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Your search keyword '"Hsiao, Meng-Hsuan"' showing total 2 results
Start Over Author "Hsiao, Meng-Hsuan" Topic biomaterials
2 results on '"Hsiao, Meng-Hsuan"'

1. Biomedical applications and colloidal properties of amphiphilically modified chitosan hybrids.

Author

Larsson, Mikael, Huang, Wei-Chen, Hsiao, Meng-Hsuan, Wang, Yen-Jen, Nydén, Magnus, Chiou, Shih-Hwa, and Liu, Dean-Mo

Subjects
*AMPHIPHILES, *CHITOSAN, *BIOPOLYMERS, *INDUSTRIAL applications, *BIOMATERIALS, *DRUG delivery systems
Abstract

Abstract: Chitosan is among the most abundant biopolymers on earth and has been either used or exhibited potential in a wide variety of industrial and biomedical applications. With the advancement of materials technologies, chitosan has been chemically modified to self-assemble into nanoarchitectures that are usable in advanced biomedical applications, such as drug nanocarriers, macroscopic injectables, tissue-engineering scaffolds, and nanoimaging agents. Colloidal amphiphilically modified chitosan (AMC) is a relatively recent material receiving increased attention with numerous publications addressing the medical advantages of specific systems. To date, many reviews have focused on the synthesis and biomedical properties of chitosan-based biomaterials, but a comprehensive study focusing on the colloidal properties of AMC in relation to biomedical performance appears to be lacking. This review provides a survey of the field, critically reviewing the colloidal properties and biomedical performance of AMC systems, such as nanoparticle drug delivery systems and macroscopic medical devices. Finally, the future development, market potential, and clinical implications of these promising colloidal-structured biomaterials are summarised. [Copyright &y& Elsevier]

Published
2013
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2. A temperature-induced and shear-reversible assembly of latanoprost-loaded amphiphilic chitosan colloids: characterization and in vivo glaucoma treatment

Author

Mikael Larsson, Catherine Jui Ling Liu, Shih Hwa Chiou, Meng Hsuan Hsiao, Dean-Mo LIu, Kuo Hsuan Hung, Yi Ling Wang, Hsiao, Meng-Hsuan, Chiou, Shih-Hwa, Larsson, Mikael, Hung, Kuo-Hsuan, Wang, Yi-Ling, Liu, Catherine Jui-Ling, and Liu, Dean-Mo

Subjects
Male, Materials science, Biocompatibility, Biomedical Engineering, Nanotechnology, Biochemistry, Biomaterials, Chitosan, Colloid, chemistry.chemical_compound, Benzalkonium chloride, In vivo, Amphiphile, medicine, Animals, Humans, Colloids, Latanoprost, amphiphilic chitosan, Molecular Biology, Aged, thermogelling, Temperature, colloidal gel, Glaucoma, General Medicine, glaucoma, chemistry, Self-healing hydrogels, Prostaglandins F, Synthetic, Rabbits, Rheology, shear-reversible, Gels, Biotechnology, medicine.drug
Abstract

Hydrogels composed of assembled colloids is a material class that is currently receiving much interest and shows great promise for use in biomedical applications. This emerging material class presents unique properties derived from the combination of nanosized domains in the form of colloidal particles with a continuous gel network and an interspersed liquid phase. Here we developed an amphiphilic chitosanbased, thermogelling, shear-reversible colloidal gel system for improved glaucoma treatment and addressed how preparation procedures and loading with the anti-glaucoma drug latanoprost and commonly used preservative benzalkonium chloride influenced the mechanical properties of and drug release from the colloidal gels. The results highlight that incorporated substances and preparation procedures have effects both on mechanical properties and drug release, but that the release of drug loaded in the colloidal carriers is mainly limited by transport out of the carriers, rather than by diffusion within the gel. The developed colloidal chitosan based gels hold outstanding biomedical potential, as confirmed by the ease of preparation and administration, low cytotoxicity in MTT assay, excellent biocompatibility and lowering of intraocular pressure for 40 days in a rabbit glaucoma model. The findings clearly justify further investigations towards clinical use in the treatment of glaucoma. Furthermore, the use of this shear-reversible colloidal gel could easily be extended to localized treatment of a number of critical conditions, from chronic disorders to cancer, potentially resulting in a number of new therapeutics with improved clinical performance. Refereed/Peer-reviewed

Published
2013

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