1. A microfluidic paper-based electrochemical biosensor array for multiplexed detection of metabolic biomarkers.
- Author
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Zhao, Chen, Thuo, Martin M, and Liu, Xinyu
- Subjects
- *
BIOSENSORS , *BIOMARKERS , *MICROFLUIDIC devices , *ELECTROCHEMICAL sensors , *POTENTIOSTAT - Abstract
Paper-based microfluidic devices have emerged as simple yet powerful platforms for performing low-cost analytical tests. This paper reports a microfluidic paper-based electrochemical biosensor array for multiplexed detection of physiologically relevant metabolic biomarkers. Different from existing paper-based electrochemical devices, our device includes an array of eight electrochemical sensors and utilizes a handheld custom-made electrochemical reader (potentiostat) for signal readout. The biosensor array can detect several analytes in a sample solution and produce multiple measurements for each analyte from a single run. Using the device, we demonstrate simultaneous detection of glucose, lactate and uric acid in urine, with analytical performance comparable to that of the existing commercial and paper-based platforms. The paper-based biosensor array and its electrochemical reader will enable the acquisition of high-density, statistically meaningful diagnostic information at the point of care in a rapid and cost-efficient way. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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