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Background: A high density of Helicobacter pylori is believed to trigger an accumulation of plasma cells in gastric mucosa as one of the inflammatory cells due to its high titer antibodies production circulated in blood system. We aimed to identify the correlation between total plasma cells and H. pylori density in gastric mucosa. Method: Endoscopic gastric biopsy tissues were stained by two different stains, Haematoxylin-Eosin and Modified Giemsa. The examination was performed by experienced pathologist. Results: The average age of chronic gastritis patients in this study was 48.80 years with standard deviation of 14.356. Out of 30 samples, 17 (56.7%) were female chronic gastritis patients. Female patients were dominating in most of categories of H. pylori density including 5 out of 9 patients (55.6%) in normal H. pylori density, 8 out of 14 patients (57.1%) in mild H. pylori density, and 3 out 5 patients (60.0%) in moderate H. pylori density. The average of total plasma cells in this study was 17.30 cells with standard deviation of 5.838. Importantly, there was no statistically significant correlation between total plasma cells and H. pylori density in gastric mucosa (p = 0.536). Although the distribution of total plasma cells was normal, there was no statistically significant difference of total plasma cells between positive and negative H. pylori density (p = 0.944). Conclusion: Plasma cells in gastric mucosa is unspecific for diagnosing H. pylori infection. Other causes associated with plasma cells are needed to be assessed for further study.