11 results on '"Cantaluppi, Vincenzo"'
Search Results
2. Interaction between systemic inflammation and renal tubular epithelial cells.
- Author
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Cantaluppi V, Quercia AD, Dellepiane S, Ferrario S, Camussi G, and Biancone L
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- Acute Kidney Injury metabolism, Animals, Disease Progression, Epithelial Cells metabolism, Epithelial-Mesenchymal Transition, Humans, Inflammation metabolism, Kidney Tubules metabolism, Acute Kidney Injury pathology, Apoptosis, Biomarkers metabolism, Epithelial Cells pathology, Inflammation pathology, Kidney Tubules pathology
- Abstract
Systemic inflammation is known to target tubular epithelial cells (TECs), leading to acute kidney injury. Tubular cells have been implicated in the response to inflammatory mediators in ischaemic and septic renal damage. Moreover, loss of tubular cells by apoptosis or epithelial-to-mesenchymal transition may ingenerate conditions that lead to progression towards chronic kidney disease. On the other hand, TECs may actively contribute to the production of inflammatory mediators that may propagate the injury locally or in distant organs. In the present review, we discuss the tubular cell response and its contribution to systemic inflammation., (© The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.)
- Published
- 2014
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3. Neutrophil gelatinase-associated lipocalin: ready for routine clinical use? An international perspective.
- Author
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Ronco C, Legrand M, Goldstein SL, Hur M, Tran N, Howell EC, Cantaluppi V, Cruz DN, Damman K, Bagshaw SM, Di Somma S, and Lewington A
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- Acute Kidney Injury blood, Acute Kidney Injury diagnosis, Acute Kidney Injury mortality, Acute Kidney Injury therapy, Acute-Phase Proteins urine, Age Factors, Biomarkers urine, Burns blood, Burns therapy, Cardiopulmonary Bypass, Cardiovascular Diseases blood, Cardiovascular Diseases diagnosis, Clinical Trials as Topic, Critical Illness, Graft Survival, Humans, Intensive Care Units, Lipocalin-2, Lipocalins urine, Natriuretic Peptide, Brain blood, Proto-Oncogene Proteins urine, Renal Replacement Therapy, Resuscitation, Sepsis blood, Sepsis diagnosis, Treatment Outcome, Biomarkers blood, Lipocalins blood, Proto-Oncogene Proteins blood
- Abstract
Acute kidney injury (AKI) remains a challenge in terms of diagnosis and classification, its morbidity and mortality remaining high in the face of improving clinical protocols. Current clinical criteria use serum creatinine (sCr) and urine output to classify patients. Ongoing research has identified novel biomarkers that may improve the speed and accuracy of patient evaluation and prognostication, yet the route from basic science to clinical practice remains poorly paved. International evidence supporting the use of plasma neutrophil gelatinase-associated lipocalin (NGAL) as a valuable biomarker of AKI and chronic kidney disease (CKD) for a number of clinical scenarios was presented at the 31st International Vicenza Course on Critical Care Nephrology, and these data are detailed in this review. NGAL was shown to be highly useful alongside sCr, urinary output, and other biomarkers in assessing kidney injury; in patient stratification and continuous renal replacement therapy (CRRT) selection in paediatric AKI; in assessing kidney injury in conjunction with sCr in sepsis; in guiding resuscitation protocols in conjunction with brain natriuretic peptide in burn patients; as an early biomarker of delayed graft function and calcineurin inhibitor nephrotoxicity in kidney transplantation from extended criteria donors; as a biomarker of cardiovascular disease and heart failure, and in guiding CRRT selection in the intensive care unit and emergency department. While some applications require further clarification by way of larger randomised controlled trials, NGAL nevertheless demonstrates promise as an independent biological marker with the potential to improve earlier diagnosis and better assessment of risk groups in AKI and CKD. This is a critical element in formulating quick and accurate decisions for individual patients, both in acute scenarios and in long-term care, in order to improve patient prognostics and outcomes.
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- 2014
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4. Epigenetic Mechanisms in Sepsis-Associated Acute Kidney Injury.
- Author
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Fiorentino, Marco, Philippe, Reginald, Palumbo, Carmen A., Prenna, Stefania, Cantaluppi, Vincenzo, and Rosa, Silva De
- Subjects
ACUTE kidney failure ,METABOLIC reprogramming ,CHRONIC kidney failure ,RENAL replacement therapy ,NON-coding RNA ,EPIGENOMICS - Abstract
Sepsis, the dysregulated immune response of the host to infections, leads to numerous complications, including multiple organ dysfunction with sepsis-associated acute kidney injury (SA-AKI) being a frequent complication associated with increased risk of mortality and the progression toward chronic kidney disease (CKD). Several mechanisms have been widely investigated in understanding the complex pathophysiology of SA-AKI, including hemodynamic alterations, inflammation, oxidative stress, and direct cellular injury driven by pathogens or cell-derived products (pathogen-associated molecular patterns and damage-associated molecular patterns). Despite advancements in the management of septic patients, the prognosis of SA-AKI patients remains significantly poor and is associated with high in-hospital mortality and adverse long-term outcomes. Therefore, recent research has focused on the early identification of specific SA-AKI endotypes and subphenotypes through epigenetic analysis and the use of potential biomarkers, either alone or in combination with clinical data, to improve prognosis. Epigenetic regulation, such as DNA methylation, histone modifications, and noncoding RNA modulation, is crucial in modulating gene expression in response to stress and renal injury in SA-AKI. At the same time, these modifications are dynamic and reversible processes that can alter gene expression in several pathways implicated in the context of SA-AKI, including inflammation, immune response, and tolerance status. In addition, specific epigenetic modifications may exacerbate renal damage by causing persistent inflammation or cellular metabolic reprogramming, leading to progression toward CKD. This review aims to provide a comprehensive understanding of the epigenetic characteristics that define SA-AKI, also exploring targeted therapies that can improve patient outcomes and limit the chronic progression of this syndrome. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Pharmacotherapy considerations in patients who develop acute kidney injury during anti-cancer therapy.
- Author
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Parodi, Emanuele, Rossi, Maura, Bottiglieri, Achille, Ladetto, Marco, Merlotti, Guido, Cantaluppi, Vincenzo, and Quaglia, Marco
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DRUG therapy ,ACUTE kidney failure ,PLANT parenchyma ,CHRONIC kidney failure ,BIOMARKERS - Abstract
Acute kidney injury (AKI) frequently develops in patients receiving cancer therapy and requires a wide differential diagnosis due to possible role of unique cancer and drug-related factors, in addition to common pre- and post-renal causes. Rapid development of new molecular targeted anti-cancer drugs and immunotherapies has opened unprecedented possibilities of treatment at the price of an increased spectrum of renal side effects. The present review aims at providing a state-of-the-art picture of AKI in cancer patient (PubMed and Embase libraries were searched from inception to January 2024), with a focus on differential diagnosis and management of diverse clinical settings. Reports of parenchymal AKI due to glomerular, microvascular, tubular and interstitial damage have been constantly increasing. Complex electrolyte and acid-base disorders can coexist. The role of renal biopsy and possible therapeutic approaches are also discussed. Onconephrology has become an important subspecialty of clinical nephrology, requiring constantly updated skills and a high degree of interdisciplinary integration to tackle diagnostic challenges and even therapeutic and ethical dilemmas. Integrated onconephrological guidelines and availability of biomarkers may provide new tools for management of this unique type of patients in the near future. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Editorial: Community series in new insights in sepsis pathogenesis and renal dysfunction: immune mechanisms and novel management strategies: volume II.
- Author
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Honore, Patrick M., Stasi, Alexandra, and Cantaluppi, Vincenzo
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KIDNEY diseases ,SEPSIS ,COVID-19 ,PATHOGENESIS - Published
- 2023
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7. Blood–Brain Barrier Biomarkers before and after Kidney Transplantation.
- Author
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Hernandez, Leah, Ward, Liam J., Arefin, Samsul, Barany, Peter, Wennberg, Lars, Söderberg, Magnus, Bruno, Stefania, Cantaluppi, Vincenzo, Stenvinkel, Peter, and Kublickiene, Karolina
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KIDNEY transplantation ,BRAIN-derived neurotrophic factor ,BLOOD-brain barrier ,CHRONIC kidney failure ,EXTRACELLULAR vesicles ,BIOMARKERS - Abstract
Kidney transplantation (KT) may improve the neurological status of chronic kidney disease (CKD) patients, reflected by the altered levels of circulating BBB-specific biomarkers. This study compares the levels of neuron specific enolase (NSE), brain-derived neurotrophic factor (BDNF), neurofilament light chain (NfL), and circulating plasma extracellular vesicles (EVs) in kidney-failure patients before KT and at a two-year follow up. Using ELISA, NSE, BDNF, and NfL levels were measured in the plasma of 74 living-donor KT patients. Plasma EVs were isolated with ultracentrifugation, and characterized for concentration/size and surface protein expression using flow cytometry from a subset of 25 patients. Lower NSE levels, and higher BDNF and NfL were observed at the two-year follow-up compared to the baseline (p < 0.05). Male patients had significantly higher BDNF levels compared to those of females. BBB biomarkers correlated with the baseline lipid profile and with glucose, vitamin D, and inflammation markers after KT. BBB surrogate marker changes in the microcirculation of early vascular aging phenotype patients with calcification and/or fibrosis were observed only in NSE and BDNF. CD31+ microparticles from endothelial cells expressing inflammatory markers such as CD40 and integrins were significantly reduced after KT. KT may, thus, improve the neurological status of CKD patients, as reflected by changes in BBB-specific biomarkers. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors.
- Author
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Cantaluppi, Vincenzo, Dellepiane, Sergio, Tamagnone, Michela, Medica, Davide, Figliolini, Federico, Messina, Maria, Manzione, Ana Maria, Gai, Massimo, Tognarelli, Giuliana, Ranghino, Andrea, Dolla, Caterina, Ferrario, Silvia, Tetta, Ciro, Segoloni, Giuseppe Paolo, Camussi, Giovanni, and Biancone, Luigi
- Subjects
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NEUTROPHILS , *GELATINASES , *LIPOCALIN-2 , *BIOMARKERS , *KIDNEY transplantation , *ORGAN donors - Abstract
Background: Delayed graft function (DGF) is an early complication of kidney transplantation (KT) associated with increased risk of early loss of graft function. DGF increases using kidneys from extended criteria donors (ECD). NGAL is a 25KDa protein proposed as biomarker of acute kidney injury. The aim of this study was to investigate the role of NGAL as an early and accurate indicator of DGF and Tacrolimus (Tac) toxicity and as a mediator of tissue regeneration in KT from ECD. Methods: We evaluated plasma levels of NGAL in 50 KT patients from ECD in the first 4 days after surgery or after Tac introduction. Results: Plasma levels of NGAL at day 1 were significantly higher in DGF group. In the non DGF group, NGAL discriminated between slow or immediate graft function and decreased more rapidly than serum creatinine. NGAL increased after Tac introduction, suggesting a role as marker of drug toxicity. In vitro, hypoxia and Tac induced NGAL release from tubular epithelial cells (TEC) favoring an autocrine loop that sustains proliferation and inhibits apoptosis (decrease of caspases and Bax/Bcl-2 ratio). Conclusions: NGAL is an early and accurate biomarker of graft function in KT from ECD favoring TEC regeneration after ischemic and nephrotoxic injury. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
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9. Recent Advances on Biomarkers of Early and Late Kidney Graft Dysfunction.
- Author
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Quaglia, Marco, Merlotti, Guido, Guglielmetti, Gabriele, Castellano, Giuseppe, and Cantaluppi, Vincenzo
- Subjects
EXTRACELLULAR vesicles ,BIOMARKERS ,KIDNEY transplantation ,RENAL biopsy ,MOLECULAR pathology ,KIDNEYS - Abstract
New biomarkers of early and late graft dysfunction are needed in renal transplant to improve management of complications and prolong graft survival. A wide range of potential diagnostic and prognostic biomarkers, measured in different biological fluids (serum, plasma, urine) and in renal tissues, have been proposed for post-transplant delayed graft function (DGF), acute rejection (AR), and chronic allograft dysfunction (CAD). This review investigates old and new potential biomarkers for each of these clinical domains, seeking to underline their limits and strengths. OMICs technology has allowed identifying many candidate biomarkers, providing diagnostic and prognostic information at very early stages of pathological processes, such as AR. Donor-derived cell-free DNA (ddcfDNA) and extracellular vesicles (EVs) are further promising tools. Although most of these biomarkers still need to be validated in multiple independent cohorts and standardized, they are paving the way for substantial advances, such as the possibility of accurately predicting risk of DGF before graft is implanted, of making a "molecular" diagnosis of subclinical rejection even before histological lesions develop, or of dissecting etiology of CAD. Identification of "immunoquiescent" or even tolerant patients to guide minimization of immunosuppressive therapy is another area of active research. The parallel progress in imaging techniques, bioinformatics, and artificial intelligence (AI) is helping to fully exploit the wealth of information provided by biomarkers, leading to improved disease nosology of old entities such as transplant glomerulopathy. Prospective studies are needed to assess whether introduction of these new sets of biomarkers into clinical practice could actually reduce the need for renal biopsy, integrate traditional tools, and ultimately improve graft survival compared to current management. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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10. The Role of Osteopontin as a Diagnostic and Prognostic Biomarker in Sepsis and Septic Shock.
- Author
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Castello, Luigi Mario, Baldrighi, Marco, Molinari, Luca, Salmi, Livia, Cantaluppi, Vincenzo, Vaschetto, Rosanna, Zunino, Greta, Quaglia, Marco, Bellan, Mattia, Gavelli, Francesco, Navalesi, Paolo, Avanzi, Gian Carlo, and Chiocchetti, Annalisa
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SEPTIC shock ,EXTRACELLULAR matrix proteins ,OSTEOPONTIN ,SEPSIS ,RECEIVER operating characteristic curves - Abstract
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host-response to infections. Osteopontin (OPN) is an extracellular matrix protein involved in the inflammatory response. Our aim was to evaluate the diagnostic and prognostic performance in sepsis of a single OPN determination in the Emergency Department (ED). We conducted a single-centre prospective observational study in an Italian ED where we enrolled 102 consecutive patients presenting with suspected infection and qSOFA ≥ 2. OPN plasma concentration was found to be an independent predictor of sepsis (OR = 1.020, 95% CI 1.002–1.039, p = 0.031) and the diagnostic receiver operating characteristic (ROC) curve resulted in an area under the curve (AUC) of 0.878. OPN levels were positively correlated to plasma creatinine (r = 0.401 with p = 0.0001), but this relation was not explained by the development of acute kidney injury (AKI), since no difference was found in OPN concentration between AKI and non-AKI patients. The analysis of 30-days mortality showed no significant difference in OPN levels between alive and dead patients (p = 0.482). In conclusion, a single determination of OPN concentration helped to identify patients with sepsis in the ED, but it was not able to predict poor prognosis in our cohort of patients. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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11. Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis
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Mattia Bellan, Marco QUAGLIA, Nerviani, Alessandra, Mauro, Daniele, Lewis, Myles, Goegan, Federica, Gibbin, Antonello, Pagani, Sara, Livia Salmi, Luca Molinari, Castello, Luigi Mario, Avanzi, Gian Carlo, Cantaluppi, Vincenzo, Mario Pirisi, Pier Paolo Sainaghi, Pitzalis, Costantino, Bellan, M., Quaglia, M., Nerviani, A., Mauro, D., Lewis, M., Goegan, F., Gibbin, A., Pagani, S., Salmi, L., Molinari, L., Castello, L. M., Avanzi, G. C., Cantaluppi, V., Pirisi, M., Sainaghi, P. P., and Pitzalis, C.
- Subjects
Lupus nephriti ,Immunology ,Receptor Protein-Tyrosine Kinases ,Systemic lupus erythematosu ,TAM receptors ,Lupus Nephritis ,Plasma ,Rheumatology ,Gas6 ,Proto-Oncogene Proteins ,Humans ,Intercellular Signaling Peptides and Proteins ,Immunology and Allergy ,Biomarkers - Abstract
Objective Growth arrest-specific 6 (Gas6) and its receptors have been shown to play a crucial role in the homeostasis of the innate immune system by regulating apoptosis and inflammation. We aimed to verify whether an impairment of this system is associated with systemic lupus erythematosus (SLE) disease activity and with lupus nephritis (LN). Methods Plasma Gas6 and the soluble cleaved form of the receptors MerTK (sMer) and Axl (sAxl) concentrations were measured in n=59 SLE patients (n=44 with nephritis, 75%) and analysed in relationship to clinical and laboratory data. Results Patients with LN were characterised by higher Gas6 (19.0 ng/mL [16.8–24.5] vs. 16.5 ng/mL [13.89–18.91]; p=0.03) and sAxl plasma levels than those without LN (31.36 ng/mL [25.1–41.4] vs. 20.2 ng/mL [15.6–30.7]; p=0.03); conversely sMer plasma concentrations were similar between groups. All the three biomarkers studied were directly correlated to creatinine and daily proteinuria, being inversely related to creatinine clearance. 39 patients had a proteinuria level of
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