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2 results on '"Noah A Stueven"'

1. A Novel Stilbene-Like Compound That Reduces Melanin through Inhibiting Melanocyte Differentiation and Proliferation without Inhibiting Tyrosinase

Author

Noah A. Stueven, Aaron Monte, Kristy Martinson, and Cheng-chen Huang

Subjects
0301 basic medicine, MAPK/ERK pathway, Aging, melanocyte, Tyrosinase, proliferation, Pharmaceutical Science, Dermatology, Melanocyte, tyrosinase, lcsh:Chemistry, Melanin, 03 medical and health sciences, 0302 clinical medicine, Melanocyte differentiation, medicine, Chemical Engineering (miscellaneous), Protein kinase A, Protein kinase B, Zebrafish, biology, Chemistry, differentiation, biology.organism_classification, zebrafish, Cell biology, 030104 developmental biology, medicine.anatomical_structure, lcsh:QD1-999, 030220 oncology & carcinogenesis, skin-lightening, Surgery
Abstract

Cosmetic practices that use skin-lightening agents to obtain desired skin tones or treat pigment abnormalities have been popular worldwide. However, the molecular and cellular mechanisms of these agents are still largely unknown. Here we identified a family of compounds, with the lead compound named A11, that exhibited strong pigment reduction in developing zebrafish embryos. The pigment inhibition lasted for several days and is effective both before and after melanogenesis. By comparison with several known skin-lightening compounds, A11 appeared to be more potent and caused slower pigment recovery after withdrawal. A11, however, did not inhibit tyrosinase or cause apoptosis in melanocytes. We further found that A11 suppressed proliferation in melanocytes and reduced the number of differentiated melanocytes by activating MAPK (mitogen-activated protein kinase) and Akt. Finally, A11 also caused melanin reduction in mammalian melanocytes. Together, A11 might be a potent skin-lightening agent with novel mechanisms.

Published
2018
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2. Tales of diversity: Genomic and morphological characteristics of forty-six Arthrobacter phages

Author

Filippa G. Bagnasco, Melinda Harrison, Garrett Finn, David Dunbar, Machika Kaku, Rahat M. Aziz, Rodney A. King, Marisa Egan, Nitish S. Chimalakonda, Hannah M. Kolev, Daniel R. Evans, Allen W. Karstens, Christopher M. McDaniel, Lee E. Hughes, Megan L. Archambault, Marie C. Pizzorno, Jennifer E. Menninger, Robert C. Benjamin, Emily M. Lehmann, Karen K. Klyczek, Jakob R. Yankauskas, Hannah McDonald, Amelia M. Schick, Josephine E. Minick, Deborah Jacobs-Sera, Jade Connor, Megan C. Hartwell, Kayla M. Robinson, Haley Broomell, Kaitlyn E. Wathen, Kelly C. Lynch, Julia Y. Lee-Soety, Victoria A. Rose, Emily L. Stowe, Vassie C. Ware, Daniel S. Thomas, Bobby L. Gaffney, Shawn C. London, Daniel A. Russell, Kathryn M. Hyduchak, Jonathan L. Weinstein, Yasmene M. Warrad, Christine Zhang, Zachary T. Vonberg, Sarah Ball, Lorianna Vanderveen, Christopher J. Blasi, Corrina Tender, Morgan P. Silva, Katelyn M. Pruett, Claire A. Rinehart, Trevor Cross, Allison R. Thompson, Jeremy W. Sieker, Carter N. Lantz, Carlos A. Guerrero Bustamante, Katherine Borst, Jessica A. Dahlke, William Casazza, Cassandra T. Ott, Sarah K. Pellerino, Kelly E. Garrigan, J. Alfred Bonilla, Zachary S. Brynell, Morgan E. Lamey, Aswathi E. Jacob, Kate Allen, Emma A. Sweet, Francis E. Mele, Sierra N. Miller, Dylan Chudoff, Ashley B. Bue, Julia Schlossman, Graham F. Hatfull, Margaret A. Kenna, Kevin Hong Chen, Conner B. Brown, Christopher R. Fratus, Quynh D. Vo, Martha Nkangabwa, Mary A. Braun, Sydney O. Burke, Natalie Barrett, Bryan C. Gibbon, Courtney T. Nabua, Catherine M. Mageeney, William J. Pinamont, Stephanie E. Simon, Porter T. Swartz, Milan Dolan, Rohan Varma, Temiloluwa O. Lawson, Ross T. Pirnie, Kevin J. Mathew, Caroline K. Napoli, Rebecca A. Garlena, Jessica E. Medrano, Bethany M. Deaton, Welkin H. Pope, Chrystal Thomas, Michael A. Goedde, Amal Farooq, Gabbi Rickstrew, Hannah L. Vaught, A. Javier Lopez, Noah A. Stueven, Amanda L. Kobokovich, Tamarah L. Adair, Elizabeth A. Oates, Jacqueline F. Wyper, Elizabeth Kriese, Victoria M. Schneider, Susheel K. Khetarpal, Emily L. Heckman, Abby K. Fahnestock, Emilee J. Plautz, Travis N. Mavrich, Amanda K. Staples, Jonathan S. Lapin, Danielle M. DeNigris, Katrina Terry, In Young Lee, Sai A. Konde, Chloe A. Sells, Jennifer Huang, Marissa M. Silvi, Tetyana Martynyuk, Katherine C. DeRuff, Isabelle L. Steed, Kyra N. Curtis, Sarah J. Degroote, Scott M. Lee, Patrick A. Rimple, C. Joel McManus, Abigail T. Sweetman, Julia A. Cautela, and Patricia Afram

Subjects
0301 basic medicine, viruses, lcsh:Medicine, Astronomical Sciences, Genome, Biochemistry, Nucleotide diversity, Bacteriophage, Database and Informatics Methods, Rhodococcus, Bacteriophages, lcsh:Science, Genetics, education.field_of_study, Viral Genomics, Multidisciplinary, biology, Genomics, Proteases, Genomic Databases, Celestial Objects, Enzymes, Actinobacteria, Viruses, Physical Sciences, Research Article, Population, Genome, Viral, Microbial Genomics, Research and Analysis Methods, Microbiology, 03 medical and health sciences, Lysogenic cycle, Virology, Arthrobacter, education, Genome size, Comparative genomics, Bacteria, lcsh:R, Organisms, Genetic Variation, Biology and Life Sciences, Computational Biology, Proteins, Comparative Genomics, biology.organism_classification, Genome Analysis, Galaxies, 030104 developmental biology, Biological Databases, Enzymology, lcsh:Q
Abstract

The vast bacteriophage population harbors an immense reservoir of genetic information. Almost 2000 phage genomes have been sequenced from phages infecting hosts in the phylum Actinobacteria, and analysis of these genomes reveals substantial diversity, pervasive mosaicism, and novel mechanisms for phage replication and lysogeny. Here, we describe the isolation and genomic characterization of 46 phages from environmental samples at various geographic locations in the U.S. infecting a single Arthrobacter sp. strain. These phages include representatives of all three virion morphologies, and Jasmine is the first sequenced podovirus of an actinobacterial host. The phages also span considerable sequence diversity, and can be grouped into 10 clusters according to their nucleotide diversity, and two singletons each with no close relatives. However, the clusters/singletons appear to be genomically well separated from each other, and relatively few genes are shared between clusters. Genome size varies from among the smallest of siphoviral phages (15,319 bp) to over 70 kbp, and G+C contents range from 45-68%, compared to 63.4% for the host genome. Although temperate phages are common among other actinobacterial hosts, these Arthrobacter phages are primarily lytic, and only the singleton Galaxy is likely temperate.

Published
2017

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