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Waste plastics represent major environmental and economic burdens due to their ubiquity, slow breakdown rates, and inadequacy of current recycling routes. Polyethylenes are particularly problematic, because they lack robust recycling approaches despite being the most abundant plastics in use today. We report a novel chemical and biological approach for the rapid conversion of polyethylenes into structurally complex and pharmacologically active compounds. We present conditions for aerobic, catalytic digestion of polyethylenes collected from post‐consumer and oceanic waste streams, creating carboxylic diacids that can then be used as a carbon source by the fungus Aspergillus nidulans. As a proof of principle, we have engineered strains of A. nidulans to synthesize the fungal secondary metabolites asperbenzaldehyde, citreoviridin, and mutilin when grown on these digestion products. This hybrid approach considerably expands the range of products to which polyethylenes can be upcycled. [ABSTRACT FROM AUTHOR]

Cover Picture: Conversion of Polyethylenes into Fungal Secondary Metabolites (Angew. Polyethylenes are first cleaved into carboxylic diacids using catalytic oxidation. Polyethylenes are first cleaved into carboxylic diacids using catalytic oxidation. [Extracted from the article]

Keywords: Biosynthesis; Catalysis; Polyethylenes; Synthetic Biology; Upcycling EN Biosynthesis Catalysis Polyethylenes Synthetic Biology Upcycling 1 1 1 01/19/23 20230123 NES 230123 B A novel, two-step chemical-biological approach b converts post-consumer polyethylenes into structurally diverse and pharmacologically active fungal natural products, as reported by Travis J. Williams, Clay C. C. Wang et al. in their Research Article (e202214609). Polyethylenes are first cleaved into carboxylic diacids using catalytic oxidation. Polyethylenes are first cleaved into carboxylic diacids using catalytic oxidation. [Extracted from the article]