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Distraction osteogenesis is an effective method for generating large amounts of bone in situ for treating pathologies such as large bone defects or skeletal malformations, for instance leg-length discrepancies. While an optimized distraction procedure might have the potential to reduce the rate of complications significantly, our knowledge of the underlying mechanobiological processes is still insufficient for systematic optimization of treatment parameters such as distraction rate or fixation stiffness. We present a novel numerical model of lateral distraction osteogenesis, based on a mechanically well-controlled in vivo experiment. This model extends an existing numerical model of callus healing with viscoplastic material properties for describing stress relaxation and stimuli history-dependent tissue differentiation, incorporating delay and memory effects. A reformulation of appositional growth based non-local biological stimuli in terms of spatial convolution as well as remeshing and solution-mapping procedures allow the model to cope with severe mesh distortions associated with large plastic deformations. With these enhancements, our model is capable of replicating the in vivo observations for lateral distraction osteogenesis in sheep using the same differentiation rules and the same set of parameters that successfully describes callus healing in sheep, indicating that tissue differentiation hypotheses originally developed for fracture healing scenarios might indeed be applicable to distraction as well. The response of the model to modified distraction parameters corresponds to existing studies, although the currently available data is insufficient for rigorous validation. As such, this study provides a first step towards developing models that can serve as tools for identifying both interesting research questions and, eventually, even optimizing clinical procedures once better data for calibration and validation becomes available. [ABSTRACT FROM AUTHOR]

The stiffness of fracture fixation devices together with musculoskeletal loading defines the mechanical environment within a long bone fracture, and can be quantified by the interfragmentary movement. In vivo results suggested that this can have acceleratory or inhibitory influences, depending on direction and magnitude of motion, indicating that some complications in fracture treatment could be avoided by optimizing the fixation stiffness. However, general statements are difficult to make due to the limited number of experimental findings. The aim of this study was therefore to numerically investigate healing outcomes under various combinations of shear and axial fixation stiffness, and to detect the optimal configuration. A calibrated and established numerical model was used to predict fracture healing for numerous combinations of axial and shear fixation stiffness under physiological, superimposed, axial compressive and translational shear loading in sheep. Characteristic maps of healing outcome versus fixation stiffness (axial and shear) were created. The results suggest that delayed healing of 3 mm transversal fracture gaps will occur for highly flexible or very rigid axial fixation, which was corroborated by in vivo findings. The optimal fixation stiffness for ovine long bone fractures was predicted to be 1000–2500 N/mm in the axial and >300 N/mm in the shear direction. In summary, an optimized, moderate axial stiffness together with certain shear stiffness enhances fracture healing processes. The negative influence of one improper stiffness can be compensated by adjustment of the stiffness in the other direction. [ABSTRACT FROM AUTHOR]

Clinical and experimental studies have shown that several mechanical factors influence the fracture healing process. One such factor, interfragmentary movement, is affected by loading and the stiffness of the fixation device. This study evaluated the stiffness of different external fixation devices for a rat femoral fracture model, using in vitro and analytical methods. The contribution to the stiffness of the fixation construct was dominated by the flexibility of the pins in relation to their offset, diameter, and material properties. The axial stiffness increased with decreasing offset and increasing pin diameter. Titanium pins resulted in significantly lower axial stiffness compared to stainless steel pins of the same design. The fixator body material and fixator length had a less pronounced influence on fixation stiffness. Mechanically characterized external fixation devices will allow in vivo study of the fracture healing process utilizing pre-calculated fracture fixation stiffness. These characterized fixation devices will allow controlled manipulation of the axial and shear interfragmentary movement to achieve a flexible fixation resulting in callus formation compared to a more rigid fixation limiting callus formation in a rat femoral fracture model. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27: 687-693, 2009 [ABSTRACT FROM AUTHOR]

Abstract: Background: The healing outcome of long bone fractures is strongly influenced by the mechanical environment. High interfragmentary movement at the fracture site is detrimental to the fracture healing process. Long bone fractures stabilized with thin intramedullary nails commonly used for unreamed intramedullary nailing might be very flexible in shear direction and therefore critical for the fracture healing outcome. The aims of this study were to simulate the shear interfragmentary movement during gait for a human tibia treated with intramedullary nailing and to investigate if this movement could be lowered by implant design modifications. Methods: The shear movement was calculated with a 3D finite element model based on computer tomograph images of a cadaver bone–implant complex of a transverse tibia fracture treated with a Stryker T2 Standard Tibial Nail. This model was validated through in vitro test results under pure shear, axial, bending and torsional loading. Findings: High shear movements of approximately 4mm were calculated during gait. These shear movements could be reduced by approximately 30% either by implant modifications or the use of a 1mm thicker nail. Combining the implant modifications with a 1mm thicker nail, the shear movements could be reduced by 54%. Interpretation: The increase of the fixation stiffness by using an implant material with a high Young''s modulus in combination with an angle–stable nail–screw fixation helps to reduce the shear movement during gait and possibly to lower the risk of a prolonged healing time with unreamed intramedullary nailing. [Copyright &y& Elsevier]

Background: The healing outcome of long bone fractures is strongly influenced by the interfragmentary movement of the bone fragments. This depends on the fixation stability, the optimum value of which is still not known. The aim of this study was to simulate a patient-specific human healing process using a numerical algorithm and to retrospectively analyse the influence of the fixation stability on the healing time. Methods: The healing simulation was processed as an initial value problem. This was iteratively solved based on two mechanical (invariants of the strain tensor, calculated through a finite element analysis) and five biological state variables (local tissue composition and blood perfusion) using a previously published fuzzy logic algorithm. For validation purposes, the calculated interfragmentary movement was compared to in vivo measurements of this patient. By changing clinically adjustable parameters of the fixation device, the influence of the fixation stability on the healing time was analysed. Finding: The time course showed good agreement of the interfragmentary movement compared with the in vivo measurements. The predicted healing time was strongly influenced by the fixation stability, i.e. by changing the parameters of the fixation device, it was possible to significantly reduce the healing time. Interpretation: The time to heal could be greatly reduced by modification of the fixator design, i.e. increasing the fixation stiffness. When using external fixation devices, this could be achieved by decreasing the free bending length of the pins, using a stiff fixation body and a stiff connection between the pins and the body. [Copyright &y& Elsevier]