1. [Preoperative and postoperative serum VEGF-C levels and its clinical significance].
- Author
-
Hai-yun S, Deng-ting C, and Shou-yi D
- Subjects
- Adult, Aged, Breast Neoplasms metabolism, Breast Neoplasms pathology, Enzyme-Linked Immunosorbent Assay, Female, Humans, Middle Aged, Postoperative Period, Preoperative Period, Biomarkers blood, Breast Neoplasms blood, Prognosis, Vascular Endothelial Growth Factor C blood
- Abstract
Aim: To investigate the breast cancer patients before and after vascular endothelial growth factor-C (VEGF-C) levels and their clinical significance., Methods: Using enzyme-linked immunosorbent assay (ELISA) determination of 64 cases of breast cancer patients before surgery, serum levels of VEGF-C change, while the control group of 30 patients measured serum VEGF-C levels., Results: Breast cancer patients a month serum levels of VEGF-C expression compare to preoperative, and its expression level decreased significantly and showed statistically significant difference (P<0.01). Metastasis of breast cancer patients before serum levels of VEGF-C expression tha those without metastasis, showed statistically significant difference (P<0.01). Breast cancer preoperative serum VEGF-C expression was significantly higher than the normal control group, showed statistically significant difference (P<0.01)., Conclusion: VEGF in breast cancer growth and plays an important role in the increase of serum VEGF-C show a more aggressive biological behavior.
- Published
- 2010