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3 results on '"Luo, Bing"'

2. Low BDNF is associated with cognitive deficits in patients with type 2 diabetes

Author

Jia Zhang, Luo Bing Tian, Dong Hao Zhou, Hui Fang, Yan Feng Zhen, Thomas R. Kosten, Xiang Yang Zhang, and Xing Yu Liu

Subjects
Adult, Male, medicine.medical_specialty, Repeatable Battery for the Assessment of Neuropsychological Status, endocrine system diseases, Hippocampus, Type 2 diabetes, Neuropsychological Tests, Young Adult, Neurotrophic factors, Diabetes mellitus, Internal medicine, Neuroplasticity, medicine, Humans, Aged, Pharmacology, Brain-derived neurotrophic factor, Brain-Derived Neurotrophic Factor, nutritional and metabolic diseases, Cognition, Middle Aged, medicine.disease, Endocrinology, Diabetes Mellitus, Type 2, nervous system, Female, Cognition Disorders, Psychology, Neuroscience, Biomarkers, Psychomotor Performance
Abstract

Studies suggest that brain-derived neurotrophic factor (BDNF) plays an essential role in regulating memory-related neuroplasticity in the hippocampus. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF; however, the correlation of BDNF with cognitive impairment in T2DM has not been investigated.We compared 208 patients with T2DM to 212 normal controls on serum BDNF and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).Serum BDNF levels were significantly decreased in T2DM patients compared to normal controls (p 0.001). The total score and nearly all indexes (all p 0.01) except for attention and visuospatial/constructional indexes (all p 0.05) of RBANS were markedly lower in T2DM than controls. There was a positive relationship between serum BDNF and delayed memory in patients with T2DM.Our results suggest that BDNF may play a role in the pathophysiology of cognitive deficits, especially delayed memory in T2DM.

Published
2012

3. Screening and identification of key genes in EBV-associated gastric carcinoma based on bioinformatics analysis.

Author

Wang, Hanqing, Zhou, Lei, Yang, Yang, and Luo, Bing

Subjects
*STOMACH cancer, *EPSTEIN-Barr virus, *BIOMARKERS, *BIOINFORMATICS, *GENE expression
Abstract

Epstein-Barr virus (EBV) infection is closely related to gastric carcinoma (GC). In this study, we identified a set of DEGs (different expression genes) between EBVaGC (EBV-associated gastric carcinoma) and EBVnGC (EBV-negative gastric carcinoma) through multiple bioinformatics analysis using the data from GEO (Gene Expression Omnibus) dataset GSE51575, and identified ten hub genes (CXCL10, C3, CXCL9, CXCL11, SST, ICAM1, CHRM2, NPY, GBP5 and GBP1). Therefore, we performed relevant survival analysis and immune infiltration analysis, then verified the mRNA expression in GC cell lines and TCGA database. CXCL11 was finally selected to be a potential biomarker for a better prognosis and tumor infiltrating. This may provide a new view about immune therapy for EBVaGC. [ABSTRACT FROM AUTHOR]

Published
2021
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