1. Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics.
- Author
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Drewniak M, Węglarz-Tomczak E, Ożga K, Rudzińska-Szostak E, Macegoniuk K, Tomczak JM, Bejger M, Rypniewski W, and Berlicki Ł
- Subjects
- Amino Acid Sequence, Biomimetic Materials chemical synthesis, Catalysis, Helix-Loop-Helix Motifs, Hydrolases chemistry, Hydrolysis, Kinetics, Peptides chemical synthesis, Protein Engineering, Protein Unfolding, Biomimetic Materials chemistry, Peptides chemistry
- Abstract
De novo designed helix-loop-helix peptide foldamers containing cis-2-aminocyclopentanecarboxylic acid residues were evaluated for their conformational stability and possible use in enzyme mimetic development. The correlation between hydrogen bond network size and conformational stability was demonstrated through CD and NMR spectroscopies. Molecules incorporating a Cys/His/Glu triad exhibited enzyme-like hydrolytic activity., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2018
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