1. Genomewide Clonal Analysis of Lethal Mutations in the Drosophila melanogaster Eye: Comparison of the X Chromosome and Autosomes
- Author
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Christopher Lee, Thanh Luu, Maurine Tong, Cheryl Chan, Thomas Walsh, Mabel Chin, Jiong Chen, Jacob Makshanoff, Diane Vo, Yuli Chang, John M. Olson, Tony Hung, Yuki Yamauchi, Manyak Saakyan, Renata P. Lerner, Elizabeth Evers, Latiffe Amado, Nick Garrone, Carol Salame, Jesse M. Zaretsky, Eric Paul, Winston Wu, Trinh Tran, David Kohanchi, James Z. Hui, Neetika Srivastava, Allison M. Yabroff, Aria Hong, Daniel Solomin, Preethi Poulose, Brian Kirkpatrick, Katherine Wu, Eunha Kim, Abbas Anwar, Diane Tan, Nneka Orjiakor, Utpal Banerjee, Lindsay Hovestreydt, Riju Gupta, Michael Hsieh, Jian-ya Lin, Jennifer Leighn. Sta.Ana, Alex Pavlenko, Ardy Davarifar, Stephanie S. Latterman, Shekhar S. Pai, Qing Xu, Phyllis Gayda, Amir Yavari, Allen Bookatz, Kathy T. Ngo, Paul D. Picard, Srpouhi Gasparyan, ToHang S. Lee, Emily Skinner, Sanjit Datta, Jennifer D. Trinh, Sarah Brewer, Courtney Gonzalez, Matteo Pellegrini, Desiree Rosselli, Gerald B. Call, Gemma Lewis, Kosha Soneji, Quynh-Minh Tran, Amy W. Ku, Farzin Farshidi, Cynthia Nguyen, Vivek Singh, Tanya Minasian, Mara Pavel-Dinu, Chad Goffstein, Bryon C. Lim, So-Youn Lee, Stephanie S. Lauw, Long H. Nguyen, Kevin Yackle, Will Yarosh, Santino Laxamana, Chelsea E. Taber, Sarah Kim, Tiffany Liu, Stacy Chan, Armonde Baghdanian, Kelly Trangsrud, Robert Kwak, Gelsey L. Goodstein, Farnaz Shadpour, Mariam Guirguis, Wah-Yung Tsang, Jayantha Thiyanaratnam, Edwin Paz, Chloe Knudsen-Robbins, Tatiana Moroz, Arlene J. Formanes, Mei L. Iao, Latifat Alli, Shawn S. Badal, Kathleen Lin, PhuongThao Tran, Jamie L. Marshall, Regan S. Wong, Akanksha Chhabra, Ran X. Zhu, Amanda Abramson, Sarah Min, Amit Misra, Vanessa Soma, Blake E. Haas, Eddie Garcia, Ndidi Onugha, Divi Ramola, Ya-Whey Wu, Bogdana Kovshilovskaya, Crystal P. Y. Lui, Kai C. Lei, Jeyling Chou, Yasaman Moshfegh, Sohrab Sidhu, Mark E. L. Landig, Michael G. Yeranosian, James S. Yu, Laura Yee, Lydia S-H. Kim, Katrina Fischer, Angela Y. Kim, Junia J. Song, Melissa M. Kelley, Sheila Lezcano, Jingwen Tan, Vincent Luong, Jennifer J. Zhou, Christopher N.H. Bui, Jenny Chan, Sophia D. Jin, Natalie Buu, Emily Weiss, Amanda O'Donahue, Christian Sanchez, Andrew Folick, Nkau X. V. Yang, Christie Sun, Lephong Pham, Stephanie Calvillo, Charles Hu, Yein Kim, Aileen Chang, George Yen, Joy Wu, Poonam Desai, Linda Kao, Emily G. Travis, Mary Unkovic, Damien Wood, Miriam Segura, Marc Uemura, Henry Lin, Maggie Wells, Miles Morimoto, Sumit Datta, Kha Nguyen, Jessica Wickland, Christina C. Seifert, Leo Thai, Bhavin Padhiar, Hei J. Chan, Yibing Chen, Abhishek Shah, Julie Hong, Cheng R. Huang, Sara A. Baumann, Xibin A. Cheng, Russell Powell, Shawn J. Cokus, Sonia Arevalo, Anna L. Abrams, Mark Engeln, Minh-Tu Do, Joseph Cao, JiEun Lee, Brenda Hermogeno, Bassel Rifai, Preethika S Ekanayake, Alison S. Teruya, Carlyn Crisostomo, Lesley L. Leung, Toni Lee, Megan King, Amy Chan, William R. Marrs, Ryan Hassid, Elena Bibikova, Adam D. Langenbacher, Francie Diep, Jun Gong, Joann S. Lee, Manish Pandya, Emil Kohan, Daniel S. Lee, Jenny Anderson, Kristin Spivey, Devon M Huff, Yulee Kim, Thomas Kho, Alma Rangel, Janet Lee, Aneet Toor, Pamela Saarikoski, Nikki Villarasa, Julie Luu, Vivian N. Becerra, Yara A. Mikhaeil, Shahbaz Farnad, Vida Chitsazzadeh, Q. Angela Fang, Ju An, Leena Tekchandani, Tharani Prasad, Elsa Beyer, Christopher M. Allen, Fleurette Chong, Eric Lee, Meghann Ribbens, Sherrylene Go, Amrita K. Cheema, Jordan Fabrikant, Michael Safaee, An-Chi Mei, Peter Lin, Jessica Murray, Nina Sanchez, Katherine Fu, Sacha L. Prashad, Artemis Deravanesian, Erin Marsh, Robyn Tikia, Raymond W. Kung, Sarah Phaklides, Oganes H. Shilgevorkyan, Peter Dang, Aadit R. Patel, Erika Stageberg, Helena Minye, Alexander N. Patananan, Albert Cespedes, Kasey Topp, Vicky Hahm, Keenan Bashour, Joo Choi, Daniel Chang, Majid Moarefi, William Kim, Farid Jamshidian, Inderroop Singh, Aileen E. Chang, Miguel Meza, Edward Kuoy, Danny Ayoub, Aya Pusic, Daniel Sitz, Marina Stavchanskiy, Sophia Wu, Emily Vollmer, Angela Delosreyes, James Jen, Ernesto Nodado, Aram Shemmassian, Kirsten Regalia, Ramnik Singh, Arthur H. Baghdanian, Steve Tovar, H-C. Angela Liu, and Katrin Kahen
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Genetics Education ,Genetics ,Mutation ,Genes, Essential ,X Chromosome ,Autosome ,Genome, Insect ,Genes, Insect ,Biology ,Eye ,biology.organism_classification ,medicine.disease_cause ,Clonal analysis ,Clone Cells ,Drosophila melanogaster ,medicine ,Eye development ,Animals ,Genes, Lethal ,Drosophila (subgenus) ,Gene ,X chromosome - Abstract
Using a large consortium of undergraduate students in an organized program at the University of California, Los Angeles (UCLA), we have undertaken a functional genomic screen in the Drosophila eye. In addition to the educational value of discovery-based learning, this article presents the first comprehensive genomewide analysis of essential genes involved in eye development. The data reveal the surprising result that the X chromosome has almost twice the frequency of essential genes involved in eye development as that found on the autosomes.
- Published
- 2007
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