistry, Pichia, Pichia pastoris, law.invention, 03 medical and health sciences, Transformation, Genetic, law, Escherichia coli, Humans, PINX1, Promoter Regions, Genetic, Telomerase, Human telomerase, biology, Tumor Suppressor Proteins, Production, Chromosome, General Medicine, Hydrogen-Ion Concentration, biology.organism_classification, Molecular biology, Yeast, Molecular Weight, 030104 developmental biology, Fermentation, Recombinant DNA, Plasmids, Biotechnology
Abstract

WOS: 000451222800011, PubMed: 29958061, PinX1 encoded by a remarkable tumor suppressor gene and located in human chromosome 8p23 is known as telomerase inhibitor. In recent years, this protein has been of interest as clinically tumor suppressor. Pichia pastoris expression system is preferred to produce heterologous proteins and is suitable for industrial and research purposes. In the present study, human PinX1 gene (hPinX1) was cloned in E. coli One Shot TOP10 cells and overexpressed in P. pastoris strain X-33 intracellularly, using a strong AOX (alcohol oxidase) promoter. The recombinant cells were grown in shaking flask. Induction time, methanol concentration and initial pH were optimized for obtaining high levels of hPinX1 protein production. Recombinant protein production was confirmed by Western blot analysis and the relative expression levels of rhPinX1 were quantified. According to Western blot analysis, molecular mass of produced hPinX1 was determined as 47.5kDa. At the end of optimization studies, the best fermentation conditions were determined as induction time 48h, methanol concentration 3% and initial culture pH 5.0. This process would be an applicable way for obtaining recombinant hPinX1 using P. pastoris expression system. This is the first report on recombinant production of hPinX1 in P. pastoris.

Published
2018
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16. Determination of the relationship between oxalate degradation and exopolysaccharide production by different Lactobacillus probiotic strains

Author

Derya Onal Darilmaz, Yavuz Beyatli, Şule Sönmez, Sabire Yazıcı Fen Edebiyat Fakültesi, and [Sonmez, Sule -- Beyatli, Yavuz] Gazi Univ, Dept Biol, Fac Sci, TR-06500 Ankara, Turkey -- [Darilmaz, Derya Onal] Aksaray Univ, Fac Sci & Letters, Dept Biotechnol & Mol Biol, TR-68100 Aksaray, Turkey

Subjects
Oxalate Degradation, 0301 basic medicine, biology, Chemistry, Process Chemistry and Technology, 030106 microbiology, food and beverages, Bioengineering, Probiotic, biology.organism_classification, law.invention, Lactobacillus, 03 medical and health sciences, 030104 developmental biology, Exopolysaccharide, law, Oxalate degradation, Food science, Food Science
Abstract

WOS: 000437683000022, The aim of this study was to evaluate the protective effects of exopolysaccharide (EPS) production on resistance to gastrointestinal digestive conditions and oxalate by probiotic strains of the species Lactobacillus rhamnosus, Lactobacillus fermentum and Lactobacillus brevis. The oxalate-degrading ability of the strains was determined using an enzymatic assay. The correlation between oxalate degradation rate and EPS production was not significant (P>0.05); however, the high-EPS-producing L.fermentumIP5 and L.brevisYG7 strains showed high oxalate-degrading activity, whereas the low-EPS-producing strain L.fermentumBP5 demonstrated low oxalate-degrading activity. The present findings suggest that dietary supplementation with the probiotic strain L.fermentumIP5 could be a promising strategy for the prevention of oxalate stone disease., Aksaray University, The authors are grateful to the Aksaray University for financial support and Aksaray University Scientific and Technological Research and Application Center (ASUBTAM) for the provision of laboratory facilities. The authors also thank Dr. Silvia Turroni for providing reference cultures (L. delbrueckii subsp. delbrueckii DSM 20074 and L. acidophilus NCFM). This text was analysed in terms of grammar and use of language by Lecturer Ekmel Emrah Hakman, MA, in the Academic Foreign Language Support Center, Aksaray University.

Published
2018
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17. Mirza (Hacızade) Gökgöl (1897–1981): the great explorer of wheat genetic resources in Turkey

Author

Alptekin Karagöz, Helmut Knüpffer, Nargiz Garaybayova, Hande Yilmaz, Karl Hammer, Benjamin Kilian, Hakan Özkan, Nusret Zencirci, Çukurova Üniversitesi, [Zencirci, Nusret -- Yilmaz, Hande] Abant Izzet Baysal Univ, Sci & Literature Fac, Dept Biol, TR-14280 Golkoy, Bolu, Turkey -- [Garaybayova, Nargiz] ANAS, Genet Resources Inst, Azadliq Ave 155, Baku 71106, Azerbaijan -- [Karagoz, Alptekin] Aksaray Univ, Aksaray Vocat Sch Tech Sci, Aksaray, Turkey -- [Hammer, Karl -- Knupffer, Helmut] Leibniz Inst Plant Genet & Crop Plant Res IPK Gat, Corrensstr 3, D-06466 Seeland, Germany -- [Kilian, Benjamin] Global Crop Div Trust, Pl Vereinten Nationen 7, D-53113 Bonn, Germany -- [Ozkan, Hakan] Univ Cukurova, Fac Agr, Dept Field Crops, TR-01330 Adana, Turkey, OZKAN, Hakan -- 0000-0003-3530-2626, Kilian, Benjamin -- 0000-0002-9145-6980, Zencirci, Nusret -- 0000-0003-3460-7575, and Teknik Bilimler Meslek Yüksekokulu

Subjects
0106 biological sciences, History, Plant Science, Biology, 010603 evolutionary biology, 01 natural sciences, Common wheat, Crop, Biography, Poppy, Genetic resources, Genetics, Cultivar, Plant breeding, Durum wheat, Triticum, Ecology, Evolution, Behavior and Systematics, business.industry, Landraces, Agronomy, Agriculture, Cool season, business, Agronomy and Crop Science, 010606 plant biology & botany
Abstract

WOS: 000425544300001, Mirza (HacA +/- zade) Gokgol (1897-1981) was a leading agro-ecological plant scientist, agronomist and breeder in Turkey. Gokgol carried out extensive breeding programmes extensively selecting from local plant genetic resources from across Turkey from 1925 till the 1950s. He collected and evaluated cultivars, landraces and wild relatives, predominantly of wheat, but also of barley, lentil and other crops in Turkey during 1929-1955. He published books on wheat and other cereals, potatoes, castor bean, sweet clover, poppy, and other crops. He was a hardworking pioneer utilizing wheat genetic resources for crop improvement. Since his ample work has hardly been accessible by the English-speaking scientific community today, we are providing an overview of his major work, mainly on wheat. The books he published can still be found in libraries, although with difficulties. However, his articles, leaflets etc., are hardly accessible. Some of them are: Turkish Wheats, vols. 1 and 2, Plant Breeding through Scientific Methods (1928, translation of a book by E. Baur), The Basics of Wheat Breeding (1954), and Agriculture and Breeding of Cool Season Cereals-Wheat, Rye, Barley, and Oats (1969). In addition to the summary of his books, we reviewed his views and discussions about the centres of origin and diversity, and compared with those of Vavilov.

Published
2018
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18. Analysis of growth curves of Guinea fowl (Numida meleagris) fed diets containing dry oregano (Origanum vulgare L.) in an organic system

Author

Mustafa Duman, Hüdaverdi Bircan, Hasan Eleroğlu, Arda Yildirim, Ali Canikli, [Eleroglu, H.] Cumhuriyet Univ, Sarkisla Asik Veysel Vocat High Sch, Sarkisla, Sivas, Turkey -- [Yildirim, A. -- Canikli, A.] Gaziosmanpasa Univ, Agr Fac, Dept Anim Sci, Tokat, Turkey -- [Duman, M.] Nigde Omer Halisdemir Univ, Lab Assistant & Vet Hlth Dept, Bor Vocat High Sch, Nigde, Turkey -- [Bircan, H.] Cumhuriyet Univ, Fac Econ & Administrator Sci, Business Dept, Sivas, Turkey, and Yildirim, Arda -- 0000-0002-5876-4228

Subjects
Guinea fowl, biology, Fowl, Gompertz function, growth parameters, Origanum, biology.organism_classification, Animal science, organic production, Inflection point, Growth models, medicine, medicine.symptom, Logistic function, Akaike information criterion, oregano levels, Weight gain, Mathematics
Abstract

WOS: 000445550800001, In this study, 240 day-old guinea fowl (Numida meleagris) keets were utilized. They were divided into four treatment groups each containing 20 chicks and were randomly distributed into 12 mobile coops placed in a 100-m(2) grazing area. Guinea fowl chicks were randomly allocated to 4 treatment diets containing 0%, 5%, 10%, and 15% dry oregano leaf (DOL) supplements. Nonlinear Gompertz and logistic growth models were used to estimate the mean age-body weight. The growth curve parameters for these models and the following characteristics for fowl were estimated: beta(0), the asymptotic weight parameter,beta(1), the scaling parameter, beta(2), the instantaneous per week growth rate; weight at age of inflection point (WIP); maximum weight gain at inflection point (MWG); and age at the inflection point (ALP). The goodness of fit (GF) for the models was assessed using the following variables: coefficients of determination (r(2)), mean square error (MSE), adjusted determination coefficient (ADR(2)), Akaike's information criteria (AIC), chi-square test (Chi.Sq(2)) and residual standard deviation (RSD). The different nonlinear function results of the individual data indicated that supplementation of diets with DOL had no significant effects on growth curve parameters when compared with the control diet. Greater correlation values were estimated among beta(0), beta(1) , beta(2), WIP, MWG and AIP in the Gompertz equation, and similar results were estimated in the logistic equation, but there was no significant correlation between beta(2)-beta(1) and beta(2)-MWG. According to the results obtained from the GF, high r(2) and ADR(2) were estimated in Gompertz and logistic equations (above 0.96)., Research Fund of Cumhuriyet University [ENF-006], This study was supported by the Research Fund of Cumhuriyet University (Project No: ENF-006).

Published
2018
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19. Determination of genetic variations in the genusDryomysThomas, 1906 (Rodentia: Gliridae) distributed in Turkey using NADH dehydrogenase 1 (ND1) gene

Author

Ercüment Çolak, Arif Can Erdik, Teoman Kankiliç, Nuri Yiğit, Tolga Kankiliç, Perinçek Seçkinozan Şeker, Engin Selvi, 0-Belirlenecek, Kankılıç, T., Department of Biotechnology, Faculty of Science and Letters, Niğde Ömer Halisdemir University, Niğde, Turkey -- Şeker, P.S., Department of Forestry, Artvin Vocational School, Artvin Çoruh University, Artvin, Turkey -- Erdik, A.C., Department of Biotechnology, Faculty of Science and Letters, Niğde Ömer Halisdemir University, Niğde, Turkey -- Kankılıç, T., Department of Biology, Faculty of Science and Letters, Aksaray University, Aksaray, Turkey -- Selvi, E., Department of Biology, Faculty of Science, Ankara University, Ankara, Turkey -- Yiğit, N., Department of Biology, Faculty of Science, Ankara University, Ankara, Turkey -- Çolak, E., Department of Biology, Faculty of Science, Ankara University, Ankara, Turkey, Sabire Yazıcı Fen Edebiyat Fakültesi, Seker, Perincek Seckinozan -- 0000-0002-6103-4840, selvi, engin -- 0000-0001-5370-3023, and [Kankilic, Teoman -- Erdik, Arif Can] Nigde Omer Halisdemir Univ, Fac Sci & Letters, Dept Biotechnol, TR-51240 Nigde, Turkey -- [Seker, Perincek Seckinozan] Artvin Coruh Univ, Artvin Vocat Sch, Dept Forestry, Artvin, Turkey -- [Kankilic, Tolga] Aksaray Univ, Fac Sci & Letters, Dept Biol, Aksaray, Turkey -- [Selvi, Engin -- Yigit, Nuri -- Colak, Ercument] Ankara Univ, Fac Sci, Dept Biol, Ankara, Turkey

Subjects
0106 biological sciences, 0301 basic medicine, Turkey, Genetic Speciation, Dryomys nitedula, Dryomys, Lineage (evolution), Rodentia, mitochondrial DNA, 010603 evolutionary biology, 01 natural sciences, Nucleotide diversity, Mitochondrial Proteins, 03 medical and health sciences, Genetic variation, Genetics, Animals, Molecular Biology, Ecosystem, Electron Transport Complex I, Polymorphism, Genetic, biology, Phylogenetic tree, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, ND1 gene, Haplotype, respiratory system, Dryomys laniger, biology.organism_classification, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, ComputingMethodologies_PATTERNRECOGNITION, 030104 developmental biology, Haplotypes, Evolutionary biology, genetic variation, InformationSystems_MISCELLANEOUS, human activities
Abstract

WOS: 000439832300013, PubMed: 29072519, Genetic diversity and phylogeny of Dryomys nitedula and Dryomys laniger from Turkey was described in the present study by using mitochondrial DNA NADH dehydrogenase 1 gene (ND1). Genetic variation in ND1 gene was determined by two model-based phylogenetic analyses and a network analysis revealed 27 haplotypes of D. nitedula constructing four main lineages (Thrace, Anatolia, North-eastern Anatolia and Savsat) that have non-overlapping geographic distributions and no shared haplotypes, but on the other hand, three haplotypes were detected in four samples of D. laniger from Turkey. It was determined that nucleotide diversity was low but haplotype diversity was high in D. laniger, whereas, D. nitedula has both high level of haplotype and nucleotide diversity. Characterization of Thrace lineage of D. nitedula with low nucleotide diversity and determination of the total nucleotide diversity of Anatolian lineages (Anatolia + North-eastern Anatolia + Savsat) to be approximately four times higher than that of Thrace lineage indicated that Anatolia may have served as a refuge for D. nitedula. Divergence times and high level of nucleotide differences between D. nitedula lineages showed that diversification of the lineages may have occurred before and during ice ages in Turkey, thought to be a refuge for post-glacial colonization and biodiversity resource of Europe. Additionally, estimated divergence times and calculated genetic distances yielded compatible results with the previous paleontological and genomic data for the diversification time of two species in the genus., Scientific Research Projects Coordination Unit of Nigde Omer Halisdemir University [YULTEP FEB 2015/06]; Scientific and Technological Research Council of Turkey (TUBITAK) [113Z822], This study was supported by Scientific Research Projects Coordination Unit of Nigde Omer Halisdemir University [grant number: YULTEP FEB 2015/06] and The Scientific and Technological Research Council of Turkey (TUBITAK) [grant number: 113Z822].

Published
2017
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20. A new chromosomal race (2n=44) ofNannospalax xanthodonfrom Turkey (Mammalia: Rodentia)

Author

Atilla Arslan, Kubilay Toyran, Tolga Kankiliç, Teoman Kankiliç, Perinçek Seçkinozan Şeker, Jan Zima, Sabire Yazıcı Fen Edebiyat Fakültesi, Seker, Perincek Seckinozan -- 0000-0002-6103-4840, and [Kankilic, Teoman] Omer Halisdemir Univ, Fac Sci & Letters, Dept Biotechnol, Nigde, Turkey -- [Arslan, Atilla] Selcuk Univ, Fac Sci, Dept Biol, Konya, Turkey -- [Seker, Perincek Seckinozan] Artvin Coruh Univ, Artvin Vocat Sch, Dept Forestry, Artvin, Turkey -- [Kankilic, Tolga] Aksaray Univ, Fac Sci & Letters, Dept Biol, Aksaray, Turkey -- [Toyran, Kubilay] Bitlis Eren Univ, Fac Sci & Letters, Dept Biol, Bitlis, Turkey -- [Zima, Jan] Czech Acad Sci, Inst Vertebrate Biol, Brno, Czech Republic

Subjects
0106 biological sciences, Genetics, Autosome, Karyotype, 010607 zoology, Chromosome, Ag-NORs, Biology, Y chromosome, 010603 evolutionary biology, 01 natural sciences, Race (biology), Evolutionary biology, Centromere, Pulumur Race, Nannospalax, Animal Science and Zoology, C-bands, Ploidy, X chromosome
Abstract

WOS: 000406791900001, A new karyotype for blind mole rats was recorded in Tunceli province in Eastern Turkey. The karyotype contained 44 chromosomes, including 13 biarmed pairs, 7 acrocentric pairs, and one heteromorphic pair with a submetacentric and an acrocentric homologue in the autosomal complement (FNa=69). The X chromosome was submetacentric and the Y chromosome medium-sized subtelocentric (FN=73). Distinct dark centromeric C-bands were observed on most of the biarmed and three pairs of the acrocentric autosomes. The NORs were detected on short arms of three subtelocentric pairs and one acrocentric pair of autosomes. The diploid number of chromosomes and the karyotype characteristics observed are obviously unique among hitherto studied populations of blind mole rats and the complement can be evaluated as a new chromosome race of Nannospalax xanthodon. The distribution ranges of individual chromosome races of the species recorded in Eastern Anatolia are revised and possible interracial hybridization is discussed in respect of the finding of a new race., TUBITAK [KBAG 112T660]; Omer Halisdemir University [FEB2011/35, FEB2013/01], This study was supported by TUBITAK (KBAG 112T660) and Omer Halisdemir University (FEB2011/35, FEB2013/01).

Published
2017
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21. Ventilation of the Deep Ocean Carbon Reservoir During the Last Deglaciation: Results From the Southeast Pacific

Author

Consuelo Martínez Fontaine, Lowell D. Stott, Ricardo De Pol-Holz, D Reyes-Macaya, Elisabeth Michel, John Southon, Giuseppe Siani, Tim DeVries, Dierk Hebbeln, Gema Martínez-Méndez, Mahyar Mohtadi, Géosciences Paris Sud (GEOPS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Univ Chile, Dept Geol, Santiago, Univ Magallanes, Ctr Invest GAIA Antarct CIGA & Network Extreme En, Punta Arenas, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Paléocéanographie (PALEOCEAN), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Univ Bremen, Ctr Marine Environm Sci, MARUM, Bremen, Department of Atmospheric and Oceanic Sciences [Los Angeles] (AOS), University of California [Los Angeles] (UCLA), University of California-University of California, Univ Southern Calif, Dept Earth Sci, Los Angeles, CA 90007, University of California [Irvine] (UCI), University of California, Center for Marine Environmental Sciences [Bremen] (MARUM), Universität Bremen, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), University of California (UC)-University of California (UC), University of California [Irvine] (UC Irvine), and University of California (UC)

Subjects
Atmospheric Science, Antarctic Intermediate Water, 010504 meteorology & atmospheric sciences, biology, Ocean current, Paleontology, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Last Glacial Maximum, 010502 geochemistry & geophysics, Oceanography, biology.organism_classification, 01 natural sciences, Deep sea, Foraminifera, Continental margin, 13. Climate action, [SDU]Sciences of the Universe [physics], Deglaciation, 14. Life underwater, Glacial period, Geology, 0105 earth and related environmental sciences
Abstract

International audience; Coeval changes in atmospheric CO2 and C-14 contents during the last deglaciation are often attributed to ocean circulation changes that released carbon stored in the deep ocean during the Last Glacial Maximum (LGM). Work is being done to generate records that allow for the identification of the exact mechanisms leading to the accumulation and release of carbon from the oceanic reservoir, but these mechanisms are still the subject of debate. Here we present foraminifera C-14 data from five cores in a transect across the Chilean continental margin between similar to 540 and similar to 3,100 m depth spanning the last 20,000 years. Our data reveal that during the LGM, waters at similar to 2,000 m were 50% to 80% more depleted in Delta C-14 than waters at similar to 1,500 m when compared to modern values, consistent with the hypothesis of a glacial deep ocean carbon reservoir that was isolated from the atmosphere. During the deglaciation, our intermediate water records reveal homogenization in the Delta C-14 values between similar to 800 and similar to 1,500 m from similar to 16.5-14.5 ka cal BP to similar to 14-12 ka cal BP, which we interpret as deeper penetration of Antarctic Intermediate Water. While many questions still remain, this process could aid the ventilation of the deep ocean at the beginning of the deglaciation, contributing to the observed similar to 40 ppm rise in atmospheric pCO(2).

Published
2019
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22. Bioacoustics characterization of some anatolian endemic and sub-endemic Katydids (Orthoptera; Tettigoniidae; Bradyporinae, Phaneropterinae and Tettigoniinae)

Author

Mehmet Sait Taylan, Hasan Sevgili, Deniz Şirin, Abbas Mol, [Taylan, Mehmet Sait] Hakkari Univ, Sci Inst, Dept Biol, Hakkari, Turkey -- [Mol, Abbas] Aksaray Univ, Emergency Aid & Disaster Management Dept, Hlth Acad, Aksaray, Turkey -- [Sevgili, Hasan] Ordu Univ, Fac Art & Sci, Dept Mol Biol & Genet, Ordu, Turkey -- [Sirin, Deniz] Namik Kemal Univ, Fac Art & Sci, Dept Biol, TR-59030 Tekirdag, Turkey, and Sağlık Bilimleri Fakültesi

Subjects
Male, Insecta, Turkey, Arthropoda, Tettigoniidae, Zoology, Tettigoniinae, Gryllidae, Endemic, Bradyporinac, Species Specificity, Genus, Phaneropterinae, Animals, Animalia, Anatolia, Pholidoptera, Phaneropteridae, Ecology, Evolution, Behavior and Systematics, Taxonomy, biology, Bradyporinae, Acoustics, Biodiversity, biology.organism_classification, Decticus, Synonym (taxonomy), Black Sea, Orthoptera, Animal Science and Zoology, Bioacoustics
Abstract

WOS: 000467326600004, Seventeen endemic and time sub-endemic species belonging to three subfamilies of Tettigoniidae (Orthoptera: Bradyporinae, Phaneropterinae and Tettigoniinae) were sampled during field trips throughout different regions of Anatolia between 2015 and 2018 (except one taxon). Acoustic parameters of these 20 bush-cricket species affiliated to 12 genera (Apholidoptera, Bradyporus, Decticus, Eupholidoptera, Parapholidoptera, Pezodrymadusa, Pholidoptera, Polysarcus, Psorodonotus, Squamiana, Uvarovistia and Yalvaciana) have been described for the first time in this study. Bioacoustical analysis shows that male calling songs are species-specific for the genera Bradyporus, Parapholidoptera, Pholidoptera, Apholidoptera, Uvarovistia and Psorodonotus. However, there are no distinct differences among species of the genus Pezodrymadusa. Moreover, our additional data on genus Eupholidoptera indicate that there are some different song patterns within the genus. The song description of Uvarovistia zebra presented here is the second bioacoustics data on this genus. The acoustical analyses data support the morpho-species hypothesis of Psorodonotus suphani Taylan & Sirin, 2014, which is known from Suphan Mountain (Bitlis province, Eastern part of Turkey) and reject Kaya & ciplak (2017), which recommended it as synonym to P. caucasicus (Fischer von Waldheim, 1846) (commonly known as a Black Sea Region species)., Hakkari University (Scientific Researches Project Coordination Unit (BAP)) [FM18BAP3], Our special thanks go to Petru GOLBAN (from Tekirdag Namik Kemal University) for his valuable comments on manuscript and proof-reading of the manuscript. This study was conducted by using facilities of Tekirdag Namik Kemal University Entomology Museum, NKUEM (Tekirdag/Turkey). This study was partly funded by Hakkari University (Scientific Researches Project Coordination Unit (BAP), No: FM18BAP3).

Published
2019

23. Structural analysis and biological functionalities of iron(III)- and manganese(III)-thiosemicarbazone complexes: in vitro anti-proliferative activity on human cancer cells, DNA binding and cleavage studies

Author

Büşra Kaya, Zehra Kübra Yılmaz, Ummugulsum Tukenmez, Belma Aslim, Bahri Ülküseven, Onur Şahin, Sağlık Hizmetleri Meslek Yüksekokulu, and [Kaya, Busra -- Ulkusever, Bahri] Istanbul Univ Cerrahpasa, Engn Fac, Dept Chem, TR-34320 Istanbul, Turkey -- [Yilmaz, Zehra Kubra -- Aslim, Belma] Gazi Univ, Fac Sci, Dept Biol, Ankara, Turkey -- [Sahin, Onur] Sinop Univ, Sci & Technol Res Applicat & Res Ctr, TR-57000 Sinop, Turkey -- [Tukenmez, Ummugulsum] Mardin Artuklu Univ, Vocat High Sch Hlth Serv, Mardin, Turkey

Subjects
Thiosemicarbazones, Stereochemistry, Iron, Intercalation (chemistry), Antineoplastic Agents, 010402 general chemistry, Cleavage (embryo), 01 natural sciences, Biochemistry, Thiosemicarbazone, Inorganic Chemistry, HeLa, chemistry.chemical_compound, Coordination Complexes, Cell Line, Tumor, Animals, Humans, Anti-proliferation, DNA binding, DNA cleavage, Manganese, MTT assay, Cytotoxicity, Gel electrophoresis, Molecular Structure, biology, 010405 organic chemistry, DNA, biology.organism_classification, Intercalating Agents, In vitro, 0104 chemical sciences, chemistry, Cattle
Abstract

WOS: 000466887300006, PubMed ID: 30895485, One iron(III) and two manganese(III) complexes based on thiosemicarbazone were synthesized and characterized using analytical and spectroscopic data. The crystallographic analysis showed the square pyramid structures of the complexes. Electronic spectra analysis was performed to determine the nature of the interaction between the complexes and calf thymus DNA (CT-DNA). DNA cleavage activities of the complexes were examined by gel electrophoresis (pBR322 DNA). The cytotoxicity of the complexes was determined against human cervical carcinoma (HeLa) and human colorectal adenocarcinoma (HT-29) cell lines by MTT assay. The results indicated that complex Fe1 is bound to CT-DNA via the intercalation mode, while complexes Mn1 and Mn2 are bound to CT-DNA via groove binding and/or electrostatic interactions rather than the intercalation mode. In addition, they showed good binding activity, which followed the order of Fe1>Mn2>Mn1. Complexes were found to promote the cleavage of DNA from supercoiled form (SC, Form I) to nicked circular form (NC, Form II) without concurrent formation of Form III, revealing the single-strand DNA cleavage. No significant cleavage was found in the presence of Mn1 and Mn2; however, it was observed at 2000 and 3000 mu M concentrations of Fe1. The ability of Fe1 to cleave DNA was greater than that of other complexes and these results are in conformity with their DNA-binding affinities. Cytotoxicity determination tests revealed that the complex Fe1 on HeLa and HT-29 cells exhibited a higher anti-proliferative effect than Mn1 and Mn2 (Fe1>Mn2>Mn1). These studies suggested that the complex Fe1 could be a good candidate as a chemotherapeutic drug targeting DNA. [GRAPHICS], Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa, This work was supported by the Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa. The authors acknowledge Scientific and Technological Research Application and Research Center, Sinop University, Turkey, for the use of the Bruker D8-QUEST diffractometer.

Published
2019

24. Synthesis and investigation of anticancer, antibacterial activities and carbonic anhydrase, acetylcholinesterase inhibition profiles of novel (3aR,4S,7R,7aS)-2-[4-[1-acetyl-5-(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-diones

Author

Parham Taslimi, Meliha Burcu Gürdere, İlhami Gülçin, Umit M. Kocyigit, Yakup Budak, Neşe Dürü, Mustafa Ceylan, Bartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümü, and [Kocyigit, Umit M.] Cumhuriyet Univ, Vocat Sch Hlth Serv, TR-58140 Sivas, Turkey -- [Budak, Yakup -- Gurdere, Meliha Burcu -- Duru, Nese -- Ceylan, Mustafa] Gaziosmanpasa Univ, Fac Arts & Sci, Dept Chem, TR-60250 Tokat, Turkey -- [Taslimi, Parham -- Gulcin, Ilhami] Ataturk Univ, Fac Sci, Dept Chem, TR-25240 Erzurum, Turkey

Subjects
Aché, Heterocyclics, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, Isozyme, chemistry.chemical_compound, Chalcone, Carbonic anhydrase, Carbonic Anhydrase I, chemistry.chemical_classification, biology, Bioorganic chemistry, 010405 organic chemistry, Aryl, General Chemistry, Antimicrobial, Acetylcholinesterase, language.human_language, 0104 chemical sciences, Enzyme inhibition, Enzyme, Anticancer, chemistry, biology.protein, language
Abstract

WOS: 000462504500015, A series of novel 1,3,5-trisubstituted pyrazoline derivatives, (3aR,4S,7R,7aS)-2-[4-[1-acetyl-5-(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-diones, were synthesized and evaluated for their antimicrobial and anticancer activities. In addition, the compounds were tested against acetylcholinesterase (AChE) enzyme and two physiologically relevant carbonic anhydrase I and II isozymes (hCA I and II). In this study, inhibition of hCA I and hCA II by the novel synthesized 1,3,5-trisubstituted pyrazolines was impressive, with K-i values in the range of 3.33-7.90nM for hCA I and 2.07-8.47nM for hCA II, while the K-i values of these compounds for AChE were recorded in the range of 9.61-48.42nM, respectively. Two compounds can be investigated as the leader compounds because of their lowest K-i values to make further detailed CA inhibition studies. [GRAPHICS] ., Scientific and Technological Research Council of Turkey (TUBITAK) [111T990], The authors are indebted to The Scientific and Technological Research Council of Turkey (TUBITAK Project No: 111T990) for financial supports.

Published
2019

25. Alkaloids Profiling of Fumaria capreolata by Analytical Platforms Based on the Hyphenation of Gas Chromatography and Liquid Chromatography with Quadrupole-Time-of-Flight Mass Spectrometry

Author

Antonio Segura-Carretero, Julio Gálvez, María del Mar Contreras, Noureddine Bribi, Ana María Gómez-Caravaca, [del Mar Contreras, Maria] Res & Dev Funct Food Ctr CIDAF, Bioregi Bldg,Hlth Sci Technol Pk, Granada 18016, Spain, [Segura-Carretero, Antonio] Res & Dev Funct Food Ctr CIDAF, Bioregi Bldg,Hlth Sci Technol Pk, Granada 18016, Spain, [del Mar Contreras, Maria] Univ Granada, Fac Sci, Dept Analyt Chem, Avda Fuentenueva S-N, E-18071 Granada, Spain, [Maria Gomez-Caravaca, Ana] Univ Granada, Fac Sci, Dept Analyt Chem, Avda Fuentenueva S-N, E-18071 Granada, Spain, [Segura-Carretero, Antonio] Univ Granada, Fac Sci, Dept Analyt Chem, Avda Fuentenueva S-N, E-18071 Granada, Spain, [Bribi, Noureddine] Univ Granada, Dept Pharmacol, Ibs GRANADA, CIBER EHD,Ctr Biomed Res CIBM, Ave Conocimiento S-N, Granada 18016, Spain, [Galvez, Julio] Univ Granada, Dept Pharmacol, Ibs GRANADA, CIBER EHD,Ctr Biomed Res CIBM, Ave Conocimiento S-N, Granada 18016, Spain, and [Bribi, Noureddine] Univ Bejaia, Fac Sci Nat & Vie, Lab Biotechnol Vegetales & Ethnobot, Bejaia 06000, Algeria

Subjects
Electrospray-ionization, Identification, Article Subject, Ms/ms, lcsh:Analytical chemistry, Isoquinoline alkaloids, Mass spectrometry, 01 natural sciences, Extracts, Fruits, Analytical Chemistry, chemistry.chemical_compound, Aporphine, Isoquinoline, Benzylisoquinoline, lcsh:QD71-142, Chromatography, biology, 010405 organic chemistry, 010401 analytical chemistry, Fumaria, biology.organism_classification, 0104 chemical sciences, Metabolism, chemistry, Fumaria capreolata, Protopine, Gas chromatography, Research Article, Model
Abstract

Two analytical platforms, gas chromatography (GC) coupled to quadrupole-time-of-flight (QTOF) mass spectrometry (MS) and reversed-phase ultrahigh performance liquid chromatography (UHPLC) coupled to diode array (DAD) and QTOF detection, were applied in order to study the alkaloid profile of Fumaria capreolata. The use of these mass analyzers enabled tentatively identifying the alkaloids by matching their accurate mass signals and suggested molecular formulae with those previously reported in libraries and databases. Moreover, the proposed structures were corroborated by studying their fragmentation pattern obtained by both platforms. In this way, 8 and 26 isoquinoline alkaloids were characterized using GC-QTOF-MS and RP-UHPLC-DAD-QTOF-MS, respectively, and they belonged to the following subclasses: protoberberine, protopine, aporphine, benzophenanthridine, spirobenzylisoquinoline, morphinandienone, and benzylisoquinoline. Moreover, the latter analytical method was selected to determine at 280 nm the concentration of protopine (9.6 ± 0.7 mg/g), a potential active compound of the extract. In conclusion, although GC-MS has been commonly used for the analysis of this type of phytochemicals, RP-UHPLC-DAD-QTOF-MS provided essential complementary information. This analytical method can be applied for the quality control of phytopharmaceuticals containing Fumaria extracts currently found in the market.

Published
2017
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26. Alleophatic effects of benzoic acid, salicylic acid and leaf extract of Persica vulgaris Mill. (Rosaceae)

Author

Hulya Ozpinar, Şeker Dağ, E. Yigit, and [Ozpinar, H.] Cumhuriyet Univ, Dept Pharmaceut Bot, Fac Pharm, TR-58140 Sivas, Turkey -- [Dag, S.] Cumhuriyet Univ, Dept Biol, Fac Sci, TR-58140 Sivas, Turkey -- [Yigit, E.] Inonu Univ, Sci & Art Fac, Dept Biol, TR-44280 Malatya, Turkey

Subjects
0106 biological sciences, Persica vulgaris Mill, Rosaceae, Plant Science, Biology, Lepidium campestre, 010603 evolutionary biology, 01 natural sciences, chemistry.chemical_compound, Botany, Benzoic acid, Allelopathy, Cultivated plant taxonomy, fungi, food and beverages, Salicylic acid, biology.organism_classification, chemistry, Germination, GC-MS, HPLC, Convolvulus, 010606 plant biology & botany
Abstract

WOS: 000390671400013, Secondary compounds in higher plants have great diversity in terms of biologic activity. Most of them are used for the defense by plants. This study aims to investigate the effects of benzoic acid, salicylic acid, and Persica vulgaris Mill. (Peach) on the germination of the seeds of cultivated plants such as Triticum aestivum L. (wheat), Zeamays L. (corn), Cicer arietinum L. (chickpea), as well as weeds such as Lepidium campestre (L.) R. Br. and Convolvulus arvensis L. Method 1, in which benzoic acid, salicylic acid, and Persica vulgaris Mill. are added to the germination environment at different doses, and Method 2, in which they are mixed with the irrigation water at the specified doses, have been employed in this study. As a result of this study, it has been determined that the leaf extract of P. vulgaris Mill., Benzoic acid, and salicylic acid prevent the growth of the root and stem in all seeds at high doses in both methods, and they increase the growth at low doses. According to the GC-MS results of the leaf extract of P. vulgaris Mill., benzoic acid has been determined to be at the highest rate. No difference has been found between months as a result of the HPLC analysis of the amounts of benzoic acid. The determination of negative effects of benzoic acid, salicylic acid, and peach leaf extract both on cultivated plants and weeds at high doses will repress the development of cultivated plants as well as weeds. Growing cultivated plants in places with peach trees may decrease the yield. The leaves should not be let decompose on the soil in defoliation season, and fallen leaves should be collected. Not collecting all of the leaves and leaving some of them may increase the development of weeds in the surrounding area since it may cause a low dose effect. (C) 2016 SAAB. Published by Elsevier B.V. All rights reserved.

Published
2017
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27. New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp

Author

David Clarke, Marcel Jaspars, Klaus D. Feussner, Marc Stierhof, Karolina Subko, Johan Isaksson, Espen Hansen, Kine Østnes Hansen, Jioji N. Tabudravu, Mukesh Sharma, Fernando Fernandez Diaz-Rullo, Ignacio Pérez-Victoria, [Stierhof, Marc] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Subko, Karolina] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Jaspars, Marcel] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Tabudravu, Jioji N.] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland, [Hansen, Kine Ostnes] UiT Arctic Univ Norway, Marbio, N-9037 Tromso, Norway, [Hansen, Espen] UiT Arctic Univ Norway, Marbio, N-9037 Tromso, Norway, [Sharma, Mukesh] Univ South Pacific, Fac Sci Technol & Environm, Inst Appl Sci, POB 1168, Suva, Fiji, [Feussner, Klaus] Univ South Pacific, Fac Sci Technol & Environm, Inst Appl Sci, POB 1168, Suva, Fiji, [Diaz-Rullo, Fernando Fernandez] Univ Aberdeen, Inst Med Sci, Aberdeen AB24 3UE, Scotland, [Isaksson, Johan] UiT Arctic Univ Norway, Dept Chem, N-9037 Tromso, Norway, [Perez-Victoria, Ignacio] Fdn MEDINA, Parque Tecnol Salud,Ave Conocimiento 34, Granada 18016, Spain, [Clarke, David] Univ Edinburgh, Sch Chem, Joseph Black Bldg,David Brewster Rd, Edinburgh EH9 3FJ, Midlothian, Scotland, EU, and NCDDG

Subjects
Asteropus, Stereochemistry, Antiproliferative activity, Latrunculia sp, 010402 general chemistry, 01 natural sciences, Biochemistry, Antifungal peptides, Cyclic depsipeptide, LCMS, Papua-new-guinea, Drug Discovery, medicine, Cytotoxic T cell, Bioorganic chemistry, Cytotoxicity, Fibroblast, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Biological activity, biology.organism_classification, NMR, 0104 chemical sciences, Sponge, medicine.anatomical_structure, Theonella-swinhoei, Cell culture, Callipeltin, Acid hydrolysis, Derivatisation
Abstract

Four new callipeltin A derivatives (N-Q) have been isolated from the Solomon Island marine sponge Asteropus sp. Their structures were established by spectroscopic techniques followed by acid hydrolysis and derivatisation of the free amino acids, and subsequent LCMS analysis of the derivatives. The compounds were evaluated for their activity against cancer cell lines A2058 (melanoma), HT-29 (colorectal adenocarcinoma) and MCF-7 (breast adenocarcinoma) and non-malignant MRC-5 fibroblast cells. While the acyclic callipeltins P and Q were inactive the cyclic callipeltins N and O showed significant cytotoxicity against all exposed cell lines with IC50 values as low as 0.16 mu M confirming the role of cyclic configuration in biological activity. (C) 2016 Elsevier Ltd. All rights reserved.

Published
2016
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28. KRAS, BRAF oncogene mutations and tissue specific promoter hypermethylation of tumor suppressor SFRP2, DAPK1, MGMT, HIC1 and p16 genes in colorectal cancer patients

Author

Kursat Karadayi, Mustafa Turan, Öztürk Özdemir, Gokhan Bagci, Binnur Bagci, Musa Sari, and [Bagci, Binnur] Cumhuriyet Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-58140 Sivas, Turkey -- [Bagci, Binnur] Cumhuriyet Univ, Adv Technol Res Ctr CUTAM, Sivas, Turkey -- [Sari, Musa] Cumhuriyet Univ, Fac Sci, Dept Biol, Sivas, Turkey -- [Karadayi, Kursat -- Turan, Mustafa] Cumhuriyet Univ, Fac Med, Dept Gen Surg, Sivas, Turkey -- [Ozdemir, Ozturk] On Sekiz Mart Univ, Fac Med, Dept Med Genet, Canakkale, Turkey -- [Bagci, Gokhan] Cumhuriyet Univ, Fac Med, Dept Med Genet, Sivas, Turkey

Subjects
Male, 0301 basic medicine, Oncology, Cancer Research, Colorectal cancer, p16, medicine.disease_cause, 0302 clinical medicine, Mutation Rate, oncogene, tumor suppressor gene, DAPK1, Promoter Regions, Genetic, DNA Modification Methylases, Aged, 80 and over, Oncogene Proteins, Mutation, General Medicine, Middle Aged, hypermethylation, 030220 oncology & carcinogenesis, DNA methylation, SFRP2, Female, KRAS, Colorectal Neoplasms, MGMT, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Tumor suppressor gene, DNA repair, Biology, BRAF, 03 medical and health sciences, KRAS Gene Mutation, Internal medicine, Genetics, medicine, Humans, Codon, neoplasms, Aged, Oncogene, Genes, p16, Tumor Suppressor Proteins, DNA Methylation, HIC1, medicine.disease, digestive system diseases, DNA Repair Enzymes, Genes, ras, 030104 developmental biology, Case-Control Studies, Cancer research, CpG Islands
Abstract

WOS: 000382801200003, PubMed ID: 27540971, BACKGROUND: Colorectal cancer is a serious disease that causes significant morbidity and mortality in developed countries. Genetic changes, such as mutations in proto-oncogenes and DNA repair genes, and loss of function in the tumor suppressor genes cause colorectal cancer development. Abnormal DNA methylation is also known to play a crucial role in colorectal carcinogenesis. OBJECTIVE: In this study, frequencies of KRAS and BRAF mutations, promoter hypermethylation profiles of SFRP2, DAPKI, MGMT, HIC1 and p16 genes, and possible associations between hypermethylation of these genes and KRAS and BRAF mutations were aimed to find out. METHODS: Ninety three colorectal cancer tissues and 14 normal colon mucosas were included in the study. Common twelve KRAS gene mutation were investigated with using reverse-hybridization strip assay method. BRAF V600E mutations were investigated with RFLP method. Hypermethylation status of five tumor suppressor genes were detected by using reverse-hybridization strip assay method after bisulfite modification of DNA. RESULTS: KRAS and BRAF mutation frequencies were determined as 54.84% and 12.9%, respectively. Promoter hypermethylation frequencies of tumor suppressor genes SFRP2, DAPK1, MGMT, HIC1 and p16 were determined as 66.7%, 45.2%, 40.9%, 40.9% and 15.1%, respectively. Statistically significant associations were found between BRAF mutation and SFRP2 and p16 tumor suppressor genes hypermethylation (SFRP2; p = 0.005, p16; p = 0.016). Compared to rectum, SFRP2 (p = 0.017) and MGMT (p = 0.013) genes have statistically significantly higher promoter hypermethylation in colon. CONCLUSIONS: Results of the current study have confirmed that KRAS mutations and SFRP2 hypermethylation can be used as genetic markers in colorectal cancer.

Published
2016
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29. Identification of Predominant Lactic Acid Bacteria and Yeasts of Turkish Sourdoughs and Selection of Starter Cultures for Liquid Sourdough Production Using Different Flours and Dough Yields

Author

Giancarlo Moschetti, Gülten Yağmur, Emel Ünal Turhan, Sezgi Leventdurur, Simel Bağder Elmacı, Luca Settanni, Hüseyin Erten, Nicola Francesca, Hasan Tangüler, Francesca, N, Settanni, L, Moschetti, G, Erten, Huseyin -- 0000-0003-1537-2416, [Yagmur, Gulten -- Tanguler, Hasan -- Leventdurur, Sezgi -- Turhan, Emel Unal -- Erten, Huseyin] Cukurova Univ, Fac Agr, Dept Food Engn, TR-01330 Adana, Turkey -- [Elmaci, Simel Bagder] Ankara Univ, Fac Engn, Dept Food Engn, TR-06110 Ankara, Turkey -- [Francesca, Nicola -- Settanni, Luca -- Moschetti, Giancarlo] Univ Palermo, Dipartimento Sci Agr & Forestali, Viale Sci 4, I-90128 Palermo, Italy -- [Tanguler, Hasan] Nigde Univ, Fac Engn, Dept Food Engn, Merkez Yerleske, TR-51245 Nigde, Turkey -- [Turhan, Emel Unal] Osmaniye Korkut Ata Univ, Kadirli Sch Appl Sci, Osmaniye, Turkey, Çukurova Üniversitesi, and 0-Belirlenecek

Subjects
0301 basic medicine, Gram-positive bacteria, 030106 microbiology, Wheat flour, Turkish sourdoughs, lactic acid bacteria, yeasts, liquid sourdough, yeasts, Titratable acid, lcsh:TX341-641, Biology, 03 medical and health sciences, chemistry.chemical_compound, Starter, Plant science, Food science, Nutrition and Dietetics, food and beverages, liquid sourdough, Turkish sourdoughs, biology.organism_classification, Lactic acid, lactic acid bacteria, 030104 developmental biology, chemistry, bacteria, lcsh:Nutrition. Foods and food supply, Bacteria, Food Science, Settore AGR/16 - Microbiologia Agraria
Abstract

WOS: 000375613200005, Eight samples of mature sourdough were collected from five provinces of Turkey. Lactic acid bacteria and yeasts were isolated and identified and used in different combinations to produce liquid sourdoughs. Microbiological and physicochemical characteristics of the experimental sourdoughs made with different flour types and dough yields were studied. The main lactic acid bacteria species identified were Lactobacillus (L.) sanfranciscensis, Pediococcus pentosaceus, L. plantarum, L. namurencis, L. rossiae, Leuconostoc mesenteroides and L. zymae. L. spicheri, L. paralimentarius, L. mindensis, L. farciminis, L. acetotolerans, L. casei, Enterococcus faecium and Enterococcus durans were also found in sourdoughs at subdominant levels. Among yeasts, mainly Saccharomyces cerevisiae, but also Pichia guiliermondii and Torulaspora delbrueckii were the predominant species of yeasts identified in sourdoughs. Lactic acid bacteria and yeasts of liquid sourdoughs after fermentation were in the range of 9.61-9.89 log cfu/g and 6.55-7.36 log cfu/g, respectively. Various chemical parameters such as pH, total titratable acidity, lactic and acetic acids, ethanol and sugars were determined for liquid sourdoughs. Acidification and metabolite contents of these products were different, depending on the starter culture, flour type and dough yield. Total titratable acidity was more pronounced in the sourdoughs produced with whole wheat flour (14.08 mL NaOH) and rye flour (13.56 mL NaOH), dough yield 250 (13.93 mL NaOH) and control sample (13.12 mL NaOH) which were produced without inoculum., Cukurova University Academic Research Projects Unit [ZF2009D20], This work has been funded by a grant from Cukurova University Academic Research Projects Unit (ZF2009D20). The authors also thank Prof. F. Ozcelik (Ankara University, Turkey), Assoc. Prof. M.S. Ozer (Cukurova University, Turkey) and Prof. H. Ozkan (Cukurova University, Turkey) for their kind collaboration.

Published
2016

30. Circum-Mediterranean phylogeography of a bat coupled with past environmental niche modeling: A new paradigm for the recolonization of Europe?

Author

Zoltan L. Nagy, Javier Juste, Öncü Maraci, Suren Gazaryan, Branko Karapandža, Pavel Hulva, Ivan Horáček, Primoz Presetnik, Raşit Bilgin, Dino Scaravelli, Daniela Hamidovic, Carlos F. Ibáñez, Panagiotis Georgiakakis, Benjamin Allegrini, Milan Paunović, Ayşegül Karataş, Mounir Abi-Said, Marcel Uhrin, Norma Fressel, Tomáš Bartonička, Kanat Gürün, Ahmet Karataş, Radek Lučan, Petr Benda, Sébastien J. Puechmaille, Haris Nicolaou, Hugo Rebelo, Rebelo, Hugo -- 0000-0002-7118-4068, Horacek, Ivan -- 0000-0002-8356-5554, Gazaryan, Irina -- 0000-0002-9670-5579, Ibanez, Carlos -- 0000-0003-1181-7641, Puechmaille, Sebastien -- 0000-0001-9517-5775, Lucan, Radek -- 0000-0002-9575-3173, Juste, Javier -- 0000-0003-1383-8462, Gurun, Kanat -- 0000-0002-0433-2593, [Bilgin, Rasit -- Gurun, Kanat -- Maraci, Oncu] Bogazici Univ, Inst Environm Sci, TR-34342 Istanbul, Turkey -- [Rebelo, Hugo] Univ Porto, Ctr Invest Biodiversidade & Recursos Genet, CIBIO InBIO, Campus Agrario Vairdo,R Padre Armando Quintas 11, P-4485661 Vairao, Portugal -- [Rebelo, Hugo] Univ Bristol, Sch Biol Sci, Woodland Rd, Bristol BS8 1UG, Avon, England -- [Puechmaille, Sebastien J.] Univ Coll Dublin, Sch Biol & Environm Sci, Dublin 4, Ireland -- [Puechmaille, Sebastien J.] Ernst Moritz Arndt Univ Greifswald, Inst Zool, D-17489 Greifswald, Germany -- [Puechmaille, Sebastien J.] CERN, GCMP, Toulouse, France -- [Presetnik, Primoz] Ctr Cartog Fauna & Flora, Klunova 3, Ljubljana, Slovenia -- [Benda, Petr -- Hulva, Pavel -- Horacek, Ivan -- Lucan, Radek K.] Charles Univ Prague, Fac Sci, Dept Zool, Vinicna 7, CZ-12844 Prague 2, Czech Republic -- [Benda, Petr] Natl Museum Nat Hist, Dept Zool, Vaclavske Namesti 68, CZ-11579 Prague 1, Czech Republic -- [Hulva, Pavel] Univ Ostrava, Dept Biol & Ecol, Chittussiho 10, Ostrava 71000, Czech Republic -- [Ibanez, Carlos -- Juste, Javier] CSIC, Estn Biol Dotiana, Avda Amer Vespucio S-N, Seville 41092, Spain -- [Hamidovic, Daniela] Croatian Biospeleol Soc, Demetrova 1, Zagreb 10000, Croatia -- [Fressel, Norma] BIUS Biol Student Assoc, Rooseveltov Trg 6, Zagreb 10000, Croatia -- [Karatas, Aysegul -- Karatas, Ahmet] Nigde Univ, Dept Biol, TR-51100 Nigde, Turkey -- [Allegrini, Benjamin] NATURALIA Environm, Gallargues Le Montueux, France -- [Georgiakakis, Panagiotis] Univ Crete, Nat Hist Museum Crete, Knossos Ave,POB 2208, GR-71409 Iraklion, Crete, Greece -- [Gazaryan, Suren] RAS, Inst Ecol Mt Terr, Armand 37A360000, Nakhik, Russia -- [Nagy, Zoltan L.] Fdn Sch, Cluj Napoca 400486, Romania -- [Abi-Said, Mounir] Anim Encounter, Aley, Lebanon -- [Abi-Said, Mounir] Lebanese Univ, Fac Sci 2, AlFanar, Lebanon -- [Bartonicka, Tomas] Masaryk Univ, Dept Bot & Zool, Kotlarska 2, CS-61137 Brno, Czech Republic -- [Nicolaou, Halls] Minist Agr Nat Resources & Environm, Dept Forestry, Pk & Environm Sect, CY-1414 Nicosia, Cyprus -- [Scaravelli, Dino] Univ Bologna, Dept Vet Med Sci, Via Tolara Sopra 50, I-40064 Ozzano Dell Emilia, Italy -- [Karapandza, Branko] Wildlife Conservat Soc Mustela, Belgrade, Serbia -- [Uhrin, Marcel] Pavol Jozef Safarik Univ Kosice, Fac Sci, Inst Biol & Ecol, Moyzesova 11, SK-04001 Kosice, Slovakia -- [Uhrin, Marcel] Czech Univ Life Sci, Fac Forestry & Wood Sci, Dept Forest Protect & Wildlife Management, Kamycka 1176, Prague 16521 6, Czech Republic -- [Paunovic, Milan] Nat Hist Museum, Belgrade, Serbia, 0-Belirlenecek, Istanbul University, The Scientific and Technological Research Council of Turkey, Fundação para a Ciência e a Tecnologia (Portugal), and Ministry of Culture (Czech Republic)

Subjects
0106 biological sciences, 0301 basic medicine, Mediterranean climate, Refugia, Biology, DNA, Mitochondrial, Models, Biological, 010603 evolutionary biology, 01 natural sciences, Mediterranean Basin, Anatolia, Levant, Middle East, 03 medical and health sciences, Africa, Northern, Refugium (population biology), Peninsula, Chiroptera, Genetics, Animals, Microsatellites, Molecular Biology, Phylogeny, Ecology, Evolution, Behavior and Systematics, geography, geography.geographical_feature_category, Ecology, Miniopterus, Genetic Variation, Miniopterus schreibersii, Last Glacial Maximum, Balkan Peninsula, 15. Life on land, North Africa, biology.organism_classification, Mitochondrial DNA, Environmental niche modelling, Europe, Phylogeography, 030104 developmental biology, Environmental niche modeling
Abstract

WOS: 000375896000026, PubMed ID: 27001602, The isolation of populations in the Iberian, Italian and Balkan peninsulas during the ice ages define four main paradigms that explain much of the known distribution of intraspecific genetic diversity in Europe. In this study we investigated the phylogeography of a wide-spread bat species, the bent-winged bat, Miniopterus schreibersii around the Mediterranean basin and in the Caucasus. Environmental Niche Modeling (ENM) analysis was applied to predict both the current distribution of the species and its distribution during the last glacial maximum (LGM). The combination of genetics and ENM results suggest that the populations of M. schreibersii in Europe, the Caucasus and Anatolia went extinct during the LGM, and the refugium for the species was a relatively small area to the east of the Levantine Sea, corresponding to the Mediterranean coasts of present-day Syria, Lebanon, Israel, and northeastern and northwestern Egypt. Subsequently the species first repopulated Anatolia, diversified there, and afterwards expanded into the Caucasus, continental Europe and North Africa after the end of the LGM. The fossil record in Iberia and the ENM results indicate continuous presence of Miniopterus in this peninsula that most probably was related to the Maghrebian lineage during the LGM, which did not persist afterwards. Using our results combined with similar findings in previous studies, we propose a new paradigm explaining the general distribution of genetic diversity in Europe involving the recolonization of the continent, with the main contribution from refugial populations in Anatolia and the Middle East. The study shows how genetics and ENM approaches can complement each other in providing a more detailed picture of intraspecific evolution. (C) 2016 Elsevier Inc. All rights reserved., Research Fund of Bogazici University, Istanbul [08M104, 09S101, 11Y00P2]; Scientific and Technological Research Council of Turkey, TUBITAK [112T698]; Fundacao para a Ciencia e Tecnologia [IF/0497/2013]; IRCSET-Marie Curie International Mobility Fellowship in Science, Engineering and Technology; Ministry of Culture of the Czech Republic [DKRVO 00023272], We would like to thank Elizabeth Hemond and three anonymous reviewers for their comments on an earlier version of the manuscript. We also would like to thank Simos Demetropoulos, Petros Lymperakis, Dina Kovac, Vida Zrncic, Darija Josic, Sanja Drakulic, Tea Knapic, Yannis Kazoglou, Elena Papadatou, Xavier Gremillet, Monika Podgorelec, Peter Vallo, Thierry Disca, Vincent Prie, members of the Win-timdouine expedition (Morocco), Wassim M. Hizem, Pr. Said Nouira, and the "Direction generale des fork de Tunisie" for their assistance with the fieldwork. This study was supported by grants from the Research Fund of Bogazici University, Istanbul (08M104, 09S101 and 11Y00P2) and the Scientific and Technological Research Council of Turkey, TUBITAK (112T698) to RB, from Fundacao para a Ciencia e Tecnologia (research contract IF/0497/2013) to HR, from the IRCSET-Marie Curie International Mobility Fellowship in Science, Engineering and Technology to SJP, and from the Ministry of Culture of the Czech Republic (# DKRVO 00023272) to PB.

Published
2016
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31. The impact of eggshell colour and spot area in Japanese quails: I. eggshell temperature during incubation and hatching results

Author

Sibel Canogullari, Sema Alaşahan, Gulsen Copur Akpinar, Mikail Baylan, [Alasahan, Sema] Mustafa Kemal Univ, Fac Vet, Dept Anim Sci, Antakya, Turkey -- [Akpinar, Gulsen Copur] Mustafa Kemal Univ, Fac Agr, Dept Anim Sci, Antakya, Turkey -- [Canogullari, Sibel] Nigde Univ, Agr Sci & Technol Fac, Dept Anim Prod & Technol, Nigde, Turkey -- [Baylan, Mikail] Cukurova Univ, Fac Agr, Dept Anim Sci, Adana, Turkey, 0-Belirlenecek, and Çukurova Üniversitesi

Subjects
0106 biological sciences, Spots, Hatching, 0402 animal and dairy science, quail, 04 agricultural and veterinary sciences, Anatomy, Biology, biology.organism_classification, 040201 dairy & animal science, 010603 evolutionary biology, 01 natural sciences, spot colour, Animal science, Incubation temperature, Digital image analysis, Coturnix coturnix, Animal Science and Zoology, lcsh:Animal culture, Eggshell, Incubation, lcsh:SF1-1100, Black spot
Abstract

WOS: 000378892800003, This study was carried out to investigate the effects of eggshell colour and spot properties (colour and size of the spot area) on eggshell incubation temperature and hatching outcomes of Japanese quail eggs (Coturnix coturnix japonica). Study material was allocated to five groups according to their eggshell and spot colours: black spots on greyish white coloured eggshell (I), blue spots on greyish white coloured eggshell (II), diffuse brown spots on greyish brown coloured eggshell (III), brown spots on light green coloured eggshell (IV), and small brown spots on greyish brown coloured eggshell (V). The size of the spotted area was determined in each egg group using digital image analysis. Mean relative weight losses of hatched and unhatched eggs between days 0-10 and 0-14 of embryonic development were 4.76% and 10.48% and 9.17% and 15.46%, respectively. The mean eggshell temperatures of hatched and unhatched eggs measured at the equatorial region on days 10 and 14 during embryonic development were 36.92 and 37.79 degrees C and 36.84 and 37.18 degrees C, respectively. Eggshell temperatures at the equatorial region on days 10 (36.89 degrees C) and 14 (37.57 degrees C) of embryonic development were lower than the fixed temperature of the incubator (37.6 degrees C). Fertility, hatchability of fertile eggs, and hatchability and embryonic mortality rates do not vary in relation to eggshell colour or the size of the spotted area., Scientific Research Project Unit of Mustafa Kemal University, Turkey [1206 M0117], This study was conducted between February and April, 2013. Present study was supported by the Scientific Research Project Unit of Mustafa Kemal University, Turkey (Project number: 1206 M0117).

Published
2016
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32. The effects of preparation period exercises on the hematological parameters of the taekwondo athletes

Author

H. Demir, Ekrem Boyali, Tarık Sevindi, Mehmet Yüksel, Spor Bilimleri Fakültesi, sevindi, tarik -- 0000-0001-7007-170X, [Boyali, E. -- Demir, H.] Selcuk Univ, Fac Sports Sci, TR-42130 Konya, Turkey -- [Sevindi, T.] Aksaray Univ, Fac Sports Sci, TR-68100 Aksaray, Turkey -- [Yuksel, M. F.] Necmettin Erbakan Univ, Fac Educ, TR-42090 Konya, Turkey, Selçuk Üniversitesi, Spor Bilimleri Fakültesi, Rekreasyon Bölümü, Boyali, E., and Demir, H.

Subjects
medicine.medical_specialty, biology, LC8-6691, Taekwondo, business.industry, Athletes, University Students, Leucocyte, 030229 sport sciences, biology.organism_classification, Special aspects of education, Erythrocyte, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Physical therapy, medicine, Training, Thrombocyte, business, Period (music)
Abstract

WOS: 000459931700002, Purpose: This study aimed at examining the effects of preparation period exercises, which were applied for eight weeks to elite level taekwondo athletes, on the hematological parameters. Material: Totally 21 athletes with international degrees from the university taekwondo team participated in this study, 12 of whom were female (Mean age: 20.3 - Mean exercise age: 8.8) and 9 of whom were male athletes (Mean age: 20.3 - Mean exercise age: 9.5). The participants attended an 8-week exercise program for 5 days a week, which included basic motoric features and technical and tactical development. 4 cc blood samples were taken from the right antecubital vein before and after the preparation period exercises. On the blood samples,WBC, GRAN, GRAN %, LYM, LYM %, MID and MID % values were examined among leukocyte sub-groups; RBC, HGB, HCT, MCV, MCH, MCHC and RDWC values were examined among the erythrocyte sub-groups, and PLT, MPV, PCT and PDW values were examined among thrombocyte sub-groups. Results: At the end of the study, we determined that there was a statistically significant increase in the MCHC values of both the male and the female taekwondo athletes. Moreover, it was determined that there were statistically significant decreases in the HCT, MCV, MCH, MPV and PCT values of the female taekwondo athletes, and in the MCV, MPV and PCT values of the male taekwondo athletes. Conclusions: As a conclusion, we can state that the 8-week exercises applied during the preparation period affected the hematological parameters of the male and female taekwondo athletes to an extent, however, this effect was limited and it did not cause an important change.

Published
2019

33. ANALYSIS OF PROMISING BARLEY (Hordeum vulgare L.) LINES PERFORMANCE BY AMMI AND GGE BIPLOT IN MULTIPLE TRAITS AND ENVIRONMENT

Author

Kendal, E., Karaman M., Tekdal S., Doğan S., and [Kendal, E.] Mardin Artuklu Univ, Dept Plant & Anim Prod, Kiziltepe Vocat & Training High Sch, Mardin, Turkey -- [Karaman, M.] Mus Alparslan Univ, Fac Appl Sci, Dept Plant & Prod Technol, Mus, Turkey -- [Tekdal, S.] GAP Int Agr Res & Training Ctr, TR-21100 Diyarbakir, Turkey -- [Dogan, S.] Siirt Univ, Inst Sci & Technol, Dept Field Crops, Siirt, Turkey

Subjects
biology, Biplot, grain yield, GEI, Multiple traits, barley, Ammi, stability, biology.organism_classification, Agronomy, breeding, Hordeum vulgare, Agronomy and Crop Science, Ecology, Evolution, Behavior and Systematics
Abstract

WOS: 000462830400242, The development of stable and adaptable new cultivars are based only on positive results obtained from the interaction between the genotype and the environment. Therefore, the study aimed to test the stability and general adaptability of promising barley lines in terms of grain yield and traits in multi -environments. For this purpose, twelve barley genotypes were used in the study. The trials were carried out with four replications in a random design at seven environments in years 2012-13 and 2013-14. The superior and stable genotypes were identified with GGE biplot and AMMI (Additive main effects and multiplicative interaction) models. The AMMI analysis showed that the major treatment sum of squares was affected by environments (80.6%), GE (14.0%) and genotypes (5.4%), respectively. On the other hand, the first two principal component axes (PCA 1 and PCA 2) contributed to the complete interaction with 88.1%, whereas, PCA 3 and PCA 4 axes only with 12.0%. The GGE biplot indicated that G4 is adaptable for all environments, while Altikat, G2 and G3 showed specific adaptation to El, E3 and E5, G6, G7 and G8 to E6, respectively. According to both techniques, G2, G3, G6, G7, G8 and Altikat were the best genotypes with high yield, whereas G4 was the best with high yield, and stable and general adaptation. The results of biplot indicated that G4 (ARUPO /K8755//MORA/3/CERISE/SHYRIHALEL I/4/CANELA/5/HART-BAR) was recommended for release and it was released as HEVSEL in 2017. On the other hand; G7 and G6 were protected as genetic material to use as parent in breeding programs for yield stability and quality respectively.

Published
2019

34. Aminopyrazole-substituted metallophthalocyanines: Preparation, aggregation behavior, and investigation of metabolic enzymes inhibition properties

Author

Umit M. Kocyigit, Emre Güzel, Mehmet Ataş, Parham Taslimi, Barış Seçkin Arslan, Faik Gökalp, İlhami Gülçin, Mehmet Nebioğlu, İlkay Şişman, [Guzel, Emre -- Arslan, Baris S. -- Nebioglu, Mehmet -- Sisman, Ilkay] Sakarya Univ, Dept Chem, TR-54050 Serdivan, Sakarya, Turkey -- [Kocyigit, Umit M.] Cumhuriyet Univ, Vocat Sch Hlth Serv, TR-58140 Sivas, Turkey -- [Atas, Mehmet] Cumhuriyet Univ, Dept Pharmaceut Microbiol, Fac Pharm, Sivas, Turkey -- [Taslimi, Parham -- Gulcin, Ilhami] Ataturk Univ, Dept Chem, Fac Sci, Erzurum, Turkey -- [Gokalp, Faik] Kirikkale Univ, Dept Math & Sci Educ, Kirikkale, Turkey, gokalp, faik -- 0000-0003-4363-3839, Guzel, Emre -- 0000-0002-1142-3936, Guzel, E, Kocyigit, UM, Arslan, BS, Atas, M, Taslimi, P, Gokalp, F, Nebioglu, M, Sisman, I, Gulcin, I, Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü, Güzel, Emre, Nebioğlu, Mehmet, Şişman, İlkay, Kırıkkale Üniversitesi, and Bartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümü

Subjects
Antifungal Agents, Indoles, aminopyrazole, carbonic anhydrase, Pharmaceutical Science, Isoindoles, Gram-Positive Bacteria, 01 natural sciences, Cholinergic Antagonists, Phthalonitrile, chemistry.chemical_compound, Structure-Activity Relationship, anticholinergic, Carbonic anhydrase, Drug Discovery, Gram-Negative Bacteria, Humans, Hypoglycemic Agents, Carbonic Anhydrase I, Carbonic Anhydrase Inhibitors, Butyrylcholinesterase, biology, 010405 organic chemistry, antidiabetic, acetylcholinesterase, Antimicrobial, Acetylcholinesterase, 0104 chemical sciences, Anti-Bacterial Agents, 010404 medicinal & biomolecular chemistry, Chemistry, phthalocyanine, chemistry, Enzyme inhibitor, Metals, Phthalocyanine, biology.protein, Pyrazoles, antimicrobial, Anticholinergics, Nuclear chemistry
Abstract

WOS: 000457586700007, PubMed ID: 30600535, The synthesis, characterization, aggregation behavior, theoretical studies, and investigation of antimicrobial, antidiabetic, and anticholinergic properties of 4-(2-(5-amino-4-(4-bromophenyl)-3-methyl-1H-pyrazol-1-yl)ethoxy)phthalonitrile (2) and its soluble aminopyrazole-substituted peripheral metallo (Mn, Co, and Ni)-phthalocyanine complexes (3-5) are reported for the first time. The synthesized compounds and phthalocyanine complexes were characterized spectroscopically. The new phthalonitrile derivative (2) and its peripheral metallophthalocyanine complexes (3-5) were found to be effective inhibitors of alpha-glycosidase, acetylcholinesterase (AChE), human carbonic anhydrase I and II isoforms (hCA I and II), and butyrylcholinesterase (BChE) with K-i values in the range of 1.55 +/- 0.47 to 10.85 +/- 3.43 nM for alpha-glycosidase, 8.44 +/- 0.32 to 21.31 +/- 7.91 nM for hCA I, 11.73 +/- 2.82 to 31.03 +/- 4.81 nM for hCA II, 101.62 +/- 26.58 to 326.54 +/- 89.67 nM for AChE, and 68.68 +/- 11.15 to 109.53 +/- 19.55 nM for BChE. This is the first study of peripherally substituted phthalocyanines containing an aminopyrazole group as potential carbonic anhydrase enzyme inhibitor. Also, the antimicrobial activities of the synthesized compounds were evaluated against six microorganisms (four bacteria and two Candida species) using the broth microdilution method. The gram-positive bacteria were detected to be more sensitive than gram-negative bacteria and yeasts in the synthesized compounds., Sakarya University [2012-02-04-036], Sakarya University, Grant number: 2012-02-04-036

Published
2019

35. Determination of the Fatty Acid Compositions of Four Onobrychis Species from Turkey

Author

Salih Görgün, Hilal Karakas, Nükhet Akpinar, Mehmet Tekin, and [Gorgun, Salih] Cumhuriyet Univ, Fac Sci, Dept Biochem, TR-58140 Sivas, Turkey -- [Akpinar, Nukhet] Cumhuriyet Univ, Fac Sci, Dept Biol, TR-58140 Sivas, Turkey -- [Tekin, Mehmet] Trakya Univ, Fac Pharm, Dept Pharmaceut Bot, TR-22030 Edirne, Turkey -- [Karakas, Hilal] Cumhuriyet Univ, Inst Sci, Dept Biochem, TR-58140 Sivas, Turkey

Subjects
chemistry.chemical_classification, chemistry, Onobrychis, biology, Fatty acid, Plant Science, General Chemistry, Food science, biology.organism_classification, General Biochemistry, Genetics and Molecular Biology
Abstract

WOS: 000461554200022, …, Cumhuriyet University (Sivas, Turkey) [F-526], This research was supported by the Research Fund of Cumhuriyet University (Sivas, Turkey) (project number F-526).

Published
2019

36. Characterisation of Streptomyces violascens OC125-8 lipase for oily wastewater treatment

Author

Rukiye Boran, Nurdan Sarac, Aysel Ugur, Ozgur Ceylan, Sağlık Hizmetleri Meslek Meslek Yüksekokulu, Boran, Rukiye -- 0000-0003-2395-2445, [Boran, Rukiye] Aksaray Univ, Vocat Sch Hlth Serv, Dept Med Serv & Techn, Med Lab Program, TR-68100 Aksaray, Turkey -- [Ugur, Aysel] Gazi Univ, Fac Dent, Dept Basic Sci, Sect Med Microbiol, TR-06510 Ankara, Turkey -- [Sarac, Nurdan] Mugla Sitki Kocman Univ, Fac Sci, Dept Biol, TR-48000 Mugla, Turkey -- [Ceylan, Ozgur] Mugla Sitki Kocman Univ, Ula Ali Kocman Vocat Sch, Food Qual Control & Anal Program, TR-48147 Mugla, Turkey, MÜ, Fen Fakültesi, Biyoloji Bölümü, Saraç, Nurdan, and Ceylan, Özgür

Subjects
Oil Degradation, Chromatography, food.ingredient, biology, Characterisation, Chemistry, Sunflower oil, Ethylenediaminetetraacetic acid, Lipase, Wastewater, Environmental Science (miscellaneous), Streptomyces violascens, Agricultural and Biological Sciences (miscellaneous), Enzyme assay, chemistry.chemical_compound, food, biology.protein, Streptomyces Violascens, Ammonium, PMSF, Corn oil, Biotechnology
Abstract

WOS: 000454678300005, PubMed: 30622843, In this study, the lipase-producing bacterium Streptomyces violascens (GenBank number MF621564) was identified, and the extracellular S. violascens OC125-8 lipase produced by this strain was characterised for use in wastewater treatment. The lipase was partially purified by ammonium sulphate precipitation at a final yield of 3.28-fold purification and a recovery of 56%. The S. violascens OC125-8 lipase exhibited optimum catalytic activity at 40 degrees C and pH 8.0; it was stable at 30-40 degrees C with more than 86% residual activity after 1h; it was also stable over a relatively broad pH range of pH 7.0-11.0, retaining 83.3-100% activity. V-max and K-m values were calculated as 0.61 mu mol/min/mg and 0.259mM, respectively. Enzyme activity significantly increased in the presence of Fe2+ ion but was inhibited by Ca2+, Mn2+, Cu2+ and Mg2+. The addition of a serine protease inhibitor, phenylmethylsulfonyl fluoride (PMSF), strongly inhibited enzyme activity while ethylenediaminetetraacetic acid (EDTA), a metal chelating agent, had no inhibitory effect. The enzyme was fairly stable in the presence of surfactants as well as sodium perborate. Examination of commercial detergent tolerance revealed that the lipase was strongly stable in Tursil (88%), Pril (97%) and Fairy (98.5%), while the lipase was activated in Omo (113.4%) and Ariel (128.3%). Moreover, the lipase showed highest activity towards olive oil (100%), sunflower oil (90%) and burned sunflower oil (55%), while corn oil (44%) and burned olive oil (15%) were less hydrolysed by the enzyme. These properties demonstrate that S. violascens OC125-8 lipase is an ideal choice for oily wastewater management.

Published
2019
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37. The effects of inulin as a prebiotic supplement and the synbiotic interactions of probiotics to improve oxalate degrading activity

Author

Yavuz Beyatli, Şule Sönmez, Derya Onal Darilmaz, [Darilmaz, Derya Onal] Aksaray Univ, Fac Sci & Letters, Dept Biotechnol & Mol Biol, TR-68100 Aksaray, Turkey -- [Sonmez, Sule -- Beyatli, Yavuz] Gazi Univ, Dept Biol, Fac Sci, TR-06500 Ankara, Turkey, and Sabire Yazıcı Fen Edebiyat Fakültesi

Subjects
0301 basic medicine, medicine.medical_treatment, Inulin, Probiotic, oxalate-degrading, Industrial and Manufacturing Engineering, Oxalate, law.invention, 03 medical and health sciences, chemistry.chemical_compound, law, Lactobacillus, medicine, Food science, 030109 nutrition & dietetics, biology, Prebiotic, synbiotic, food and beverages, biology.organism_classification, 030104 developmental biology, chemistry, prebiotic, Food Science
Abstract

WOS: 000454536700014, This paper examines the impact of inulin, Lactobacillus spp. (candidate probiotics), and synbiotic (inulin + Lactobacillus spp.) preparation on oxalate degrading activity and viability of Escherichia coli. In this study, the lowest viability of E. coli was recorded for the synbiotic treatments of Lactobacillus fermentum BP5 (59%) and IP5 (60%). The oxalate degrading activity of L. fermentum IP5 was 38.18 and 29.60% higher than the other strains after growth in 10 mM and 20 mM MRS-ox plus 5% inulin media, respectively. The mixture of three strains demonstrated higher oxalate degrading capacity than the individual strains and showed the same good growth rates (9.43 CFU mL(-1)) as individuals. The study concludes that the addition of prebiotics has a significant effect on probiotics; therefore, a combination of L. fermentum IP5 with inulin could be a viable probiotic-based functional food approach in administering oxalate metabolism and also treatment of E. coli-related infections., Aksaray University, This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors. The authors are grateful to Aksaray University for financial support and Aksaray University Scientific and Technological Research and Application Center (ASUBTAM) for the provision of laboratory facilities. The authors also thank Dr. Silvia Turroni for providing reference cultures (L. delbrueckii DSM 20074 and L. acidophilus NCFM). This text was analysed in terms of grammar and use of language by Lecturer Ekmel Emrah Hakman, MA, in the Academic Foreign Language Support Center, Aksaray University.

Published
2019

38. Catalyzing transcriptomics research in cardiovascular disease: The CardioRNA COST action CA17129

Author

Da Costa Gomes, Clarissa Pedrosa, Ágg, Bence, Andova, Andrejaana, Arslan, Serdal, Baker, Andrew, Barteková, Monika, Beis, Dimitris, Betsou, Fay, Bezzina Wettinger, Stephanie, Bugarski, Branko, Condorelli, Gianluigi, Da Silva, Gustavo José Justo, Danilin, Sabrina, De Gonzalo-Calvo, David, Buil, Alfonso, Carmo-Fonseca, Maria, Enguita, Francisco J., Felekkis, Kyriacos, Ferdinandy, Peter, Gyöngyösi, Mariann, Hackl, Matthias, Karaduzovic-Hadziabdic, Kanita, Hellemans, Jan, Heymans, Stephane, Hlavackova, Markéta, Hoydal, Morten Andre, Jankovic, Aleksandra, Jusic, Amela, Kardassis, Dimitris, Kerkelä, Risto, Kuster, Gabriela M., Lakkisto, Päivi, Leszek, Przemyslaw, Lustrek, Mitja, Maegdefessel, Lars, Martelli, Fabio, Novella, Susana, O’Brien, Timothy, Papaneophytou, Christos, Pedrazzini, Thierry, Pinet, Florence, Popescu, Octavian, Potoˇcnjak, Ines, Robinson, Emma L., Sasson, Shlomo, Scholz, Markus, Simionescu, Maya, Stoll, Monika, Varga, Zoltan V., Vinciguerra, Manlio, Xuereb, Angela, Yilmaz, Mehmet Birhan, Emanueli, Costanza, Devaux, Yvan, Formosa, Melissa Marie, EU-CardioRNA COST Action (CA17129), Repositório da Universidade de Lisboa, Luxembourg Institute of Health (LIH), Semmelweis University [Budapest], Jozef Stefan Institute [Ljubljana] (IJS), Cumhuriyet University [Sivas, Turkey], Queen's Medical Researche Institute, University of Edinburgh, Slovak Academy of Sciences (SAS), Biomedical Research Foundation of the Academy of Athens (BRFAA), Integrated BioBank of Luxembourg (IBBL), University of Malta [Malta], Faculty of Technology and Metallurgy [University of Belgrade], University of Belgrade [Belgrade], Humanitas Clinical and Research Center [Rozzano, Milan, Italy], Oslo University Hospital [Oslo], University of Oslo (UiO), Firalis SAS, Spanish National Research Council (CSIC), Universidade de Lisboa (ULISBOA), University of Cyprus [Nicosia], Medizinische Universität Wien = Medical University of Vienna, International University of Sarajevo, Maastricht University [Maastricht], Czech Academy of Sciences [Prague] (CAS), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), Institute for Biological Research Sinisa Stankovic [Belgrade] (IBISS), University of Tuzla, University of Crete [Heraklion] (UOC), Institute of Molecular Biology and Biotechnology (IMBB-FORTH), Foundation for Research and Technology - Hellas (FORTH), University of Oulu, University Hospital Basel [Basel], University of Basel (Unibas), Minerva Foundation Institute for Medical Research, Karolinska Institutet [Stockholm], Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Universitat de València (UV), National University of Ireland [Galway] (NUI Galway), Université de Lausanne (UNIL), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Babes-Bolyai University [Cluj-Napoca] (UBB), The Hebrew University of Jerusalem (HUJ), Leipzig University, Institute of Cellular Biology and Pathology Nicolae Simionescu, Westfälische Wilhelms-Universität Münster (WWU), Dokuz Eylül Üniversitesi = Dokuz Eylül University [Izmir] (DEÜ), National Heart and Lung Institute [London] (NHLI), Royal Brompton and Harefield NHS Foundation Trust-Imperial College London, EU-CardioRNA COST Action (CA17129), European Cooperation in Science and Technology, [Gomes, Clarissa Pedrosa da Costa -- Devaux, Yvan] Luxembourg Inst Hlth, Cardiovasc Res Unit, L-1445 Strassen, Luxembourg -- [Agg, Bence -- Ferdinandy, Peter -- Varga, Zoltan V.] Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, H-1085 Budapest, Hungary -- [Andova, Andrejaana -- Lustrek, Mitja] Jozef Stefan Inst, Dept Intelligent Syst, Ljubljana 1000E, Slovenia -- [Arslan, Serdal] Cumhuriyet Univ, Fac Med, Dept Med Biol, TR-58140 Sivas, Turkey -- [Baker, Andrew] Univ Edinburgh, Ctr Cardiovasc Sci, Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland -- [Bartekova, Monika] Slovak Acad Sci, Ctr Expt Med, Inst Heart Res, Bratislava 84104, Slovakia -- [Beis, Dimitris] Acad Athens, Biomed Res Fdn, Athens 11527, Greece -- [Betsou, Fay] Integrated BioBank Luxembourg, L-3550 Dudelange, Luxembourg -- [Wettinger, Stephanie Bezzina -- Xuereb, Angela] Univ Malta, Fac Hlth Sci, MSD-2080 Msida, Malta -- [Bugarski, Branko] Univ Belgrade, Fac Technol & Met, Belgrade 11000, Serbia -- [Condorelli, Gianluigi] Humanitas Res Hosp, Dept Cardiovasc, I-20089 Rozzano, Italy -- [da Silva, Gustavo Jose Justo] Oslo Univ Hosp, Inst Expt Med Res, PB 4956 Nydalen, NO-0424 Oslo, Norway -- [da Silva, Gustavo Jose Justo] Univ Oslo, PB 4956 Nydalen, NO-0424 Oslo, Norway -- [Danilin, Sabrina] Firalis, F-68330 Huningue, France -- [de Gonzalo-Calvo, David] CSIC, Inst Biomed Res Barcelona IIBB, Barcelona 08036, Spain -- [Buil, Alfonso] Mental Hlth Ctr Sct Hans, DK-4000 Roskilde, Denmark -- [Carmo-Fonseca, Maria -- Enguita, Francisco J.] Univ Lisbon, Fac Med, Inst Med Mol, P-1649028 Lisbon, Portugal -- [Felekkis, Kyriacos -- Papaneophytou, Christos] Univ Nicosia, Sch Sci & Engn, Dept Life & Hlth Sci, CY-2417 Nicosia, Cyprus -- [Gyoengyoesi, Mariann] Med Univ Vienna, Dept Cardiol, A-1090 Vienna, Austria -- [Hackl, Matthias] TAmiRNA, A-1190 Vienna, Austria -- [Karaduzovic-Hadziabdic, Kanita] Int Univ Sarajevo, Fac Engn & Nat Sci, Sarajevo 71210, Bosnia & Herceg -- [Hellemans, Jan] Biogazelle, B-9052 Zwijnaarde, Belgium -- [Heymans, Stephane] Maastricht Univ, Fac Hlth Med & Life Sci, Sch Cardiovasc Dis, NL-6229 ER Maastricht, Netherlands -- [Hlavackova, Marketa] Czech Acad Sci, Inst Physiol, Dept Dev Cardiol, Prague 14220, Czech Republic -- [Hoydal, Morten Andre] NTNU Norwegian Univ Technol & Sci, Fac Med & Hlth Sci, Dept Circulat & Med Imaging, NO-7489 Trondheim, Norway -- [Jankovic, Aleksandra] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Physiol, Belgrade 11000, Serbia -- [Jusic, Amela] Univ Tuzla, Fac Nat Sci & Math, Dept Biol, Tuzla 75000, Bosnia & Herceg -- [Kardassis, Dimitris] Univ Crete, Med Sch, Dept Basic Sci, Iraklion 71003, Crete, Greece -- [Kardassis, Dimitris] Fdn Res & Technol Hellas, Inst Mol Biol & Biotechnol, Iraklion 71003, Crete, Greece -- [Kerkela, Risto] Univ Oulu, Res Unit Biomed, Oulu 90014, Finland -- [Kuster, Gabriela M.] Univ Hosp, Dept Biomed & Clin Cardiol, CH-4031 Basel, Switzerland -- [Kuster, Gabriela M.] Univ Basel, CH-4031 Basel, Switzerland -- [Lakkisto, Paivi] Minerva Fdn, Helsinki 00290, Finland -- [Leszek, Przemyslaw] Cardinal Stefan Wyszynski Inst Cardiol, PL-04628 Warsaw, Poland -- [Maegdefessel, Lars] Karolinska Inst, Ctr Mol Med, S-17176 Stockholm, Sweden -- [Martelli, Fabio] IRCCS Policlin San Donato, Mol Cardiol Lab, I-20097 Milan, Italy -- [Novella, Susana] Univ Valencia, Dept Physiol, Valencia 46010, Spain -- [Novella, Susana] INCLIVA Biomed Res Inst INCLIVA, Valencia 46010, Spain -- [O'Brien, Timothy] Natl Univ Ireland Galway, Regenerat Med Inst REMEDI, Galway H91 TK33, Ireland -- [Pedrazzini, Thierry] Univ Lausanne, Med Sch, Dept Cardiovasc Med, Expt Cardiol Unit,Div Cardiol, CH-1011 Lausanne, Switzerland -- [Pinet, Florence] Inst Pasteur, INSERM, F-59019 Lille, France -- [Popescu, Octavian] Babes Bolyai Univ, Cluj Napoca 400084, Romania -- [Potocnjak, Ines] Univ Hosp Ctr Sisters Char, Inst Clin Med Res & Educ, Zagreb 10000, Croatia -- [Robinson, Emma] Maastricht Univ, Fac Hlth Med & Life Sci, Ctr Heart Failure Res, Dept Cardiol, NL-6229 ER Maastricht, Netherlands -- [Sasson, Shlomo] Hebrew Univ Jerusalem, Fac Med, Inst Drug Res, IL-91120 Jerusalem, Israel -- [Scholz, Markus] Univ Leipzig, Med Fac, Inst Med Informat Stat & Epidemiol, D-04107 Leipzig, Germany -- [Simionescu, Maya] Inst Cellular Biol & Pathol Nicolae Simionescu, Bucharest 050568, Romania -- [Stoll, Monika] Westfalische Wilhelms Univ Munster, Inst Human Genet, Dept Genet Epidemiol, D-48149 Munster, Germany -- [Vinciguerra, Manlio] Int Clin Res Ctr, Brno 65691, Czech Republic -- [Yilmaz, Mehmet Birhan] Dokuz Eylul Univ, Fac Med, Dept Cardiol, TR-35340 Izmir, Turkey -- [Emanueli, Costanza] Imperial Coll London, Fac Med, Natl Heart & Lung Inst, London W12 0HH, England, Hlavackova, Marketa -- 0000-0003-3842-6907, Devaux, Yvan -- 0000-0002-5321-8543, Gyongyosi, Mariann -- 0000-0002-7083-2107, Sasson, Shlomo -- 0000-0002-9343-526X, Buil, Alfonso -- 0000-0002-3097-1014, Hoydal, Morten -- 0000-0003-1804-2578, Justo da Silva, Gustavo -- 0000-0002-1651-7966, Baker, Andrew -- 0000-0003-1441-5576, Lakkisto, Paivi -- 0000-0001-9935-6573, Pinet, Florence -- 0000-0002-5471-1487, Martelli, Fabio -- 0000-0002-8624-7738, Robinson, Emma -- 0000-0002-4866-731X, Novella, Susana -- 0000-0001-8303-7252, Jusic, Amela -- 0000-0003-2835-4284, Beis, Dimitris -- 0000-0003-2579-7848, O'Brien, Timothy -- 0000-0001-9028-5481, Popescu, Octavian -- 0000-0002-2597-7155, Felekkis, Kyriacos -- 0000-0002-0919-0037, de Gonzalo Calvo, David -- 0000-0003-2240-3532, Universidade de Lisboa = University of Lisbon (ULISBOA), University of Cyprus [Nicosia] (UCY), Université de Lausanne = University of Lausanne (UNIL), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), RS: CARIM - R2.02 - Cardiomyopathy, RS: CARIM - R2 - Cardiac function and failure, and RS: Carim - H02 Cardiomyopathy

Subjects
Project Report, 0301 basic medicine, medicine.medical_specialty, Biochemistry & Molecular Biology, Knowledge management, lcsh:QH426-470, BIOMARKERS, best practices and guidelines, cardiovascular disease, personalized medicine, transcriptomics, translational research, Context (language use), Translational research, Disease, 030204 cardiovascular system & hematology, Biology, Biochemistry, LONG NONCODING RNAS, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, CIRCULATING MICRORNAS, TARGETS, Genetics, medicine, Cost action, Set (psychology), Molecular Biology, ComputingMilieux_MISCELLANEOUS, Genetics & Heredity, Science & Technology, business.industry, Cardiovascular system -- Diseases, Public health, Medicine -- Research -- International cooperation, 3. Good health, lcsh:Genetics, 030104 developmental biology, Action (philosophy), PERSPECTIVES, Personalized medicine, Translational research, biomedical, business, Transcriptome, Life Sciences & Biomedicine
Abstract

WOS: 000474931400001, PubMed ID: 30934986, Cardiovascular disease (CVD) remains the leading cause of death worldwide and, despite continuous advances, better diagnostic and prognostic tools, as well as therapy, are needed. The human transcriptome, which is the set of all RNA produced in a cell, is much more complex than previously thought and the lack of dialogue between researchers and industrials and consensus on guidelines to generate data make it harder to compare and reproduce results. This European Cooperation in Science and Technology (COST) Action aims to accelerate the understanding of transcriptomics in CVD and further the translation of experimental data into usable applications to improve personalized medicine in this field by creating an interdisciplinary network. It aims to provide opportunities for collaboration between stakeholders from complementary backgrounds, allowing the functions of different RNAs and their interactions to be more rapidly deciphered in the cardiovascular context for translation into the clinic, thus fostering personalized medicine and meeting a current public health challenge. Thus, this Action will advance studies on cardiovascular transcriptomics, generate innovative projects, and consolidate the leadership of European research groups in the field. COST (European Cooperation in Science and Technology) is a funding organization for research and innovation networks (www.cost.eu)., COST (European Cooperation in Science and Technology) Action EU-CardioRNA [CA17129], This work is supported by COST (European Cooperation in Science and Technology) Action EU-CardioRNA CA17129. YD is the chair and CE is the vice-chair of the European COST Action CA17129, CardioRNA.

Published
2019
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39. Cost-effectiveness of boron (B) removal from irrigation water: an economic water treatment model (EWTM) for farmers to prevent boron toxicity

Author

Cengiz Türe, Onur Can Türker, Anıl Yakar, Çağdaş Saz, Sabire Yazıcı Fen Edebiyat Fakültesi, and [Turker, Onur Can] Aksaray Univ, Fac Sci & Letters, Dept Biol, Aksaray, Turkey -- [Yakar, Anil -- Ture, Cengiz -- Saz, Cagdas] Eskisehir Tech Univ, Dept Biol, Fac Sci, Eskisehir, Turkey

Subjects
Irrigation, Agricultural Irrigation, Cost effectiveness, Health, Toxicology and Mutagenesis, Lemna gibba, Cost-Benefit Analysis, 010501 environmental sciences, Irrigation Water, 01 natural sciences, Dried Plants, Water scarcity, Water Purification, Phragmites, Boron Removal, Lemna Gibba, Environmental Chemistry, Araceae, 0105 earth and related environmental sciences, Boron, Farmers, biology, business.industry, Sorption, General Medicine, Hydrogen-Ion Concentration, biology.organism_classification, Pulp and paper industry, Pollution, Models, Economic, Agriculture, Wetlands, Environmental science, Water treatment, Adsorption, business, Water Pollutants, Chemical
Abstract

Türker, Onur Can ( Aksaray, Yazar ), Protection of water sources which are used for irrigation has raised great interest in the last years among the environmental strategists due to potential water scarcity worldwide. Excessive boron (B) in irrigation water poses crucial environmental problems in the agricultural zones and it leads to toxicity symptoms in crops, as well as human beings. In the present research, economic water treatment models consist of dried common wetland plants (Lemna gibba, Phragmites australis, and Typha latifolia) and Lemna gibba accumulation was tested and assessed to create a simple, cost-effective, and eco-friendly method for B removal from irrigation water. Significant amount of B was removed from irrigation water samples by EWTMs and B concentrations decreased below

Published
2019

40. Karyotype analyses of 25 Turkish taxa of Astragalus from the sections Macrophyllium Hymenostegis, Hymenocoleus, and Anthylloidei (Fabaceae)

Author

Esra Martin, Seher Karaman Erkul, Gizem Icyer Dogan, Haul Erhan Eroglu, [Martin, Esra] Necmettin Erbakan Univ, Fac Sci, Dept Biotechnol, Konya, Turkey -- [Icyer Dogan, Gizem] Necmettin Erbakan Univ, Grad Sch Nat & Appl Sci, Dept Biol, Konya, Turkey -- [Karaman Erkul, Seher] Aksaray Univ, Fac Sci & Arts, Dept Biol, Aksaray, Turkey -- [Eroglu, Haul Erhan] Yozgat Bozok Univ, Fac Sci & Arts, Dept Biol, Yozgat, Turkey, and Fen-Edebiyat Fakültesi

Subjects
0106 biological sciences, 0303 health sciences, biology, Turkish, Astragalus, Karyotype, Fabaceae, Plant Science, 15. Life on land, biology.organism_classification, 01 natural sciences, Hymenocoleus, language.human_language, Bitki Bilimleri, 030308 mycology & parasitology, karyotype, 03 medical and health sciences, Taxon, Botany, asymmetry index, Astragalus,asymmetry index,Fabaceae,karyotype, language, 010606 plant biology & botany
Abstract

WOS: 000460568300009, The karyotype analyses and chromosomal data of 25 taxa belonging to the sections Macrophyllium, Hymenostegis, Hymenocoleus, and Anthylloidei of the genus Astragalus naturally distributed in Turkey are described. The cytogenetic data obtained were evaluated systematically. The following somatic chromosome numbers were found: 2n = 16 for A. oleaefolius, A. dipodurus, A. cephalotes, and A. yukselii; 2n = 32 for A. longifolius; and 2n = 48 for A. isauricus in the sect. Macrophyllium; 2n = 16 for A. zohrabi, A. sosnowskyi, A. velenovskyi, A. trifoliastrum, and A. uraniolimneus; 2n = 18 for A. hymenocystis; 2n= 48 for A. lagopoides, A. gueruenensis, and A. ciloensis; and 2n = 64 for A. hirticalyx in the sect. Hymenostegis; 2n = 48 for A. vaginans in the sect. Hymenocoleus; and 2n= 16 for A. szowitsii, A. ermineus, A. zederbaueri, A. anthylloides, A. halicacabus, A. chardinii, and A. wagneri; and 2n = 48 for A. surugensis in the sect. Anthylloidei. In all taxa, the karyotype results were obtained for the first time. A. szowitsii is the most symmetrical karyotype in both index values. While A. zohrabi is the most asymmetrical karyotype in intrachromosomal asymmetry, A. wagneri is the most asymmetrical karyotype in interchromosomal asymmetry., TUBITAK [TBAG-110T911, KBAG-113Z899], We wish to thank TUBITAK (project number: TBAG-110T911 and KBAG-113Z899) for its financial support and we are grateful to Dr Z Aytac and Dr M Ekici (Gazi University) for their invaluable advice.

Published
2019

41. SAR Evaluation of Disubstituted Tacrine Analogues as Promising Cholinesterase and Carbonic Anhydrase Inhibitors

Author

Salih Okten, Makbule Ekiz, Ahmet Tutar, Burcu Butun, Umit Muhammet Kocyigit, Gulactı Topcu, Ilhami Gulcin, Okten, S, Ekiz, M, Tutar, A, Butun, B, Kocyigit, UM, Topcu, G, Gulcin, I, Sakarya Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü, Tutar, Ahmet, Kırıkkale Üniversitesi, BÜTÜN, Burcu, [Okten, Salih] Kirikkale Univ, Fac Educ, Dept Maths & Sci Educ, Yahsihan, Kirikkale, Turkey -- [Ekiz, Makbule -- Tutar, Ahmet] Sakarya Univ, Fac Art & Sci, Dept Chem, TR-54187 Serdivan, Sakarya, Turkey -- [Butun, Burcu] Bezmialem Vakif Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34093 Istanbul, Turkey -- [Kocyigit, Umit Muhammet] Cumhuriyet Univ, Vocat Sch Hlth Serv, Dept Med Tech, TR-58140 Sivas, Turkey -- [Topcu, Gulacti] Bezmialem Vakif Univ, Fac Pharm, Dept Pharmacognosy Phytochem, TR-34093 Istanbul, Turkey -- [Gulcin, Ilhami] Ataturk Univ, Fac Sci, Dept Chem, TR-25240 Erzurum, Turkey, and Okten, Salih -- 0000-0001-9656-1803

Subjects
Carbonic anhydrase, biology, Chemistry, Tacrine derivatives, Pharmacology, ÖKTEN S., EKIZ M., TUTAR A., BÜTÜN B., Koçyiğit Ü. M. , TOPÇU G., Gülçin İ., -SAR Evaluation of Disubstituted Tacrine Analogues as Promising Cholinesterase and Carbonic Anhydrase Inhibitors-, INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, cilt.13, ss.23-30, 2019, Anticholinegic, Tacrine, Butyrylcholinesterase, medicine, biology.protein, Acetylcholinesterase, Pharmacology & Pharmacy, General Pharmacology, Toxicology and Pharmaceutics, medicine.drug, Cholinesterase, SAR
Abstract

WOS: 000466869900012, Background: The inhibition of both hydrolysis products of acetylcholine (ACh), Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE), is essential for successful treatment of Alzhemier patients. Objectives: This study was investigated inhibition potentials of recently synthesized disubstituted tacrines derivatives on going our research against AChE, BChE and carbonic anhydrase cyctosolic (hCA I and H) enzymes to explore the Structure activity relationship (SAR). Methods: Inhibitory activities of tested compounds against AChE and BChE were measured by spectrophotometric method, developed by Ellman et al. Furthermore, the disubstituted tacrines were determined as inhibitors of two physiologically relevant CA isoforms, the cytosolic hCA I and H by an esterase assay method. Results: The silyl, thiomethyl and cyano substituted seven membered hydrocycle tacrines (9, 11 and 14) significantly inhibited AChE, compared with starting compound 3 (6,8-dibromo-2,3,4,5-teytrahydro-1H-cyclohepta[1,2-b] quinoline) and reference compounds, galantamine and tacrine, while methoxy substituted seven membered hydrocycle tacrine derivative 10 showed selective inhibition against BChE (IC50 = 563 nM). Interestingly, disubstituted tacrines displayed higher or parallel inhibition to galantamine. Additionally, all these tacrine analogues were recorded to be powerful inhibitor compounds of the cytosolic isoenzyme hCA I with K-i in the range of 43.81-471.67 nM, as well as a moderate selectivity toward hCA II isoenzyme with K-i in the range from 87.14 to 614.68 nM compared with AZA, as standard. Conclusion: The disubstituted seven membered hydrocycle tacrine analogues 9-12 and 14 may have promising anti Alzhemier drug candidate and dibromo six membered hydrocycle 2 and dibromo seven membered hydrocycle 3 derivatives may be novel hCA I and II enzyme inhibitors., Sakarya University Research Fund [2014-0204-008], This study was supported by grants from the Sakarya University Research Fund (Project number: 2014-0204-008).

Published
2019

42. The first mitogenomes of the superfamily Pamphilioidea (Hymenoptera: Symphyta): Mitogenome architecture and phylogenetic inference

Author

Ertan Mahir Korkmaz, Mahir Budak, Hasan H. Basibuyuk, Yaoyao Zhang, Shiyu Du, Meicai Wei, Gengyun Niu, Merve Nur Aydemir, Özgül Doğan, [Niu, Gengyun -- Wei, Meicai] Jiangxi Normal Univ, Coll Life Sci, 99 Ziyang Rd, Nanchang 330022, Jiangxi, Peoples R China -- [Korkmaz, Ertan Mahir -- Dogan, Ozgul -- Aydemir, Merve Nur -- Budak, Mahir] Sivas Cumhuriyet Univ, Dept Mol Biol & Genet, Fac Sci, Sivas, Turkey -- [Zhang, Yaoyao -- Du, Shiyu] Cent South Univ Forestry & Technol, Key Lab Cultivat & Protect Nonwood Forest Trees, Minist Educ, 498 South Shaoshan Rd, Changsha 410004, Hunan, Peoples R China -- [Basibuyuk, Hasan Huseyin] Akdeniz Univ, Dept Gerontol, Fac Hlth Sci, Antalya, Turkey, Niu, Gengyun -- 0000-0003-0505-7180, Basibuyuk, Hasan Huseyin -- 0000-0001-6504-6139, DOGAN, Ozgul -- 0000-0003-0182-8654, Budak, Mahir -- 0000-0001-5610-486X, aydemir, merve nur -- 0000-0001-6328-626X, and Korkmaz, Ertan Mahir -- 0000-0003-0699-1354

Subjects
Mitochondrial DNA, Symphyta, 02 engineering and technology, DNA, Mitochondrial, Biochemistry, Evolution, Molecular, 03 medical and health sciences, Monophyly, RNA, Transfer, Mitochondrial genome, Structural Biology, Megalodontes, Animals, Molecular Biology, Phylogeny, 030304 developmental biology, 0303 health sciences, biology, Phylogenetic tree, Gene rearrangement, Megalodontesidae, High-Throughput Nucleotide Sequencing, Molecular Sequence Annotation, GC skew, General Medicine, 15. Life on land, 021001 nanoscience & nanotechnology, biology.organism_classification, Hymenoptera, Evolutionary biology, Genome, Mitochondrial, 0210 nano-technology
Abstract

WOS: 000456899300021, PubMed ID: 30448489, The Pamphilioidea represents a small superfamily of the phytophagous suborder Symphyta (Hymenoptera). Here, nearly complete mitochondrial genomes (mitogenomes) of three pamphilioid species: Chinolyda flagellicornis (Pamphiliidae), Megalodontes spiraeae and M. cephalotes (Megalodontesidae) were newly sequenced using next generation sequencing and comparatively analysed with the previously reported symphytan mitogenomes. A positive AT skew (0.013) and a negative GC skew (-0.194) were found in pamphilioid mitogenome, and a deviation from strand asymmetry was also observed in the PCGs encoded on both strands. Several gene rearrangement events were observed in four tRNA gene clusters (WCY, IQM, ARNS1EF and TP clusters), which have not been reported from symphytan mitogenomes to date. As the most parsimonious explanation, compared with the inferred insect ancestral mitogenome architecture, the occurrence of gene rearrangements in pamphilioid mitogenomes requires totally five evolutionary steps, including four transpositions and one inversion. The predicted secondary structures of tRNAs, rrnS and rrnL genes are mostly consistent with reported hymenopteran species. Phylogenetic analyses recovered the monophyly of superfamily Pamphilioidea and indicated the relationship Tenthredinoidea + (Pamphilioidea + (Cephoidea + (Orussoidea + Apocrita))) with strong nodal supports. (C) 2018 Elsevier B.V. All rights reserved., TUBITAK (The Scientific and Technological Research Council of Turkey) [112T418]; National Natural Science Foundation of China [31501885, 31672344], This study was financially supported by TUBITAK (The Scientific and Technological Research Council of Turkey, a research project with grant number 112T418) and National Natural Science Foundation of China (No. 31501885, 31672344). The members of Cumhuriyet University Molecular Systematics Research Group (CUMSAG) and Lab of Insect Systematics and Evolutionary Biology (LISEB) from Central South University of Forestry and Technology are thanked for their contributions in laboratory work. We thank two anonymous reviewers for their careful reading of the manuscript and many constructive comments.

Published
2019

43. Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Author

Zeineb, Zian, Brown, Peter, Tan, Aik-Choon, El-Esawi, Mohamed A., Liehr, Thomas, Blanck, Oliver, Gladue, Douglas P., Almeida, Gabriel M. F., Cernava, Tomislav, Sorzano, Carlos O., Yeung, Andy W. K., Engel, Michael S., Chandrasekaran, Arun Richard, Muth, Thilo, Staege, Martin S., Daulatabad, Swapna V., Widera, Darius, Zhang, Junpeng, Meule, Adrian, Honjo, Ken, Pourret, Olivier, Yin, Cong-Cong, Zhang, Zhongheng, Cascella, Marco, Flegel, Willy A., Goodyear, Carl S., Raaij, Mark J. van, Bukowy-Bieryllo, Zuzanna, Campana, Luca G., Kurniawan, Nicholas A., Lalaouna, David, Hüttner, Felix J., Ammerman, Brooke A., Ehret, Felix, Cobine, Paul A., Tan, Ene-Choo, Han, Hyemin, Xia, Wenfeng, McCrum, Christopher, Dings, Ruud P. M., Marinello, Francesco, Nilsson, Henrik, Nixon, Brett, Voskarides, Konstantinos, Yang, Long, Costa, Vincent D., Bengtsson-Palme, Johan, Bradshaw, William, Grimm, Dominik G., Kumar, Nitin, Martis, Elvis, Prieto, Daniel, Sabnis, Sandeep C., Amer, Said E. D. R., Liew, Alan W. C., Perco, Paul, Rahimi, Farid, Riva, Giuseppe, Zhang, Chongxing, Devkota, Hari P., Ogami, Koichi, Basharat, Zarrin, Fierz, Walter, Siebers, Robert, Tan, Kok-Hian, Boehme, Karen A., Brenneisen, Peter, Brown, James A. L., Dalrymple, Brian P., Harvey, David J., Ng, Grace, Werten, Sebastiaan, Bleackley, Mark, Dai, Zhanwu, Dhariwal, Raman, Gelfer, Yael, Hartmann, Marcus D., Miotla, Pawel, Tamaian, Radu, Govender, Pragashnie, Gurney-Champion, Oliver J., Kauppila, Joonas H., Zhang, Xiaolei, Echeverría, Natalia, Subhash, Santhilal, Sallmon, Hannes, Tofani, Marco, Bae, Taeok, Bosch, Oliver, Cuív, Páraic O., Danchin, Antoine, Diouf, Barthelemy, Eerola, Tuomas, Evangelou, Evangelos, Filipp, Fabian V., Klump, Hannes, Kurgan, Lukasz, Smith, Simon S., Terrier, Olivier, Tuttle, Neil, Ascher, David B., Janga, Sarath C., Schulte, Leon N., Becker, Daniel, Browngardt, Christopher, Bush, Stephen J., Gaullier, Guillaume, Ide, Kazuki, Meseko, Clement, Werner, Gijsbert D. A., Zaucha, Jan, Al-Farha, Abd A., Greenwald, Noah F., Popoola, Segun I., Rahman, Md Shaifur, Xu, Jialin, Yang, Sunny Y., Hiroi, Noboru, Alper, Ozgul M., Baker, Chris I., Bitzer, Michael, Chacko, George, Debrabant, Birgit, Dixon, Ray, Forano, Evelyne, Gilliham, Matthew, Kelly, Sarah, Klempnauer, Karl-Heinz, Lidbury, Brett A., Lin, Michael Z., Lynch, Iseult, Ma, Wujun, Maibach, Edward W., Mather, Diane E., Nandakumar, Kutty S., Ohgami, Robert S., Parchi, Piero, Tressoldi, Patrizio, Xue, Yu, Armitage, Charles, Barraud, Pierre, Chatzitheochari, Stella, Coelho, Luis P., Diao, Jiajie, Doxey, Andrew C., Hu, Pingzhao, Kaiser, Stefan, Mitchell, Kate M., Salama, Mohamed F., Shabalin, Ivan G., Song, Haijun, Stevanovic, Dejan, Yadollahpour, Ali, Zeng, Erliang, Zinke, Katharina, Alimba, C. G., Beyene, Tariku J., Cao, Zehong, Chan, Sherwin S., Gatchell, Michael, Kleppe, Andreas, Piotrowski, Marcin, Torga, Gonzalo, Woldesemayat, Adugna A., Cosacak, Mehmet I., Haston, Scott, Ross, Stephanie A., Williams, Richard, Wong, Alvin, Abramowitz, Matthew K., Effiong, Andem, Lee, Senhong, Abid, Muhammad Bilal, Agarabi, Cyrus, Alaux, Cedric, Albrecht, Dirk R., Atkins, Gerald J., Beck, Charles R., Bonvin, A. M. J. J., Bourke, Emer, Brand, Thomas, Braun, Ralf J., Bull, James A., Cardoso, Pedro, Carter, Dee, Delahay, Robin M., Ducommun, Bernard, Duijf, Pascal H. G., Epp, Trevor, Eskelinen, Eeva-Liisa, Fallah, Mazyar, Farber, Debora B., Fernandez-Triana, Jose, Feyerabend, Frank, Florio, Tullio, Friebe, Michael, Furuta, Saori, Gabrielsen, Mads, Gruber, Jens, Grybos, Malgorzata, Han, Qian, Heinrich, Michael, Helanterä, Heikki, Huber, Michael, Jeltsch, Albert, Jiang, Fan, Josse, Claire, Jurman, Giuseppe, Kamiya, Haruyuki, Keersmaecker, Kim de, Kristiansson, Erik, Leeuw, Frank-Erik de, Li, Jiuyong, Liang, Shide, Lopez-Escamez, Jose A., Lopez-Ruiz, Francisco J., Marchbank, Kevin J., Marschalek, Rolf, Martín, Carmen S., Miele, Adriana E., Montagutelli, Xavier, Morcillo, Esteban, Nicoletti, Rosario, Niehof, Monika, O’Toole, Ronan, Ohtomo, Toshihiko, Oster, Henrik, Palma, Jose-Alberto, Paterson, Russell, Peifer, Mark, Portilla, Maribel, Portillo, M. C., Pritchard, Antonia L., Pusch, Stefan, Raghava, Gajendra P. S., Roberts, Nicola J., Ross, Kehinde, Schuele, Birgitt, Sergeant, Kjell, Shen, Jun, Stella, Alessandro, Sukocheva, Olga, Uversky, Vladimir N., Vanneste, Sven, Villet, Martin H., Viveiros, Miguel, Vorholt, Julia A., Weinstock, Christof, Yamato, Masayuki, Zabetakis, Ioannis, Zhao, Xin, Ziegler, Andreas, Aizat, Wan M., Atlas, Lauren, Bridges, Kristina M., Chakraborty, Sayan, Deschodt, Mieke, Domingues, Helena S., Esfahlani, Shabnam S., Falk, Sebastian, Guisado, J. L., Kane, Nolan C., Kueberuwa, Gray, Lau, Colleen L., Liang, Dai, Liu, Enwu, Luu, Andreas M., Ma, Chuang, Ma, Lisong, Moyer, Robert, Norris, Adam D., Panthee, Suresh, Parsons, Jerod R., Peng, Yousong, Pinto, Inês Mendes, Reschke, Cristina R., Sillanpää, Elina, Stewart, Christopher J., Uhle, Florian, Yang, Hui, Zhou, Kai, Zhu, Shu, Ashry, Mohamed, Bergsland, Niels, Berthold, Maximilian, Chen, Chang-Er, Colella, Vito, Cuypers, Maarten, Eskew, Evan A., Fan, Xiao, Gajda, Maksymilian, Gonzálezlez-Prendes, Rayner, Goodin, Amie, Graham, Emily B., Groen, Ewout J. 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Univ, Univ Exeter, Hillingdon Hosp NHS Fdn Trust, Natl & Kapodistrian Univ Athens, Lausanne Univ Hosp, Queens Univ Belfast, Cold Spring Harbor Lab, Hosp Clin Porto Alegre, Univ Paris 05, Indian Inst Adv Res, Bambino Ges Childrens Res Hosp, Univ Cadiz, Mansoura Univ Hosp, Ctr Expertise & Biol Diagnost Cameroon, Swiss Fed Labs Mat Sci & Technol, Assiut Univ, Univ Derby, SUNY Stony Brook, Walter & Eliza Hall Inst Med Res, Janelia Res Campus, USDA ARS, Med Univ Graz, Ajou Univ, Univ Dundee, Tech Univ Dresden, Natl Univ Hlth Syst, Univ Canterbury, Univ Hosp Southern Denmark, Baylor Coll Med, Adnan Menderes Univ Aydin, Oasi Res Inst IRCCS, LSHTM, Leibniz Univ Hannover, Xi An Jiao Tong Univ, Shenzhen Univ, Cent South Univ, Univ Bridgeport, Texas Tech Univ, Univ Montana, NHLBI, Cleveland Clin, NARO, Eduardo Mondlane Univ, RAS, Beijing Inst Technol, Univ Hlth Network, Univ Bath, Fisheries & Oceans Canada, Queensland Govt, Uppsala Univ, Childrens Canc Hosp, Leibniz Inst Nat Prod Res & Infect Biol, Duy Tan Univ, Henan Agr Univ, Beijing Inst Microbiol & Epidemiol, Minist Hlth, Prince Sattam Bin Abdulaziz Univ, Univ Auckland, Osped Niguarda Ca Granda, Univ Vet Med, Univ Saskatchewan, Univ Coimbra, South Cent High Specialty Hosp, Wageningen Bioveterinary Res, Guangdong Second Prov Gen Hosp, Hiroshima Univ, Univ Iceland, Kathmandu Univ, Fraunhofer MEVIS, Univ Tehran Med Sci, Univ Messina, AO Papardo Hosp Messina, Univ Stirling, Saveh Univ Med Sci, Gakujutsu Shien Co Ltd, Univ Plymouth, CHU Toulouse, Azorean Biodivers Grp, Univ Acores, Univ Malawi, Bioself Commun, Ahmadu Bello Univ, Dalhousie Univ, VisMederi Srl, Amer Univ Beirut, Mechnikov Res Inst Vaccines & Sera, Vreden Russian Res Inst Traumatol & Orthopaed, Hangzhou Ctr Dis Control & Prevent, Kaohsiung Med Univ, Zoetis, Aintree Univ Hosp NHS Fdn Trust, Wrightington Hosp, Loyola Univ, Atkins Vet Serv, Kangwon Natl Univ, Kakatiya Med Coll, Univ Antioquia, IISER, Univ Rosario, Univ Hosp Basel, Univ Hosp Munster, Univ Kentucky, Univ Calif Irvine, Univ Hosp Leuven, Chongqing Med Univ, Childrens Hosp Kings Daughters, China Three Gorges Univ, and Xiangtan Univ

Subjects
Technology and Engineering, SCIENTIFIC SEARCH, Expert-curated database, Biokemia, solu- ja molekyylibiologia - Biochemistry, cell and molecular biology, Databases, RElevant LIterature SearcH consortium, Medicine and Health Sciences, Biomedical research, benchmarking, Biology, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Settore MED/42 - IGIENE GENERALE E APPLICATA, database, Computer. Automation, Science & Technology, 0804 Data Format, relisch, Scientific research in health sciences, Mathematics and Statistics, litearture search, relisch , database, biomedical research, Biomedical literature, Original Article, RELISH, Mathematical & Computational Biology, RECOMMENDER-SYSTEMS, Life Sciences & Biomedicine, Mathematics, 0807 Library and Information Studies
Abstract

Made available in DSpace on 2020-12-11T01:57:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-10-29 Griffith University Gowonda HPC Cluster Queensland Cyber Infrastructure Foundation Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research. 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Spain Council Agr Res & Econ, Res Ctr Olive Citrus & Tree Fruit, Caserta, Italy Fraunhofer Inst Toxicol & Expt Med ITEM, Preclin Pharmacol & Vitro Toxicol, Hannover, Germany Univ Tasmania, Sch Med, Hobart, Tas, Australia Chugai Pharmaceut Co Ltd, Oncol Lifecycle Management Dept, Tokyo, Japan Univ Lubeck, Inst Neurobiol, Lubeck, Germany NYU, Sch Med, Neurol, New York, NY USA Univ Putra Malaysia, Dept Plant Pathol, Seri Kembangan, Malaysia Univ N Carolina, Biol, Chapel Hill, NC 27515 USA Univ Southampton, Fac Hlth Sci, Southampton, Hants, England Univ Highlands & Islands, Genet & Immunol Res Grp, Inverness, Scotland Heidelberg Univ, Inst Pathol, Heidelberg, Germany Indraprastha Inst Informat Technol, Dept Computat Biol, New Delhi, India Glasgow Caledonian Univ, Sch Hlth & Life Sci, Glasgow, Lanark, Scotland Liverpool John Moores Univ, Pharm & Biomol Sci, Liverpool, Merseyside, England Parkinsons Inst & Clin Ctr, Basic Res, Sunnyvale, CA USA Luxembourg Inst Sci & Technol, Environm Res & Innovat, Luxembourg, Luxembourg Univ Wollongong, Sch Comp & Informat Technol, Wollongong, NSW, Australia Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, Bari, Italy Flinders Univ S Australia, Coll Nursing & Hlth Sci, Adelaide, SA, Australia Univ S Florida, Mol Med, Tampa, FL USA Univ Texas Dallas, Behav & Brain Sci, Richardson, TX 75083 USA Rhodes Univ, Zool & Entomol, Grahamstown, South Africa Univ Nova Lisboa, Inst Higiene & Med Trop, Lisbon, Portugal Swiss Fed Inst Technol, Inst Microbiol, Zurich, Switzerland Inst Ulm, German Red Cross Blood Serv, Immunohaematol, Ulm, Germany Tokyo Womens Med Univ, Inst Adv Biomed Engn & Sci, Tokyo, Japan Univ Limerick, Biol Sci, Limerick, Ireland McGill Univ, Dept Anim Sci, Montreal, PQ, Canada StatSol, Lubeck, Germany Univ KwaZulu Natal, Sch Math Stat & Comp Sci, Pietermaritzburg, South Africa Univ Kebangsaan Malaysia, Inst Syst Biol INBIOSIS, Bangi, Malaysia NIH, Natl Ctr Complementary & Integrat Hlth, Bldg 10, Bethesda, MD 20892 USA Univ Kansas, Med Ctr, Family Med Res Div, Kansas City, KS 66103 USA ASTAR, Inst Mol & Cell Biol, Multimodal Mol Biol, Singapore, Singapore Univ Leuven, Dept Chron Dis Metab & Ageing, Leuven, Belgium Int Iberian Nanotechnol Lab INL, Braga, Portugal Anglia Ruskin, Comp & Technol, Cambridge, England Max Planck Inst Biochem, Struct Cell Biol, Planegg, Germany Univ Seville, Dept Comp Architecture & Technol, Seville, Spain Univ Colorado, EBIO, Boulder, CO 80309 USA Univ Manchester, Canc Sci, Manchester, Lancs, England Australian Natl Univ, Res Sch Populat Hlth, Canberra, ACT, Australia Singapore MIT Alliance Res & Technol, Biosyst, Singapore, Singapore Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Musculoskeletal Hlth & Ageing Res Program, Melbourne, Vic, Australia Ruhr Univ Bochum, Gen Surg, St Josef Hosp, Bochum, Germany Northwest A&F Univ, Coll Life Sci, Xianyang, Shaanxi, Peoples R China Australian Natl Univ, Res Sch Biol, Div Plant Sci, Canberra, ACT, Australia Battelle Mem Inst, Clin & Nonclin Res, Columbus, OH USA Southern Methodist Univ, Biol Sci, Dallas, TX 75275 USA Teikyo Univ, Inst Med Mycol, Tokyo, Japan Tempus Labs, Bioinformat, Chicago, IL USA Hunan Univ, Coll Biol, Changsha, Hunan, Peoples R China Inst Cochin, Dept Infect Immun & Inflammat, Paris, France Royal Coll Surgeons Ireland, FutureNeuro Res Ctr Physiol & Med Phys, Dublin, Ireland Univ Jyvaskyla, Gerontol Res Ctr, Jyvaskyla, Finland Heidelberg Univ, Dept Anesthesiol, Heidelberg, Germany Penn State Univ, Biol, University Pk, PA 16802 USA Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing, Peoples R China Univ Sci & Technol China, Sch Life Sci, Hefei, Anhui, Peoples R China Michigan State Univ, Anim Sci, E Lansing, MI 48824 USA SUNY Buffalo, Jacobs Sch Med & Biomed Sci, Dept Neurol, Buffalo Neuroimaging Anal Ctr, New York, NY USA Univ Rostock, Inst Biol Sci, Rostock, Germany South China Normal Univ, Sch Environm, Environm Res Inst, Guangzhou, Guangdong, Peoples R China Univ Bari, Dept Vet Med, Bari, Italy Radboud Univ Nijmegen, Med Ctr, Primary & Community Care, Nijmegen, Netherlands EcoHlth Alliance, New York, NY USA Mayo Clin, Cardiovasc Dept, Rochester, MN USA Med Univ Silesia, Sch Med Katowice, Dept Epidemiol, Katowice, Poland Univ Lleida, Anim Sci, Lleida, Spain Univ Florida, Coll Pharm, Pharmaceut Outcomes & Policy, Gainesville, FL USA Pacific Northwest Natl Lab, Earth & Biol Sci Directorate, Richland, WA 99352 USA Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Midlothian, Scotland Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA Univ Penn, Radiol, Philadelphia, PA 19104 USA Humanitas Univ & Res Hosp, Asthma & Allergy Unit, Biomed Sci Personalized Med, Rozzano, Italy Australian Natl Univ, Dept Quantum Sci, Canberra, ACT, Australia Carl von Ossietzky Univ Oldenburg, Ecol Genom, Oldenburg, Germany Int Med Univ, Paediat Dent & Orthodont, Kuala Lumpur, Malaysia Univ Ottawa, Sch Nursing, Ottawa, ON, Canada Maastricht Univ, Dept Educ Support, Maastricht, Netherlands Univ Manchester, Math, Manchester, Lancs, England Kings Coll London, Fac Life Sci & Med, Sch Populat Hlth Sci, London, England Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia Harbin Med Univ, Publ Hlth Sch, Epidemiol, Harbin, Heilongjiang, Peoples R China UiT Arctic Univ Norway, Dept Chem, Tromso, Norway Cornell Univ, Biol Stat & Computat Biol, Ithaca, NY USA East China Normal Univ, Sch Ecol & Environm Sci, Shanghai Key Lab Urban Ecol Proc & Ecorestorat, Shanghai, Peoples R China Johannes Gutenberg Univ Mainz, Fac Biol, Mainz, Germany Univ Massachusetts, Food Sci, Amherst, MA 01003 USA Max Planck Inst Terr Microbiol, Complex Adapt Traits Res Grp, Marburg, Germany NIHR Biomed Res Ctr Resp, Ctr Exercise & Rehabil Sci, Leicester, Leics, England Yale Univ, Dept Internal Med, Sect Endocrinol, New Haven, CT USA Sardar Patel Univ, Dept Biosci, Anand, Gujarat, India Univ Tokyo, Dept Appl Phys, Tokyo, Japan Univ Cologne, Vivo Res Facil ivRF, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany Natl Open Univ Nigeria, Dept Publ Hlth Sci, Lagos, Nigeria Univ Hosp Regensburg, Dept Radiol, Regensburg, Germany Natl Univ Singapore, Geog, Singapore, Singapore Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia Abdelmalek Essaadi Univ, Fac Sci & Techn Tangier, Biomed Genom & Oncogenet Res Lab, Tetouan, Morocco Tech Univ Munich, Fac Sport & Hlth Sci, Exercise Biol Grp, Munich, Germany Univ Santiago de Compostela, Dept Psicoloxia Social Basica & Metodoloxia, Galiza, Spain Griffith Univ, Signal Proc Lab, Brisbane, Qld, Australia Univ Ghent, Dept Neurol, Ghent, Belgium Ghent Univ Hosp, Ghent, Belgium Univ Ghent, Fac Vet Med, Merelbeke, Belgium Albert Einstein Coll Med, Inst Clin & Translat Res, New York, NY USA Anglia Ruskin Univ, Fac Med Sci, Cambridge, England Peking Univ, Coll Chem & Mol Engn, Beijing, Peoples R China Herlev & Gentofte Hosp, Dept Dermatol & Allergy, Hellerup, Denmark Lady Cilento Childrens Hosp, Med Imaging & Nucl Med, Brisbane, Qld, Australia Univ Gambia, Sch Med & Allied Hlth Sci, Nursing & Reprod Hlth, Brikama, Gambia Univ Sydney, Woolcock Inst Med Res, Sydney, NSW, Australia Wayne State Univ, Comp Sci, Detroit, MI USA Aberdeen Royal Infirm, Otolaryngol, Aberdeen, Scotland Univ Toronto, Lab Med & Pathobiol, Toronto, ON, Canada Chinese Univ Hong Kong, Inst Ageing, Hong Kong, Peoples R China Univ Nebraska Med Ctr, Emergency Med, Omaha, NE USA Univ Florida, Coll Med, Pathol, Gainesville, FL USA Univ Texas MD Anderson Canc Ctr, Radiat Oncol, Houston, TX 77030 USA Univ Pisa, Translat Res NTMS, Pisa, Italy Magna Grecia Univ, Clin & Expt Med, Catanzaro, Italy Univ Vermont, Larner Coll Med, Pediat, Burlington, VT USA Sun Yat Sen Univ, Canc Ctr, Diagnost & Intervent Ultrasound, Guangzhou, Guangdong, Peoples R China Fudan Univ, Inst Brain Sci, Shanghai, Peoples R China Shanxi Agr Univ, Coll Agron, Jinzhong, Shanxi, Peoples R China Univ Toronto, Inst Med Sci, Toronto, ON, Canada Univ Adelaide, ARCPOH, Adelaide, SA, Australia Pelita Harapan Univ, Fac Med, Cardiol & Vasc Med, Tangerang, Indonesia Inst Mental Hlth, Res Div, Singapore, Singapore UCL, MRC Clin Trials Unit, London, England Univ Padua, Dept Philosophy Sociol Educ & Appl Psychol FISPPA, Padua, Italy Univ Lubeck, Dept Psychiat & Psychotherapy, Lubeck, Germany Dalian Univ Technol, Ctr Mol Med, Dalian, Liaoning, Peoples R China Tianjin United Family Healthcare, Reprod Med, Tianjin, Peoples R China Univ Autonoma Barcelona, Dept Engn Quim Biol & Ambiental, Barcelona, Spain Sao Paulo State Univ UNESP, Dept Anim Sci, Sao Paulo, Brazil Helmholtz Zentrum Munchen, Inst Computat Biol, Canc Syst Biol, Ingolstadter Land Str 1, D-85764 Munich, Germany Univ Tokyo, Dept Cardiovasc Med, Tokyo, Japan Sao Paulo State Univ, Vet Clin, Sao Paulo, Brazil Zhejiang Univ, Inst Biotechnol, Hangzhou, Zhejiang, Peoples R China Aarhus Univ, Dept Mol Biol & Genet, Aarhus, Denmark Univ Manchester, St Marys Hosp, Maternal & Fetal Hlth, Manchester, Lancs, England Univ New Mexico, Internal Med, Albuquerque, NM 87131 USA Mayo Clin, Div Biomed Stat & Informat, Jacksonville, FL 32224 USA King Saud Univ, Plant Prod, Riyadh, Saudi Arabia Polish Acad Sci, Inst Genet & Anim Breeding, Dept Mol Biol, Warsaw, Poland Queensland Univ Technol, Optometry & Vis Sci, Brisbane, Qld, Australia Univ Nottingham, Sch Life Sci, Nottingham, England Canc Council Queensland, Canc Res Ctr, Brisbane, Qld, Australia Umea Univ, Dept Chem, Umea, Sweden Publ Hlth England, Ctr Radiat Chem & Environm Hazards, Bristol, Avon, England Univ Campania L Vanvitelli, DISTABIF, Caserta, Italy Bartshealth, Obstet & Gyanecol, London, England Univ Clermont Auvergne, GReD Lab, Clermont Ferrand, France INRA Abeilles & Environm, Avignon, France Queensland Univ Technol, Sch Publ Hlth & Social Work, Brisbane, Qld, Australia Univ Penn, Psychiat, Philadelphia, PA 19104 USA Novosibirsk State Univ, Res Inst Physiol & Basic Med, Novosibirsk, Russia UCL, Dept Chem, London, England La Trobe Univ, Anim Plant & Soil Sci, Melbourne, Vic, Australia Univ Arizona, Epidemiol & Biostat, Tucson, AZ USA Univ Groningen, Univ Med Ctr Groningen, ERIBA, Groningen, Netherlands Univ Gothenburg, Inst Clin Sci, Dept Radiat Phys, Gothenburg, Sweden SUNY Upstate Med Univ, Biochem & Mol Biol, Syracuse, NY 13210 USA Fundacao Oswaldo Cruz, Ctr Pesquisas Goncalo Moniz, Salvador, Bahia, Brazil Inst Environm Sci & Res ESR, Food Water & Environm Microbiol, Christchurch, New Zealand Univ Otago, Food Sci, Dunedin, New Zealand Florida Atlantic Univ, Biomed Sci, Boca Raton, FL 33431 USA Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia Univ Hosp Wurzburg, Inst Clin Neurobiol, Wurzburg, Germany Inst Trop Med, Publ Hlth, Antwerp, Belgium Univ Thessaly, Sch Hlth Sci, Fac Med, Dept Rheumatol & Clin Immunol, Larisa, Greece Univ Basel, UZB Univ Ctr Dent Med, Dept Orthodont & Pediat Dent, Basel, Switzerland Sorbonne Univ, Museum Natl Hist Nat, Inst Systemat Evolut Biodiversite ISYEB, MNHN,CNRS,UMR 7205,EPHE, Paris, France CNRS, Inst Adv Biosci, Paris, France Univ Western Australia, Sch Mol Sci, Perth, WA, Australia Univ Ft Hare, Biochem & Microbiol, Alice, South Africa Univ Tubingen, Phys, Tubingen, Germany Griffith Univ, Sch Environm & Sci, Brisbane, Qld, Australia Philosoph Theol Hsch Vallendar, Stat & Standardised Methods, Vallendar, Germany Imperial Coll London, Life Sci, London, England Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE USA Technol Univ Dublin, FOCAS Res Inst, Dublin, Ireland INSERM, Natl Inst Hlth & Med Res, Canc Res Ctr Toulouse, Paris, France Univ Santiago de Compostela, Dept Bioloxia Func, Grp BRAINSHARK, Galiza, Spain Univ Nebraska, Biol, Kearney, NE USA Univ Autonoma Barcelona, Dept Genet & Microbiol, Barcelona, Spain Univ Pisa, Chem & Ind Chem, Pisa, Italy Univ Manchester, Wellcome Trust Ctr Cell Matrix Res, Manchester, Lancs, England Univ Montpellier, CNRS, Inst Human Genet, Montpellier, France Czech Acad Sci, Inst Organ Chem & Biochem, Prague, Czech Republic CSIC, Natl Ctr Biotechnol CNB, Computat Syst Biol Grp, Madrid, Spain Natl Cheng Kung Univ, Dept Biochem & Mol Biol, Tainan, Taiwan Harvard Med Sch, Schepens Eye Res Inst, Ophthalmol, Boston, MA 02115 USA Lanzhou Univ, Hosp 2, Dept Gen Surg, Lanzhou, Gansu, Peoples R China Univ Technol Sydney, Sch Life Sci, Sydney, NSW, Australia JT Chen Clin, Gynecol, Tokyo, Japan Univ Western Australia, Sch Agr & Environm, Perth, WA, Australia Beijing Normal Univ, Fac Geog Sci, Beijing, Peoples R China Univ Missouri, Elect Engn & Comp Sci, Columbia, MO USA Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth, Amsterdam, Netherlands Semmelweis Univ, Med Biochem, Budapest, Hungary Queen Elizabeth Hosp, Dept Clin Oncol, Hong Kong, Peoples R China Univ Pittsburgh, Chem, Pittsburgh, PA USA GB Pant Inst Post Grad Med Educ & Res, Neurol, New Delhi, India Univ Copenhagen, Vet & Anim Sci, Copenhagen, Denmark Univ Palermo, Biomed Dept Internal & Specialist Med DIBIMIS, Sect Endocrinol, Palermo, Italy UCL, NPP, London, England Univ Florida, Microbiol & Cell Sci, Gainesville, FL USA Univ Salford, Sch Hlth Sci, Manchester, Lancs, England Cardiff Univ, Inst Med Genet, Cardiff, S Glam, Wales INSERM, ICO Canc Ctr, Angers, France Univ Colombo, Fac Med, Microbiol, Colombo, Sri Lanka Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China Univ Porto, Fac Pharm, Porto, Portugal Univ Nottingham, Div Primary Care, Nottingham, England Univ Illinois, Pharm Syst Outcomes & Policy, Chicago, IL USA Pontificia Univ Catolica Goias, Escola Ciencias Agr & Biol, Goiania, Go, Brazil China Japan Friendship Hosp, Dept Oncol, Beijing, Peoples R China Boston Univ, Chem, Boston, MA 02215 USA Amer Univ, Environm Sci, Washington, DC 20016 USA Carleton Univ, Neurosci, Ottawa, ON, Canada Univ Regina, Chem & Biochem, Regina, SK, Canada Univ Montreal, 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Univ Georgia, Epidemiol, Athens, GA 30602 USA Univ Freiburg, Med Ctr, Dept Plast & Hand Surg, Freiburg, Germany Sidra Med, Res, Doha, Qatar Rostock Univ, Med Ctr, Dept Oral Maxillofacial & Plast Surg, Rostock, Germany Harvard Med Sch, Brigham & Womens Hosp, Emergency Med, Boston, MA 02115 USA AgResearch, Forage Sci, Palmerston North, New Zealand Univ Calif Los Angeles, Med, Los Angeles, CA USA Arizona State Univ, Biodesign Inst, Virginia G Piper Ctr Personalized Diagnost, Tempe, AZ USA Sheffield Hallam Univ, Res Inst, Mat & Engn, Sheffield, S Yorkshire, England Aneurin Bevan Univ Healthboard, Resp Med, Newport, Shrops, England Univ Calif San Francisco, Neurol Surg, San Francisco, CA 94143 USA Univ Western Australia, UWA Dent Sch, Perth, WA, Australia Fordham Univ, Biol Sci, Bronx, NY 10458 USA Univ Helsinki, Inst Biotechnol, Helsinki, Finland Fujian Normal Univ, Coll Life Sci, Fuzhou, Fujian, Peoples R China Univ Fukui, Dept Frontier Fiber Technol & Sci, Fukui, Japan Univ Southampton, Fac Med, Clin & Expt Sci, Southampton, Hants, England Univ Urbino, Dept Biomol Sci, Urbino, Italy Osped San Luigi, Allergol Unit, Turin, Italy Muljibhai Patel Urol Hosp, Dept Urol, Nadiad, Gujarat, India Univ Granada, Stratig & Paleontol, Granada, Spain Massey Univ, Sch Vet Sci, Auckland, New Zealand CNR, High Performance Comp & Networking Inst, Naples, Italy Univ Childrens Hosp Zurich, Div Metab, Zurich, Switzerland Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland Univ Melbourne, Biochem & Mol Biol, Parkville, Vic, Australia Inst Pasteur, Leptospirosis Res & Expertise Unit, Noumea, New Caledonia Tsinghua Univ, Sch Life Sci, Beijing, Peoples R China Cheikh Anta Diop Univ UCAD, Sci Fac, Biol Anim Dept, Dakar, Senegal Providence Portland Med Ctr, Earle A Chiles Res Inst, Portland, OR USA Agr & Agri Food Canada, Lacombe Res & Dev Ctr, Lacombe, AB, Canada Alberta Innovates, Performance Management & Evaluat, Edmonton, AB, Canada Univ Malaga, CSIC, Inst Hortofruticultura Subtrop Mediterranea La Ma, IHSM,UMA, Malaga, Spain James Cook Univ, Coll Publ Hlth Med & Vet Sci, Cairns, Qld, Australia European Commiss, Joint Res Ctr, Ispra, Italy Univ Montpellier, Montpellier, France CSIRO, Floreat, WA, Australia Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Guangdong, Peoples R China Vanderbilt Univ, Pharmacol, 221 Kirkland Hall, Nashville, TN 37235 USA RIKEN, KFU RIKEN Translat Genom Unit, Yokohama, Kanagawa, Japan Univ Tubingen, Neurobiol Vocal Commun, Tubingen, Germany Univ Colorado, UCCS Ctr Biofrontiers Inst, Colorado Springs, CO 80907 USA Fred Hutchinson Canc Ctr, Div Basic Sci, Seattle, WA USA Univ Geneva, Fac Med, Primary Care Unit, Geneva, Switzerland Ernst Moritz Arndt Univ Greifswald, Dept Mol Genet & Infect Biol, Greifswald, Germany East China Univ Sci & Technol, Dept Fine Chem, Shanghai, Peoples R China Ohio State Univ, Surg, Columbus, OH 43210 USA Oragenics, R&D, Tampa, FL USA Natl Environm Agcy, Environm Hlth Inst, Singapore, Singapore Friedrich Loeffler Inst, Inst Diagnost Virol, Greifswald, Germany Queen Elizabeth Hosp, Oncol, Woodville, SA, Australia USDA, Emerging Pests & Pathogens Res Unit, Ithaca, NY USA Univ Freiburg, Med Ctr, Dept Neurosurg, Epilepsy Ctr, Freiburg, Germany Univ Hong Kong, Fac Educ, Informat & Technol Studies, Hong Kong, Peoples R China Univ Tokyo, Grad Sch Agr & life Sci, Agr & Environm Biol, Tokyo, Japan Univ Pittsburgh, Dept Med, Pittsburgh Heart Lung & Blood Vasc Med Inst, Pittsburgh, PA USA Guys & St Thomas NHS Fdn Trust, Directorate Transplant Renal & Urol, London, England Univ Sarajevo, Clin Ctr, Clin Heart Blood Vessel & Rheumat Dis, Sarajevo, Bosnia & Herceg Univ Kent, Sch Math Stat & Actuarial Sci, Canterbury, Kent, England Tokyo Inst Technol, Dept Life Sci & Technol, Tokyo, Japan Univ Appl Sci Munich, Laser Ctr Dept Appl Sci & Mechatron, Munich, Germany CIC NanoGUNE, Nanodevices, San Sebastian, Spain Vrije Univ Amsterdam Med Ctr, Gynaecol, Amsterdam, Netherlands Cardiff Univ, Med Sch, Div Populat Med, Cardiff, S Glam, Wales Karolinska Inst, Dept Med, Solna, Sweden Natl Inst Genet, Ctr Informat Biol, Mishima, Shizuoka, Japan Murdoch Univ, Harry Perkins Inst Med Res, Perth, WA, Australia Univ Limerick, Phys Educ & Sport Sci, Limerick, Ireland Ruhr Univ Bochum, Campus Clin Gynecol, Univ Str, Bochum, Germany Southwest Med Univ, Sch Publ Hlth, Epidemiol & Biostat, Luzhou, Sichuan, Peoples R China Beijing Canc Hosp, Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Ctr Mol Diagnost, Beijing, Peoples R China Chinese Acad Sci, Chengdu Inst Biol, Herpetol Dept, Chengdu, Sichuan, Peoples R China Key Lab Nano Biol Effects & Safety, Beijing, Peoples R China NIBR, PK Sci, Basel, Switzerland Daejeon St Marys Hosp, Pain Ctr, Daejeon, South Korea Univ Western Ontario, Sch Hlth Studies, London, ON, Canada Univ Aberdeen, Hlth Psychol Grp, Aberdeen, Scotland Univ Colorado, Anesthesiol, Anschutz Med Campus, Boulder, CO 80309 USA Univ Antwerp, UZA Antwerp Univ Hosp, Crit Care Med, Edegem, Belgium Aarhus Univ Hosp, Endocrinol, Aarhus, Denmark Univ Pretoria, Ctr Transport Dev, Ind & Syst Engn, Pretoria, South Africa Duke Univ, Dept Biostat & Bioinformat, Durham, NC USA Pontificia Univ Catolica Goias, Med Pharmaceut & Biomed Sci Sch, Goiania, Go, Brazil Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden UCL, Clin Educ & Hlth Psychol, London, England KRIBB, Dev & Differentiat Res Ctr, Daejeon, South Korea Univ dArtois, Lab Barriere Hematoencephal, Arras, France AstraZeneca, IMED Biotech Unit, Discovery Sci, Quantitat Biol, Cambridge, England Pacific Northwest Natl Lab, Environm Mol Sci Lab, Richland, WA 99352 USA Coventry Univ, Appl Maths Res Ctr, Stat Phys Grp, Coventry, W Midlands, England Wilton Ctr, Invista Performance Technol, Cleveland, England Thunen Inst Forest Genet, Genome Res, Grosshansdorf, Germany Lebanese Amer Univ, Nat Sci, Byblos, Lebanon Takeda, Evidence & Value Generat, Osaka, Japan King Abdullah Int Med 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Univ Calif Los Angeles, Sch Dent, Sect Periodont, Los Angeles, CA 90024 USA Aalborg Univ Hosp, Dept Clin Biochem, Aalborg, Denmark Manipal Acad Higher Educ, Pharm Practice, Manipal, Karnataka, India Univ Tokyo, Inst Med Sci, Dept Radiol, Tokyo, Japan Cukurova Univ, Family Med, Fac Med, Adana, Turkey Catholic Univ Korea, Coll Med, Dept Humanities & Social Med, Seoul, South Korea Univ Ghent, Food Technol Safety & Hlth, Ghent, Belgium UNSW Sydney, Sch Biol Earth & Environm Sci BEES, Sydney, NSW, Australia St Vincent Shoulder & Sports Clin, Res Unit, Vienna, Austria Cornell Univ, Biomed Engn, Ithaca, NY USA Leibniz Inst Plant Genet & Crop Plant Res IPK, Res Grp Bioinformat & Informat Technol, Gatersleben, Germany Univ Europea Madrid, Sch Doctoral Studies, Madrid, Spain CSIRO Mfg, Biomed Mfg, Melbourne, Vic, Australia Depaul Univ, Biol Sci, Chicago, IL 60604 USA Konkuk Univ, Dept Anim Sci & Technol, Seoul, South Korea Chang Gung Univ, Grad Inst Med Mechatron, Taoyuan, Taiwan Korea Univ, 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Germany Cardiff Univ, Sch Psychol, Cardiff, S Glam, Wales Imperial Coll London, Chem Engn, London, England Lund Univ, Skane Univ Hosp, Clin Sci, Malmo, Sweden Sahlgrens Acad, Inst Clin Sci, Dept Mol & Clin Med, Gothenburg, Sweden Univ Cent Lancashire, Sch Pharm & Biomed Sci, Preston, Lancs, England Hosp Univ Doctor Peset, Psychiat & Clin Psychol, Valencia, Spain Ctr Biol Mol Severo Ochoa, Genome Dynam & Funct, Madrid, Spain Unvivers Hosp Lille, Dept Intens Care, Lille, France Kansai Med Univ, Surg, Osaka, Japan Univ Toulouse, Inst Natl Polytech Toulouse, Ecole Natl Super Agron Toulouse, Lab Genom & Biotechnol Fruit, Toulouse, France UiT Arctic Univ Norway, Inst Psychol, Tromsto, Norway Queens Univ, Ctr Publ Hlth, Belfast, Antrim, North Ireland Univ Manchester, Ctr Primary Care & Hlth Serv Res, Manchester, Lancs, England Griffith Univ, Menzies Hlth Inst, Gold Coast, Qld, Australia Anglia Ruskin Univ, FHSCE, Cambridge, England Univ Lleida, Dept Expt Med, Lleida, Spain NIEHS, Biomol Screening Branch, Div Natl Toxicol Program, POB 12233, Res Triangle Pk, NC 27709 USA Albany Med Coll, Immunol & Microbial Dis, Albany, NY 12208 USA Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia Univ Kent, Sch Biosci, Canterbury, Kent, England Univ Bourgogne Franche Comte, INSERM, LNC, UMR 1231, Besancon, France Ritsumeikan Univ, Coll Life Sci, Dept Biotechnol, Shiga, Japan Kent State Univ, Biol Sci, Kent, OH 44242 USA Natl Inst Infect Dis, Dept Safety Res Blood & Biol Prod, Tokyo, Japan European Inst Marine Studies, Lab Microbiol Extreme Environm, Plouzane, France Univ Iowa, Dept Pharmacol, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA Natl Univ Singapore, Biol Sci, Singapore, Singapore Conservatoire Natl Arts & Metiers, Lab GBA, EA4627, Paris, France Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA Lomonosov Moscow State Univ, Belozersky Inst Physicochem Biol, Moscow, Russia Jikei Univ, Sch Med, Dept Mol Biol, Tokyo, Japan Univ South Wales, Genom & Computat Biol, Treforest, Wales Duke Univ, Med Ctr, Obstet & Gynecol, Durham, NC USA Univ Technol Sydney, Climate Change Cluster, Sydney, NSW, Australia Nagoya Univ, Grad Sch Med, Dept Radiol, Nagoya, Aichi, Japan Western Sydney Univ, Sch Sci & Hlth, Sydney, NSW, Australia TEI Epirus, Dept Speech & Language Therapy, Ioannina, Greece Indiana Univ Purdue Univ, Orthopaed Surg, Indianapolis, IN 46202 USA Oniris, Vet Pathol, Nantes, France Royal Vet Coll, Pathobiol & Populat Sci, Hatfield, Herts, England Univ Ghent, Lab Pharmaceut Biotechnol, Ghent, Belgium Norwegian Inst Nat Res, Terr Ecol, Trondheim, Norway Univ Calif Merced, Mol & Cell Biol, Merced, CA USA Univ Dublin, Trinity Coll Dublin, Sch Engn, Ctr Transport Res, Dublin, Ireland Lund Univ, Inst Clin Sci, Nephrol, Malmo, Sweden Univ Birmingham, Mech Engn, Birmingham, W Midlands, England Lund Univ, Inst Clin Sci, OB GYN, Lund, Sweden Fdn Jimenez Diaz Hosp, Nephrol & Hypertens, Madrid, Spain Queensland Univ Technol, Sch Chem Phys & Mech Engn, Brisbane, Qld, Australia Otto von Guericke Univ, Psychol, Magdeburg, Germany Univ Med Ctr Gottingen, Dept Expt Neurodegenerat, Gottingen, Germany Harvard Med Sch, Spaulding Rehabil Hosp, Phys Med & Rehabil, Boston, MA 02115 USA Quadram Inst Biosci, Sci Operat, Norwich, Norfolk, England Ostbayer Tech Hsch Regensburg OTH Regensburg, Regensburg Med Image Comp ReMIC, Regensburg, Germany Deakin Univ, Fac Arts & Educ, Melbourne, Vic, Australia Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England INSERM, Natl Inst Hlth & Med Res, Biochem & Mol Biol, Paris, France Univ Liege, Tax Inst, Liege, Belgium Univ Leeds, Sch Mol & Cellular Biol, Leeds, W Yorkshire, England IRCCS Ist Giannina Gaslini, UOC Genet Med, Genoa, Italy Res Diets Inc, Sci, New Brunswick, NJ USA Univ Perugia, Dept Phys & Geol, Perugia, Italy Walter Reed Natl Mil Med Ctr, Cellular Immunol, Bethesda, MD USA Univ Fed Santa Catarina, Biol Sci Ctr, Microbiol Immunol & Parasitol Dept, Florianopolis, SC, Brazil Univ Edinburgh, Royal Infirm, Ctr Liver & Digest Disorders, Edinburgh, Midlothian, Scotland Orion Pharma, Crit Care Proprietary Prod Div, Espoo, Finland MIT, Dept Civil & Environm Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA Univ Turin, Dept Vet Sci, Turin, Italy Univ G dAnnunzio, Dept Psychol Hlth & Territorial Sci, Chieti, Italy NYU, Sch Med, OB GYN, New York, NY USA Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland Univ Turku, Dept Biol, Turku, Finland Tech Univ Berlin, Bioanalyt, Berlin, Germany Univ Goettingen, Inst Phys Biophys 3, Gottingen, Germany Univ Texas MD Anderson Canc Ctr, Inst Appl Canc Sci, Translat Res Adv Therapeut & Innovat Oncol TRACTI, Houston, TX 77030 USA Univ Liege, Life Sci, Liege, Belgium Tarbiat Modares Univ, Fac Med Sci, Dept Toxicol, Tehran, Iran ARS, USDA, Stoneville, MS USA Univ Regensburg, RCI Regensburg Ctr Intervent Immunol, Regensburg, Germany Univ Nottingham, Sch Psychol, Nottingham, England NIH, Pathol Lab, Bethesda, MD 20892 USA Univ Carlos III Madrid, Elect Engn, Madrid, Spain Inst Med Mol, Chem Biol, Lisbon, Portugal Univ Costa Rica, CIET, San Jose, Costa Rica Univ Stavanger, Fac Hlth Sci, Stavanger, Norway Erasmus MC, Urol, Rotterdam, Netherlands Univ Edinburgh, Sch Biol Sci, Edinburgh, Midlothian, Scotland German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Bioinformat & Syst Biol IBIS, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany Leiden Univ, Huygens Kamerlingh Onnes Lab, Leiden, Netherlands Univ Vienna, Nutr Sci, Vienna, Austria Kolling Inst Med Res, Med, St Leonards, NSW, Australia Johns Hopkins Sch Med, Biol Chem, Baltimore, MD USA Univ Montreal, Med Nutr & Microbiome Lab, Montreal, PQ, Canada GlaxoSmithKline, Cell & Gene Therapy, Stevenage, Herts, England Univ Trieste, Life Sci, Trieste, Italy Rhein Westfal TH Aachen, Dept Radiol, Aachen, Germany Univ Duisburg Essen, Univ Hosp Essen, West German Canc Ctr, Dept Med Oncol, Essen, Germany Med Univ Vienna, Obstet & 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Pittsburgh, PA USA Univ Lausanne, Ctr Integrat Genom, Lausanne, Switzerland Univ Queensland, Sch Pharm, Brisbane, Qld, Australia Leibniz Inst Plant Genet & Crop Plant Res IPK Gat, Genebank, Gatersleben, Germany Piramal Imaging, Res & Dev, Berlin, Germany Univ Leeds, Civil Engn, Leeds, W Yorkshire, England Univ Missouri, Chem & Biochem, St Louis, MO 63121 USA US Geol Survey, Coastal & Marine Geol Program, Pacific Coastal & Marine Sci Ctr, Santa Cruz, CA USA Ajinomoto Genet Res Inst, Moscow, Russia Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, Dept Plant Biotechnol, Krakow, Poland Univ Puerto Rico, Engn Sci & Mat, Mayaguez, PR USA Univ Regina, Dept Chem & Biochem, Regina, SK, Canada Argonne Natl Lab, Ctr Nanoscale Mat, 9700 S Cass Ave, Argonne, IL 60439 USA Univ Sunshine Coast, Sunshine Coast Mind & Neurosci Thompson Inst, Sippy Downs, Qld, Australia Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol & Hepatol, Beijing, Peoples R China Griffith Univ, Griffith Ctr Social & Cultural Res, Gold Coast, Qld, Australia Tohoku Univ, Inst Dev Aging Canc, Dept Mol Oncol, Sendai, Miyagi, Japan Indiana Univ, Comp Sci, Bloomington, IN USA Fukushima Med Univ, Sch Med, Dept Pulm Med, Fukushima, Japan MEDIVIR AB, Biol, Huddinge, Sweden Western Sydney Univ, Neuroimmunol, Sydney, NSW, Australia Univ Jordan, Nutr & Food Technol, Amman, Jordan Thunen Inst Forest Genet, Fed Res Ctr Rura Areas Forestry & Fisheries, Inst Biodivers, Grosshansdorf, Germany Univ Edinburgh, Inst Cell Biol, Edinburgh, Midlothian, Scotland Univ Edinburgh, Ctr Integrat Physiol, Edinburgh, Midlothian, Scotland Univ Toronto, Struct Genom Consortium, Toronto, ON, Canada Canadian Mem Chiropract Coll, Grad Educ & Res, Toronto, ON, Canada Agilent Technol, R&D, Leuven, Belgium Univ British Columbia, Sch Nursing, Vancouver, BC, Canada Monash Univ, Monash Hlth, Sch Clin Sci, Stroke & Ageing Res,Dept Med, Melbourne, Vic, Australia French Natl Canc Inst, Innovat, Transfer, Biol, Boulogne, France Ludwig Maximilians Univ Munchen, Phys Chem, NanoBioSci, Munich, Germany Bandung Inst Technol, Sch Pharm, Med Chem, Bandung, Indonesia Univ Luxembourg, Life Sci Res Unit, Luxembourg, Luxembourg Lund Univ, Skane Univ Hosp, Dept Gastroenterol, Malmo, Sweden Millennium Hlth, Translat Genet, San Diego, CA USA Aristotle Univ Thessaloniki, Med Dept 2, Clin Res & Evidence Based Med Unit, Thessaloniki, Greece Jan Kochanowski Univ Humanities & Sci, Piotrkow Trybunalski Branch, Dept Psychol, Kielce, Poland McMaster Univ, Engn Phys, Hamilton, ON, Canada Marche Polytech Univ, Dept Agr Food & Environm Sci, Ancona, Italy Kuwait Univ, Fac Med, Microbiol, Kuwait, Kuwait Fujita Hlth Univ, Dept Breast Surg, Toyoake, Aich, Japan North West Reg Spinal Injuries Ctr, Spinal Injuries Ctr, Southport, Merseyside, England Luxembourg Inst Hlth, Competence Ctr Methodol & Stat, Luxembourg, Luxembourg Nestle Inst Hlth Sci SA, Metab Hlth, Ecublens, Vaud, Switzerland Ctr Inflammat Res VIB, Ghent, Belgium Univ Ghent, Dept Biomed Mol Biol, Ghent, Belgium Univ Lisbon, Inst Educ, Curriculo Formacao Prof & Tecnol, Lisbon, Portugal Univ Edinburgh, Ctr Inflammat Res, Edinburgh, Midlothian, Scotland Univ Melbourne, Sch BioSci, Parkville, Vic, Australia Northumbria Univ, Comp & Informat Sci, Newcastle Upon Tyne, Tyne & Wear, England Univ Valencia, Endocrinol, Valencia, Spain INRS, Inst Armand Frappier, Laval, PQ, Canada Univ Laval, INAF, Sch Nutr, Quebec City, PQ, Canada Univ Konstanz, Dept Biol, Constance, Germany Univ Cote dAzur, LAMHESS, Nice, France Scion, Syst Ecol, Christchurch, New Zealand CUNY, Grad Sch Publ Hlth & Hlth Policy, Epidemiol & Biostat, New York, NY 10021 USA Univ Queensland, Sch Dent, Brisbane, Qld, Australia George Inst Global Hlth, Renal & Metab Div, Sydney, NSW, Australia Wuhan Univ, Coll Chem & Mol Sci, Wuhan, Hubei, Peoples R China Griffith Univ, Sch Environm & Sci, Gold Coast, Qld, Australia Univ Minnesota, Radiat Oncol, Minneapolis, MN USA Goethe Univ, Fac Med, Frankfurt, Germany Natl Yunlin Univ Sci & Technol, Dept & Grad Sch Safety & Environm Engn, Touliu, Yunlin, Taiwan Massey Univ, Sch Sport Exercise & Nutr, Auckland, New Zealand Univ Florida, Wildlife Ecol & Conservat, Gainesville, FL USA Bournemouth Univ, Dept Psychol, Poole, Dorset, England Robert Koch Inst, Project Grp P2, Berlin, Germany Univ Edinburgh, MRC Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland Univ Basel, Biozentrum, Basel, Switzerland Univ Wollongong, Sch Med, Wollongong, NSW, Australia Univ Cologne, Inst Human Genet, Cologne, Germany Rural Econ Branch, Econ Res Serv, Washington, DC USA Uivers Bordeaux, CNRS, Inst Neurosci Cognit & Integrat Aquitaine, Bordeaux, France Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA Univ Calif Riverside, Mat Sci & Engn Program, Riverside, CA 92521 USA Mackay Med Coll, Dept Med, New Taipei, Taiwan Univ Bern, Div Anim Welf, Bern, Switzerland Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97201 USA Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Med Sci, Shanghai, Peoples R China McMaster Univ, Biol, Hamilton, ON, Canada Univ S Florida, Dept Cell Biol Microbiol & Mol Biol, Tampa, FL USA Hacettepe Univ, Inst Canc, Med Oncol, Ankara, Turkey City Univ Hong Kong, Dept Elect Engn, Hong Kong, Peoples R China Natl Taiwan Univ, Dept Entomol, Taipei, Taiwan Chinese Acad Agr Sci, Inst Environm & Sustainable Dev Agr, Ecol Secur, Beijing, Peoples R China Florida State Univ, Inst Mol Biophys, Chem & Biochem, Tallahassee, FL USA Peking Univ, Shenzhen Grad Sch, State Key Lab Chem Oncogen, Lab Computat Chem & Drug Design, Shenzhen, Peoples R China Univ Helsinki, Fac Pharm, Div Pharmaceut Chem & Technol, Drug Res Program, Helsinki, Finland Tohoku Univ, Microbial Biotechnol, Sendai, Miyagi, Japan Tianjin Med Univ, Sch Basical Med Sci, Dept Pharmacol, Tianjin, Peoples R China Dana Farber Canc Inst, Biostat & Computat Biol, Boston, MA 02115 USA Natl Hlth Res Inst, Inst Mol & Genom Med, Zhunan, Taiwan Univ Oxford, Physiol Anat & Genet, Oxford, England George Washington Univ, Phys, Washington, DC USA Univ Nebraska, Sch Biol Sci, Lincoln, NE USA Toronto Gen Hosp, Res Inst, Dept Lab Med & Pathobiol, Toronto, ON, Canada Univ Texas Dallas, Biol Sci, Richardson, TX 75083 USA NYU, Dept Chem, New York, NY USA Shandong Univ, Sch Math & Stat, Jinan, Shandong, Peoples R China Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei, Anhui, Peoples R China Purdue Univ, Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA NIBSC, Adv Therapies, Ridge, Herts, England Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Pulm & Crit Care Med, Shanghai, Peoples R China Charite Med Univ Berlin, Dermatol & Allergy, Berlin, Germany Univ Hosp St Etienne, Hematol, St Etienne, France Inland Norway Univ Appl Sci, Inst Biotechnol, Elverum, Norway Univ Jordan, Pediat, Amman, Jordan Inst Pasteur, Mol Mycol Unit, Paris, France Cardiff Univ, Sch Med, Inst Psychol Med & Clin Neurosci, Med Res Council Ctr Neuropsychiat Genet & Genom, Cardiff, S Glam, Wales Zurich Univ Appl Sci, Social Work, Zurich, Switzerland Jawaharlal Nehru Univ, Sch Life Sci, New Delhi, India Univ Burgundy Franche Comte, LE2I, Dijon, France Univ Roehampton, Life Sci, London, England Ghent Univ Hosp, Gen & HPB Surg, Ghent, Belgium Univ Wurzburg, Insect Fungus Symbiosis Lab, Wurzburg, Germany Radboud Univ Nijmegen, Behav Sci Inst, Nijmegen, Netherlands Fraunhofer WKI, Applicat Ctr HOFZET, Hannover, Germany UCL, Struct & Mol Biol, London, England Univ Amsterdam, Dev Psychol, Amsterdam, Netherlands Aalborg Univ, Hlth Sci & Technol, CNAP, SMI, Aalborg, Denmark VA Pittsburgh Healthcare Syst, Ctr Hlth Equity Res & Promot, Pittsburgh, PA USA Cedars Sinai Med Ctr, Neurosurg, Los Angeles, CA 90048 USA Sun Yat Sen Univ, Sch Data & Comp Sci, Guangzhou, Guangdong, Peoples R China Dezhou Univ, Shandong Prov Key Lab Biophys, Guangzhou, Guangdong, Peoples R China Maison Teledetection, Inst Rech Dev, UMR Espace DEv, Montpellier, France Xiamen Univ, Sch Life Sci, Xiamen, Fujian, Peoples R China Nanjing Univ, Sch Med, Jinling Hosp, Natl Clin Res Ctr Kidney Dis,Dept Med Imaging, Nanjing, Jiangsu, Peoples R China Univ Kent, Sch Social Policy Sociol & Social Res, Canterbury, Kent, England Univ Fed Minas Gerais, Infect Dis & Trop Med, Belo Horizonte, MG, Brazil Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, Braga, Portugal Univ Montreal, Biochim & Med Mol, Montreal, PQ, Canada Johns Hopkins Bloomberg Sch Publ Hlth, Epidemiol, Baltimore, MD USA Max Planck Inst Biol Ageing, Metab & Genet Regulat Ageing, Cologne, Germany Univ Swaziland, Hlth Sci, Kwaluseni, Eswatini Queensland Univ Technol, Inst Future Environm, Brisbane, Qld, Australia Ctr Sci Monaco, Dept Biol Med, Monaco, Monaco HELIOS Hosp, Urol, Bad Saarow Pieskow, Germany Tech Univ Carolo Wilhelmina Braunschweig, Inst Microbiol, Braunschweig, Germany Univ Barcelona, Barcelona Ctr Maternal Fetal & Neonatal Med, Fetal i D Fetal Med Res Ctr, IDIBAPS BCNatal,Hosp Clin, Barcelona, Spain Univ Barcelona, Hosp St Joan de Deu, Barcelona, Spain Friedrich Loeffler Inst, Inst Bacterial Infect & Zoonoses, Jena, Germany Charite Med Univ Berlin, Neurol, Berlin, Germany Dublin City Univ, Natl Inst Cellular Biotechnol, Mol Therapeut Canc Ireland, Dublin, Ireland Schoen Clin Roseneck, Prien Am Chiemsee, Germany Univ Med Ctr Hamburg Eppendorf, Inst Sex Res & Forens Psychiat, Hamburg, Germany Nankai Univ, Sch Math Sci, Tianjin, Peoples R China Nankai Univ, LPMC, Tianjin, Peoples R China Univ Oxford, Oncol, Oxford, England Royal Holloway Univ London, Class, Egham, Surrey, England Cornell Univ, Clin Sci, Ithaca, NY USA Univ KwaZulu Natal, Pharmaceut Chem, Westville Campus, Durban, South Africa Royal Coll Surgeons Ireland, Med, Dublin, Ireland Univ Oslo, Dept Immunol, Oslo, Norway Bermuda Inst Ocean Sci, Marine Nitrogen Cycling Lab, St Georges, Bermuda Kanazawa Univ, Inst Liberal Arts & Sci, Kanazawa, Ishikawa, Japan World Hlth Org Reg Off Africa, Brazzaville, Rep Congo Univ Hosp BesanCon, Infect Control Dept, Besancon, France Galapagos NV, Clin Dev, Mechelen, Belgium Univ Tasmania, Integrated Marine Observing Syst, Hobart, Tas, Australia Georg August Univ Gottingen, Albrecht von Haller Inst Plant Sci, Dept Systemat Biodivers & Evolut Plants, Gottingen, Germany Univ Occupat & Environm Hlth, Dept Psychiat, Fukuoka, Fukuoka, Japan IMDEA Food, Program Precis Nutr & Aging, Madrid, Spain Radboud Univ Nijmegen, Med Sch, IQHealthcare, Nijmegen, Netherlands Maastricht Univ, Dept Cardiovasc Surg, Maastricht, Netherlands German Diabet Ctr, Inst Clin Biochem & Pathobiochem, Dusseldorf, Germany Juntendo Univ, Grad Sch Med, Dept Radiol, Tokyo, Japan Deakin Univ, Sch Informat Technol, Melbourne, Vic, Australia Max Planck Inst Eusenforschung, Dept Interface Chem & Surface Sci, Dusseldorf, Germany Edge Hill Univ, Dept Psychol, Ormskirk, England Aga Khan Univ, Psychiat, Karachi, Pakistan KRIBB, Korean Bioinformat Ctr, Seoul, South Korea Cardinal Hlth Specialty Solut, Hlth Econ & Outcomes Res, Dallas, TX USA Klinikum Univ Munchen, Div Clin Pharmacol, Munich, Germany Univ Pittsburgh, Neurol Surg, Pittsburgh, PA USA Rhein Westfal TH Aachen, Dept Child & Adolescent Psychiat Psychosomat & Ps, Aachen, Germany Univ Copenhagen, Inst Mol & Cellular Biol, Copenhagen, Denmark St Jude Childrens Res Hosp, Struct Biol, 332 N Lauderdale St, Memphis, TN 38105 USA Royal Shrewsbury Hosp, Colorectal Surg, Shrewsbury, Salop, England Univ Nottingham, Fac Med & Hlth Sci, Nottingham, England Karolinska Inst, Dept Physiol & Pharmacol, Solna, Sweden Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Jilin, Jilin, Peoples R China Univ British Columbia, Pediat, Vancouver, BC, Canada Chinese Acad Agr Sci, State Key Lab Cotton Biol, Res Base Anyang Inst Technol, Cotton Germplasm Resources,Inst Cotton Res, Beijing, Peoples R China Chinese Univ Hong Kong, Anaesthesia & Intens Care, Hong Kong, Peoples R China Univ Macau, ICMS, Zhuhai, Guangdong, Peoples R China North China Elect Power Univ, Sch Renewable Energy, Beijing, Peoples R China Justus Liegbig Univ, Dept Internal Med, Giessen, Germany Aarhus Univ, Biosci, Aarhus, Denmark Univ Dublin, Trinity Coll Dublin, Irish Longitudinal Study Ageing TILDA, Dublin, Ireland Univ Groningen, Univ Med Ctr Groningen, Hematol, Groningen, Netherlands Vrije Univ Amsterdam Med Ctr, Child Neurol, Amsterdam, Netherlands EBI, EMBL, Cambridge, England Max Planck Inst Marine Microbiol, HGF MPG Joint Res Grp Deep Sea Ecol & Technol, Bremen, Germany Max Planck Inst Human Dev, Ctr Adapt Rat, Berlin, Germany King Faisal Univ, Math, Al Hufuf, Saudi Arabia Griffith Univ, Sch Nursing & Midwifery, Gold Coast, Qld, Australia Iowa State Univ, Roy J Carver Dept Biochemsitry Biophys & Mol Biol, Ames, IA USA Delft Univ Technol, Fac Mech Maritime & Mat Engn, Engn Thermodynam Proc & Energy Dept, Leeghwaterstr 39, NL-2628 CB Delft, Netherlands Univ Nebraska Med Ctr, Coll Allied Hlth Profess, Cytotechnol Educ, Omaha, NE USA Shinko Mem Hosp, Dept Cardiovasc Med, Kobe, Hyogo, Japan Imperial Coll London, Mat, London, England Tech Univ Munich, Dept Surg, Munich, Germany Chinese Acad Agr Sci, Res Inst Pomol, Minist Agr, Lab Qual & Safety Risk Assessment Fruit Xingcheng, Shenyang, Liaoning, Peoples R China James Madison Univ, Commun Sci & Disorders, Harrisonburg, VA 22807 USA Univ Hosp Ulm, Inst Orthopaed Res & Biomech, Ulm, Germany Univ Essex, Sch Hlth & Social Care, Colchester, Essex, England Alpha Altis, Res Serv, Nottingham, England Erasmus MC, Med Oncol, Rotterdam, Netherlands Fed Univ Oye, Dept Ind Chem, Ekiti, Nigeria Duke Univ, Med Ctr, Cell Biol, Durham, NC USA Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England Univ Manchester, Canc Res UK Manchester Inst, Manchester, Lancs, England Helsinki Univ Hosp, Childrens Hosp, Helsinki, Finland Univ Aveiro, CESAM Ctr Environm & Marine Studies, Dept Biol, Aveiro, Portugal Univ Botswana, Psychol, Gaborone, Botswana Univ Fed Bahia, Nursing Sch, Salvador, BA, Brazil Queen Mary Univ London, Biol & Expt Psychol, London, England Natl Univ Pharm, Med Chem Dept, Kharkov, Ukraine Univ Bolton, Dept Educ & Psychol, Bolton, England La Trobe Univ, Dept Chem & Phys, Melbourne, Vic, Australia Gen Hosp Northern Theater Command, Dept Gastroenterol, Shenyang, Liaoning, Peoples R China Doctors Hosp, Dept Nephrol, Athens, Greece Univ Hosp Essen, Pediat 3, Essen, Germany Imperial Coll London, Infect Dis Epidemiol, London, England Sorbonne Univ, Dept Psychiat, Paris, France UNSW Sydney, Educ, Sydney, NSW, Australia Stanford Univ, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA Hannover Med Sch, Clin Laryngol Rhinol & Otol, Hannover, Germany Curtin Univ, Ctr Aboriginal Studies, Perth, WA, Australia Iran Univ Sci & Technol, Biomed Engn Dept, Tehran, Iran Univ Calif San Francisco, Anesthesiol, San Francisco, CA 94143 USA Khalifa Univ Sci & Technol, Mech Engn, Abu Dhabi, U Arab Emirates Univ Florida, Hort Sci, Gainesville, FL USA James Cook Univ, Australian Inst Trop Hlth & Med, Ctr Biodiscovery & Mol Dev Therapeut, Cairns, Qld, Australia Univ Porto, Fac Med, CINTESIS, Porto, Portugal Shaoxing Peoples Hosp, Med Res Ctr, Shaoxing, Zhejiang, Peoples R China NIH, Dept Transfus Med, Bethesda, MD 20892 USA AIIMS, Dept Biotechnol, New Delhi, India Univ Ottawa, Biochem Microbiol & Immunol, Ottawa, ON, Canada Univ Oslo, Inst Clin Med, Div Mental Hlth & Addict, Oslo, Norway Univ Groningen, Univ Med Ctr Groningen, Dept Radiol, Groningen, Netherlands Univ Hong Kong, Sch Nursing, Hong Kong, Peoples R China Tokyo Med Univ, Ibaraki Med Ctr, Urol, Tokyo, Japan Univ Hosp Zurich, Dept Radiat Oncol, Zurich, Switzerland Univ Maryland, Inst Human Virol, Div Immunotherapy, Baltimore, MD 21201 USA Univ Maryland, Dept Surg, Baltimore, MD 21201 USA Stellenbosch Univ, Fac Med & Hlth Sci, Div Mol Biol & Human Genet, Stellenbosch, South Africa China Agr Univ, Coll Biol Sci, Beijing, Peoples R China Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka, Japan Univ Washington, Biochem, Seattle, WA 98195 USA Natl Res Council Italy, Inst Biosci & BioResources, Naples, Italy Univ Lyon, Phys, Lyon, France Univ Basel, Fac Psychol, Ctr Social Psychol, Basel, Switzerland Queen Mary Univ London, Barts Canc Inst, Ctr Mol Oncol, London, England EBI, EMBL, Samples Phenotypes & Ontol Team, Cambridge, England Charles Sturt Univ, Fac Arts & Educ, Bathurst, NSW, Australia Shandong Univ, Helmholtz Inst Biotechnol, Sch Life Sci, State Key Lab Microbial Technol, Jinan, Shandong, Peoples R China Shantou Univ, Dept Biol, Shantou, Guangdong, Peoples R China Shanxi Univ, Inst Biomed Sci, Taiyuan, Shanxi, Peoples R China St Jude Childrens Res Hosp, Computat Biol, 332 N Lauderdale St, Memphis, TN 38105 USA Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Heilongjiang, Peoples R China NIH, Radiol & Imaging Sci, Bldg 10, Bethesda, MD 20892 USA Georgia Inst Technol, Dept Biol Sci, Atlanta, GA 30332 USA XtalPi Inc, Cambridge, MA USA Consejo Nacl Invest Cient & Tecn, Partner Inst Max Planck Soc, Inst Invest Biomed Buenos Aires IBioBA, Bioinformat, Buenos Aires, DF, Argentina Univ Sydney, Save Sight Inst, Sydney, NSW, Australia Univ South Australia, Canc Res Inst, Australian Ctr Precis Hlth, Adelaide, SA, Australia Jinan Univ, Inst Life & Hlth Engn, Guangdong Higher Educ Inst, Key Lab Funct Prot Res, Guangzhou, Guangdong, Peoples R China Univ Texas Hlth Sci Ctr Houston, Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA Weill Cornell Med, Dept Microbiol & Immunol, New York, NY USA Guangdong Inst Appl Biol Resources, Biotechnol Lab, Guangzhou, Guangdong, Peoples R China Shandong Normal Univ, Coll Life Sci, Jinan, Shandong, Peoples R China Shandong Univ, Life Sci Dept, Jinan, Shandong, Peoples R China South China Agr Univ, Integrat Microbiol Res Ctr, Guangzhou, Guangdong, Peoples R China Liaoning Acad Agr Sci, Crop Mol Improving Lab, Shenyang, Liaoning, Peoples R China Lawson Hlth Res Inst, Med Biophys, London, ON, Canada Univ Melbourne, Infrastruct Engn, Parkville, Vic, Australia Univ Canberra, Fac Hlth, Canberra, ACT, Australia Univ Cambridge, MRC Cognit & Brain Sci Unit, Cambridge, England Emory Univ, Biostat & Bioinformat, Atlanta, GA 30322 USA Johns Hopkins Sch Med, Anesthesiol & Crit Care Med, Baltimore, MD USA Nottingham Trent Univ, Sch Anim Rural & Environm Sci, Nottingham, England Univ Exeter, Biosci, Exeter, Devon, England Hillingdon Hosp NHS Fdn Trust, London, England Univ Glasgow, MRC CSO Social & Publ Hlth Sci Unit, Glasgow, Lanark, Scotland Natl & Kapodistrian Univ Athens, Evaggelismos Athens Hosp, ICU, Athens, Greece Univ Newcastle, Biol Sci, Callaghan, NSW, Australia Coventry Univ, Fac Hlth & Life Sci, Ctr Innovat Res Life Course, Coventry, W Midlands, England Lausanne Univ Hosp, Serv Endocrinol Diabet & Metab, Lausanne, Switzerland Charles Sturt Univ, Sch Community Hlth, Bathurst, NSW, Australia Queens Univ Belfast, Inst Global Food Secur, Belfast, Antrim, North Ireland Natl Univ Singapore, Inst Policy Studies, Singapore, Singapore Univ Penn, Intitute Med & Engn, Philadelphia, PA 19104 USA Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA Univ Michigan, EECS, Ann Arbor, MI 48109 USA Univ British Columbia, Ctr Blood Res, Vancouver, BC, Canada UiT Arctic Univ Norway, Dept Hlth & Care Sci, Fac Hlth Sci, Tromso, Norway Hosp Clin Porto Alegre, Physiotherapy, Porto Alegre, RS, Brazil Univ Paris 05, Med Sch, Paris, France Chinese Acad Agr Sci, Inst Crop Sci, Natl Key Facil Crop Gene Resources & Genet Improv, Beijing, Peoples R China Univ Ghent, Expt Clin & Hlth Psychol, Ghent, Belgium Indian Inst Adv Res, Bioinformat & Struct Biol, Gandhinagar, Gujart, India Bambino Ges Childrens Res Hosp, Lab Mol Med, Rome, Italy Heidelberg Univ, Ctr Infect Dis Parasitol, Heidelberg, Germany Stanford Univ, Elect Engn, Palo Alto, CA 94304 USA Univ Cadiz, Biol, Andalucia, Spain Mansoura Univ Hosp, Gen Surg, Mansoura, Egypt Inst Pasteur, Virol Pole, Dakar, Senegal Cardiff Univ, Div Canc & Genet, Cardiff, S Glam, Wales Ctr Expertise & Biol Diagnost Cameroon, Food Safety & Environm Microbiol, Yaounde, Cameroon Swiss Fed Labs Mat Sci & Technol, Lab Thin Films & Photovolta, Dubendorf, Switzerland Assiut Univ, Assiut Urol & Nephrol Hosp, Fac Med, Assiut, Egypt UCL, GEE, London, England UCL, IHA, London, England Univ Derby, Univ Derby Online Learning, Derby, England SUNY Stony Brook, Family Populat & Prevent Med, Stony Brook, NY 11794 USA Walter & Eliza Hall Inst Med Res, Mol Med Div, Melbourne, Vic, Australia Newcastle Univ, Northern Inst Canc Res, Newcastle Upon Tyne, Tyne & Wear, England German Ctr Neurodegenerat Dis, Clin Dementia Res, Bonn, Germany Sorbonne Univ, CNRS, UMR 7144, Stn Biol, Paris, France Univ Barcelona, Odontoestomatol, Barcelona, Spain Janelia Res Campus, Comp Sci, Ashburn, VA USA Univ Oxford, Ctr Trop Med & Global Hlth, Oxford, England Univ Bern, ARTORG Ctr Biomed Engn Res, Bern, Switzerland Australian Natl Univ, Eccles Inst Neurosci, John Curtain Sch Med Res, Canberra, ACT, Australia John Innes Ctr, Metab Biol, Norwich, Norfolk, England USDA ARS, Genom & Bioinformat Res Unit, Raleigh, NC 27695 USA Med Univ Graz, Inst Med Informat Stat & Documentat, Holzinger Grp, Graz, Austria Ajou Univ, Pharm, Suwon, South Korea City Univ Hong Kong, Sch Energy & Environm, Hong Kong, Peoples R China Univ British Columbia, Sch Kinseiol, Vancouver, BC, Canada Univ Copenhagen, Marine Biol Sect, Dept Biol, Copenhagen, Denmark Univ Vienna, Dept Commun, Vienna, Austria Univ Dundee, Sch Social Sci, Dundee, Scotland Tech Univ Dresden, Inst Bot, Dresden, Germany Univ Oxford, Div Struct Biol, Oxford, England Natl Univ Hlth Syst, Med, Singapore, Singapore Univ Canterbury, Sch Biol Sci, Christchurch, New Zealand Univ Hosp Southern Denmark, Focused Res Unit Mol Diagnost & Clin Res, Odense, Denmark Univ Oxford, Primary Care Hlth Sci, Oxford, England Baylor Coll Med, Verna & Marrs McLean Dept Biochem & Mol Biol, Houston, TX 77030 USA Adnan Menderes Univ Aydin, Fac Nursing, Dept Publ Hlth Nursing, Aydin, Turkey Oasi Res Inst IRCCS, Dept Neurol IC, Troina, Italy Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA Kings Coll London, Kings Ctr Mil Hlth Res, London, England LSHTM, Dept Infect Dis Epidemiol, London, England Leibniz Univ Hannover, BMWZ Organ Chem, Hannover, Germany Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Xian, Shaanxi, Peoples R China Univ South Australia, Sch Pharm & Med Sci, Adelaide, SA, Australia Univ Fed Santa Catarina, Dept Phys Educ, Florianopolis, SC, Brazil Southern Med Univ, Nanfang Hosp, Dept Oncol, Guangzhou, Guangdong, Peoples R China Stanford Univ, Hansen Expt Phys Lab, Palo Alto, CA 94304 USA Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Inst Translat Med, Shenzhen, Guangdong, Peoples R China Univ Hong Kong, Dept Stat & Actuarial Sci, Hong Kong, Peoples R China UCL, Dept Mech Engn, London, England ASTAR, Singapore Immunol Network, Lab Microbial Immun, Singapore, Singapore Cent South Univ, State Key Lab Powder Met, Changsha, Hunan, Peoples R China Univ Aberdeen, Inst Appl Hlth Sci, Aberdeen, Scotland Univ Bridgeport, Biomed Engn, Bridgeport, CT 06601 USA Texas Tech Univ, Hlth Sci Ctr, Pharmaceut Sci, Lubbock, TX 79430 USA Univ Montana, Ecosyst & Conservat Sci, Missoula, MT 59812 USA Univ Goettingen, Dept Syst Neurosci, Gottingen, Germany NHLBI, Lab Syst Genet, Bldg 10, Bethesda, MD 20892 USA Cleveland Clin, Lou Ruvo Ctr Brain Hlth, Imaging, Las Vegas, NV USA Flinders Univ S Australia, Coll Nursing & Hlth Sci, Nutr & Dietet, Adelaide, SA, Australia Univ Padua, Dept Math, Padua, Italy Lund Univ, Fac Law, Lund, Sweden Univ Gothenburg, Dept Microbiol & Immunol, Gothenburg, Sweden NARO, Kachwekano Zardi, Entebbe, Uganda Natl Yunlin Univ Sci & Technol, Bachelor Program Interdisciplinary Studies, Touliu, Yunlin, Taiwan Aarhus Univ, Dept Biomed, Danish Res Inst Translat Neurosci DANDRITE, Aarhus, Denmark Eduardo Mondlane Univ, Math & Comp Sci, Maputo, Mozambique Univ Bern, Dept Old Age Psychiat & Psychotherapy, Bern, Switzerland RAS, Inst Cytol, Lab Cytol Unicellular Organisms, St Petersburg, Russia Beijing Inst Technol, Sch Chem & Chem Engn, Beijing, Peoples R China Univ Queensland, Queensland Alliance Agr & Food Innovat, Brisbane, Qld, Australia Fraunhofer Inst Toxicol & Expt Med ITEM, Inhalat Toxicol, Hannover, Germany Univ Hong Kong, Publ Hlth, Hong Kong, Peoples R China Univ Hlth Network, Anesthesia & Pain Med, Toronto, ON, Canada Univ Toronto, Toronto, ON, Canada Univ Bath, Dept Hlth, Bath, Avon, England Univ Copenhagen, Computat & RNA Biol, Copenhagen, Denmark Fisheries & Oceans Canada, Bedford Inst Oceanog, Dartmouth, NS, Canada Goethe Univ, CEF MC, BMLS, Phys Biol, Frankfurt, Germany Albert Einstein Coll Med, Anat & Struct Biol, New York, NY USA Queensland Govt, Dept Environm & Sci, Brisbane, Qld, Australia Uppsala Univ, Vasc Surg Sect, Dept Surg Sci, Uppsala, Sweden Childrens Canc Hosp, Res, Cairo, Egypt Leibniz Inst Nat Prod Res & Infect Biol, Bio Pilot Plant, Jena, Germany Duy Tan Univ, Inst Res & Dev, Da Nang, Vietnam Univ Helsinki, Helsinki Inst Life Sci HiLIFE, Helsinki, Finland Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld, Australia George Inst Global Hlth, Sydney, NSW, Australia Griffith Univ, Griffith Inst Drug Discovery, Brisbane, Qld, Australia Dezhou Univ, Coll Phys & Elect Informat, Shandong Prov Key Lab Biophys, Dezhou, Peoples R China Henan Agr Univ, Coll Life Sci, Zhengzhou, Henan, Peoples R China Univ Tokyo, Publ Hlth, Tokyo, Japan Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China Univ Illinois, Dept Med, Chicago, IL USA Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China Minist Hlth, Key Lab Neonatal Dis, Shanghai, Peoples R China Covenant Univ, Dept Phys, Ota, Nigeria Prince Sattam Bin Abdulaziz Univ, Dept Phys Therapy & Hlth Rehabil, Al Kharj, Saudi Arabia Lund Univ, Cognit Sci, Malmo, Sweden Natl Open Univ Nigeria, Dept Publ & Environm Hlth, Abuja, Nigeria Peking Univ, Sch Publ Hlth, Dept Lab Sci & Technol, Beijing, Peoples R China Univ Sydney, Sch Publ Hlth, Menzies Ctr Hlth Policy, Sydney, NSW, Australia Univ Auckland, Dept Elect & Comp Engn, Auckland, New Zealand Beijing Univ Chinese Med, Res Ctr TCM Informat Engn, Beijing, Peoples R China Osped Niguarda Ca Granda, Cardiac Surg, Milan, Italy Univ Vet Med, Clin Horses, Hannover, Germany Harbin Med Univ, Lab Med Genet, Harbin, Heilongjiang, Peoples R China Univ Saskatchewan, Dept Psychol, Saskatoon, SK, Canada Univ Coimbra, Ctr Studies Geog & Spatial Planning CEGOT, Coimbra, Portugal Univ Groningen, Univ Med Ctr Groningen, Epidemiol, Groningen, Netherlands South Cent High Specialty Hosp, Dept Neurol & Neurosurg, Pemex, Mexico Shandong Agr Univ, Coll Informat Sci & Engn, Tai An, Shandong, Peoples R China Curtin Univ, Natl Drug Res Inst, Perth, WA, Australia Wageningen Bioveterinary Res, Bacteriol & Epidemiol, Lelystad, Netherlands Guangdong Second Prov Gen Hosp, Dept Rheumatol & Immunol, Guangzhou, Guangdong, Peoples R China Erasmus MC, Biomed Rngineering, Rotterdam, Netherlands Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Hiroshima, Japan Univ Iceland, Sch Hlth Sci, Reykjavik, Iceland Ohio State Univ, Mat Sci & Engn, Columbus, OH 43210 USA Kathmandu Univ, Sch Med Sci, Dept Physiotherapy, Dhulikhel, Nepal Univ Queensland, Sch Biomed Sci, Brisbane, Qld, Australia Fraunhofer MEVIS, Image Guided Therapies, Bremen, Germany Natl Univ Hlth Syst, Haematol Oncol, Singapore, Singapore Sun Yat Sen Univ, Canc Ctr, Breast Oncol, Guangzhou, Guangdong, Peoples R China Med Coll Wisconsin, Pharmacol & Toxicol, Wauwatosa, WI USA Queensland Univ Technol, Sci & Engn Fac, Sch Chem Phys & Mech Engn, Brisbane, Qld, Australia Univ Turin, Dept Mol Biotechnol & Hlth Sci, Turin, Italy Univ Tehran Med Sci, Sch Rehabil, Physiotherapy Dept, Tehran, Iran Univ Helsinki, Dept Forest Sci, Helsinki, Finland Univ Messina, Human Pathol, Messina, Italy AO Papardo Hosp Messina, Messina, Italy Univ Ibadan, Coll Med, Inst Child Hlth, Ibadan, Nigeria King Faisal Univ, Coll Med, Fac Ophthalmol, Al Hasa, Saudi Arabia Univ Stirling, Inst Social Mkt, Stirling, Scotland Saveh Univ Med Sci, Social Determinants Hlth Res Ctr, Saveh, Iran Gakujutsu Shien Co Ltd, Tokyo, Japan Chinese Acad Sci, Inst Geochem, Guiyang, Guizhou, Peoples R China Univ Plymouth, Med Sch, Plymouth, Devon, England CHU Toulouse, Immunol, Toulouse, France Azorean Biodivers Grp, Ctr Ecol Evolut & Environm Changes, Azores, Portugal Univ Acores, Azores, Portugal RIKEN, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan Peking Univ, Sch Publ Hlth, Dept Global Hlth, Beijing, Peoples R China Chang Gung Univ, Chang Gung Mem Hosp, Dept Neurol, Linkou Med Ctr, Taoyuan, Taiwan Chang Gung Univ, Coll Med, Taoyuan, Taiwan Univ Malawi, Coll Med, Biomed Sci Dept, Blantyre, Malawi Univ Malawi, Coll Med, Pharm Dept, Blantyre, Malawi Bioself Commun, Biocurat, Marseille, France Peking Univ, Hosp 3, Dept Neurol, Beijing, Peoples R China Ahmadu Bello Univ, Fac Basic Clin Sci, Coll Hlth Sci, Dept Pathol, Zaria, Nigeria Dalhousie Univ, Dept Anesthesia Pain Management & Perioperat Med, Halifax, NS, Canada VisMederi Srl, Siena, Italy UCL, Canc Res UK, London, England UCL, UCL Canc Trials Ctr, London, England Univ Ottawa, Family Med, Ottawa, ON, Canada China Agr Univ, Coll Engn, Beijing, Peoples R China Leiden Univ, Leiden Acad Ctr Drug Res, Div Drug Discovery & Safety, Leiden, Netherlands Sun Yat Sen Univ, Affiliated Hosp 1, Dept Intervent Radiol, Guangzhou, Guangdong, Peoples R China Amer Univ Beirut, Med Ctr, Infect Dis, Beirut, Lebanon Sheffield Hallam Univ, Dept Social Work Social Care & Community Studies, Sheffield, S Yorkshire, England Mechnikov Res Inst Vaccines & Sera, Viral Hepatitis, Moscow, Russia Univ Ottawa, Pediat, Ottawa, ON, Canada Vreden Russian Res Inst Traumatol & Orthopaed, Dept Wound Infect Treatment & Prevent, St Petersburg, Russia Hangzhou Ctr Dis Control & Prevent, Dept TB Control & Prevent, Hangzhou, Zhejiang, Peoples R China Kaohsiung Med Univ, Dept Biotechnol, Kaohsiung, Taiwan Zoetis, Diagnost, Kalamazoo, MI USA Aintree Univ Hosp NHS Fdn Trust, Head & Neck Oncol Res, Liverpool, Merseyside, England Wrightington Hosp, Trauma & Orthopaed, Manchester, Lancs, England Loyola Univ, Med Ctr, Dept Psychiat, 2160 S 1st Ave, Maywood, IL 60153 USA Atkins Vet Serv, Microbiol, Calgary, AB, Canada Univ Porto, FADEUP, CIAFEL, Porto, Portugal Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore Kangwon Natl Univ, Coll Biotechnol & Biosci, Dept Food Sci & Biotechnol, Chunchon, South Korea Kakatiya Med Coll, Internal Med, Warangal, Telangana, India Univ Antioquia, Vet Med Sch, CIBAV Res Grp, Medellin, Colombia IISER, Dept Phys, Soft & Act Matter Grp, Tirupati 517507, Andhra Pradesh, India Univ Rosario, Sch Med & Hlth, Ctr Studies Phys Activ Measurements, Bogota, Colombia Univ Hosp Essen, Cardiol & Vasc Med, Essen, Germany Univ Hosp Basel, Endocrinol, Basel, Switzerland Univ Tubingen, Inst Med Genet & Appl Genom, Tubingen, Germany Univ Hosp Munster, Div Gen Internal Med Nephrol & Rheumatolog, Dept Med D, Munster, Germany Univ Kentucky, Dept Nephrol, Lexington, KY USA Univ Freiburg, Dept Anaesthesiol & Crit Care, Med Ctr, Freiburg, Germany Univ Calif Irvine, Dept Med, Orange, CA 92668 USA Univ Hosp Leuven, Dept Urol, Leuven, Belgium Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China Univ Florida, Orthopaed & Rehabil, Gainesville, FL USA Chongqing Med Univ, Affiliated Hosp 1, Chongqing Key Lab Mol Oncol & Epigenet, Chongqing, Peoples R China Tsinghua Univ, Dept Chem Engn, Beijing, Peoples R China Yonsei Univ, Coll Med, Dept Pharmacol, Seoul, South Korea Childrens Hosp Kings Daughters, Eastern Virginia Med Sch, Dept Pediat, Norfolk, VA USA China Three Gorges Univ, Coll Sci, Dept Math, Yichang, Peoples R China Xiangtan Univ, Coll Informat Engn, Xiangtan, Hunan, Peoples R China Univ Hlth Network, Mood Disorders & Psychopharmacol, Toronto, ON, Canada Sao Paulo State Univ UNESP, Dept Anim Sci, Sao Paulo, Brazil Sao Paulo State Univ, Vet Clin, Sao Paulo, Brazil

Published
2019
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44. In vitro cytotoxic and in vivo antitumoral activities of some aminomethyl derivatives of 2,4‐dihydro‐3H‐1,2,4‐triazole‐3‐thiones—Evaluation of their acetylcholinesterase and carbonic anhydrase enzymes inhibition profiles

Author

Ali Osman Çeribaşi, Umit M. Kocyigit, Mehmet Çiftçi, Parham Taslimi, Metin Koparir, İrfan Timur, Mustafa Karatepe, Taner Daştan, Suleyman Sandal, İlhami Gülçin, [Timur, Irfan -- Ciftci, Mehmet] Bingol Univ, Fac Sci, Dept Chem, Bingol, Turkey -- [Kocyigit, Umit M.] Cumhuriyet Univ, Vocat Sch Hlth Serv, TR-58140 Sivas, Turkey -- [Dastan, Taner] Cumhuriyet Univ, Yildizeli Vocat Sch, Dept Med Serv & Tech, Sivas, Turkey -- [Sandal, Suleyman] Inonu Univ, Fac Med, Dept Physiol, Malatya, Turkey -- [Ceribasi, Ali Osman] Firat Univ, Fac Vet Med, Dept Pathol, Elazig, Turkey -- [Taslimi, Parham -- Gulcin, Ilhami] Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey -- [Koparir, Metin -- Karatepe, Mustafa] Firat Univ, Fac Sci, Dept Biochem, Elazig, Turkey, CERIBASI, Ali Osman -- 0000-0002-6096-4042, Gulcin, ilhami -- 0000-0001-5993-1668, and Bartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümü

Subjects
0301 basic medicine, Antioxidant, MDA, Health, Toxicology and Mutagenesis, medicine.medical_treatment, carbonic anhydrase, Triazole, Toxicology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Carbonic anhydrase, medicine, enzyme inhibition, Molecular Biology, chemistry.chemical_classification, 030102 biochemistry & molecular biology, biology, Chemistry, Vitamin E, General Medicine, Acetylcholinesterase, In vitro, Enzyme inhibition, triazole, Enzyme, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, antitumoural activity, Antitumoural activity
Abstract

WOS: 000455510900008, PubMed ID: 30368973, The 1,2,4-triazole and its derivatives were reported to exhibit various pharmacological activities such as antimicrobial, analgesic, anti-inflammatory, antitumoural, cytotoxic, and antioxidant properties. In this study, a series of triazole compounds (M1-M10) were evaluated for some biological activities. In vitro qualifications of these compounds on acetylcholinesterase (AChE) and human carbonic anhydrase enzyme activities were performed. Also, their antitumoral activities in human colon cancer (HT29) cell line cultures were examined. In addition, colon cancer experimentation was induced in rats by an in vivo method, and the in vivo anticancer effects of triazole derivatives were investigated. Also, the effects of these derivatives in levels of antioxidant vitamin A, vitamin E, and MDA were studied in rat liver and blood samples. Most of the compounds were found to exhibit significant antioxidant and antitumoral activities. All the compounds had cytotoxic activities on HT29 cell lines with their IC50 values lower than 10 mu M concentrations. The low IC50 values of the compounds are M1 (3.88 mu M), M2 (2.18 mu M), M3 (4.2 mu M), M4 (2.58 mu M), M5 (2.88 mu M), M6 (2.37 mu M), M7 (3.49 mu M), M8 (4.01 mu M), M9 (8.90 mu M), and M10 (3.12 mu M).

Published
2018
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45. Bosumtwi impact structure, Ghana: Evidence for fluidized emplacement of the ejecta

Author

Olivier Vanderhaeghe, M. S. Sapah, Mark Jessell, Daniel Boamah, David Baratoux, Cheikh Ahmadou Bamba Niang, Gayane Faye, Wolf Uwe Reimold, Sylvain Bouley, Géosciences Environnement Toulouse (GET), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Laboratoire des Mécanismes et Transfert en Géologie (LMTG), Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Inst Fondamental Afrique Noire Cheikh Anta Diop, Dakar, Senegal, Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Leibniz Inst Evolut & Biodivers Sci, Museum Nat Kunde, Invalidenstr 43, D-10115 Berlin, Germany, Univ Brasilia, Lab Geodynam Geochronol & Envoironmental Sci, Inst Geosci, Brasilia, DF, Brazil, Univ Ghana, Dept Earth Sci, Accra, Ghana, Univ Western Australia, Ctr Explorat Targeting, Sch Earth Sci, 35 Stirling Highway, Crawley, WA 6009, Australia, Geol Survey Dept, Accra, Ghana, Univ Cheikh Anta Diop, Lab Teledetect Appl, Inst Sci Terre, Dakar, Senegal, Géosciences Paris Sud (GEOPS), and Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)

Subjects
geography, Solar System, Plateau, geography.geographical_feature_category, biology, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Venus, Mars Exploration Program, 010502 geochemistry & geophysics, biology.organism_classification, 01 natural sciences, Geophysics, Impact crater, 13. Climate action, Space and Planetary Science, Ridge, [SDU]Sciences of the Universe [physics], 0103 physical sciences, Impact structure, Petrology, Ejecta, 010303 astronomy & astrophysics, Geology, 0105 earth and related environmental sciences
Abstract

International audience; The about 10.5 km diameter Bosumtwi impact crater is one of the youngest large impact structures on Earth. The crater rim is readily noticed on topographic maps or in satellite imagery. It defines a circular basin filled by water (Lake Bosumtwi) and lacustrine sediments. The morphology of this impact structure is also characterized by a circular plateau extending beyond the rim and up to 9-10 km from the center of the crater (about 2 crater radii). This feature comprises a shallow ring depression, also described as an annular moat, and a subdued circular ridge at its outer edge. The origin of this outermost feature could so far not be elucidated based on remote sensing data only. Our approach combines detailed topographic analysis, including roughness mapping, with airborne radiometric surveys (mapping near-surface K, Th, U concentrations) and field observations. This provides evidence that the moat and outer ring are features inherited from the impact event and represent the partially eroded ejecta layer of the Bosumtwi impact structure. The characteristics of the outer ridge indicate that ejecta emplacement was not purely ballistic but requires ejecta fluidization and surface flow. The setting of Bosumtwi ejecta can therefore be considered as a terrestrial analog for rampart craters, which are common on Mars and Venus, and also found on icy bodies of the outer solar system (e.g., Ganymede, Europa, Dione, Tethys, and Charon). Future studies at Bosumtwi may therefore help to elucidate the mechanism of formation of rampart craters.

Published
2018
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46. Synthesis and characterization of Cu(II) complexes of 2-amino-6-sulfamoylbenzothiazole and their inhibition studies on carbonic anhydrase isoenzymes

Author

Zeynep Alkan Alkaya, Tuncay Tunç, Cengiz Yenikaya, Metin Bülbül, Halil İlkimen, Ekrem Tunca, Musa Sarı, [Alkaya, Zeynep Alkan] Usak Univ, Banaz Vocat Sch, Dept Chem & Chem Proc Technol, TR-64500 Banaz, Usak, Turkey -- [Ilkimen, Halil -- Yenikaya, Cengiz] Dumlupinar Univ, Fac Arts & Sci, Dept Chem, TR-43100 Kutahya, Turkey -- [Tunca, Ekrem -- Bulbul, Metin] Dumlupinar Univ, Fac Arts & Sci, Dept Biochem, TR-43100 Kutahya, Turkey -- [Tunc, Tuncay] Aksaray Univ, Dept Sci Educ, Fac Educ, TR-68100 Aksaray, Turkey -- [Sari, Musa] Gazi Univ, Dept Phys Educ, TR-06500 Ankara, Turkey, Eğitim Fakültesi, and Uşak Üniversitesi, Banaz Meslek Yüksekokulu, Kimya Teknolojisi Bölümü

Subjects
Salt (chemistry), 010402 general chemistry, 01 natural sciences, Medicinal chemistry, Isozyme, Esterase, Proton transfer, 2-Amino-6-sulfamoylbenzothiazole, Metal complex, Inorganic Chemistry, Metal, Carbonic anhydrase, Materials Chemistry, medicine, Physical and Theoretical Chemistry, chemistry.chemical_classification, biology, 010405 organic chemistry, Chemistry, In vitro, 0104 chemical sciences, Statistical analyses, visual_art, visual_art.visual_art_medium, biology.protein, Acetazolamide, medicine.drug
Abstract

WOS: 000440125700023, 2-Amino-6-sulfamoylbenzothiazole (SMABT) and its proton transfer compound (HSMABT)(+)(HDPC)(-) (1) with 2,6-pyridinedicarboxylic acid (H2DPC), and their Cu(II) complexes (2 of SMABT, 3 and 4 of 1) have been prepared and characterized by spectroscopic techniques. Additionally, single crystal X-ray diffraction techniques were applied to all complexes. All compounds, including acetazolamide (AAZ) as the control compound, were also evaluated for their in vitro inhibition effects on human hCA I and hCA II for their hydratase and esterase activities. The synthesized complexes have remarkable inhibitory effects on hCA I and hCA II isoenzymes. The inhibition potentials of the proton transfer salt (1) and the metal complexes (2-4) are comparable with AAZ. Esterase K-i values of the compounds (1-4) are in the range of 0.089 +/- 0.008 mu M-0.149 +/- 0.017 mu M for hCA I and 0.046 +/- 0.008 mu M-0.085 +/- 0.019 mu M for hCA II. Inhibition data have been analyzed by using a one-way analysis of variance for multiple comparisons (p < 0.0001). (C) 2018 Published by Elsevier Ltd., Dumlupinar University Research Fund [2014/18]; Aksaray University of Science and Technology Application and Research Center [2010K120480], The authors acknowledge the support provided by Dumlupinar University Research Fund (grant No. 2014/18). In addition, the authors acknowledge Aksaray University of Science and Technology Application and Research Center, for the use of the Bruker SMART BREEZE CCD diffractometer (purchased under grant No. 2010K120480 of the State of Planning Organization).

Published
2018

47. Stability and bifurcation analysis in a host-parasitoid model with Hassell growth function

Author

Figen Kangalgil, Senol Kartal, and [Kangalgil, Figen] Cumhuriyet Univ, Dept Math, Fac Sci, Sivas, Turkey -- [Kartal, Senol] Nevsehir Haci Bektas Veli Univ, Dept Sci & Math Educ, Fac Educ, Nevsehir, Turkey

Subjects
Equilibrium point, Host-parasitoid model, 01 natural sciences, Stability (probability), 010305 fluids & plasmas, Parasitoid, Bifurcation theory, 0103 physical sciences, Applied mathematics, 0101 mathematics, Bifurcation, Mathematics, Algebra and Number Theory, Partial differential equation, Phase portrait, biology, lcsh:Mathematics, Applied Mathematics, Host–parasitoid model, lcsh:QA1-939, biology.organism_classification, Nonlinear Sciences::Chaotic Dynamics, 010101 applied mathematics, Local stability, Population model, Ordinary differential equation, Analysis
Abstract

WOS: 000438871000001, In this paper, a discrete-time host-parasitoid model with Hassell growth function for the host is considered. The sufficient conditions for the existence of the equilibrium points are obtained and a local stability analysis of the model is performed. By using the bifurcation theory it is shown that the system undergoes a Neimark-Sacker bifurcation. In addition, bifurcation diagrams and phase portraits of the model are given.

Published
2018

48. SP1-mediated downregulation of ADAMTS3 gene expression in osteosarcoma models

Author

Feray Köçkar, A. Tuğsen Aydemir, Meltem Alper, [Aydemir, A. Tugsen] Balikesir Univ, Fac Sci & Literature, Dept Biol, TR-10145 Balikesir, Turkey -- [Alper, Meltem] Aksaray Univ, Aksaray Vocat Sch Tech Sci, TR-68100 Aksaray, Turkey -- [Kockar, Feray] Balikesir Univ, Fac Sci & Literature, Dept Mol Biol, TR-10145 Balikesir, Turkey, and Aksaray Teknik Bilimler Meslek Yüksekokulu

Subjects
0301 basic medicine, Sp1 Transcription Factor, Saos-2, Type II collagen, CAAT box, Down-Regulation, Bone Neoplasms, Biology, Models, Biological, 03 medical and health sciences, 0302 clinical medicine, ADAMTS Proteins, Transcriptional regulation, Cell Line, Tumor, Gene expression, Genetics, Humans, Computer Simulation, Cloning, Molecular, Promoter Regions, Genetic, Gene, Osteosarcoma, Binding Sites, Promoter, General Medicine, MG-63, Cell biology, SP1, Gene Expression Regulation, Neoplastic, Procollagen peptidase, 030104 developmental biology, ADAMTS3, 030220 oncology & carcinogenesis, CpG Islands, Collagen, Procollagen N-Endopeptidase, Type I collagen
Abstract

WOS: 000433015400001, PubMed: 29518549, ADAMTS3 is a member of procollagen N-proteinase subfamily of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) gene family. It has an important function in the procollagen maturation process. The removal of N-peptidases is required for the accurate processing of fibrillar collagens. Otherwise, several disorders can occur that is related with the collagenous tissues. ADAMTS3 mainly maturates type II collagen molecule which is the main component of the bone and cartilage. There are several expression studies about ADAMTS3 gene however its transcriptional regulation has not been lightened up, yet. Here we first time cloned and functionally analyzed the promoter region of ADAMTS3 gene, approximately 1380 bp upstream of the transcription start site. Transient transfection experiments showed that all truncated promoter constructs are active and 171 bp fragment is sufficient to activate gene expression in both Saos-2 and MG63 cells. In silico analysis showed that ADAMTS3 has a TATA-less promoter and contains several SP1/GC box binding motifs and a CpG island. Therefore we mainly investigated the SP1 dependent regulation of ADAMTS3 promoter. SP1 downregulated ADAMTS3 transcriptional activity. As consistent with the transcriptional activity, mRNA, and protein expression levels were also decreased by SP1. On the other hand, functional binding of the SP1 on multiple regions of ADAMTS3 promoter was confirmed by EMSA studies. As ADAMTS3 is responsible for the collagen maturation and biosynthesis, further we investigated the effect of SP1 on type I II and III collagen gene expressions. We point out that SP1 increased type II and III collagen expression and in contrast decreased type I collagen expression levels in Saos-2 cells. mRNA expression level was decreased for all collagen types in MG63 model. Decrease in the type II collagen expression was also demonstrated at the protein level by SP1. Collectively these results provide first findings for the SP1-related transcriptional regulation of ADAMTS3 and collagen genes in osteosarcoma cell lines., Scientific and Technological Research Council of Turkey (TUBITAK) [114Z025], This work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) (114Z025).

Published
2018

49. Persistent Organic Chlorinated Compound Residues in the Breast Milk of Female Seasonal Agricultural Workers

Author

Enes Atmaca, Zeynep Şimşek, Kafiye Eroğlu, Zehra Gölbaşı, Fatma Koruk, Yavuz Kürşad Daş, [Eroglu, Kafiye] Koc Univ, Hemsirelik Fak, Sch Nursing, Davutpasa Cad, Topkapi Istanbul, Turkey -- [Das, Yavuz Kursad -- Atmaca, Enes] 19 Mayis Univ, Fac Vet Med, Dept Pharmacol & Toxicol, Kurupelit Kampusu, Atakum Samsun, Turkey -- [Golbasi, Zehra] Cumhuriyet Univ, Dept Nursing, Fac Hlth Sci, Sivas, Turkey -- [Simsek, Zeynep] Bilgi Univ, Sch Hlth, Haciahmet Mahallesi,Pir Husamettin Sokak, Istanbul, Turkey -- [Koruk, Fatma] Harran Univ, Sch Hlth Sci, Dept Nursing, Saglik Bilimleri Fak, Merkezi Derslik, Sanliurfa, Turkey, and Ondokuz Mayıs Üniversitesi

Subjects
Adult, Turkey, 010501 environmental sciences, Breast milk, Biology, 01 natural sciences, maternal health, Toxicology, Interviews as Topic, chemistry.chemical_compound, Young Adult, Occupational Exposure, Surveys and Questionnaires, Hydrocarbons, Chlorinated, Humans, 0105 earth and related environmental sciences, Retrospective Studies, Pollutant, Public information, Milk, Human, business.industry, organic chemicals, 010401 analytical chemistry, Public Health, Environmental and Occupational Health, Pesticide Residues, Polychlorinated biphenyl, Agriculture, Hexachlorobenzene, environmental epidemiology, humanities, 0104 chemical sciences, Dichlorodiphenyldichloroethylene, chemistry, breast feeding, Correlation analysis, occupational health, Female, business, toxicology
Abstract

WOS: 000446585900028, PubMed ID: 29851746, Objective: This retrospective descriptive study aimed to investigate organochlorine compounds in women who breastfeed and work as a seasonal agricultural worker (SAW). Methods: It was carried out on 100 woman working as SAW. Data were collected with a questionnaire by face-to-face interview and analyzed the residues of 27 items of organochlorine pesticides, dichlorodiphenyltrichloroethane (DDT) metabolites and polychlorinated biphenyls, from persistent organic pollutants in mothers' 50mL breast milk. Descriptive statistics, Chi-square test, and correlation analysis were used to evaluate data. Results: Polychlorinated biphenyl (PCB) 28 component was determined in almost all women's milk and more than half of collected milk contained beta-hexachlorocyclohexane (HCH), PCB52, pp'-dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB), PCB70, pp'-dichlorodiphenyltrichloroethane (DDT) ve Gamma HCH, respectively. Conclusion: It was recommended that necessary legal regulations and public information policy about that subject should exist., Scientific and Technological Research Council of Turkey (TUBITAK) [114S163], This work was supported (project number: 114S163) by the Scientific and Technological Research Council of Turkey (TUBITAK). The funders had no role in the design of the study, collection and analysis of the data, decision to publish, or preparation of the manuscript.

Published
2018

50. A Comparison of the Inhibitory Effects of Anti-Cancer Drugs on Thioredoxin Reductase and Glutathione S-Transferase in Rat Liver

Author

Deryanur Kilic, Uğur Güller, Ilknur Ozgencli, Harun Budak, Ömer İrfan Küfrevioğlu, Mehmet Çiftçi, Fen-Edebiyat Fakültesi, deryanur -- 0000-0002-9115-136X, and [Ozgencli, Ilknur -- Budak, Harun] Ataturk Univ, Sci Fac, Dept Mol Biol & Genet, TR-25240 Erzurum, Turkey -- [Ozgencli, Ilknur -- Kilic, Deryanur -- Kufrevioglu, Omer, I] Ataturk Univ, Sci Fac, Dept Chem, Erzurum, Turkey -- [Kilic, Deryanur] Aksaray Univ, Art & Sci Fac, Dept Chem, Aksaray, Turkey -- [Guller, Ugur] Igdir Univ, Dept Food Engn, Engn Fac, Igdir, Turkey -- [Ciftci, Mehmet] Bingol Univ, Art & Sci Fac, Dept Chem, Bingol, Turkey

Subjects
Male, Cancer Research, Thioredoxin-Disulfide Reductase, Anticancer Drug, Thioredoxin reductase, Antineoplastic Agents, Pharmacology, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Animals, Enzyme Inhibitors, Thioredoxin Reductase, Rat Liver, 030304 developmental biology, Inhibition, Glutathione Transferase, Cisplatin, chemistry.chemical_classification, 0303 health sciences, biology, Glutathione, Molecular Docking, Rats, Molecular Docking Simulation, Enzyme, Glutathione S-transferase, Paclitaxel, chemistry, Liver, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Doxorubicin Hydrochloride, Methotrexate, medicine.drug, Glutathione S-Transferase
Abstract

WOS: 000458732100013, PubMed: 30198440, Background: While Thioredoxin Reductase (TrxR) plays an important role in regulation of the intracellular redox balance and various signalling pathways, Glutathione S-Transferase (GSTs) enzymes belong to the detoxification family that catalyse the conjugation of glutathione with various endogenous and xenobiotic electrophiles. Since TrxR and GSTs are overexpressed in many cancer cells, they have been identified as potential targets to develop chemotherapeutic strategies. Method: The mitochondrial TrxR (TrxR2) enzyme and the cytosolic CYST enzyme was purified from rat liver via affinity chromatography. After the purification, the in vitro inhibition effects of some anticancer drugs (cisplatin, calcium folinate, carboplatin, epirubicin hydrochloride, doxorubicin hydrochloride, paclitaxel, etoposide, fluorouracil, and methotrexate) were investigated on both enzymes. Since only methotrexate inhibits both enzymes among all the anticancer drugs, a molecular docking study was performed to determine the binding site and the binding affinity of methotrexate to the enzymes. Results: Firstly, TrxR2 and GST were found to have a specific activity of 0.436, 1765 EU/mg proteins with a yield of 39.20%, 31.28% and 207.6, 3516.6 of purification fold, respectively. While TrxR2 was strongly inhibited by all of the anticancer drugs, GST was not inhibited by any of the anticancer drugs except methotrexate. Conclusion: Both enzymes were inhibited by only methotrexate in rat liver, and methotrexate was well placed in the active sites of both proteins. Therefore, it may be argued that methotrexate may be a more effective anticancer drug than all other drugs used in this study against the multi drug resistance that will occur during chemotherapy., Ataturk University Scientific Research Projects Coordination Commission (ATAUNIBAP) [PRJ2015/97, PRJ2015/357], This work was financially supported by Ataturk University Scientific Research Projects Coordination Commission (ATAUNIBAP) with project number PRJ2015/97 and PRJ2015/357. The author(s) have no potential conflict of interest with respect to the research, authorship, and/or publication of this article. Conceived and designed the experiments: Harun Budak (group leader) and Ilknur Ozgencli. Performed the experiments: Harun Budak, Ilknur Ozgencli, Deryanur Kilic, Ugur Guller, Mehmet Ciftci, and Omer I. Kufrevioglu. Analysed the data: Harun Budak, Ilknur Ozgencli, Deryanur Kilic, and Ugur Guller. Contributed reagents/materials/analysis tools: Harun Budak. Wrote the paper: Harun Budak, Ilknur Ozgencli, Deryanur Kilic, and Ugur Guller. All authors read and approved the final manuscript.

Published
2018

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