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Your search keyword '"Pilar Martínez-Matsumoto"' showing total 2 results
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2 results on '"Pilar Martínez-Matsumoto"'

1. Serum concentrations of apoptosis-associated molecules in septic children with leukemia, neutropenia and fever

Author

Ana Elena Limón-Rojas, Erika Melchy Perez, Federico Javier Ortiz-Ibarra, Paola Guadalupe Castro-Oteo, Pilar Martínez-Matsumoto, Patricia Galindo-Delgado, Yvonne Rosenstein, Vicente Madrid-Marina, Alfredo Lagunas-Martínez, María Fernanda Fernández-Bautista, and Jesús Reyna-Figueroa

Subjects
0301 basic medicine, Male, Fas Ligand Protein, Neutropenia, Adolescent, Fever, Severity of Illness Index, Flow cytometry, Sepsis, 03 medical and health sciences, 0302 clinical medicine, medicine, Diagnostic biomarker, Humans, Prospective Studies, fas Receptor, Child, medicine.diagnostic_test, business.industry, Tumor Necrosis Factor-alpha, Hematology, Serum concentration, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Leukemia, 030104 developmental biology, Apoptosis, Receptors, Tumor Necrosis Factor, Type I, 030220 oncology & carcinogenesis, Immunology, Tumor necrosis factor alpha, Female, business, Biomarkers
Abstract

It has been shown that Fas, Fas-L, TNF and TNFR-1 display high serum concentrations in subjects with sepsis. This suggests that these are potential severity markers. However, the serum concentration of these molecules in children with leukemia and suspected sepsis has to be established before proposing their use as diagnostic biomarkers. We included children

Published
2016

2. [Procalcitonin as a diagnostic biomarker of sepsis in children with cancer, fever and neutropenia: literature review]

Author

Jesús, Reyna-Figueroa, Alfredo, Lagunas-Martínez, Pilar, Martínez Matsumoto, and Vicente, Madrid-Marina

Subjects
Calcitonin, Neutropenia, Fever, Neoplasms, Sepsis, Humans, Protein Precursors, Child, Biomarkers
Abstract

Among cancer and septic patients, there is a deregulation of common events such as inflammation. This fact limits the use of biomarkers to diagnose sepsis. Through a search in the PubMed database, we identified the clinical studies that evaluated procalcitonin as a biomarker among children with cancer and sepsis; we analyzed its characteristics, advantages and disadvantages. Most of the studies suggest that with a cut-off point between 0.5 ng/dl and 1 mg/dl, procalcitonin displays a sensitivity of 59-78%, a specificity of 76%, a predictive value of 93% and a negative predictive value of 45% to diagnose sepsis. The procalcitonin values were not modified by the use of chemotherapy or steroids. In the past few years, encouraging results have been obtained when using it as a biomarker in children with cancer, particularly with neutropenia and fever.

Published
2014

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