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Plastic has become essential for our economy and the packaging industry. However, plastic use is linked to environmental problems such as waste generation and loss of resources, since only 42% of the plastic used for packaging purposes is recycled. Another problem associated with the use of plastic materials is caused by their abandonment in the environment since they are non-degradable polymers. This paper analyses the environmental performance of using biodegradable poly-lactic acid bags, pure (PLA) and reinforced with nanoclays (PLA + NC), in comparison to conventional alternatives made of polyethylene (PE) and polypropylene (PP) for being used to pack fresh bakery products. The results reveal that for Climate Change and Fossil Resources use, PLA + NC performs better than the alternatives. In the case of Climate Change, it has 45% less impact than low density polyethylene (LDPE), 39% less than PP, and 2% less than PLA. However, the use of PLA + NC, results in higher impacts on Land Use and Water Use, because this is produced from crops. Compared with PLA, PLA + NC has 5% less impact on these impact categories, but between 99 and 100% more impact on Land Use and between 79 and 81% more impact on Water use than PP and LDPE. Thus, poly-lactic acid bags reinforced with nanoclays are shown as an alternative for fossil-based polymers (PE and PP) for certainty type of applications when we focus on Climate Change and Fossil resources use reduction. In this sense, the results also reveal that the most environmentally friendly end-of-life for PLA and PLA + NC is incineration instead of composting. • Comparison of fossil based (PP and PE) and plant-based polymers (PLA and PLA+NC). • LCA of different plastic bags to pack fresh bakery products. • PLA + NC is recommended if water vapour transmission rate is not critical for packing. • PLA and PLA + NC have more impact on land and water use than PP and PE. • PLA and PLA + NC have less impact on climate change and fossil resources use. [ABSTRACT FROM AUTHOR]