1. 14-Noreudesmane sesquiterpenes from leaves of Nicotiana tabacum and their antiviral activity
- Author
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Yang Liu, Shang Shanzhai, Sun Han-dong, Chen Yongkuan, Zhu Donglai, Yang Guangyu, Pu Jian-Xin, Zhao Wei, and Tang Jian-Guo
- Subjects
biology ,Mosaic virus ,010405 organic chemistry ,Chemistry ,viruses ,Nicotiana tabacum ,fungi ,food and beverages ,Positive control ,Plant Science ,biology.organism_classification ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Botany ,Agronomy and Crop Science ,Two-dimensional nuclear magnetic resonance spectroscopy ,Biotechnology - Abstract
Three new 14-noreudesmane sesquiterpenes ( 1 3 ) as well as four known ones ( 4 7 ) were isolated from the leaves of Nicotiana tabacum . Their structures were determined mainly by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds 17 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compound 1 exhibited moderate anti-TMV activity with inhibition rate of 46.7%, which were higher than that of positive control (ningnanmycin).
- Published
- 2016