1. MicroRNA and gynecological cancers: Focus on miR-195.
- Author
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Davoodvandi, Amirhossein, Rafiyan, Mahdi, Mansournia, Mohammad Ali, Rajabpoor Nikoo, Nesa, Saati, Maryam, Samimi, Mansooreh, and Asemi, Zatollah
- Subjects
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CANCER cell proliferation , *CANCER stem cells , *INHIBITION of cellular proliferation , *MICRORNA , *EPITHELIAL-mesenchymal transition , *TUMOR suppressor genes - Abstract
Different cancer types have been shown to have down-regulated expression levels of miR-195 as an anti-tumor agent. MiR-195 family members can inhibit cancer cell proliferation, angiogenesis, epithelial-mesenchymal transition and metastases, immunosuppression, glycolysis, drug resistance, and cancer stem cell development by targeting the 3′-UTR of the mRNA of different pro-tumor genes. MiR-195 identified as a tumor suppressor miR in a variety of cancers, most notably gynecological malignancies such as cervical, endometrial, and ovarian carcinoma. As a result, restoring miR-195 expression should be regarded as a potential therapy for either prevention or treatment of gynecological cancers. This review will present the most recent data about miR-195-mediated anti-tumor effects in gynecological malignancies, emphasizing its downstream signaling pathways and target genes, as well as prospective treatment techniques. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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